|
CA1247538A
(en)
*
|
1982-05-21 |
1988-12-28 |
Mark C. Glassy |
Human-human hybridomas for solid tumors
|
|
US4618577A
(en)
*
|
1983-02-09 |
1986-10-21 |
The Regents Of The University Of California |
Human-human hybridoma, CLNH5
|
|
US4939240A
(en)
*
|
1983-03-04 |
1990-07-03 |
Health Research, Inc. |
Monoclonal antibodies to human breast carcinoma cells and their use in diagnosis and therapy
|
|
CA1215331A
(en)
*
|
1983-03-04 |
1986-12-16 |
Tsann M. Chu |
Monoclonal antibodies to human breast carcinoma cells and their use in diagnosis and therapy
|
|
US4613576A
(en)
*
|
1983-03-09 |
1986-09-23 |
Sloan-Kettering Institute For Cancer Research |
Human monoclonal antibodies to cancer cells
|
|
US4693966A
(en)
*
|
1983-03-11 |
1987-09-15 |
Sloan-Kettering Institute For Cancer Research |
Human monoclonal antibodies from lymphocytes of patients with malignant melanoma
|
|
SE8401945L
(sv)
*
|
1983-04-08 |
1984-11-13 |
Kureha Chemical Ind Co Ltd |
Antikropp mot cancer i urinblasan hos menniska
|
|
WO1985002411A1
(en)
*
|
1983-11-25 |
1985-06-06 |
The University Of Melbourne |
Cell line and monoclonal antibody
|
|
NZ210867A
(en)
*
|
1984-01-31 |
1989-01-06 |
Litton Bionetics Inc |
Tumour-specific monoclonal antibodies, production thereof and use
|
|
EP0157613A3
(en)
*
|
1984-03-30 |
1987-09-30 |
Syntex (U.S.A.) Inc. |
Monoclonal antibodies specific for human basal cell and malignant squamous cell protein, hybridomas therefor, malignancy test methods and diagnostic kits
|
|
US4886745A
(en)
*
|
1984-03-30 |
1989-12-12 |
Syntex Inc. |
Monoclonal antibody specific for human basal cell surface antigen
|
|
JPS6133125A
(ja)
*
|
1984-07-25 |
1986-02-17 |
Morinaga & Co Ltd |
ヒト単クロ−ン性抗肺ガン細胞抗体
|
|
US4761377A
(en)
*
|
1984-10-15 |
1988-08-02 |
The Regents Of The University Of California |
Human-human hybrid cell lines that produce antibodies against antigenic determinants on cancer cells
|
|
JPS61130300A
(ja)
*
|
1984-11-27 |
1986-06-18 |
ザ ボ−ド オブ トラステイ−ズ オブ ザ レランド スタンフオ−ド ジユニア ユニバ−シテイ |
ヒトモノクロ−ナル抗体
|
|
US5106746A
(en)
*
|
1985-05-22 |
1992-04-21 |
E. I. Du Pont De Nemours And Company |
Process for the in vitro immunization of human splenocytes against tumor associated antigens
|
|
US5776093A
(en)
*
|
1985-07-05 |
1998-07-07 |
Immunomedics, Inc. |
Method for imaging and treating organs and tissues
|
|
JPH0655680B2
(ja)
*
|
1985-10-26 |
1994-07-27 |
萩原 義秀 |
悪性腫瘍用ヒトモノクロナル抗体複合剤
|
|
EP0222360A3
(en)
*
|
1985-11-12 |
1989-03-15 |
Biotherapeutics Inc. |
A method of producing a patient-specific cytotoxic reagent and composition
|
|
JPH0767388B2
(ja)
*
|
1986-01-13 |
1995-07-26 |
三菱化学株式会社 |
抗体産生細胞株の樹立方法
|
|
US5434076A
(en)
*
|
1989-12-18 |
1995-07-18 |
Board Of Regents, The University Of Texas System |
Tumor-specific, cell surface-binding monoclonal antibodies
|
|
US5281710A
(en)
*
|
1990-08-01 |
1994-01-25 |
The Scripps Research Institute |
Dynemicin analogs: synthesis, methods of preparation and use
|
|
JPH04346792A
(ja)
*
|
1991-05-22 |
1992-12-02 |
Hagiwara Yoshihide |
抗癌ヒトモノクローナル抗体のアミノ酸配列及びそれをコードするdna塩基配列
|
|
EP0528663B1
(en)
*
|
1991-08-16 |
1997-10-29 |
Kabushiki Kaisha Toshiba |
Monoclonal antibody to a synaptophysin
|
|
KR20010022846A
(ko)
|
1997-08-15 |
2001-03-26 |
나가야마 오사무 |
항 인터루킨-6 수용체 항체를 유효성분으로서 함유하는 전신성 홍반성 낭창의 예방 및/또는 치료제
|
|
ES2307526T3
(es)
|
1999-08-23 |
2008-12-01 |
Chugai Seiyaku Kabushiki Kaisha |
Potenciadores de la expresion del antigeno hm1.24.
|
|
EP1222854B1
(en)
|
1999-10-01 |
2011-02-16 |
Chugai Seiyaku Kabushiki Kaisha |
Prevention and treatment of diseases associated with blood coagulation
|
|
JP3986439B2
(ja)
|
2001-02-07 |
2007-10-03 |
中外製薬株式会社 |
造血器腫瘍の治療剤
|
|
UA80091C2
(en)
|
2001-04-02 |
2007-08-27 |
Chugai Pharmaceutical Co Ltd |
Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
|
|
KR101080021B1
(ko)
|
2002-02-14 |
2011-11-04 |
추가이 세이야쿠 가부시키가이샤 |
항체함유 용액제제
|
|
EP1541165A4
(en)
|
2002-08-27 |
2009-06-24 |
Chugai Pharmaceutical Co Ltd |
METHOD FOR STABILIZING PROTEIN PREPARATION
|
|
DK1561756T3
(en)
|
2002-09-11 |
2016-02-15 |
Chugai Pharmaceutical Co Ltd |
PROCEDURE FOR CLEANING PROTEIN.
|
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
|
US7863042B2
(en)
|
2003-06-18 |
2011-01-04 |
Chugai Seiyaku Kabushiki Kaisha |
Fucose transporter
|
|
EP2311468B1
(en)
|
2003-08-08 |
2014-01-15 |
Perseus Proteomics Inc. |
Gene overexpressed in cancer
|
|
ATE512232T1
(de)
|
2003-12-03 |
2011-06-15 |
Chugai Pharmaceutical Co Ltd |
Expressionssystem mit einem säuger-beta-actin- promotor
|
|
US20080206229A1
(en)
|
2003-12-12 |
2008-08-28 |
Koichiro Ono |
Modified Antibodies Recognizing Receptor Trimers or Higher Multimers
|
|
CN102702353A
(zh)
|
2004-07-09 |
2012-10-03 |
中外制药株式会社 |
抗-磷脂酰肌醇蛋白聚糖3抗体
|
|
US20090061485A1
(en)
|
2004-12-22 |
2009-03-05 |
Chugai Seiyaku Kabushiki Kaisha |
Method of Producing an Antibody Using a Cell in Which the Function of Fucose Transporter Is Inhibited
|
|
TWI671403B
(zh)
|
2005-03-31 |
2019-09-11 |
中外製藥股份有限公司 |
控制組裝之多肽的製造方法
|
|
CA2610987C
(en)
|
2005-06-10 |
2013-09-10 |
Chugai Seiyaku Kabushiki Kaisha |
Stabilizer for protein preparation comprising meglumine and use thereof
|
|
AR061400A1
(es)
|
2005-10-14 |
2008-08-27 |
Chugai Kabushiki Kaisha |
Agentes para suprimir el dano a los islotes transplantados despues del transplante de islotes
|
|
JP5398987B2
(ja)
|
2005-11-14 |
2014-01-29 |
セルミド リミテッド |
調節性t細胞の機能異常に基づく疾患の治療方法及び予防方法
|
|
AR057582A1
(es)
|
2005-11-15 |
2007-12-05 |
Nat Hospital Organization |
Agentes para suprimir la induccion de linfocitos t citotoxicos
|
|
KR20080084818A
(ko)
|
2005-11-25 |
2008-09-19 |
각고호우징 게이오기주크 |
전립선암 치료제
|
|
AU2007208678B2
(en)
|
2006-01-27 |
2013-01-10 |
Chugai Seiyaku Kabushiki Kaisha |
Therapeutic agents for diseases involving choroidal neovascularization
|
|
DK2009101T3
(en)
|
2006-03-31 |
2018-01-15 |
Chugai Pharmaceutical Co Ltd |
Antibody modification method for purification of a bispecific antibody
|
|
DK3056568T3
(da)
|
2006-03-31 |
2021-11-01 |
Chugai Pharmaceutical Co Ltd |
Fremgangsmåder til kontrollering af antistoffers blodfarmakokinetik
|
|
EP2011870A4
(en)
|
2006-04-14 |
2010-09-15 |
Medical & Biol Lab Co Ltd |
MUTANT POLYPEPTIDE WITH EFFECTOR FUNCTION
|
|
RU2511406C2
(ru)
|
2006-06-08 |
2014-04-10 |
Чугаи Сейяку Кабусики Кайся |
Профилактическое или лекарственное средство для воспалительного заболевания
|
|
KR20090021217A
(ko)
|
2006-06-14 |
2009-02-27 |
추가이 세이야쿠 가부시키가이샤 |
조혈 줄기세포 증가 촉진제
|
|
EP2048230A4
(en)
|
2006-07-13 |
2010-01-20 |
Chugai Pharmaceutical Co Ltd |
Cell death inducer
|
|
EP2574625B1
(en)
|
2006-07-21 |
2015-02-25 |
HuBit genomix, Inc. |
Remedy for renal disease
|
|
EP1882697B1
(en)
|
2006-07-24 |
2010-04-21 |
Institut Pasteur |
Antibodies, antibody fragments and scFv binding to post-translationally modified neurotrophins
|
|
EP2050466B1
(en)
|
2006-08-14 |
2015-10-28 |
Chugai Seiyaku Kabushiki Kaisha |
Diagnosis and treatment of cancer using anti-desmoglein-3 antibodies
|
|
US20100297103A1
(en)
|
2006-09-14 |
2010-11-25 |
Medical & Biological Laboratories Co., Ltd. |
Antibody having enhanced adcc activity and method for production thereof
|
|
US9017684B2
(en)
|
2006-10-12 |
2015-04-28 |
Chugai Seiyaku Kabushiki Kaisha |
Diagnosis and treatment of cancer using anti-EREG antibody
|
|
WO2008047925A1
(en)
|
2006-10-20 |
2008-04-24 |
Forerunner Pharma Research Co., Ltd. |
Pharmaceutical composition comprising anti-hb-egf antibody as active ingredient
|
|
JP5618172B2
(ja)
|
2007-01-05 |
2014-11-05 |
国立大学法人東京大学 |
抗prg−3抗体を用いる癌の診断および治療
|
|
WO2008105560A1
(ja)
|
2007-02-27 |
2008-09-04 |
Forerunner Pharma Research Co., Ltd. |
抗grp78抗体を有効成分として含む医薬組成物
|
|
JP5469456B2
(ja)
|
2007-06-25 |
2014-04-16 |
中外製薬株式会社 |
ADCC活性又はCDC活性を有する抗Prominin−1抗体
|
|
US20100129355A1
(en)
|
2007-07-26 |
2010-05-27 |
Osaka University |
Therapeutic agents for ocular inflammatory disease comprising interleukin 6 receptor inhibitor as active ingredient
|
|
EP3689912A1
(en)
|
2007-09-26 |
2020-08-05 |
Chugai Seiyaku Kabushiki Kaisha |
Method of modifying isoelectric point of antibody via amino acid substitution in cdr
|
|
CN101815532B
(zh)
|
2007-10-02 |
2012-08-15 |
中外制药株式会社 |
以白细胞介素6受体抑制剂为有效成分的移植物抗宿主病治疗剂
|
|
US20120047586A9
(en)
|
2007-10-24 |
2012-02-23 |
Otsuka Chemical Co., Ltd |
Polypeptide having enhanced effector function
|
|
EP2216344B1
(en)
|
2007-11-14 |
2017-06-28 |
Chugai Seiyaku Kabushiki Kaisha |
Diagnosis and treatment of cancer using anti-gpr49 antibody
|
|
AU2008321835B2
(en)
|
2007-11-15 |
2014-11-20 |
Chugai Seiyaku Kabushiki Kaisha |
Monoclonal antibody capable of binding to anexelekto, and use thereof
|
|
BRPI0821145B8
(pt)
|
2007-12-05 |
2021-05-25 |
Chugai Pharmaceutical Co Ltd |
uso de um anticorpo anti-nr10 como agente preventivo ou terapêutico para prurido
|
|
KR101840994B1
(ko)
|
2007-12-05 |
2018-03-21 |
추가이 세이야쿠 가부시키가이샤 |
항nr10 항체 및 그의 이용
|
|
JPWO2009075344A1
(ja)
|
2007-12-12 |
2011-04-28 |
独立行政法人国立がん研究センター |
M−csf受容体を分子標的とするmll白血病及びmoz白血病治療剤、およびその利用
|
|
PE20091174A1
(es)
|
2007-12-27 |
2009-08-03 |
Chugai Pharmaceutical Co Ltd |
Formulacion liquida con contenido de alta concentracion de anticuerpo
|
|
US9274119B2
(en)
|
2008-01-11 |
2016-03-01 |
The University Of Tokyo |
Anti-CLDN6 antibody
|
|
KR102057826B1
(ko)
|
2008-04-11 |
2019-12-20 |
추가이 세이야쿠 가부시키가이샤 |
복수 분자의 항원에 반복 결합하는 항원 결합 분자
|
|
EP2116261A1
(en)
|
2008-05-07 |
2009-11-11 |
Institut Pasteur |
Sub-region of a plasmodium protein with improved vaccine potential and medical uses thereof
|
|
WO2009147781A1
(ja)
|
2008-06-02 |
2009-12-10 |
国立大学法人東京大学 |
抗がん剤
|
|
CN104906581A
(zh)
|
2008-06-05 |
2015-09-16 |
国立研究开发法人国立癌症研究中心 |
神经浸润抑制剂
|
|
US8575314B2
(en)
|
2008-06-20 |
2013-11-05 |
National University Corporation Okayama University |
Antibody against oxidized LDL/β2GPI complex and use of the same
|
|
WO2010074192A1
(ja)
|
2008-12-26 |
2010-07-01 |
国立大学法人東京大学 |
抗lgr7抗体を用いる癌の診断および治療
|
|
JP2010210772A
(ja)
|
2009-03-13 |
2010-09-24 |
Dainippon Screen Mfg Co Ltd |
液晶表示装置の製造方法
|
|
KR20120051603A
(ko)
|
2009-05-01 |
2012-05-22 |
고쿠리츠다이가쿠호징 도쿄다이가쿠 |
항카드헤린 항체
|
|
US20120141501A1
(en)
|
2009-05-29 |
2012-06-07 |
Forerunner Pharma Research Co. Ltd |
Pharmaceutical Composition Containing Antagonist of EGF Family Ligand as Component
|
|
TW201600110A
(zh)
|
2009-07-31 |
2016-01-01 |
Shin Maeda |
癌之轉移抑制劑
|
|
TW201118166A
(en)
|
2009-09-24 |
2011-06-01 |
Chugai Pharmaceutical Co Ltd |
HLA class I-recognizing antibodies
|
|
TWI609698B
(zh)
|
2010-01-20 |
2018-01-01 |
中外製藥股份有限公司 |
穩定化的含抗體溶液製劑
|
|
CN102892787B
(zh)
|
2010-02-10 |
2015-04-29 |
富士胶片Ri制药株式会社 |
放射性金属标记抗钙粘素抗体
|
|
JPWO2011105573A1
(ja)
|
2010-02-26 |
2013-06-20 |
株式会社 未来創薬研究所 |
抗icam3抗体およびその用途
|
|
TWI667257B
(zh)
|
2010-03-30 |
2019-08-01 |
中外製藥股份有限公司 |
促進抗原消失之具有經修飾的FcRn親和力之抗體
|
|
JP6051049B2
(ja)
|
2010-05-28 |
2016-12-21 |
中外製薬株式会社 |
抗腫瘍t細胞応答増強剤
|
|
WO2012061120A1
(en)
|
2010-10-25 |
2012-05-10 |
Regents Of The University Of Minnesota |
Therapeutic composition for treatment of glioblastoma
|
|
HRP20181438T1
(hr)
|
2010-10-29 |
2018-11-16 |
Perseus Proteomics Inc. |
Protutijelo protiv cdh3 s visokom sposobnošću internaliziranja
|
|
EP2735315B1
(en)
|
2011-07-19 |
2019-10-02 |
Chugai Seiyaku Kabushiki Kaisha |
Stable protein-containing preparation containing argininamide or valinamide
|
|
JP6101205B2
(ja)
|
2011-08-23 |
2017-03-22 |
中外製薬株式会社 |
抗腫瘍活性を有する新規な抗ddr1抗体
|
|
TW201817744A
(zh)
|
2011-09-30 |
2018-05-16 |
日商中外製藥股份有限公司 |
具有促進抗原清除之FcRn結合域的治療性抗原結合分子
|
|
EP2772268B8
(en)
|
2011-10-28 |
2020-01-08 |
Chugai Seiyaku Kabushiki Kaisha |
Cancer stem cell-specific molecule
|
|
JP6371059B2
(ja)
|
2011-10-31 |
2018-08-08 |
中外製薬株式会社 |
重鎖と軽鎖の会合が制御された抗原結合分子
|
|
EP2848686B1
(en)
|
2012-04-04 |
2024-12-25 |
Perseus Proteomics Inc. |
Conjugate of anti-cdh3 (p-cadherin) antibody and drug
|
|
EP2876160B1
(en)
|
2012-07-06 |
2020-05-13 |
Kyoto Prefectural Public University Corporation |
Differentiation marker for and differentiation control for ocular cells
|
|
CN104797710A
(zh)
|
2012-09-27 |
2015-07-22 |
中外制药株式会社 |
Fgfr3融合基因和以其作为标靶的药物
|
|
WO2014200018A1
(ja)
|
2013-06-11 |
2014-12-18 |
独立行政法人 国立精神・神経医療研究センター |
再発寛解型多発性硬化症(rrms)患者の治療予後予測方法、及び新規治療適応判断方法
|
|
TWI715524B
(zh)
|
2013-12-27 |
2021-01-11 |
日商中外製藥股份有限公司 |
等電點低之抗體的精製方法
|
|
ES2756175T3
(es)
|
2013-12-27 |
2020-04-27 |
Chugai Pharmaceutical Co Ltd |
Genes mutantes guardián de fgfr y fármacos que se dirigen a los mismos
|
|
JP6858559B2
(ja)
|
2014-08-20 |
2021-04-14 |
中外製薬株式会社 |
蛋白質溶液の粘度測定方法
|
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
|
TWI805046B
(zh)
|
2015-02-27 |
2023-06-11 |
日商中外製藥股份有限公司 |
Il-6受體抗體用於製備醫藥組成物的用途
|
|
CN110475790A
(zh)
|
2017-03-24 |
2019-11-19 |
全药工业株式会社 |
抗IgM/B细胞表面抗原双特异性抗体
|
|
EP3698808B1
(en)
|
2017-10-20 |
2025-01-01 |
Hyogo College Of Medicine |
Anti-il-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion
|
|
WO2019151418A1
(ja)
|
2018-01-31 |
2019-08-08 |
元一 加藤 |
Il-6阻害剤を含有する喘息の治療剤
|
|
BR112021016619A2
(pt)
|
2019-02-28 |
2021-11-03 |
Juntendo Educational Found |
Anticorpo capaz de se ligar à calreticulina mutante de forma clivada e agente de diagnóstico, profilático ou terapêutico para neoplasmas mieloproliferativos
|
|
CN114072173A
(zh)
|
2019-04-17 |
2022-02-18 |
国立大学法人广岛大学 |
以联合施用il-6抑制剂和ccr2抑制剂为特征的泌尿系统癌症治疗剂
|
|
WO2020250940A1
(ja)
|
2019-06-11 |
2020-12-17 |
小野薬品工業株式会社 |
免疫抑制剤
|
|
WO2021206078A1
(ja)
|
2020-04-06 |
2021-10-14 |
株式会社PhotoQ3 |
腫瘍細胞を死滅させるための医薬
|
|
WO2022025030A1
(ja)
|
2020-07-28 |
2022-02-03 |
中外製薬株式会社 |
新規改変型抗体を含む、針シールドを備えた針付プレフィルドシリンジ製剤
|
|
US20240092890A1
(en)
|
2020-08-27 |
2024-03-21 |
Juntendo Educational Foundation |
Anti-cleaved mutant calr-cd3 bispecific antibody and pharmaceutical composition
|
|
MX2023010491A
(es)
|
2021-03-12 |
2023-09-18 |
Chugai Pharmaceutical Co Ltd |
Composicion farmaceutica para el tratamiento o la prevencion de la miastenia gravis.
|
|
EP4412583A1
(en)
|
2021-10-04 |
2024-08-14 |
Novartis AG |
Surfactant stabilizers
|
|
KR20240011866A
(ko)
|
2021-12-01 |
2024-01-26 |
추가이 세이야쿠 가부시키가이샤 |
항체 함유 제제의 조제 방법
|
|
EP4483899A1
(en)
|
2022-02-25 |
2025-01-01 |
Juntendo Educational Foundation |
Medicine comprising combination of anti-mutant-calr antibody and another drug
|
|
WO2025198912A1
(en)
|
2024-03-21 |
2025-09-25 |
Hoffmann-La Roche Inc. |
Methods of treating myasthenia gravis
|