GB1419788A
(en)
|
1972-08-02 |
1975-12-31 |
Pfizer |
Herbicidal method using 2-trifuluromethyl-4-quinolinols
|
WO1992000075A1
(en)
|
1990-06-29 |
1992-01-09 |
Pfizer Inc. |
Pyridopyrazine derivatives for treating substance abuse and addiction
|
ATE161530T1
(de)
|
1992-09-04 |
1998-01-15 |
Takeda Chemical Industries Ltd |
Kondensierte heterozyklische verbindungen, deren herstellung und verwendung
|
US5750349A
(en)
|
1993-01-25 |
1998-05-12 |
Takeda Chemical Industries Ltd. |
Antibodies to β-amyloids or their derivatives and use thereof
|
ATE242243T1
(de)
|
1995-03-24 |
2003-06-15 |
Takeda Chemical Industries Ltd |
Zyklische verbindungen, ihre herstellung und ihre verwendung als tachykininrezeptorantagonisten
|
DE19709877A1
(de)
|
1997-03-11 |
1998-09-17 |
Bayer Ag |
1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
|
AU743827B2
(en)
|
1997-04-09 |
2002-02-07 |
Intellect Neurosciences, Inc. |
Recombinant antibodies specific for beta-amyloid ends, DNA encoding and methods of use thereof
|
US8173127B2
(en)
|
1997-04-09 |
2012-05-08 |
Intellect Neurosciences, Inc. |
Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof
|
GB9722520D0
(en)
|
1997-10-24 |
1997-12-24 |
Pfizer Ltd |
Compounds
|
TWI239847B
(en)
|
1997-12-02 |
2005-09-21 |
Elan Pharm Inc |
N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
|
US6743427B1
(en)
|
1997-12-02 |
2004-06-01 |
Neuralab Limited |
Prevention and treatment of amyloidogenic disease
|
CA2322156A1
(en)
|
1998-03-03 |
1999-09-10 |
Ppg Industries Ohio, Inc. |
Impregnated glass fiber strands and products including the same
|
US20020132817A1
(en)
|
1998-03-19 |
2002-09-19 |
Hideaki Natsugari |
Heterocyclic compounds, their production and use
|
CA2352612A1
(en)
|
1998-11-27 |
2000-06-08 |
Hideo Fukui |
Pharmaceuticals
|
DE60106394T3
(de)
|
2000-02-24 |
2013-07-25 |
Washington University St. Louis |
Humanisierte antikörper, die amyloid beta peptid sequestrieren
|
DE10045112A1
(de)
|
2000-09-11 |
2002-03-21 |
Merck Patent Gmbh |
Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems
|
EP1335738A4
(en)
|
2000-11-03 |
2004-09-08 |
Proteotech Inc |
METHODS OF ISOLATING AMYLOID INHIBITOR COMPOUNDS AND USE OF COMPOUNDS USED FROM UNCARIA TOMENTOSA AND PARENT PLANTS
|
EP1432444A4
(en)
|
2001-08-17 |
2005-11-02 |
Lilly Co Eli |
ANTI-BETA ANTIBODIES
|
US20030195205A1
(en)
|
2001-11-02 |
2003-10-16 |
Pfizer Inc. |
PDE9 inhibitors for treating cardiovascular disorders
|
DE10238724A1
(de)
|
2002-08-23 |
2004-03-04 |
Bayer Ag |
Alkyl-substituierte Pyrazolpyrimidine
|
DE10238723A1
(de)
|
2002-08-23 |
2004-03-11 |
Bayer Ag |
Phenyl-substituierte Pyrazolyprimidine
|
WO2004024078A2
(en)
|
2002-09-11 |
2004-03-25 |
Merck & Co., Inc. |
Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors
|
KR20050071564A
(ko)
|
2002-10-09 |
2005-07-07 |
리나트 뉴로사이언스 코퍼레이션 |
아밀로이드 베타 펩티드에 대한 항체를 사용하여알츠하이머병을 치료하는 방법 및 그의 조성물
|
CA2501799C
(en)
|
2002-10-09 |
2008-06-17 |
Pfizer Products Inc. |
Pyrazole compounds for treatment of neurodegenerative disorders
|
WO2004035577A2
(en)
|
2002-10-16 |
2004-04-29 |
Gilead Sciences, Inc. |
Pre-organized tricyclic integrase inhibitor compounds
|
US20040220186A1
(en)
|
2003-04-30 |
2004-11-04 |
Pfizer Inc. |
PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
|
BRPI0410630A
(pt)
|
2003-06-19 |
2006-06-13 |
Pfizer Prod Inc |
antagonista de nk1
|
CA2534532A1
(en)
|
2003-08-21 |
2005-03-10 |
Pfizer Products, Inc. |
Compounds for the treatment of neurodegenerative disorders
|
EP1666061A1
(en)
|
2003-09-09 |
2006-06-07 |
Takeda Pharmaceutical Company Limited |
Use of antibody
|
US7572799B2
(en)
|
2003-11-24 |
2009-08-11 |
Pfizer Inc |
Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
|
GB0327319D0
(en)
|
2003-11-24 |
2003-12-24 |
Pfizer Ltd |
Novel pharmaceuticals
|
US20070155731A1
(en)
|
2004-01-28 |
2007-07-05 |
Gabor Butora |
Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity
|
BRPI0507374A
(pt)
|
2004-02-02 |
2007-07-10 |
Pfizer Prod Inc |
moduladores do receptor de histamina-3
|
US7820680B2
(en)
|
2004-03-09 |
2010-10-26 |
Merck & Co., Inc. |
HIV integrase inhibitors
|
KR100814599B1
(ko)
|
2004-03-23 |
2008-03-17 |
화이자 프로덕츠 인크. |
신경퇴행성 장애 치료용 이미다졸 화합물
|
PL1742642T3
(pl)
|
2004-04-14 |
2009-06-30 |
Gilead Sciences Inc |
Analogi fosfonianowe związków inhibitorów integrazy HIV
|
US7456164B2
(en)
|
2004-05-07 |
2008-11-25 |
Pfizer, Inc |
3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
|
EP1595881A1
(en)
|
2004-05-12 |
2005-11-16 |
Pfizer Limited |
Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands
|
NZ552480A
(en)
|
2004-07-30 |
2010-01-29 |
Rinat Neuroscience Corp |
Antibodies directed against amyloid-beta peptide and methods of using same
|
FR2877015B1
(fr)
|
2004-10-21 |
2007-10-26 |
Commissariat Energie Atomique |
Revetement nanostructure et procede de revetement.
|
GB0423356D0
(en)
|
2004-10-21 |
2004-11-24 |
Merck Sharp & Dohme |
Therapeutic agents
|
US20090074775A1
(en)
|
2004-12-22 |
2009-03-19 |
David Michael Holtzman |
Use Of Anti-AB Antibody To Treat Traumatic Brain Injury
|
PE20061323A1
(es)
|
2005-04-29 |
2007-02-09 |
Rinat Neuroscience Corp |
Anticuerpos dirigidos contra el peptido amiloide beta y metodos que utilizan los mismos
|
EP1881825B1
(en)
|
2005-05-10 |
2013-07-24 |
Merck Sharp & Dohme Corp. |
Hiv integrase inhibitors
|
PL1881985T3
(pl)
|
2005-05-12 |
2011-05-31 |
Pfizer |
Bezwodne krystaliczne postacie N-[1-(2-etoksyetylo)-5-(N-etylo-N-metyloamino)-7-(4-metylopirydyn-2-yloamino)-1H-pirazolo[4,3-d]pirymidyno-3-karbonylo]metano-sulfonoamidu
|
WO2006126082A2
(en)
|
2005-05-24 |
2006-11-30 |
Pharmacia & Upjohn Company Llc |
Pyridine [3,4-b] pyrazinones as pde-5 inhibitors
|
CA2603830A1
(en)
|
2005-05-24 |
2006-11-30 |
Pharmacia & Upjohn Co Llc |
PYRIDINE [2,3-B] PYRAZINONES
|
WO2006126083A1
(en)
|
2005-05-24 |
2006-11-30 |
Pharmacia & Upjohn Company Llc |
Pyridine [3 , 4-b] pyrazinone compounds as pde-5 inhibitors
|
US7812040B2
(en)
|
2005-06-22 |
2010-10-12 |
Pfizer Inc. |
Histamine-3 receptor antagonists
|
US20070060534A1
(en)
|
2005-06-30 |
2007-03-15 |
Threshold Pharmaceuticals, Inc. |
Anthracycline analogs
|
US8158673B2
(en)
|
2005-10-27 |
2012-04-17 |
Pfizer Inc. |
Histamine-3 receptor antagonists
|
WO2007052124A1
(en)
|
2005-11-04 |
2007-05-10 |
Pfizer Limited |
Tetrahydronaphthyridine derivative
|
EP1948614A2
(en)
|
2005-11-18 |
2008-07-30 |
Takeda San Diego, Inc. |
Glucokinase activators
|
US20080275251A1
(en)
|
2005-11-18 |
2008-11-06 |
Glaxo Group Limited |
Novel Intermediates and Their Use
|
US20070117839A1
(en)
|
2005-11-24 |
2007-05-24 |
Eisai R&D Management Co., Ltd. |
Two cyclic cinnamide compound
|
TWI386207B
(zh)
|
2005-11-24 |
2013-02-21 |
Eisai R&D Man Co Ltd |
味啉類型之肉桂醯胺化合物
|
WO2007063385A2
(en)
|
2005-12-01 |
2007-06-07 |
Pfizer Products Inc. |
Spirocyclic amine histamine-3 receptor antagonists
|
WO2007069053A1
(en)
|
2005-12-14 |
2007-06-21 |
Pfizer Products Inc. |
Benzimidazole antagonists of the h-3 receptor
|
KR20080095885A
(ko)
*
|
2006-01-20 |
2008-10-29 |
쉐링 코포레이션 |
벤젠설포닐-크로만, 티오크로만, 테트라하이드로나프탈렌 및 관련된 감마 세크라타제 억제제
|
WO2007088450A2
(en)
|
2006-02-01 |
2007-08-09 |
Pfizer Products Inc. |
Chromane antagonist of the h-3 receptor
|
WO2007088462A1
(en)
|
2006-02-01 |
2007-08-09 |
Pfizer Products Inc. |
Spirochromane antagonists of the h-3 receptor
|
WO2007099423A1
(en)
|
2006-03-02 |
2007-09-07 |
Pfizer Products Inc. |
1-pyrrolidine indane derivatives as histamine-3 receptor antagonists
|
TWI378091B
(en)
|
2006-03-09 |
2012-12-01 |
Eisai R&D Man Co Ltd |
Multi-cyclic cinnamide derivatives
|
CA2643055A1
(en)
|
2006-03-13 |
2007-09-20 |
Pfizer Products Inc. |
Tetralines antagonists of the h-3 receptor
|
SI2013208T1
(sl)
|
2006-04-21 |
2011-09-30 |
Pfizer Prod Inc |
Piridin(3,4-b)pirazinoni
|
JP5271895B2
(ja)
|
2006-05-15 |
2013-08-21 |
メルク・シャープ・アンド・ドーム・コーポレーション |
抗糖尿病性の二環式化合物
|
WO2007136714A2
(en)
|
2006-05-16 |
2007-11-29 |
Gilead Sciences, Inc. |
Integrase inhibitors
|
WO2007135969A1
(ja)
|
2006-05-19 |
2007-11-29 |
Eisai R & D Management Co., Ltd. |
ウレア系-シンナミド誘導体
|
WO2007138431A2
(en)
|
2006-05-30 |
2007-12-06 |
Pfizer Products Inc. |
Azabicyclic ether histamine-3 antagonists
|
WO2008090429A1
(en)
|
2007-01-22 |
2008-07-31 |
Pfizer Products Inc. |
Tosylate salt of a therapeutic compound and pharmaceutical compositions thereof
|
AU2008215948A1
(en)
|
2007-02-12 |
2008-08-21 |
Merck & Co., Inc. |
Piperazine derivatives for treatment of AD and related conditions
|
CA2676920A1
(en)
|
2007-02-12 |
2008-08-21 |
Merck & Co., Inc. |
Piperidine derivatives
|
PE20081791A1
(es)
|
2007-02-28 |
2009-02-07 |
Eisai Randd Man Co Ltd |
Dos derivados ciclicos de oxomorfolina
|
WO2008137102A2
(en)
|
2007-05-04 |
2008-11-13 |
Torreypines Therapeutics, Inc. |
Methods of modulating amyloid beta and compounds useful therefor
|
EP2155737A1
(en)
|
2007-05-07 |
2010-02-24 |
Schering Corporation |
Gamma secretase modulators
|
CN101675045B
(zh)
|
2007-05-11 |
2012-11-28 |
弗·哈夫曼-拉罗切有限公司 |
作为β-淀粉样蛋白调节剂的杂芳基苯胺
|
TW200908968A
(en)
|
2007-05-29 |
2009-03-01 |
Sgx Pharmaceuticals Inc |
Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators
|
BRPI0812491A2
(pt)
|
2007-06-01 |
2014-12-02 |
Schering Corp |
Moduladores de gama secretase
|
KR20100037053A
(ko)
|
2007-06-01 |
2010-04-08 |
쉐링 코포레이션 |
감마 세크레타제 조절인자
|
WO2008156580A1
(en)
|
2007-06-13 |
2008-12-24 |
Merck & Co., Inc. |
Triazole derivatives for treating alzheimer's disease and related conditions
|
US20110053918A1
(en)
|
2007-06-29 |
2011-03-03 |
Zhaoning Zhu |
Gamma secretase modulators
|
PE20090957A1
(es)
|
2007-08-06 |
2009-07-13 |
Schering Corp |
Moduladores de gamma secretasa
|
JP5433418B2
(ja)
|
2007-08-31 |
2014-03-05 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
多環式化合物
|
US7935815B2
(en)
|
2007-08-31 |
2011-05-03 |
Eisai R&D Management Co., Ltd. |
Imidazoyl pyridine compounds and salts thereof
|
MX2010002674A
(es)
|
2007-09-06 |
2010-03-25 |
Schering Corp |
Moduladores de gamma secretasa.
|
JP2010540524A
(ja)
|
2007-09-28 |
2010-12-24 |
シェーリング コーポレイション |
ガンマセクレターゼモジュレーター
|
GB0720444D0
(en)
|
2007-10-18 |
2007-11-28 |
Glaxo Group Ltd |
Novel compounds
|
WO2009061699A1
(en)
|
2007-11-05 |
2009-05-14 |
Schering Corporation |
Gamma secretase modulators
|
CA2707722A1
(en)
|
2007-12-06 |
2009-06-11 |
Schering Corporation |
Gamma secretase modulators
|
MX2010006378A
(es)
|
2007-12-11 |
2010-09-07 |
Schering Corp |
Moduladores de gamma secretasa.
|
US20100298372A1
(en)
|
2007-12-11 |
2010-11-25 |
Schering Corporation |
Gamma secretase modulators
|
EP2231602A1
(en)
|
2007-12-13 |
2010-09-29 |
Amgen, Inc |
Gamma secretase modulators
|
US7923450B2
(en)
|
2008-01-11 |
2011-04-12 |
Hoffmann-La Roche Inc. |
Modulators for amyloid beta
|
MX2010008700A
(es)
|
2008-02-22 |
2010-08-30 |
Hoffmann La Roche |
Moduladores de beta-amiloide.
|
US20100137320A1
(en)
|
2008-02-29 |
2010-06-03 |
Schering Corporation |
Gamma secretase modulators
|
EP2257542A1
(en)
|
2008-02-29 |
2010-12-08 |
Schering Corporation |
Gamma secretase modulators for the treatment of alzheimer ' s disease
|
JP2011520809A
(ja)
|
2008-05-05 |
2011-07-21 |
アムジエン・インコーポレーテツド |
γセクレターゼモジュレーターとしての尿素化合物
|
FR2933700B1
(fr)
*
|
2008-07-08 |
2010-07-30 |
Sanofi Aventis |
Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
|
TW201006801A
(en)
|
2008-07-18 |
2010-02-16 |
Lilly Co Eli |
Imidazole carboxamides
|
EP2312945A4
(en)
|
2008-08-13 |
2012-05-09 |
Merck Sharp & Dohme |
PURE DERIVATIVES FOR THE TREATMENT OF MORBUS ALZHEIMER
|
US8685972B2
(en)
|
2008-08-13 |
2014-04-01 |
Merck Sharp & Dohme Corp. |
Pyrimidine derivatives for treatment of alzheimer's disease
|
JP2012501336A
(ja)
|
2008-08-27 |
2012-01-19 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
シンナミド化合物の製造法
|
BRPI0920651A2
(pt)
|
2008-10-09 |
2016-01-12 |
Hoffmann La Roche |
moduladores para amiloide beta
|
WO2010054064A1
(en)
|
2008-11-06 |
2010-05-14 |
Schering Corporation |
Gamma secretase modulators
|
RU2011116447A
(ru)
|
2008-11-06 |
2012-12-20 |
Астразенека Аб |
Модуляторы амилоида бета
|
JP2012508182A
(ja)
|
2008-11-06 |
2012-04-05 |
シェーリング コーポレイション |
γ−セクレターゼ調節剤
|
CN102209537A
(zh)
|
2008-11-10 |
2011-10-05 |
弗·哈夫曼-拉罗切有限公司 |
杂环γ分泌酶调节剂
|
WO2010071741A1
(en)
|
2008-12-16 |
2010-06-24 |
Merck Sharp & Dohme Corp. |
Triazole derivatives for treatment of alzheimer's disease
|
EP2379075A4
(en)
|
2008-12-16 |
2012-05-30 |
Merck Sharp & Dohme |
TRIAZOL DERIVATIVES FOR THE TREATMENT OF ALZHEIMER DISEASE
|
PA8854101A1
(es)
|
2008-12-18 |
2010-07-27 |
Ortho Mcneil Janssen Pharm |
Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
|
EP2379525B1
(en)
|
2008-12-19 |
2015-07-29 |
Boehringer Ingelheim International GmbH |
Cyclic pyrimidin-4-carboxamides as ccr2 receptor antagonists for treatment of inflammation, asthma and copd
|
AR074702A1
(es)
|
2008-12-22 |
2011-02-02 |
Schering Corp |
Moduladores de gamma secretasa y composiciones farmaceuticas que los contienen
|
JP2012513399A
(ja)
|
2008-12-22 |
2012-06-14 |
シェーリング コーポレイション |
γ−セクレターゼ調節剤
|
TW201030002A
(en)
|
2009-01-16 |
2010-08-16 |
Bristol Myers Squibb Co |
Bicyclic compounds for the reduction of beta-amyloid production
|
CN102325765B
(zh)
|
2009-02-06 |
2014-12-24 |
杨森制药公司 |
作为γ-分泌酶调节剂的取代的双环杂环化合物
|
TWI461425B
(zh)
|
2009-02-19 |
2014-11-21 |
Janssen Pharmaceuticals Inc |
作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
|
JP2012121809A
(ja)
|
2009-02-26 |
2012-06-28 |
Eisai R & D Management Co Ltd |
多環式化合物の製造法およびその中間体
|
JP2012051805A
(ja)
|
2009-02-26 |
2012-03-15 |
Eisai R & D Management Co Ltd |
テトラヒドロトリアゾロピリジン誘導体の製造方法
|
JP2012051806A
(ja)
|
2009-02-26 |
2012-03-15 |
Eisai R & D Management Co Ltd |
イミダゾリルピラジン誘導体
|
JP2012051807A
(ja)
|
2009-02-26 |
2012-03-15 |
Eisai R & D Management Co Ltd |
アリールイミダゾール化合物
|
CN102333778B
(zh)
|
2009-02-26 |
2015-05-13 |
卫材R&D管理有限公司 |
四氢三唑并吡啶衍生物的盐及其晶体
|
JP2012519682A
(ja)
|
2009-03-03 |
2012-08-30 |
ファイザー・インク |
ガンマ−セクレターゼモジュレーターとしての新規フェニルイミダゾールおよびフェニルトリアゾール
|
JP5771207B2
(ja)
|
2009-08-07 |
2015-08-26 |
ダウ アグロサイエンシィズ エルエルシー |
有害生物防除組成物
|
EP2491026A1
(en)
*
|
2009-10-20 |
2012-08-29 |
Pfizer Inc. |
Novel heteroaryl imidazoles and heteroaryl triazoles as gamma-secretase modulators
|
SG10201502073PA
(en)
*
|
2009-12-22 |
2015-05-28 |
Vertex Pharma |
Isoindolinone inhibitors of phosphatidylinositol 3-kinase
|
EP2691393B1
(en)
|
2011-03-31 |
2016-09-14 |
Pfizer Inc |
Novel bicyclic pyridinones
|
AU2013261023B2
(en)
*
|
2012-05-16 |
2016-11-24 |
Cellzome Limited |
Substituted 3, 4 - dihydro - 2H - pyrido [1, 2 -a] pyrazine - 1, 6 - dione derivatives useful for the treatment of (inter alia) Alzheimer's disease
|
UA110688C2
(uk)
|
2012-09-21 |
2016-01-25 |
Пфайзер Інк. |
Біциклічні піридинони
|
TWI614238B
(zh)
|
2012-09-21 |
2018-02-11 |
必治妥美雅史谷比公司 |
雙(氟烷基)-1,4-苯并二氮呯酮化合物及其前藥
|
EP2953949B1
(en)
|
2012-12-20 |
2016-09-28 |
Janssen Pharmaceutica NV |
Novel tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators
|
US10246454B2
(en)
|
2013-01-17 |
2019-04-02 |
Janssen Pharmaceutica Nv |
Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators
|
EP3052495B1
(en)
|
2013-10-04 |
2019-06-26 |
Pfizer Inc |
Novel bicyclic pyridinones as gamma-secretase modulators
|
US11497586B2
(en)
|
2014-03-21 |
2022-11-15 |
Align Technology, Inc. |
Segmented orthodontic appliance with elastics
|
CR20160454A
(es)
|
2014-04-01 |
2016-12-06 |
Pfizer |
CROMENO Y 1,1 a,2,7b—TETRAHIDROCICLOPROPA[C]CROMENO PIRIDOPIRAZINADIONAS NOVEDOSAS
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