BR0317965A - Derivados de ácidos indenoncarboxìlicos e sua aplicação para o tratamento de e prevenção de diabetes e dislipidemia - Google Patents

Derivados de ácidos indenoncarboxìlicos e sua aplicação para o tratamento de e prevenção de diabetes e dislipidemia

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Publication number
BR0317965A
BR0317965A BR0317965-6A BR0317965A BR0317965A BR 0317965 A BR0317965 A BR 0317965A BR 0317965 A BR0317965 A BR 0317965A BR 0317965 A BR0317965 A BR 0317965A
Authority
BR
Brazil
Prior art keywords
saturated
optionally substituted
group
unsaturated
aliphatic hydrocarbon
Prior art date
Application number
BR0317965-6A
Other languages
English (en)
Inventor
Nathalie Adje
Michel Brunet
Didier Roche
Jean-Jacques Zeiller
Stephane Yvon
Valerie Guyard-Dangremont
Francis Contard
Daniel Guerrier
Gerard Ferrand
Yves Bonhomme
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR0317965A publication Critical patent/BR0317965A/pt

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    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • A61P3/06—Antihyperlipidemics
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"DERIVADOS DE áCIDOS INDENONCARBOXìLICOS E SUA APLICAçãO PARA O TRATAMENTO DE E PREVENçãO DE DIABETES E DISLIPIDEMIA". A presente invenção refere-se a um composto da fórmula (I): na qual: n é um número inteiro escolhido entre 1, 2 e 3; Y representa 0; N-OR¬ 9¬, no qual R¬ 9¬ representa H ou um grupo alifático à base de hidrocarboneto saturado; CR¬ 10¬R¬ 11¬, no qual R¬ 10¬ e R¬ 11¬, os quais podem ser idênticos ou diferentes, representam H ou um grupo alifático à base de hidrocarboneto saturado; R¬ 1¬ e R¬ 2¬, os quais podem ser idênticos ou diferentes, representam H ou uma cadeia à base de hidrocarboneto alifático saturado; ou alternativamente R¬ 1¬ e R¬ 2¬ formam juntos uma cadeia opcionalmente substituída à base de hidrocarboneto alifático saturado; os radicais R¬ 3¬ E R¬ 4¬, os quais podem ser idênticos ou diferentes, tomam qualquer um dos significados dados acima para R¬ 1¬e R¬ 2¬, ou alternativamente R¬ 1¬ e o grupo R¬ 4¬ carregado pelo carbono alfa a CR¬ 1¬R¬ 2¬ representam nada e uma ligação dupla liga o carbono de CR¬ 1¬R¬ 2¬ ao carbono de alfa CR¬ 3¬R¬ 4¬; ou alternativamente um dos radicais R¬ 1¬ e R¬ 2¬ forma com um dos radicais R¬ 3¬ e R¬ 4¬ uma cadeia à base de hidrocarboneto alifático saturado ou insaturado opcionalmente substituído; um dos radicais R¬ 5¬ e R¬ 6¬ representa W, e o outro representa Z o qual é escolhido entre um radical à base de hidrocarboneto alifático saturado ou insaturado; um radical carbocíclico ou heterocíclico saturado, insaturado e/ou aromático opcionalmente substituído; um radical -alk-Cy, no qual aik representa uma cadeia de alquileno e Cy representa um radical heterocíclico ou carbocíclico saturado, insaturado e/ou aromático opcionalmente substituído; W representa -XL-CO~ 2~R¬ 7¬; -X-L-Tet, no qual X e L são conforme definido abaixo e Tet representa tetrazol opcionalmente substituído; no qual L representa uma cadeia à base de hidrocarboneto alifático saturado ou insaturado, a qual é opcionalmente substituída e/ou opcionalmente interrompida por arileno opcionalmente substituído; X representa 0; NR¬ 8¬, no qual R¬ 8¬ representa H; um grupo à base de hidrocarboneto alifático saturado; um grupo -CO-R<39> ou -SO~ 2~-R<39>, no qual R<39> toma qualquer um dos significados dados abaixo para R¬ 7¬ com a exceção de H; ou R¬ 8¬ representa um grupo carbocíclico aromático opcionalmente substituído; ou X representa S(O)~ m~, no qual m é escolhido entre 0, 1 e 2; R¬ 7¬ representa H; um grupo à base de hidrocarboneto alifático saturado ou insaturado; um grupo carbocíclico, saturado, insaturado e/ou aromático opcionalmente substituído; um grupo heterocíclico saturado, insaturado e/ou aromático, opcionalmente substituído; e os derivados, sais, solvatos e estereoisómeros dos mesmos farmaceuticamente aceitáveis, e também misturas dos mesmos em todas as proporções, o qual pode ser usado no tratamento de dislipidemia, aterosclerose e diabetes.
BR0317965-6A 2003-01-13 2003-12-16 Derivados de ácidos indenoncarboxìlicos e sua aplicação para o tratamento de e prevenção de diabetes e dislipidemia BR0317965A (pt)

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FR0300318A FR2849849B1 (fr) 2003-01-13 2003-01-13 Nouveaux acides carboxyliques et derives pour le traitement et la prevention du diabete et des dyslipemies
PCT/EP2003/014296 WO2004063148A1 (en) 2003-01-13 2003-12-16 Indenoncarboxylic acids derivatives and their use for the treatment of and preventing diabetes and dyslipidaemia

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AR (1) AR042830A1 (pt)
AU (1) AU2003294861B2 (pt)
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US20060111445A1 (en) 2006-05-25
ES2636992T3 (es) 2017-10-10
AU2003294861A1 (en) 2004-08-10
PL378197A1 (pl) 2006-03-06
ZA200506414B (en) 2007-04-25
CN1738795A (zh) 2006-02-22
EP1583738A1 (en) 2005-10-12
KR20050091086A (ko) 2005-09-14
FR2849849B1 (fr) 2006-08-04
CA2513310A1 (en) 2004-07-29
FR2849849A1 (fr) 2004-07-16
WO2004063148A1 (en) 2004-07-29
US7482484B2 (en) 2009-01-27
CA2513310C (en) 2012-11-27
EP1583738B1 (en) 2017-05-10
JP4762551B2 (ja) 2011-08-31
JP2006513242A (ja) 2006-04-20
AR042830A1 (es) 2005-07-06
RU2005125635A (ru) 2006-02-27
MXPA05007497A (es) 2005-09-21
AU2003294861B2 (en) 2010-05-20

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