MXPA05007497A - Derivados de acidos indenocarboxilicos y su uso para el tratamiento y prevencion de diabetes y dislipidemia. - Google Patents
Derivados de acidos indenocarboxilicos y su uso para el tratamiento y prevencion de diabetes y dislipidemia.Info
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- MXPA05007497A MXPA05007497A MXPA05007497A MXPA05007497A MXPA05007497A MX PA05007497 A MXPA05007497 A MX PA05007497A MX PA05007497 A MXPA05007497 A MX PA05007497A MX PA05007497 A MXPA05007497 A MX PA05007497A MX PA05007497 A MXPA05007497 A MX PA05007497A
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- saturated
- optionally substituted
- group
- unsaturated
- aliphatic hydrocarbon
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- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
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Abstract
La presente invencion se refiere a un compuesto de la formula: (ver formula I) en la que: n es un numero entero seleccionado entre 1, 2 y 3; Y representa O; N-OR9, en el que R9 representa H o un grupo alifatico hidrocarbonado saturado; CR10R11, en el que R10 y R11, que pueden ser identicos o diferentes, representan H o un grupo alifatico hidrocarbonado saturado; R1 y R2, que pueden ser identicos o diferentes, representan H o una cadena hidrocarbonada alifatica saturada; o, de modo alternativo, R1 y R2 forman juntos una cadena hidrocarbonada alifatica saturada opcionalmente sustituida; los radicales R3 y R4, que pueden ser identicos o diferentes, toman cualquiera de los significados indicados con anterioridad para R1 y R2, o de modo alternativo, R1 y el grupo R4 que lleva el carbono alfa de CR1R2 no representan nada y un doble enlace une el carbono de CR1R2 al carbono CR3R4 situado en alfa; o de modo alternativo, uno de los radicales R1 y R2 forma con uno de los radicales R3 y R4 una cadena hidrocarbonada alifatica saturada o insaturada opcionalmente sustituida; uno de los radicales R5 y R6 representa W, y el otro representa Z que esta seleccionado entre un radical hidrocarbonado alifatico saturado o insaturado; un radical carbociclico o heterociclico saturado, insaturado y/o aromatico opcionalmente sustituido; un radical -alk-Cy, en el que alk representa una cadena de alquileno y Cy representa un radical heterociclico o carbociclico saturado, insaturado y/o aromatico opcionalmente sustituido; W representa -XL-CO2R7; -X-L-Tet, en el que X y L son como se definen mas abajo y Tet representa tetrazol opcionalmente sustituido; en la que L representa una cadena hidrocarbonada alifatica saturada o insaturada, que esta opcionalmente sustituida y/u opcionalmente interrumpida por arileno opcionalmente sustituido; X representa O; NR8, en el que R8 representa H; un grupo hidrocarbonado alifatico saturado; un grupo -CO-R' o -SO2-R', en el que R' toma cualquiera de los significados indicados mas abajo para R7 a excepcion de H; o R8 representa un grupo carbociclico aromatico opcionalmente sustituido; o X representa S(O)m, en el que m esta seleccionado entre 0, 1 y 2; R7 representa H; un grupo hidrocarbonado alifatico saturado o insaturado; un grupo carbociclico saturado, insaturado y/o aromatico opcionalmente sustituido; un grupo heterociclico saturado, insaturado y/o aromatico opcionalmente sustituido; y sus derivados, sales, solvatos y estereoisomeros farmaceuticamente aceptables, y tambien sus mezclas en todas las proporciones, los cuales pueden usarse en el tratamiento de dislipidemia aterosclerosis y diabetes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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FR0300318A FR2849849B1 (fr) | 2003-01-13 | 2003-01-13 | Nouveaux acides carboxyliques et derives pour le traitement et la prevention du diabete et des dyslipemies |
PCT/EP2003/014296 WO2004063148A1 (en) | 2003-01-13 | 2003-12-16 | Indenoncarboxylic acids derivatives and their use for the treatment of and preventing diabetes and dyslipidaemia |
Publications (1)
Publication Number | Publication Date |
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MXPA05007497A true MXPA05007497A (es) | 2005-09-21 |
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Application Number | Title | Priority Date | Filing Date |
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MXPA05007497A MXPA05007497A (es) | 2003-01-13 | 2003-12-16 | Derivados de acidos indenocarboxilicos y su uso para el tratamiento y prevencion de diabetes y dislipidemia. |
Country Status (16)
Country | Link |
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US (1) | US7482484B2 (es) |
EP (1) | EP1583738B1 (es) |
JP (1) | JP4762551B2 (es) |
KR (1) | KR20050091086A (es) |
CN (1) | CN1738795A (es) |
AR (1) | AR042830A1 (es) |
AU (1) | AU2003294861B2 (es) |
BR (1) | BR0317965A (es) |
CA (1) | CA2513310C (es) |
ES (1) | ES2636992T3 (es) |
FR (1) | FR2849849B1 (es) |
MX (1) | MXPA05007497A (es) |
PL (1) | PL378197A1 (es) |
RU (1) | RU2005125635A (es) |
WO (1) | WO2004063148A1 (es) |
ZA (1) | ZA200506414B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2845087B1 (fr) * | 2002-10-01 | 2004-12-24 | Merck Sante Sas | Nouveaux acides arylhexadienoiques substitues et leurs esters,utilisables dans le traitement et la prevention du diabete, des dyslipidemies,de l'atherosclerose, compositions pharmaceutiques les contenant et procedes de preparation |
JP5566004B2 (ja) * | 2007-11-14 | 2014-08-06 | 株式会社Dnpファインケミカル宇都宮 | アルコキシインダノン誘導体の製造方法 |
WO2010070076A1 (en) * | 2008-12-19 | 2010-06-24 | Crystax Pharmaceuticals, S.L. | Alkanoic acid derivatives and their therapeutic use as hdac inhibitors |
NZ594236A (en) | 2009-01-26 | 2014-08-29 | Univ Taipei Medical | Use of pterosin compounds for treating diabetes and obesity |
NZ595978A (en) | 2009-05-04 | 2013-11-29 | Prometic Biosciences Inc | Substituted aromatic compounds and pharmaceutical uses thereof |
US10800726B2 (en) | 2014-06-30 | 2020-10-13 | The Uab Research Foundation | Rexinoid compounds and methods of using rexinoid compounds for treating metabolic disorders and cancer |
AU2021205974A1 (en) * | 2020-01-09 | 2022-07-21 | Senseion Therapeutics, Inc. | Suppression of inflammasome activation |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3668241A (en) * | 1968-11-25 | 1972-06-06 | Merck & Co Inc | Substituted 1-oxoinden-5-yloxy alkanoic acids |
JPS5312421A (en) * | 1976-07-20 | 1978-02-03 | Sankyo Co Ltd | Fungicides for agriculture and horticulture |
US5128362A (en) * | 1988-01-15 | 1992-07-07 | Abbott Laboratories | 1-aminomethyl-1,2,3,4-tetrahydronaphthalenes |
US5604260A (en) * | 1992-12-11 | 1997-02-18 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
JPH0859458A (ja) * | 1994-08-25 | 1996-03-05 | Zeria Pharmaceut Co Ltd | インダン誘導体を含有する高脂血症治療剤 |
EP0848699B1 (en) * | 1995-07-26 | 2001-10-24 | Takeda Chemical Industries, Ltd. | Benzocycloalkene compounds with melatonine receptor binding affinity, their production and use |
US5780465A (en) * | 1997-04-03 | 1998-07-14 | Dow Agrosciences Llc | 4-substituted 5-polycyclylpyrimidine herbicides |
US6613917B1 (en) * | 2000-03-23 | 2003-09-02 | Allergan, Inc. | Amines substituted with a dihydronaphthalenyl, chromenyl, or thiochromenyl group, an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity |
WO2002022113A2 (en) * | 2000-09-13 | 2002-03-21 | Bristol-Myers Squibb Company | Retinoic acid receptor antagonists as promoters of angiogenesis |
ES2264482T3 (es) * | 2001-05-15 | 2007-01-01 | F. Hoffmann-La Roche Ag | Derivados de oxazol sustituidos por acido carboxilico para uso como activadores de ppar-alfa y gamma en el tratamiento de diabetes. |
-
2003
- 2003-01-13 FR FR0300318A patent/FR2849849B1/fr not_active Expired - Fee Related
- 2003-12-16 US US10/542,028 patent/US7482484B2/en not_active Expired - Fee Related
- 2003-12-16 CA CA2513310A patent/CA2513310C/en not_active Expired - Fee Related
- 2003-12-16 KR KR1020057012917A patent/KR20050091086A/ko not_active Application Discontinuation
- 2003-12-16 EP EP03785831.3A patent/EP1583738B1/en not_active Expired - Lifetime
- 2003-12-16 RU RU2005125635/04A patent/RU2005125635A/ru not_active Application Discontinuation
- 2003-12-16 ES ES03785831.3T patent/ES2636992T3/es not_active Expired - Lifetime
- 2003-12-16 JP JP2004565980A patent/JP4762551B2/ja not_active Expired - Fee Related
- 2003-12-16 AU AU2003294861A patent/AU2003294861B2/en not_active Ceased
- 2003-12-16 CN CNA2003801087318A patent/CN1738795A/zh active Pending
- 2003-12-16 MX MXPA05007497A patent/MXPA05007497A/es not_active Application Discontinuation
- 2003-12-16 WO PCT/EP2003/014296 patent/WO2004063148A1/en active Application Filing
- 2003-12-16 PL PL378197A patent/PL378197A1/pl unknown
- 2003-12-16 BR BR0317965-6A patent/BR0317965A/pt not_active Application Discontinuation
-
2004
- 2004-01-09 AR ARP040100059A patent/AR042830A1/es unknown
-
2005
- 2005-08-11 ZA ZA200506414A patent/ZA200506414B/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20060111445A1 (en) | 2006-05-25 |
ES2636992T3 (es) | 2017-10-10 |
AU2003294861A1 (en) | 2004-08-10 |
PL378197A1 (pl) | 2006-03-06 |
ZA200506414B (en) | 2007-04-25 |
CN1738795A (zh) | 2006-02-22 |
EP1583738A1 (en) | 2005-10-12 |
KR20050091086A (ko) | 2005-09-14 |
FR2849849B1 (fr) | 2006-08-04 |
CA2513310A1 (en) | 2004-07-29 |
FR2849849A1 (fr) | 2004-07-16 |
WO2004063148A1 (en) | 2004-07-29 |
BR0317965A (pt) | 2005-11-29 |
US7482484B2 (en) | 2009-01-27 |
CA2513310C (en) | 2012-11-27 |
EP1583738B1 (en) | 2017-05-10 |
JP4762551B2 (ja) | 2011-08-31 |
JP2006513242A (ja) | 2006-04-20 |
AR042830A1 (es) | 2005-07-06 |
RU2005125635A (ru) | 2006-02-27 |
AU2003294861B2 (en) | 2010-05-20 |
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