RS53813B1 - Derivati hromenona sa anti-tumorskim delovanjem - Google Patents

Derivati hromenona sa anti-tumorskim delovanjem

Info

Publication number
RS53813B1
RS53813B1 RS20150090A RSP20150090A RS53813B1 RS 53813 B1 RS53813 B1 RS 53813B1 RS 20150090 A RS20150090 A RS 20150090A RS P20150090 A RSP20150090 A RS P20150090A RS 53813 B1 RS53813 B1 RS 53813B1
Authority
RS
Serbia
Prior art keywords
ethyl
alkyl
oxo
chromene
formula
Prior art date
Application number
RS20150090A
Other languages
English (en)
Serbian (sr)
Inventor
Bernard Christophe Barlaam
Sebastien Louis Degorce
Christine Marie Paul Lambert-Van Der Brempt
Remy Robert Morgentin
Patrick Ple
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of RS53813B1 publication Critical patent/RS53813B1/sr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • A61K31/277Nitriles; Isonitriles having a ring, e.g. verapamil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RS20150090A 2009-10-27 2010-10-25 Derivati hromenona sa anti-tumorskim delovanjem RS53813B1 (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09306017 2009-10-27
PCT/GB2010/051788 WO2011051704A1 (en) 2009-10-27 2010-10-25 Chromenone derivatives with anti-tumour activity

Publications (1)

Publication Number Publication Date
RS53813B1 true RS53813B1 (sr) 2015-06-30

Family

ID=43085922

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20150090A RS53813B1 (sr) 2009-10-27 2010-10-25 Derivati hromenona sa anti-tumorskim delovanjem

Country Status (41)

Country Link
US (5) US8399460B2 (enExample)
EP (1) EP2493870B1 (enExample)
JP (2) JP5657010B2 (enExample)
KR (1) KR101738195B1 (enExample)
CN (2) CN102712615B (enExample)
AR (1) AR078786A1 (enExample)
AU (1) AU2010311107B9 (enExample)
BR (1) BR112012010124B8 (enExample)
CA (1) CA2776994C (enExample)
CL (1) CL2012001056A1 (enExample)
CO (1) CO6541528A2 (enExample)
CR (1) CR20120217A (enExample)
CU (1) CU20120069A7 (enExample)
CY (1) CY1116143T1 (enExample)
DK (1) DK2493870T3 (enExample)
DO (1) DOP2012000124A (enExample)
EA (1) EA020523B9 (enExample)
EC (1) ECSP12011838A (enExample)
ES (1) ES2530943T3 (enExample)
GT (1) GT201200126A (enExample)
HN (1) HN2012000889A (enExample)
HR (1) HRP20150146T1 (enExample)
IL (1) IL219191A0 (enExample)
IN (1) IN2012DN03328A (enExample)
ME (1) ME02050B (enExample)
MX (1) MX2012005027A (enExample)
MY (1) MY179833A (enExample)
NI (1) NI201200081A (enExample)
NZ (1) NZ599457A (enExample)
PE (1) PE20130149A1 (enExample)
PH (1) PH12012500804A1 (enExample)
PL (1) PL2493870T3 (enExample)
PT (1) PT2493870E (enExample)
RS (1) RS53813B1 (enExample)
SA (1) SA110310808B1 (enExample)
SI (1) SI2493870T1 (enExample)
SM (1) SMT201500036B (enExample)
TW (1) TWI483939B (enExample)
UA (1) UA107474C2 (enExample)
UY (1) UY32978A (enExample)
WO (1) WO2011051704A1 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX315904B (es) 2008-05-30 2013-11-29 Amgen Inc Inhibidores de fosfoinosituro-3 cinasa.
US8399460B2 (en) * 2009-10-27 2013-03-19 Astrazeneca Ab Chromenone derivatives
UY34013A (es) * 2011-04-13 2012-11-30 Astrazeneca Ab ?compuestos de cromenona con actividad anti-tumoral?.
AU2014208964B2 (en) 2013-01-23 2016-09-01 Astrazeneca Ab Chemical compounds
MX362905B (es) * 2013-03-04 2019-02-25 Astrazeneca Ab Tratamiento de combinacion.
WO2015191754A2 (en) 2014-06-13 2015-12-17 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
WO2015191726A1 (en) 2014-06-13 2015-12-17 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
NZ726052A (en) 2014-06-13 2018-04-27 Gilead Sciences Inc Phosphatidylinositol 3-kinase inhibitors
SG11201609527PA (en) 2014-06-13 2016-12-29 Gilead Sciences Inc Quinazolinone derivatives as phosphatidylinositol 3-kinase inhibitors
EP3154958B1 (en) 2014-06-13 2020-10-07 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
CN104803921A (zh) * 2015-03-14 2015-07-29 长沙深橙生物科技有限公司 一种苯取代嘧啶衍生物的制备方法
CN104744376A (zh) * 2015-03-14 2015-07-01 长沙深橙生物科技有限公司 一种2-异丙基嘧啶衍生物的制备方法
KR101766731B1 (ko) 2015-06-23 2017-08-10 충남대학교산학협력단 강심 활성을 갖는 크로메논 유도체 및 이를 포함하는 심부전의 예방 또는 치료용 약학 조성물
KR102630111B1 (ko) * 2015-10-09 2024-01-25 얀센 파마슈티카 엔브이 PI3Kβ 저해제로서의 퀴녹살린 및 피리도피라진 유도체
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
WO2018057808A1 (en) 2016-09-23 2018-03-29 Gilead Sciences, Inc. Benzimidazole derivatives and their use as phosphatidylinositol 3-kinase inhibitors
AR121719A1 (es) 2020-04-03 2022-06-29 Petra Pharma Corp Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades
KR20210141214A (ko) * 2020-05-15 2021-11-23 제이투에이치바이오텍 (주) 3원환 화합물 및 이의 의약 용도
EP4284375A4 (en) * 2021-02-01 2025-04-23 Geode Therapeutics Inc. PHOSPHOINOSITIDE 3-KINASE BETA INHIBITORS AND COMPOSITIONS AND METHODS THEREFOR
IL308191A (en) * 2021-05-03 2024-01-01 Petra Pharma Corp Allosteric chromanone inhibitors of PHOSPHOINOSITIDE 3-KINASE (PI3K) for the treatment of diseases
CR20230517A (es) * 2021-05-03 2023-11-28 Petra Pharma Corp Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades
MX2023013987A (es) * 2021-05-27 2024-02-12 Petra Pharma Corp Inhibidores alostéricos de cromenona de la fosfoinosítido 3-quinasa (pi3k) para el tratamiento contra el cáncer.
TW202329930A (zh) * 2021-09-30 2023-08-01 美商佩特拉製藥公司 用於治療疾病之磷酸肌醇3-激酶(pi3k)之異位色烯酮抑制劑
WO2023060262A1 (en) * 2021-10-07 2023-04-13 Relay Therapeutics, Inc. Pi3k-alpha inhibitors and methods of use thereof
EP4444714A4 (en) * 2021-12-08 2025-10-29 Nanjing Zenshine Pharmaceuticals Co Ltd CONDENSED HETEROCYCLIC COMPOUNDS USED AS PI3KALPHA INHIBITORS
WO2024003241A1 (en) 2022-06-30 2024-01-04 Astrazeneca Ab Treatment for immuno-oncology resistant subjects with an anti pd-l1 antibody an antisense targeted to stat3 and an inhibitor of ctla-4
EP4602031A1 (en) * 2022-10-14 2025-08-20 Genesis Therapeutics, Inc. Methods for treating cancer
WO2025026442A1 (zh) * 2023-08-02 2025-02-06 郑州同源康医药有限公司 稠环类化合物及其用途

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6027A (en) * 1849-01-09 Rotary blacksmith s twyer
FI912995A0 (fi) 1988-12-21 1991-06-19 Upjohn Co Atiaterosklerotiska och antirombotiska 1-benzopyran-4-oner och 2-amino-1,3-benzoxazin-4-oner.
JPH05509302A (ja) 1990-06-20 1993-12-22 ジ・アップジョン・カンパニー 抗アテローム性動脈硬化性および抗血栓性1―ベンゾピラン―4―オン類および2―アミノ―1,3―ベンゾオキサジン―4―オン類
DE4318756A1 (de) 1993-06-05 1994-12-08 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
JP4471404B2 (ja) 1996-02-13 2010-06-02 アストラゼネカ ユーケイ リミテッド Vegfインヒビターとしてのキナゾリン誘導体
KR100489174B1 (ko) 1996-03-05 2005-09-30 제네카-파마 소시에떼아노님 4-아닐리노퀴나졸린유도체
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
PL205557B1 (pl) 1999-02-10 2010-05-31 Astrazeneca Ab Pochodne indolu
JP4820518B2 (ja) 2000-01-24 2011-11-24 アストラゼネカ アクチボラグ モルホリノ置換化合物治療薬
BR0111230A (pt) 2000-05-31 2003-06-10 Astrazeneca Ab Composto, e, uso e processo para a preparação do mesmo
UA73993C2 (uk) 2000-06-06 2005-10-17 Астразенека Аб Хіназолінові похідні для лікування пухлин та фармацевтична композиція
BR0112224A (pt) 2000-07-07 2003-06-10 Angiogene Pharm Ltd Composto, composição farmacêutica, uso de um composto ou de um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo, e, processo para preparar um composto
SK52003A3 (en) 2000-07-07 2003-07-01 Angiogene Pharm Ltd Colchinol derivatives as angiogenesis inhibitors, method for their preparation and pharmaceutical composition comprising the same
EP1537102A4 (en) 2002-08-16 2010-12-08 Astrazeneca Ab INHIBITORS OF PHOSPHOINOSITIDE-3-KINASE BETA
AR054438A1 (es) * 2005-04-15 2007-06-27 Kudos Pharm Ltd Inhibidores de adn -pk
WO2007045876A1 (en) 2005-10-21 2007-04-26 Merz Pharma Gmbh & Co. Kgaa Chromenones and their use as modulators of metabotropic glutamate receptors
CN101506211B (zh) * 2006-04-04 2013-05-22 加利福尼亚大学董事会 激酶拮抗剂
WO2008064244A2 (en) 2006-11-20 2008-05-29 The Trustees Of Columbia University In The City Of New York Phosphoinositide modulation for the treatment of neurodegenerative diseases
EP2112145A1 (en) 2008-04-24 2009-10-28 AxoGlia Therapeutics S.A. Chromenone derivatives useful for the treatment of neurodegenerative diseases
WO2010134082A1 (en) 2009-05-21 2010-11-25 Proteologics Ltd Chromenone derivatives for treatment of cancer
US8399460B2 (en) * 2009-10-27 2013-03-19 Astrazeneca Ab Chromenone derivatives

Also Published As

Publication number Publication date
ME02050B (me) 2015-05-20
ES2530943T3 (es) 2015-03-09
MY179833A (en) 2020-11-17
UY32978A (es) 2011-05-31
US9029374B2 (en) 2015-05-12
SI2493870T1 (sl) 2015-03-31
HN2012000889A (es) 2015-08-03
BR112012010124B8 (pt) 2021-05-25
GT201200126A (es) 2014-03-03
KR20120098724A (ko) 2012-09-05
PL2493870T3 (pl) 2015-04-30
HK1206335A1 (zh) 2016-01-08
AU2010311107B9 (en) 2014-06-19
CA2776994A1 (en) 2011-05-05
CN104447657A (zh) 2015-03-25
DOP2012000124A (es) 2012-07-15
SMT201500036B (it) 2015-05-05
AR078786A1 (es) 2011-11-30
BR112012010124B1 (pt) 2021-02-17
AU2010311107B2 (en) 2014-03-27
SA110310808B1 (ar) 2013-11-24
CR20120217A (es) 2012-06-28
HRP20150146T1 (hr) 2015-05-22
CN104447657B (zh) 2016-08-17
PE20130149A1 (es) 2013-03-10
CA2776994C (en) 2017-10-31
PH12012500804A1 (en) 2022-10-03
CO6541528A2 (es) 2012-10-16
TWI483939B (zh) 2015-05-11
JP5657010B2 (ja) 2015-01-21
JP5872016B2 (ja) 2016-03-01
US20160272607A1 (en) 2016-09-22
CL2012001056A1 (es) 2012-10-05
NI201200081A (es) 2012-11-07
US20110098271A1 (en) 2011-04-28
BR112012010124A2 (pt) 2016-06-07
US20130158026A1 (en) 2013-06-20
CN102712615B (zh) 2014-12-17
AU2010311107A1 (en) 2012-05-03
ECSP12011838A (es) 2012-06-29
JP2015078202A (ja) 2015-04-23
DK2493870T3 (en) 2015-02-23
EP2493870B1 (en) 2014-12-17
IN2012DN03328A (enExample) 2015-10-23
EA201200618A1 (ru) 2012-12-28
CY1116143T1 (el) 2017-02-08
JP2013508449A (ja) 2013-03-07
EA020523B1 (ru) 2014-11-28
EA020523B9 (ru) 2015-01-30
HK1174027A1 (en) 2013-05-31
NZ599457A (en) 2014-04-30
CU20120069A7 (es) 2012-10-15
US8399460B2 (en) 2013-03-19
PT2493870E (pt) 2015-02-18
MX2012005027A (es) 2012-09-07
TW201121960A (en) 2011-07-01
UA107474C2 (uk) 2015-01-12
CN102712615A (zh) 2012-10-03
WO2011051704A1 (en) 2011-05-05
US9718800B2 (en) 2017-08-01
US20160060240A1 (en) 2016-03-03
EP2493870A1 (en) 2012-09-05
KR101738195B1 (ko) 2017-05-19
US20140194419A1 (en) 2014-07-10
US8673906B2 (en) 2014-03-18
IL219191A0 (en) 2012-06-28

Similar Documents

Publication Publication Date Title
DK2493870T3 (en) CHROMENONDERIVATER WITH antitumor activity
AU2012241594B2 (en) Chromenone compounds as PI 3 -kinase inhibitors for the treatment of cancer
HK1206335B (en) Chromenone derivatives with anti-tumour activity
HK1174027B (en) Chromenone derivatives with anti-tumour activity
HK1193823B (en) Chromenone compounds as pi 3 -kinase inhibitors for the treatment of cancer