DK0676964T3 - Nitrosylering af enzym-SH-grupper som en terapeutisk modalitet - Google Patents
Nitrosylering af enzym-SH-grupper som en terapeutisk modalitetInfo
- Publication number
- DK0676964T3 DK0676964T3 DK92924388T DK92924388T DK0676964T3 DK 0676964 T3 DK0676964 T3 DK 0676964T3 DK 92924388 T DK92924388 T DK 92924388T DK 92924388 T DK92924388 T DK 92924388T DK 0676964 T3 DK0676964 T3 DK 0676964T3
- Authority
- DK
- Denmark
- Prior art keywords
- nitrosylation
- enzyme
- groups
- therapeutic modality
- modality
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3153—Streptokinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79166891A | 1991-11-14 | 1991-11-14 | |
US94383592A | 1992-09-14 | 1992-09-14 | |
PCT/US1992/009667 WO1993009806A1 (en) | 1991-11-14 | 1992-11-13 | Nitrosylation of protein sh groups and amino acid residues as a therapeutic modality |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0676964T3 true DK0676964T3 (da) | 2001-02-05 |
Family
ID=27121187
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00108907T DK1023900T3 (da) | 1991-11-14 | 1992-11-13 | Farmaceutisk præparat indeholdende S-nitroso-lipoproteiner og anvendelse deraf |
DK00108908T DK1023905T3 (da) | 1991-11-14 | 1992-11-13 | Farmaceutisk præparat indeholdende S-nitroso-immunoglobuliner og anvendelse deraf |
DK92924388T DK0676964T3 (da) | 1991-11-14 | 1992-11-13 | Nitrosylering af enzym-SH-grupper som en terapeutisk modalitet |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00108907T DK1023900T3 (da) | 1991-11-14 | 1992-11-13 | Farmaceutisk præparat indeholdende S-nitroso-lipoproteiner og anvendelse deraf |
DK00108908T DK1023905T3 (da) | 1991-11-14 | 1992-11-13 | Farmaceutisk præparat indeholdende S-nitroso-immunoglobuliner og anvendelse deraf |
Country Status (7)
Country | Link |
---|---|
US (5) | US5593876A (da) |
EP (4) | EP1023900B1 (da) |
AU (2) | AU3071592A (da) |
CA (1) | CA2125037C (da) |
DE (3) | DE69231666T2 (da) |
DK (3) | DK1023900T3 (da) |
WO (1) | WO1993009806A1 (da) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6291424B1 (en) * | 1991-11-14 | 2001-09-18 | Brigham And Women's Hospital | Nitrosated and nitrosylated heme proteins |
WO1994022482A1 (en) * | 1993-03-26 | 1994-10-13 | Biorelease Technologies, Inc. | Compositions including heme-containing proteins and methods relating thereto |
WO1995007691A1 (en) * | 1993-09-17 | 1995-03-23 | Brigham And Women's Hospital | Use of nitric oxide-adducts to prevent thrombosis on artificial and vascular surfaces |
GB9423868D0 (en) * | 1994-11-25 | 1995-01-11 | Wellcome Found | Compounds for use in medicine |
US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
US6043232A (en) * | 1997-07-23 | 2000-03-28 | Nitromed, Inc. | Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
US6051588A (en) * | 1995-04-19 | 2000-04-18 | Nitromed Inc | Nitroso esters of β-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
US5612314A (en) * | 1995-04-21 | 1997-03-18 | Brigham & Women's Hospital | Nitrosylated neuropeptides |
US6916471B2 (en) | 1995-09-15 | 2005-07-12 | Duke University | Red blood cells loaded with S-nitrosothiol and uses therefor |
US6627738B2 (en) * | 1995-09-15 | 2003-09-30 | Duke University | No-modified hemoglobins and uses therefor |
US6911427B1 (en) | 1995-09-15 | 2005-06-28 | Duke University | No-modified hemoglobins and uses therefore |
US6855691B1 (en) | 1995-09-15 | 2005-02-15 | Duke University | Methods for producing and using S-nitrosohemoglobins |
US6153186A (en) * | 1995-09-15 | 2000-11-28 | Duke University Medical Center | Red blood cells loaded with S-nitrosothiol and uses therefor |
US6197745B1 (en) * | 1995-09-15 | 2001-03-06 | Duke University | Methods for producing nitrosated hemoglobins and therapeutic uses therefor |
US5932538A (en) * | 1996-02-02 | 1999-08-03 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
US5994294A (en) * | 1996-02-02 | 1999-11-30 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
US20020143007A1 (en) * | 1996-02-02 | 2002-10-03 | Garvey David S. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use |
US6323211B1 (en) | 1996-02-02 | 2001-11-27 | Nitromed, Inc. | Compositions and methods for treating sexual dysfunctions |
US6469065B1 (en) | 1996-02-02 | 2002-10-22 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use |
US20050065161A1 (en) * | 1996-02-02 | 2005-03-24 | Nitromed, Inc. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses |
US6294517B1 (en) | 1996-02-02 | 2001-09-25 | Nitromed, Inc. | Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use |
US5824669A (en) | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
US6057367A (en) * | 1996-08-30 | 2000-05-02 | Duke University | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses |
ATE397061T1 (de) * | 1997-01-08 | 2008-06-15 | Invitrogen Corp | Verfahren zur herstellung von proteinen |
EP1015490B1 (en) * | 1997-02-06 | 2004-04-14 | Duke University | No-modified hemoglobins and uses therefor |
AU6782198A (en) * | 1997-03-27 | 1998-10-20 | Trustees Of Boston University | Novel antiplatelet agent |
JP4777489B2 (ja) * | 1997-03-31 | 2011-09-21 | ザ チルドレンズ メディカル センター コーポレーション | アポトーシス性酵素を不活性化するためのニトロシル化 |
US6617355B1 (en) * | 1997-05-21 | 2003-09-09 | The University Of Virginia Patent Foundation | Treating asthma by preventing and/or accomodating S-nitrosothiol breakdown |
DK1659179T3 (da) * | 1998-02-05 | 2011-10-10 | Glaxosmithkline Biolog Sa | Tumor-associerede antigenderivater fra MAGE-familien og nucleinsyresekvenser kodende for dem anvendt til fremstilling af fusionsproteiner og sammensætninger til vaccination |
AU763000B2 (en) | 1998-10-30 | 2003-07-10 | Nicox S.A. | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use |
ES2147162B1 (es) | 1999-01-27 | 2001-03-16 | Lacer Sa | "s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias". |
US7045152B2 (en) | 1999-09-08 | 2006-05-16 | Duke University | Treating pulmonary disorders with gaseous agent causing repletion of GSNO |
US6314956B1 (en) | 1999-09-08 | 2001-11-13 | Duke University | Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders |
JP2004506221A (ja) * | 2000-08-11 | 2004-02-26 | インヴィトロジェン コーポレーション | 高度に均一な電気泳動用分子マーカー |
US20040014082A1 (en) * | 2000-08-11 | 2004-01-22 | Invitrogen Corporation | Highly homogeneous molecular markers for electrophoresis |
US6417347B1 (en) | 2000-08-24 | 2002-07-09 | Scimed Life Systems, Inc. | High yield S-nitrosylation process |
US6780849B2 (en) | 2000-12-21 | 2004-08-24 | Scimed Life Systems, Inc. | Lipid-based nitric oxide donors |
CA2446064A1 (en) | 2001-05-02 | 2002-11-07 | Nitromed, Inc. | Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use |
CA2459647A1 (en) * | 2001-08-20 | 2003-02-27 | University Of Virginia Patent Foundation | Use of s-nitrosothiol signaling to treat disordered control of breathing |
US20050261475A1 (en) * | 2004-02-13 | 2005-11-24 | Harvard Medical School | Solid-phase capture-release-tag methods for phosphoproteomic analyses |
GB0415757D0 (en) * | 2004-07-14 | 2004-08-18 | Nat Blood Authority | Methods |
SE0402221D0 (sv) * | 2004-09-14 | 2004-09-14 | Aerocrine Ab | Treatment of insufficient perfusion |
US8067464B2 (en) | 2004-10-04 | 2011-11-29 | Nitromed, Inc. | Compositions and methods using apocynin compounds and nitric oxide donors |
AU2006249323B2 (en) | 2005-05-27 | 2012-08-30 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications |
EP1915157A4 (en) | 2005-08-02 | 2010-09-01 | Nicox Sa | NICKEL OXYGENIZING ANTIMICROBIAL COMPOUNDS, COMPOSITIONS AND USE PROCESSES |
WO2007126609A1 (en) | 2006-03-29 | 2007-11-08 | Nitromed, Inc. | Nitric oxide enhancing prostaglandin compounds, compositions and methods of use |
EP1939179A1 (en) | 2006-12-28 | 2008-07-02 | Lacer, S.A. | Stable S-nitrosothiols, method of synthesis and use |
EP2310065A2 (en) * | 2008-06-26 | 2011-04-20 | Boston Scientific Scimed, Inc. | Medical device coatings containing charged materials |
US20100098733A1 (en) * | 2008-10-16 | 2010-04-22 | Novan, Inc. | Nitric oxide releasing particles for oral care applications |
MY184447A (en) | 2009-06-09 | 2021-04-01 | Prolong Pharmaceuticals Llc | Hemoglobin compositions |
DK2467173T3 (da) | 2009-08-21 | 2019-07-29 | Novan Inc | Sårbandager, fremgangsmåder til anvendelse heraf og fremgangsmåder til dannelse deraf |
CN102711729B (zh) | 2009-08-21 | 2015-04-01 | 诺万公司 | 局部用凝胶 |
EP2488591A1 (en) * | 2009-10-13 | 2012-08-22 | Novan, Inc. | Nitric oxide-releasing coatings |
US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
EP2681286B1 (en) | 2011-02-28 | 2018-08-15 | Novan, Inc. | Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same |
WO2016073835A1 (en) * | 2014-11-06 | 2016-05-12 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods of diazeniumdiolate-based prodrugs for treating cancer |
WO2020181194A1 (en) | 2019-03-07 | 2020-09-10 | University Of Padova | Compositions and methods of use comprising substances with neural plasticity actions administered at non-psychedelic/psychotomimetic dosages and formulations |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4666884A (en) * | 1984-04-10 | 1987-05-19 | New England Deaconess Hospital | Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls |
US5069936A (en) * | 1987-06-25 | 1991-12-03 | Yen Richard C K | Manufacturing protein microspheres |
US5002964A (en) * | 1988-06-15 | 1991-03-26 | Brigham & Women's Hospital | S-nitrosocaptopril compounds and the use thereof |
US5025001A (en) * | 1988-06-15 | 1991-06-18 | Brigham And Women's Hospital | S-nitroso derivatives of ACE inhibitors and the use thereof |
US4900719A (en) * | 1988-08-05 | 1990-02-13 | The Ohio State University | Nitrosothiols as hypotensive agents |
EP0412699B1 (en) * | 1989-08-07 | 1994-04-27 | Takeda Chemical Industries, Ltd. | Nitrosothiol derivatives, their production and use |
US5380758A (en) * | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
US5385937A (en) * | 1991-04-10 | 1995-01-31 | Brigham & Women's Hospital | Nitrosation of homocysteine as a method for treating homocysteinemia |
US5459076A (en) * | 1992-04-22 | 1995-10-17 | Brigham And Women's Hospital | Method for detecting nitric oxide, nitrosonium equivalents, S-nitrosothiols and S-nitroso-proteins in biological systems |
US5298506A (en) * | 1992-05-08 | 1994-03-29 | Brigham And Women's Hospital | Use of guanylate cyclase inhibitors in the treatment of shock |
US5346599A (en) * | 1993-01-26 | 1994-09-13 | Jonathan Stamler | Capillary zone electrophoretic detection of biological thiols and their S-nitrosated and oxidized derivatives |
US5427797A (en) * | 1993-04-06 | 1995-06-27 | Brigham And Women's Hospital | Systemic effects of nitric oxide inhalation |
-
1992
- 1992-11-13 DE DE69231666T patent/DE69231666T2/de not_active Expired - Fee Related
- 1992-11-13 EP EP00108907A patent/EP1023900B1/en not_active Expired - Lifetime
- 1992-11-13 DK DK00108907T patent/DK1023900T3/da active
- 1992-11-13 CA CA002125037A patent/CA2125037C/en not_active Expired - Fee Related
- 1992-11-13 AU AU30715/92A patent/AU3071592A/en not_active Abandoned
- 1992-11-13 EP EP00108906A patent/EP1025853A3/en not_active Withdrawn
- 1992-11-13 EP EP92924388A patent/EP0676964B1/en not_active Expired - Lifetime
- 1992-11-13 DK DK00108908T patent/DK1023905T3/da active
- 1992-11-13 DK DK92924388T patent/DK0676964T3/da active
- 1992-11-13 DE DE69233491T patent/DE69233491T2/de not_active Expired - Fee Related
- 1992-11-13 DE DE69233474T patent/DE69233474T2/de not_active Expired - Fee Related
- 1992-11-13 EP EP00108908A patent/EP1023905B1/en not_active Expired - Lifetime
- 1992-11-13 WO PCT/US1992/009667 patent/WO1993009806A1/en active IP Right Grant
-
1994
- 1994-08-09 US US08/287,830 patent/US5593876A/en not_active Expired - Fee Related
-
1995
- 1995-05-09 US US08/437,884 patent/US6562344B1/en not_active Expired - Fee Related
-
1997
- 1997-07-03 AU AU28494/97A patent/AU709725B2/en not_active Ceased
- 1997-08-06 US US08/907,217 patent/US5863890A/en not_active Expired - Fee Related
-
2002
- 2002-08-13 US US10/216,865 patent/US7157500B2/en not_active Expired - Fee Related
-
2006
- 2006-05-05 US US11/418,367 patent/US20060198831A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0676964A1 (en) | 1995-10-18 |
EP1023905B1 (en) | 2005-01-26 |
US6562344B1 (en) | 2003-05-13 |
US7157500B2 (en) | 2007-01-02 |
DE69231666D1 (de) | 2001-03-01 |
DE69233474T2 (de) | 2006-03-30 |
EP0676964A4 (en) | 1995-08-10 |
WO1993009806A1 (en) | 1993-05-27 |
DE69231666T2 (de) | 2001-05-10 |
EP1023905A2 (en) | 2000-08-02 |
US20060198831A1 (en) | 2006-09-07 |
EP1023900A3 (en) | 2000-11-08 |
AU709725B2 (en) | 1999-09-02 |
EP1023900B1 (en) | 2005-03-16 |
EP1023905A3 (en) | 2000-11-08 |
EP1023900A2 (en) | 2000-08-02 |
US5863890A (en) | 1999-01-26 |
DK1023900T3 (da) | 2005-06-06 |
US20030007967A1 (en) | 2003-01-09 |
DE69233491D1 (de) | 2005-04-21 |
CA2125037A1 (en) | 1993-05-27 |
AU3071592A (en) | 1993-06-15 |
EP1025853A3 (en) | 2000-11-08 |
CA2125037C (en) | 2001-02-20 |
DK1023905T3 (da) | 2005-05-30 |
DE69233491T2 (de) | 2006-04-06 |
EP1025853A2 (en) | 2000-08-09 |
EP0676964B1 (en) | 2001-01-24 |
US5593876A (en) | 1997-01-14 |
DE69233474D1 (de) | 2005-03-03 |
AU2849497A (en) | 1997-10-16 |
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