IN2012DN03328A - - Google Patents

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Publication number
IN2012DN03328A
IN2012DN03328A IN3328DEN2012A IN2012DN03328A IN 2012DN03328 A IN2012DN03328 A IN 2012DN03328A IN 3328DEN2012 A IN3328DEN2012 A IN 3328DEN2012A IN 2012DN03328 A IN2012DN03328 A IN 2012DN03328A
Authority
IN
India
Prior art keywords
medicament
pharmaceutically
manufacture
processes
formula
Prior art date
Application number
Other languages
English (en)
Inventor
Bernard Christophe BALRAAM
Sebastien Louis Degorce
Der Brempt Christine Lambert-Van
Remy Robert Morgentin
Partick PLE
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of IN2012DN03328A publication Critical patent/IN2012DN03328A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IN3328DEN2012 2009-10-27 2010-10-25 IN2012DN03328A (enExample)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09306017 2009-10-27
PCT/GB2010/051788 WO2011051704A1 (en) 2009-10-27 2010-10-25 Chromenone derivatives with anti-tumour activity

Publications (1)

Publication Number Publication Date
IN2012DN03328A true IN2012DN03328A (enExample) 2015-10-23

Family

ID=43085922

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3328DEN2012 IN2012DN03328A (enExample) 2009-10-27 2010-10-25

Country Status (41)

Country Link
US (5) US8399460B2 (enExample)
EP (1) EP2493870B1 (enExample)
JP (2) JP5657010B2 (enExample)
KR (1) KR101738195B1 (enExample)
CN (2) CN104447657B (enExample)
AR (1) AR078786A1 (enExample)
AU (1) AU2010311107B9 (enExample)
BR (1) BR112012010124B8 (enExample)
CA (1) CA2776994C (enExample)
CL (1) CL2012001056A1 (enExample)
CO (1) CO6541528A2 (enExample)
CR (1) CR20120217A (enExample)
CU (1) CU20120069A7 (enExample)
CY (1) CY1116143T1 (enExample)
DK (1) DK2493870T3 (enExample)
DO (1) DOP2012000124A (enExample)
EA (1) EA020523B9 (enExample)
EC (1) ECSP12011838A (enExample)
ES (1) ES2530943T3 (enExample)
GT (1) GT201200126A (enExample)
HN (1) HN2012000889A (enExample)
HR (1) HRP20150146T1 (enExample)
IL (1) IL219191A0 (enExample)
IN (1) IN2012DN03328A (enExample)
ME (1) ME02050B (enExample)
MX (1) MX2012005027A (enExample)
MY (1) MY179833A (enExample)
NI (1) NI201200081A (enExample)
NZ (1) NZ599457A (enExample)
PE (1) PE20130149A1 (enExample)
PH (1) PH12012500804A1 (enExample)
PL (1) PL2493870T3 (enExample)
PT (1) PT2493870E (enExample)
RS (1) RS53813B1 (enExample)
SA (1) SA110310808B1 (enExample)
SI (1) SI2493870T1 (enExample)
SM (1) SMT201500036B (enExample)
TW (1) TWI483939B (enExample)
UA (1) UA107474C2 (enExample)
UY (1) UY32978A (enExample)
WO (1) WO2011051704A1 (enExample)

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JP5599783B2 (ja) 2008-05-30 2014-10-01 アムジエン・インコーポレーテツド Pi3キナーゼの阻害薬
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CA2952025A1 (en) 2014-06-13 2015-12-17 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
CA2952044C (en) 2014-06-13 2019-01-29 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
MX2016016538A (es) 2014-06-13 2017-05-01 Gilead Sciences Inc Derivados de quinazolinona como inhibidores de fosfatidilinositol 3-cinasa.
MX2016016516A (es) 2014-06-13 2017-05-01 Gilead Sciences Inc Inhibidores de fosfatidilinositol 3-cinasa.
CN104744376A (zh) * 2015-03-14 2015-07-01 长沙深橙生物科技有限公司 一种2-异丙基嘧啶衍生物的制备方法
CN104803921A (zh) * 2015-03-14 2015-07-29 长沙深橙生物科技有限公司 一种苯取代嘧啶衍生物的制备方法
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TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
AR121719A1 (es) * 2020-04-03 2022-06-29 Petra Pharma Corp Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades
KR20210141214A (ko) * 2020-05-15 2021-11-23 제이투에이치바이오텍 (주) 3원환 화합물 및 이의 의약 용도
CN117615763A (zh) * 2021-02-01 2024-02-27 健道生物医药有限公司 磷酸肌醇3激酶β抑制剂及其组合物和制备方法
MX2023013082A (es) * 2021-05-03 2024-01-08 Petra Pharma Corp Inhibidores alostéricos de cromenona de la fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades.
CA3217937A1 (en) 2021-05-03 2022-11-10 Erin Danielle ANDERSON Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease
CN117597343A (zh) * 2021-05-03 2024-02-23 佩特拉制药公司 用于治疗疾病的磷酸肌醇3-激酶(pi3k)的变构色烯酮抑制剂
MX2023013987A (es) * 2021-05-27 2024-02-12 Petra Pharma Corp Inhibidores alostéricos de cromenona de la fosfoinosítido 3-quinasa (pi3k) para el tratamiento contra el cáncer.
CN117769546A (zh) * 2021-05-27 2024-03-26 佩特拉制药公司 用于治疗疾病的磷酸肌醇3-激酶(pi3k)的变构色烯酮抑制剂
CN118043044A (zh) * 2021-09-30 2024-05-14 佩特拉制药公司 用于治疗疾病的磷酸肌醇3-激酶(pi3k)的变构色烯酮抑制剂
TW202329930A (zh) 2021-09-30 2023-08-01 美商佩特拉製藥公司 用於治療疾病之磷酸肌醇3-激酶(pi3k)之異位色烯酮抑制劑
EP4412606A4 (en) * 2021-10-07 2025-09-24 Relay Therapeutics Inc PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF
EP4444714A4 (en) * 2021-12-08 2025-10-29 Nanjing Zenshine Pharmaceuticals Co Ltd CONDENSED HETEROCYCLIC COMPOUNDS USED AS PI3KALPHA INHIBITORS
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Also Published As

Publication number Publication date
ECSP12011838A (es) 2012-06-29
CN102712615B (zh) 2014-12-17
CN104447657A (zh) 2015-03-25
NZ599457A (en) 2014-04-30
PT2493870E (pt) 2015-02-18
JP5872016B2 (ja) 2016-03-01
EP2493870A1 (en) 2012-09-05
MY179833A (en) 2020-11-17
JP5657010B2 (ja) 2015-01-21
US8399460B2 (en) 2013-03-19
US8673906B2 (en) 2014-03-18
BR112012010124B1 (pt) 2021-02-17
SI2493870T1 (sl) 2015-03-31
RS53813B1 (sr) 2015-06-30
DOP2012000124A (es) 2012-07-15
KR20120098724A (ko) 2012-09-05
CA2776994A1 (en) 2011-05-05
CU20120069A7 (es) 2012-10-15
CO6541528A2 (es) 2012-10-16
US9718800B2 (en) 2017-08-01
CA2776994C (en) 2017-10-31
US20140194419A1 (en) 2014-07-10
SA110310808B1 (ar) 2013-11-24
EA020523B1 (ru) 2014-11-28
CN104447657B (zh) 2016-08-17
DK2493870T3 (en) 2015-02-23
US9029374B2 (en) 2015-05-12
NI201200081A (es) 2012-11-07
BR112012010124A2 (pt) 2016-06-07
TW201121960A (en) 2011-07-01
ES2530943T3 (es) 2015-03-09
HK1174027A1 (en) 2013-05-31
PL2493870T3 (pl) 2015-04-30
CL2012001056A1 (es) 2012-10-05
ME02050B (me) 2015-05-20
AU2010311107B2 (en) 2014-03-27
UA107474C2 (uk) 2015-01-12
MX2012005027A (es) 2012-09-07
AU2010311107B9 (en) 2014-06-19
JP2015078202A (ja) 2015-04-23
CN102712615A (zh) 2012-10-03
WO2011051704A1 (en) 2011-05-05
CY1116143T1 (el) 2017-02-08
EP2493870B1 (en) 2014-12-17
PH12012500804A1 (en) 2022-10-03
US20160060240A1 (en) 2016-03-03
AR078786A1 (es) 2011-11-30
US20160272607A1 (en) 2016-09-22
GT201200126A (es) 2014-03-03
KR101738195B1 (ko) 2017-05-19
EA020523B9 (ru) 2015-01-30
US20110098271A1 (en) 2011-04-28
PE20130149A1 (es) 2013-03-10
TWI483939B (zh) 2015-05-11
UY32978A (es) 2011-05-31
HK1206335A1 (zh) 2016-01-08
HN2012000889A (es) 2015-08-03
AU2010311107A1 (en) 2012-05-03
HRP20150146T1 (hr) 2015-05-22
SMT201500036B (it) 2015-05-05
US20130158026A1 (en) 2013-06-20
CR20120217A (es) 2012-06-28
EA201200618A1 (ru) 2012-12-28
JP2013508449A (ja) 2013-03-07
IL219191A0 (en) 2012-06-28
BR112012010124B8 (pt) 2021-05-25

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