FR2845087B1 - Nouveaux acides arylhexadienoiques substitues et leurs esters,utilisables dans le traitement et la prevention du diabete, des dyslipidemies,de l'atherosclerose, compositions pharmaceutiques les contenant et procedes de preparation - Google Patents

Nouveaux acides arylhexadienoiques substitues et leurs esters,utilisables dans le traitement et la prevention du diabete, des dyslipidemies,de l'atherosclerose, compositions pharmaceutiques les contenant et procedes de preparation

Info

Publication number
FR2845087B1
FR2845087B1 FR0212135A FR0212135A FR2845087B1 FR 2845087 B1 FR2845087 B1 FR 2845087B1 FR 0212135 A FR0212135 A FR 0212135A FR 0212135 A FR0212135 A FR 0212135A FR 2845087 B1 FR2845087 B1 FR 2845087B1
Authority
FR
France
Prior art keywords
atherosclerosis
diabetes
prevention
treatment
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0212135A
Other languages
English (en)
Other versions
FR2845087A1 (fr
Inventor
Michel Brunet
Jean Jacques Zeiller
Gerard Ferrand
Yves Bonhomme
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
Merck Sante SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0212135A priority Critical patent/FR2845087B1/fr
Application filed by Merck Sante SAS filed Critical Merck Sante SAS
Priority to RU2005113717/04A priority patent/RU2005113717A/ru
Priority to AU2003255412A priority patent/AU2003255412B2/en
Priority to KR1020057005605A priority patent/KR20050070026A/ko
Priority to PCT/EP2003/008887 priority patent/WO2004031116A1/fr
Priority to CNB038236532A priority patent/CN1325462C/zh
Priority to DK03798876.3T priority patent/DK1546083T3/da
Priority to PT03798876T priority patent/PT1546083E/pt
Priority to ES03798876T priority patent/ES2350101T3/es
Priority to DE60333765T priority patent/DE60333765D1/de
Priority to CA2500649A priority patent/CA2500649C/fr
Priority to JP2004540560A priority patent/JP4486499B2/ja
Priority to EP03798876A priority patent/EP1546083B1/fr
Priority to SI200331883T priority patent/SI1546083T1/sl
Priority to US10/530,022 priority patent/US7737176B2/en
Priority to BR0314826-2A priority patent/BR0314826A/pt
Priority to MXPA05003388A priority patent/MXPA05003388A/es
Priority to AT03798876T priority patent/ATE477232T1/de
Priority to PL03374489A priority patent/PL374489A1/xx
Publication of FR2845087A1 publication Critical patent/FR2845087A1/fr
Application granted granted Critical
Publication of FR2845087B1 publication Critical patent/FR2845087B1/fr
Priority to ZA200503416A priority patent/ZA200503416B/en
Priority to CY20101100882T priority patent/CY1110814T1/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
FR0212135A 2002-10-01 2002-10-01 Nouveaux acides arylhexadienoiques substitues et leurs esters,utilisables dans le traitement et la prevention du diabete, des dyslipidemies,de l'atherosclerose, compositions pharmaceutiques les contenant et procedes de preparation Expired - Fee Related FR2845087B1 (fr)

Priority Applications (21)

Application Number Priority Date Filing Date Title
FR0212135A FR2845087B1 (fr) 2002-10-01 2002-10-01 Nouveaux acides arylhexadienoiques substitues et leurs esters,utilisables dans le traitement et la prevention du diabete, des dyslipidemies,de l'atherosclerose, compositions pharmaceutiques les contenant et procedes de preparation
US10/530,022 US7737176B2 (en) 2002-10-01 2003-08-11 Substituted arylhexadienoic acids and esters thereof which can be used for the treatment and prevention of diabetes, dyslipidaemia and atherosclerosis, pharmaceutical compositions comprising them and processes for the preparation of them
SI200331883T SI1546083T1 (sl) 2002-10-01 2003-08-11 Nove substituirane arilheksadienojske kisline in njihovi estri ki se lahko uporabljajo za zdravljenje in preprečevanje diabetesa dislipidemije in ateroskleroze farmacevtski sestavki ki jih vsebujejo in postopek njihove priprave
PCT/EP2003/008887 WO2004031116A1 (fr) 2002-10-01 2003-08-11 Nouveaux acides aryl-hexadienoiques substitues et leurs esters pouvant etre utilises pour le traitement et la prevention du diabete, de la dyslipidemie et de l'atherosclerose, compositions pharmaceutiques les contenant et procedes de preparation
AU2003255412A AU2003255412B2 (en) 2002-10-01 2003-08-11 Novel substituted arylhexadienoic acids and esters thereof which can be used for the treatment and prevention of diabetes, dyslipidaemia and atherosclerosis, pharmaceutical compositions comprising them and processes for the preparation of them
DK03798876.3T DK1546083T3 (da) 2002-10-01 2003-08-11 Hidtil ukendte substituerede arylhexadienonsyrer og estere deraf der kan anvendes i behandlingen og forebyggelse af diabetes, dyslipidæmi og atherosklerose, farmaceutiske præparater omfattende dem og fremgangsmåder til fremstillinger af dem
PT03798876T PT1546083E (pt) 2002-10-01 2003-08-11 Novos ácidos arilhexadienóicos substituídos e seus ésteres que podem ser utilizados para o tratamento e a prevenção de diabetes, dislipidemia e aterosclerose, composições farmacêuticas que os compreendem e processos para a sua preparação
BR0314826-2A BR0314826A (pt) 2002-10-01 2003-08-11 ácido arilhexadienóicos substituìdos e ésteres destes que podem ser empregados para o tratamento e prevenção de diabetes, dislipidemia e aterosclerose, composições farmacêuticas compreendendo-os e processos para a preparação das mesmas
DE60333765T DE60333765D1 (de) 2002-10-01 2003-08-11 Neue substituierte arylhexadiensäuren und ester davon, die sich zur behandlung und prävention von diabetes, dyslipidämie und arteriosklerose eignen, pharmazeutische zusammensetzungen, die diese enthalten, und verfahren zu deren herstellung
CA2500649A CA2500649C (fr) 2002-10-01 2003-08-11 Acides arylhexadienoiques substitues et leurs esters pouvant etre utilisses pour le traitement et la prevention du diabete, de la dyslipidemie et de l'atherosclerose, et procedes de preparation
RU2005113717/04A RU2005113717A (ru) 2002-10-01 2003-08-11 Новые замещенные арилгексадиеновые кислоты и их сложные эфиры, которые могут применяться для лечения и профилактики диабета, дислипидемии и атеросклероза, фармацевтические композиции, которые их содержат, и способ их получения
EP03798876A EP1546083B1 (fr) 2002-10-01 2003-08-11 Nouveaux acides aryl-hexadienoiques substitues et leurs esters pouvant etre utilises pour le traitement et la prevention du diabete, de la dyslipidemie et de l'atherosclerose, compositions pharmaceutiques les contenant et procedes de preparation
KR1020057005605A KR20050070026A (ko) 2002-10-01 2003-08-11 당뇨병, 이상지혈증 및 아테롬성 동맥경화증의 치료 및예방을 위해 사용가능한 신규한 치환 아릴헥사디엔산 및이의 에스테르, 이를 포함하는 약제학적 조성물 및 이의제조 방법
CNB038236532A CN1325462C (zh) 2002-10-01 2003-08-11 取代的芳基己二烯酸及其酯、其药物组合物及其制备方法
ES03798876T ES2350101T3 (es) 2002-10-01 2003-08-11 Nuevos ácidos arilhexadienoicos substituidos y sus ésteres que pueden ser empleados para el tratamiento y la prevención de la diabetes, de la dislipidemia y de la aterosclerosis, composiciones farmacéuticas que los comprenden y procedimientos para la preparación de los mismos.
MXPA05003388A MXPA05003388A (es) 2002-10-01 2003-08-11 Nuevos acidos arilhexadienoicos sustituidos y esteres de los mismos que pueden ser usados para el tratamiento y la prevencion de diabetes, dislipidemia y aterosclerosis, compisiciones farmaceuticas que los contienen y procedimientos para su preparaci
AT03798876T ATE477232T1 (de) 2002-10-01 2003-08-11 Neue substituierte arylhexadiensäuren und ester davon, die sich zur behandlung und prävention von diabetes, dyslipidämie und arteriosklerose eignen,pharmazeutische zusammensetzungen, die diese enthalten, und verfahren zu deren herstellung
PL03374489A PL374489A1 (en) 2002-10-01 2003-08-11 Novel substituted arylhexadienoic acids and esters thereof which can be used for the treatment and prevention of diabetes, dyslipidaemia and atherosclerosis, pharmaceutical compositions comprising them and processes for the preparation of them
JP2004540560A JP4486499B2 (ja) 2002-10-01 2003-08-11 糖尿病、脂質代謝異常およびアテローム性動脈硬化症の治療および予防に使用できる新規な置換アリールへキサジエン酸およびそのエステル、これらを含有する医薬組成物、ならびにこれらの調製方法
ZA200503416A ZA200503416B (en) 2002-10-01 2005-04-28 Novel substituted arylhexadienoic acids and esters thereof which can be used for the treatment and prevention of diabetes, dyslipidaemia and atherosclerosis, pharmaceutical compositions comprising them and processes for the preparation of them
CY20101100882T CY1110814T1 (el) 2002-10-01 2010-10-05 Νεα υποκατεστημενα αρυλοεξαδιενικα οξεα και εστερες αυτων τα οποια μπορουν να χρησιμοποιηθουν για την αγωγη και προληψη του διαβητη, δυσλιπιδαιμιας και αθηροσκληρωσης, φαρμακευτικες συνθεσεις που τα περιλαμβανουν και διεργασιες για την παρασκευη αυτων

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0212135A FR2845087B1 (fr) 2002-10-01 2002-10-01 Nouveaux acides arylhexadienoiques substitues et leurs esters,utilisables dans le traitement et la prevention du diabete, des dyslipidemies,de l'atherosclerose, compositions pharmaceutiques les contenant et procedes de preparation

Publications (2)

Publication Number Publication Date
FR2845087A1 FR2845087A1 (fr) 2004-04-02
FR2845087B1 true FR2845087B1 (fr) 2004-12-24

Family

ID=31985377

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0212135A Expired - Fee Related FR2845087B1 (fr) 2002-10-01 2002-10-01 Nouveaux acides arylhexadienoiques substitues et leurs esters,utilisables dans le traitement et la prevention du diabete, des dyslipidemies,de l'atherosclerose, compositions pharmaceutiques les contenant et procedes de preparation

Country Status (21)

Country Link
US (1) US7737176B2 (fr)
EP (1) EP1546083B1 (fr)
JP (1) JP4486499B2 (fr)
KR (1) KR20050070026A (fr)
CN (1) CN1325462C (fr)
AT (1) ATE477232T1 (fr)
AU (1) AU2003255412B2 (fr)
BR (1) BR0314826A (fr)
CA (1) CA2500649C (fr)
CY (1) CY1110814T1 (fr)
DE (1) DE60333765D1 (fr)
DK (1) DK1546083T3 (fr)
ES (1) ES2350101T3 (fr)
FR (1) FR2845087B1 (fr)
MX (1) MXPA05003388A (fr)
PL (1) PL374489A1 (fr)
PT (1) PT1546083E (fr)
RU (1) RU2005113717A (fr)
SI (1) SI1546083T1 (fr)
WO (1) WO2004031116A1 (fr)
ZA (1) ZA200503416B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013177360A (ja) 2011-08-02 2013-09-09 Sumitomo Chemical Co Ltd α−ケトアルデヒド化合物の製造方法
EP2758041B1 (fr) 2011-09-20 2021-01-13 Basf Se Modulateurs sous-moléculaires du récepteur de froid et de menthol trpm8 et leur utilisation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3615157A1 (de) * 1986-05-05 1987-11-12 Schwabe Willmar Gmbh & Co 5-arylalkyl-4-alkoxy-2(5h)-furanone, zwischenprodukte und verfahren zu ihrer herstellung sowie ihre anwendung als therapeutische wirkstoffe
RU2051673C1 (ru) * 1992-02-07 1996-01-10 Общество с ограниченной ответственностью "ЛОШТАК" Антиатеросклеротическое и антиатерогенное средство
FR2849849B1 (fr) * 2003-01-13 2006-08-04 Merck Sante Sas Nouveaux acides carboxyliques et derives pour le traitement et la prevention du diabete et des dyslipemies
FR2869610B1 (fr) * 2004-05-03 2006-07-28 Merck Sante Soc Par Actions Si Derives de l'acide pentenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et leurs applications therapeutiques

Also Published As

Publication number Publication date
RU2005113717A (ru) 2006-01-20
DK1546083T3 (da) 2010-10-04
US7737176B2 (en) 2010-06-15
CY1110814T1 (el) 2015-06-10
EP1546083B1 (fr) 2010-08-11
BR0314826A (pt) 2005-08-02
US20060052447A1 (en) 2006-03-09
AU2003255412B2 (en) 2009-09-10
ATE477232T1 (de) 2010-08-15
KR20050070026A (ko) 2005-07-05
WO2004031116A1 (fr) 2004-04-15
JP4486499B2 (ja) 2010-06-23
PT1546083E (pt) 2010-11-17
CN1325462C (zh) 2007-07-11
ES2350101T3 (es) 2011-01-18
FR2845087A1 (fr) 2004-04-02
JP2006501284A (ja) 2006-01-12
CN1688534A (zh) 2005-10-26
DE60333765D1 (de) 2010-09-23
CA2500649C (fr) 2011-07-12
CA2500649A1 (fr) 2004-04-15
ZA200503416B (en) 2006-12-27
EP1546083A1 (fr) 2005-06-29
PL374489A1 (en) 2005-10-31
AU2003255412A1 (en) 2004-04-23
SI1546083T1 (sl) 2010-11-30
MXPA05003388A (es) 2005-06-22

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Effective date: 20070629