EA200201201A1 - Соединения с сульфамидной группой и содержащие эти соединения фармацевтические композиции - Google Patents

Соединения с сульфамидной группой и содержащие эти соединения фармацевтические композиции

Info

Publication number
EA200201201A1
EA200201201A1 EA200201201A EA200201201A EA200201201A1 EA 200201201 A1 EA200201201 A1 EA 200201201A1 EA 200201201 A EA200201201 A EA 200201201A EA 200201201 A EA200201201 A EA 200201201A EA 200201201 A1 EA200201201 A1 EA 200201201A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
group
erythrocytes
absorption
substances
Prior art date
Application number
EA200201201A
Other languages
English (en)
Other versions
EA006432B1 (ru
Inventor
Вальтер Эльгер
Александер Хиллиш
Аннемари Хедден
Зигфрид Шварц
Клаус Шёллькопф
Original Assignee
Шеринг Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7644802&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200201201(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Шеринг Акциенгезельшафт filed Critical Шеринг Акциенгезельшафт
Publication of EA200201201A1 publication Critical patent/EA200201201A1/ru
Publication of EA006432B1 publication Critical patent/EA006432B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0044—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

В заявке описываются соединения, которые в качестве пролекарства и/или носителя обеспечивают возможность абсорбции (поглощения) активного вещества эритроцитами и/или связывание активного вещества с эритроцитами, при этом абсорбция указанных соединений эритроцитами и/или связывание этих соединений с эритроцитами осуществляется благодаря наличию группы -SONRR, в которой Rи Rнезависимо друг от друга обозначают атом водорода, ацильную группу, алкильную группу, циклоалкильную группу, арильную группу, цианогруппу или гидроксигруппу. Предлагаемое в изобретении пролекарство позволяет придать таким активным веществам, как присутствующие в живом организме вещества, природные вещества и синтетические вещества, обладающим ценными терапевтическими свойствами, способность для их целенаправленного перорального применения с высокой эффективностью уже при первом введении ("эффект первого прохождения"), соответственно повысить решающим образом их пероральную активность.Отчет о международном поиске был опубликован 2002.06.20.
EA200201201A 2000-05-31 2001-05-08 Соединения с сульфамидной группой и содержащие эти соединения фармацевтические композиции EA006432B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10027887A DE10027887A1 (de) 2000-05-31 2000-05-31 Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
PCT/EP2001/005169 WO2001091797A2 (de) 2000-05-31 2001-05-08 Verbindungen mit einer sulfonamidgruppe und diese verbindungen enthaltende pharmazeutische zusammensetzungen

Publications (2)

Publication Number Publication Date
EA200201201A1 true EA200201201A1 (ru) 2003-06-26
EA006432B1 EA006432B1 (ru) 2005-12-29

Family

ID=7644802

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200201201A EA006432B1 (ru) 2000-05-31 2001-05-08 Соединения с сульфамидной группой и содержащие эти соединения фармацевтические композиции

Country Status (29)

Country Link
US (2) US7507725B2 (ru)
EP (1) EP1294402B2 (ru)
JP (1) JP2003534386A (ru)
KR (3) KR20080038460A (ru)
CN (1) CN1441678A (ru)
AT (1) ATE315407T1 (ru)
AU (2) AU6593301A (ru)
BG (1) BG107556A (ru)
BR (1) BR0111294A (ru)
CA (1) CA2410630A1 (ru)
CZ (1) CZ2003621A3 (ru)
DE (2) DE10027887A1 (ru)
DK (1) DK1294402T4 (ru)
EA (1) EA006432B1 (ru)
ES (1) ES2256256T5 (ru)
HR (1) HRP20021038B1 (ru)
HU (1) HUP0301949A3 (ru)
IL (2) IL152932A0 (ru)
ME (1) MEP14608A (ru)
MX (1) MXPA02011844A (ru)
NO (1) NO20025739D0 (ru)
NZ (1) NZ535201A (ru)
PL (1) PL206462B1 (ru)
PT (1) PT1294402E (ru)
SK (1) SK2912003A3 (ru)
UA (1) UA76953C2 (ru)
WO (1) WO2001091797A2 (ru)
YU (1) YU90102A (ru)
ZA (1) ZA200209490B (ru)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10027887A1 (de) * 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US8026229B2 (en) * 2001-08-13 2011-09-27 Sterix Limited Antitumor-active 2-alkoxyestradiol sulfamates
US20050282793A1 (en) * 2004-05-21 2005-12-22 Ralf Wyrwa Steroid prodrugs with androgenic action
US7534780B2 (en) * 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
DE102004025985A1 (de) * 2004-05-21 2005-12-15 Schering Ag Estriol- und Estetrol-Prodrugs
DE102004025986A1 (de) * 2004-05-21 2005-12-15 Schering Ag Steroid-Prodrugs mit androgener Wirkung
DE102004025966A1 (de) * 2004-05-21 2005-12-15 Schering Ag Estradiol-Prodrugs
US20050277625A1 (en) * 2004-05-21 2005-12-15 Ralf Wyrwa Estriol and estetrol prodrugs
DE102005057225A1 (de) * 2005-11-29 2007-05-31 Bayer Schering Pharma Ag Prodrugs ERß-selektiver Substanzen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US20070197488A1 (en) * 2005-11-29 2007-08-23 Olaf Peters Prodrugs of ERbeta-selective substances, process for their production, and pharmaceutical compositions that contain these compounds
DE102005057224A1 (de) 2005-11-29 2007-05-31 Bayer Schering Pharma Ag Prodrugs ERß-selektiver Substanzen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US20070123500A1 (en) * 2005-11-29 2007-05-31 Gerd Mueller Prodrugs of ERbeta-selective substances, processes for their preparation and pharmaceutical compositions comprising these compounds
US20070135375A1 (en) * 2005-11-30 2007-06-14 Ralf Wyrwa Sulfamoyl sulfonate prodrugs
DE102005057421A1 (de) * 2005-11-30 2007-05-31 Bayer Schering Pharma Ag Heteroaromatische Sulfonamid-Prodrugs
US20070135399A1 (en) * 2005-11-30 2007-06-14 Ralf Wyrwa Heteroaromatic sulphonamide prodrugs
DE102005057408A1 (de) * 2005-11-30 2007-05-31 Bayer Schering Pharma Ag Sulfamoylsulfonat-Prodrugs
US8777182B2 (en) 2008-05-20 2014-07-15 Grinon Industries Fluid transfer assembly and methods of fluid transfer
NZ589747A (en) 2008-05-20 2012-04-27 Grinon Ind Fluid container with a magnetic coupling device at the bottom
US9100458B2 (en) * 2008-09-11 2015-08-04 At&T Intellectual Property I, L.P. Apparatus and method for delivering media content
CN101987104A (zh) * 2009-08-05 2011-03-23 天津金耀集团有限公司 一种杂芳香基氨磺酰基羧酸酯碳酸酐酶抑制剂的眼用组合物
CN101987102A (zh) * 2009-08-05 2011-03-23 天津金耀集团有限公司 一种糖皮质激素杂芳香基氨磺酰基羧酸酯的眼用抗炎组合物
CZ307182B6 (cs) 2011-12-30 2018-02-28 Grinon Industries Souprava pro přečerpávání tekutin a metody přečerpávání tekutin
PE20160655A1 (es) * 2013-07-11 2016-07-08 Evestra Inc Profarmacos de formacion de compuestos
EP3173113A1 (en) * 2015-11-27 2017-05-31 Sanofi-Aventis Deutschland GmbH An injection needle assembly
DK3380149T3 (da) 2015-11-27 2020-02-03 Sanofi Aventis Deutschland Lægemiddeladministrationsanordning med en hætte
US10624903B2 (en) 2017-10-19 2020-04-21 Evestra, Inc. Longer-acting progestin prodrug contraceptives

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1203042B (de) 1963-11-21 1965-10-14 Schering Ag Fungizide Mittel
GB1593609A (en) 1978-01-31 1981-07-22 Christiaens Sa A Pyridine sulfonamides
US4244940A (en) * 1978-09-05 1981-01-13 Bio-Rad Laboratories, Inc. Single-incubation two-site immunoassay
US4513006A (en) * 1983-09-26 1985-04-23 Mcneil Lab., Inc. Anticonvulsant sulfamate derivatives
GB8327256D0 (en) * 1983-10-12 1983-11-16 Ici Plc Steroid derivatives
US5001234A (en) † 1987-04-16 1991-03-19 The Upjohn Company Cyclic hydrocarbons with an aminoalkyl sidechain
US4792569A (en) * 1987-08-27 1988-12-20 Mcneilab, Inc. Anticonvulsant phenethyl sulfamates
US5116828A (en) 1989-10-26 1992-05-26 Nippon Zoki Pharmaceutical Co., Ltd. Pharmaceutical composition for treatment of osteoporosis
US5025031A (en) * 1989-11-30 1991-06-18 A. H. Robins Co., Inc. Aryl and aryloxyalkyl sulfamate esters useful as anticonvulsants
GB9118478D0 (en) 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
DE4236237A1 (de) 1992-10-27 1994-04-28 Behringwerke Ag Prodrugs, ihre Herstellung und Verwendung als Arzneimittel
US5384327A (en) 1992-12-22 1995-01-24 Mcneilab, Inc. Anticonvulsant sorbopyranose sulfamates
IL109431A (en) * 1993-05-14 2001-01-11 Warner Lambert Co Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds
DE4429398C2 (de) 1994-08-09 1997-09-11 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur hormonalen Kontrazeption
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US5571933A (en) 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
US5705495A (en) * 1995-10-19 1998-01-06 Jenapharm Gmbh & Co. Kg. Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds
DE19540233B4 (de) * 1995-10-19 2005-08-25 Schering Ag Sulfamat-Derivate von 1,3,5(10)-Estratrien-Derivaten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE19712488A1 (de) † 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
DE19723794A1 (de) * 1997-06-06 1998-12-10 Jenapharm Gmbh Nichtestrogene Derivate des Estradiols mit antioxidativer Aktivität
EP1100736A1 (en) * 1998-07-29 2001-05-23 Crisplant A/S Parcel singulation system
US6583130B1 (en) 1999-09-13 2003-06-24 Schering Ag C13-substituted estra-1,3,5,(10)-trien-3-yl sulfamates, methods of preparing same, and pharmaceutical compositions containing these compounds
US6958327B1 (en) * 1999-11-02 2005-10-25 Schering, Ag 18 Norsteroids as selectively active estrogens
SK10022002A3 (sk) 2000-01-14 2002-12-03 Sterix Limited Farmaceutický prostriedok a jeho použitie
SK14632002A3 (sk) 2000-04-12 2003-03-04 Schering Aktiengesellschaft Substituované estratriény a ich použitie ako selektívne účinných estrogénov
DE10027887A1 (de) 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US6355666B1 (en) 2000-06-23 2002-03-12 Medinox, Inc. Protected forms of pharmacologically active agents and uses therefor
JP2005511475A (ja) 2001-03-02 2005-04-28 ブリストル−マイヤーズ スクイブ カンパニー メラノコルチン受容体のモジュレーターとして有用な化合物及びそれを含む製薬組成物
WO2002076464A1 (en) * 2001-03-22 2002-10-03 Arena Pharmaceuticals, Inc. Anti-psychosis combination
US6956031B2 (en) 2002-03-27 2005-10-18 Schering Aktiengesellschaft 11β-Substituted 19-nor-17-α-pregna-1,3,5(10)-trien-17β-ols with a 21,16α-lactone ring
DE10226326A1 (de) 2002-06-11 2004-01-15 Schering Ag 9-alpha-substiuierte Estratriene als selektiv wirksame Estrogene
US7414043B2 (en) 2002-06-11 2008-08-19 Schering Ag 9-α-substituted estratrienes as selectively active estrogens
EP1689410B1 (en) 2003-11-26 2008-05-21 Bayer Schering Pharma Aktiengesellschaft Prevention and treatment of hypertensive heart diseases by the selective estrogens 8beta-vinyl-estra-1,3,5(10)-trien-3,17beta-diol and 17beta-fluor-9alpha-vinyl-estra-1,3,5(10)-trien-3,16alpha-diol
US7534780B2 (en) 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
US20050277625A1 (en) 2004-05-21 2005-12-15 Ralf Wyrwa Estriol and estetrol prodrugs
DE102004025966A1 (de) 2004-05-21 2005-12-15 Schering Ag Estradiol-Prodrugs
DE102004025986A1 (de) 2004-05-21 2005-12-15 Schering Ag Steroid-Prodrugs mit androgener Wirkung
DE102004025985A1 (de) 2004-05-21 2005-12-15 Schering Ag Estriol- und Estetrol-Prodrugs
AR053845A1 (es) 2005-04-15 2007-05-23 Tibotec Pharm Ltd 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450

Also Published As

Publication number Publication date
WO2001091797A3 (de) 2002-06-20
SK2912003A3 (en) 2003-09-11
US20040014781A1 (en) 2004-01-22
MXPA02011844A (es) 2004-05-17
EP1294402B2 (de) 2009-08-12
PL206462B1 (pl) 2010-08-31
ES2256256T3 (es) 2006-07-16
IL152932A (en) 2007-07-04
HRP20021038A2 (en) 2004-10-31
EA006432B1 (ru) 2005-12-29
DE50108674D1 (de) 2006-04-06
KR20030017524A (ko) 2003-03-03
ZA200209490B (en) 2005-03-10
US7507725B2 (en) 2009-03-24
CA2410630A1 (en) 2002-11-28
CN1441678A (zh) 2003-09-10
EP1294402B1 (de) 2006-01-11
JP2003534386A (ja) 2003-11-18
DK1294402T3 (da) 2006-05-22
HRP20021038B1 (en) 2008-08-31
NZ535201A (en) 2007-01-26
AU2001265933B2 (en) 2007-10-18
IL152932A0 (en) 2003-06-24
BG107556A (bg) 2004-01-30
CZ2003621A3 (cs) 2003-12-17
HUP0301949A3 (en) 2010-01-28
HUP0301949A2 (hu) 2003-09-29
YU90102A (sh) 2006-05-25
WO2001091797A2 (de) 2001-12-06
NO20025739L (no) 2002-11-29
ATE315407T1 (de) 2006-02-15
PT1294402E (pt) 2006-05-31
EP1294402A2 (de) 2003-03-26
DK1294402T4 (da) 2009-11-23
BR0111294A (pt) 2003-06-10
NO20025739D0 (no) 2002-11-29
UA76953C2 (en) 2006-10-16
US20090023896A1 (en) 2009-01-22
ES2256256T5 (es) 2009-12-11
MEP14608A (en) 2010-06-10
PL361426A1 (en) 2004-10-04
AU6593301A (en) 2001-12-11
KR20090090398A (ko) 2009-08-25
KR20080038460A (ko) 2008-05-06
DE10027887A1 (de) 2001-12-13

Similar Documents

Publication Publication Date Title
EA200201201A1 (ru) Соединения с сульфамидной группой и содержащие эти соединения фармацевтические композиции
BR0111126A (pt) Derivados de aminoácidos cìclicos úteis como agentes farmacêuticos
EA200000592A1 (ru) Азаполициклические соединения, конденсированные с арилом
RU2225404C2 (ru) ПРОИЗВОДНЫЕ ПИПЕРАЗИНА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ОБЛАДАЮЩАЯ ИНГИБИРУЮЩЕЙ АКТИВНОСТЬЮ В ОТНОШЕНИИ ФАКТОРА Хa
EA200100203A1 (ru) Производные 4,4-биарилпиперидина с активностью в отношении опиоидных рецепторов
YU21803A (sh) Farmaceutski aktivni derivati sulfonamida koji imaju i lipofilne i jonizujuće osobine kao inhibitori protein-junkinaza
ATE383339T1 (de) Amin-derivate zur behandlung von apoptosis
EA199800943A1 (ru) Производные мочевины и их применение в качестве ингибиторов инозин-5`-монофосфат- дегидрогеназы
EA200201271A1 (ru) Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
EA200200417A1 (ru) Фармацевтически активные производные сульфонамида
EA200601846A1 (ru) Содержащие бензоксазины лекарственные комбинации для лечения заболеваний дыхательных путей
EA200200479A1 (ru) Новые олигосахариды, их получение и содержащие их фармацевтические композиции
YU13396A (sh) N-(3-benzofuranil) urea derivati, postupci za njihovo dobijanje, kompozicije koje ih sadrže i njihova upotreba u lekovima
EA200401526A1 (ru) Новые соединения и их применение
BR0112337A (pt) Derivados de fosfolipìdeos de ácido valpróico e suas misturas
EA200000431A3 (ru) Новые замещенные димерные соединения, способ их получения и фармацевтические композиции, содержащие их
MA28286A1 (fr) Dérivés de 1-N-phenyl-amino-1H-imidazole et compositions pharmaceutiques les contenant
EA200000996A1 (ru) Конденсированные с арилом азаполициклические соединения
EA200401250A1 (ru) Фармацевтические композиции на основе микрочастиц для внутриопухолевого введения
EA200101241A1 (ru) Производные индола
ATE13423T1 (de) Guanidinderivate und diese enthaltende pharmazeutische zusammensetzungen.
ATE241376T1 (de) Zusammensetzungen, die dolastatin-15-analoge in kombination mit taxane und dessen derivaten enthalten
FR2756826B1 (fr) Nouveaux derives tetrahydropyridiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2766487B1 (fr) Thiazolobenzoheterocycles, leur preparation et les medicaments les contenant
EA200000261A2 (ru) Новые замещенные димерные соединения, способ их получения и содержащая их фармацевтическая композиция

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU