BR0314826A - ácido arilhexadienóicos substituìdos e ésteres destes que podem ser empregados para o tratamento e prevenção de diabetes, dislipidemia e aterosclerose, composições farmacêuticas compreendendo-os e processos para a preparação das mesmas - Google Patents

ácido arilhexadienóicos substituìdos e ésteres destes que podem ser empregados para o tratamento e prevenção de diabetes, dislipidemia e aterosclerose, composições farmacêuticas compreendendo-os e processos para a preparação das mesmas

Info

Publication number
BR0314826A
BR0314826A BR0314826-2A BR0314826A BR0314826A BR 0314826 A BR0314826 A BR 0314826A BR 0314826 A BR0314826 A BR 0314826A BR 0314826 A BR0314826 A BR 0314826A
Authority
BR
Brazil
Prior art keywords
atherosclerosis
diabetes
prevention
processes
preparation
Prior art date
Application number
BR0314826-2A
Other languages
English (en)
Inventor
Michel Brunet
Jean-Jacques Zeiller
Gerard Ferrand
Yves Bonhomme
Original Assignee
Merck Patent Ges Mit Berschron
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Ges Mit Berschron filed Critical Merck Patent Ges Mit Berschron
Publication of BR0314826A publication Critical patent/BR0314826A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

"áCIDOS ARILHEXADIENóICOS SUBSTITUìDOS E éSTERES DESTES QUE PODEM SER EMPREGADOS PARA O TRATAMENTO E PREVENçãO DE DIABETES, DISLIPIDEMIA E ATEROSCLEROSE, COMPOSIçõES FARMACêUTICAS COMPREENDENDO-OS E PROCESSOS PARA A PREPARAçãO DAS MESMAS". A presente invenção refere-se a compostos da fórmula (I), e aos sais farmaceuticamente aceitáveis destes, a processos para a preparação deles e a composições farmacêuticas compreendendo-os, os quais são úteis especialmente para o tratamento e prevenção de dislipidemia, aterosclerose e diabetes.
BR0314826-2A 2002-10-01 2003-08-11 ácido arilhexadienóicos substituìdos e ésteres destes que podem ser empregados para o tratamento e prevenção de diabetes, dislipidemia e aterosclerose, composições farmacêuticas compreendendo-os e processos para a preparação das mesmas BR0314826A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0212135A FR2845087B1 (fr) 2002-10-01 2002-10-01 Nouveaux acides arylhexadienoiques substitues et leurs esters,utilisables dans le traitement et la prevention du diabete, des dyslipidemies,de l'atherosclerose, compositions pharmaceutiques les contenant et procedes de preparation
PCT/EP2003/008887 WO2004031116A1 (en) 2002-10-01 2003-08-11 Novel substituted arylhexadienoic acids and esters thereof which can be used for the treatment and prevention of diabetes, dyslipidaemia and atherosclerosis, pharmaceutical compositions comprising them and processes for the preparation of them

Publications (1)

Publication Number Publication Date
BR0314826A true BR0314826A (pt) 2005-08-02

Family

ID=31985377

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0314826-2A BR0314826A (pt) 2002-10-01 2003-08-11 ácido arilhexadienóicos substituìdos e ésteres destes que podem ser empregados para o tratamento e prevenção de diabetes, dislipidemia e aterosclerose, composições farmacêuticas compreendendo-os e processos para a preparação das mesmas

Country Status (21)

Country Link
US (1) US7737176B2 (pt)
EP (1) EP1546083B1 (pt)
JP (1) JP4486499B2 (pt)
KR (1) KR20050070026A (pt)
CN (1) CN1325462C (pt)
AT (1) ATE477232T1 (pt)
AU (1) AU2003255412B2 (pt)
BR (1) BR0314826A (pt)
CA (1) CA2500649C (pt)
CY (1) CY1110814T1 (pt)
DE (1) DE60333765D1 (pt)
DK (1) DK1546083T3 (pt)
ES (1) ES2350101T3 (pt)
FR (1) FR2845087B1 (pt)
MX (1) MXPA05003388A (pt)
PL (1) PL374489A1 (pt)
PT (1) PT1546083E (pt)
RU (1) RU2005113717A (pt)
SI (1) SI1546083T1 (pt)
WO (1) WO2004031116A1 (pt)
ZA (1) ZA200503416B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013177360A (ja) 2011-08-02 2013-09-09 Sumitomo Chemical Co Ltd α−ケトアルデヒド化合物の製造方法
EP2758041B1 (de) 2011-09-20 2021-01-13 Basf Se Niedermolekulare modulatoren des kälte-menthol-rezeptors trpm8 und deren verwendung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3615157A1 (de) * 1986-05-05 1987-11-12 Schwabe Willmar Gmbh & Co 5-arylalkyl-4-alkoxy-2(5h)-furanone, zwischenprodukte und verfahren zu ihrer herstellung sowie ihre anwendung als therapeutische wirkstoffe
RU2051673C1 (ru) * 1992-02-07 1996-01-10 Общество с ограниченной ответственностью "ЛОШТАК" Антиатеросклеротическое и антиатерогенное средство
FR2849849B1 (fr) * 2003-01-13 2006-08-04 Merck Sante Sas Nouveaux acides carboxyliques et derives pour le traitement et la prevention du diabete et des dyslipemies
FR2869610B1 (fr) * 2004-05-03 2006-07-28 Merck Sante Soc Par Actions Si Derives de l'acide pentenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et leurs applications therapeutiques

Also Published As

Publication number Publication date
PL374489A1 (en) 2005-10-31
FR2845087B1 (fr) 2004-12-24
RU2005113717A (ru) 2006-01-20
PT1546083E (pt) 2010-11-17
ES2350101T3 (es) 2011-01-18
DE60333765D1 (de) 2010-09-23
DK1546083T3 (da) 2010-10-04
JP2006501284A (ja) 2006-01-12
CN1688534A (zh) 2005-10-26
ZA200503416B (en) 2006-12-27
CA2500649C (en) 2011-07-12
KR20050070026A (ko) 2005-07-05
EP1546083A1 (en) 2005-06-29
CN1325462C (zh) 2007-07-11
AU2003255412A1 (en) 2004-04-23
AU2003255412B2 (en) 2009-09-10
JP4486499B2 (ja) 2010-06-23
ATE477232T1 (de) 2010-08-15
MXPA05003388A (es) 2005-06-22
US7737176B2 (en) 2010-06-15
US20060052447A1 (en) 2006-03-09
CY1110814T1 (el) 2015-06-10
FR2845087A1 (fr) 2004-04-02
WO2004031116A1 (en) 2004-04-15
SI1546083T1 (sl) 2010-11-30
CA2500649A1 (en) 2004-04-15
EP1546083B1 (en) 2010-08-11

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]