IL87946A - Antitumor and antibacterial substituted disulfide analogs of the alpha1, alpha2, alpha3, alpha4, bets of the ll-33288 complex a1, beta2, gamma and delta components of the LL-33288 complex - Google Patents

Antitumor and antibacterial substituted disulfide analogs of the alpha1, alpha2, alpha3, alpha4, bets of the ll-33288 complex a1, beta2, gamma and delta components of the LL-33288 complex

Info

Publication number
IL87946A
IL87946A IL8794688A IL8794688A IL87946A IL 87946 A IL87946 A IL 87946A IL 8794688 A IL8794688 A IL 8794688A IL 8794688 A IL8794688 A IL 8794688A IL 87946 A IL87946 A IL 87946A
Authority
IL
Israel
Prior art keywords
trlvalent
divalent
complex
antitumor
disulfide
Prior art date
Application number
IL8794688A
Other languages
English (en)
Other versions
IL87946A0 (en
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of IL87946A0 publication Critical patent/IL87946A0/xx
Publication of IL87946A publication Critical patent/IL87946A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL8794688A 1987-10-30 1988-10-06 Antitumor and antibacterial substituted disulfide analogs of the alpha1, alpha2, alpha3, alpha4, bets of the ll-33288 complex a1, beta2, gamma and delta components of the LL-33288 complex IL87946A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11494087A 1987-10-30 1987-10-30

Publications (2)

Publication Number Publication Date
IL87946A0 IL87946A0 (en) 1989-03-31
IL87946A true IL87946A (en) 1995-06-29

Family

ID=22358378

Family Applications (2)

Application Number Title Priority Date Filing Date
IL8794788A IL87947A (en) 1987-10-30 1988-10-06 Targeted forms of methyltrithio antitumor agents and process for their preparation
IL8794688A IL87946A (en) 1987-10-30 1988-10-06 Antitumor and antibacterial substituted disulfide analogs of the alpha1, alpha2, alpha3, alpha4, bets of the ll-33288 complex a1, beta2, gamma and delta components of the LL-33288 complex

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL8794788A IL87947A (en) 1987-10-30 1988-10-06 Targeted forms of methyltrithio antitumor agents and process for their preparation

Country Status (19)

Country Link
EP (2) EP0313873B1 (de)
JP (2) JP2820256B2 (de)
KR (2) KR970011385B1 (de)
AR (1) AR246083A1 (de)
AT (2) ATE112172T1 (de)
AU (2) AU618763B2 (de)
BR (1) BR1100939A (de)
CA (1) CA1321582C (de)
DE (2) DE3851682T2 (de)
DK (2) DK174739B1 (de)
ES (2) ES2059464T3 (de)
FI (2) FI91262C (de)
HK (2) HK131997A (de)
IE (2) IE65053B1 (de)
IL (2) IL87947A (de)
NO (2) NO173506C (de)
NZ (2) NZ226726A (de)
PT (2) PT88882B (de)
ZA (2) ZA888123B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079233A (en) * 1987-01-30 1992-01-07 American Cyanamid Company N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
US5606040A (en) * 1987-10-30 1997-02-25 American Cyanamid Company Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
IL115770A (en) * 1989-04-14 1999-03-12 American Cyanamid Co Substituted disulfides of formula q-sp-ss-w their preparation and use for inhibiting the growth of tumours and for treating bacterial infections
GB9007384D0 (en) * 1990-04-02 1990-05-30 Duncan Ruth Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups
US5712374A (en) * 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US5714586A (en) * 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
US6395511B1 (en) 1998-11-27 2002-05-28 Darwin Discovery, Ltd. Nucleic acids encoding a novel family of TGF-β binding proteins from humans
NZ511705A (en) * 2001-05-14 2004-03-26 Horticulture & Food Res Inst Methods and rapid immunoassay device for detecting progesterone and other steroids
EA015166B1 (ru) 2003-06-16 2011-06-30 Ю-Си-Би Мэньюфэкчуринг, Инк. Иммуногенные пептиды склеростина (sost), индуцирующие образование специфических антител
WO2008028050A2 (en) * 2006-08-30 2008-03-06 Wisconsin Alumni Research Foundation Reversible natural product glycosyltransferase-catalyzed reactions, compounds and related methods
KR100979928B1 (ko) * 2008-07-16 2010-09-03 한주학 수직축형 부력풍차
CA2929283C (en) * 2013-11-04 2022-07-19 Pfizer Inc. Intermediates and methods for synthesizing calicheamicin derivatives
MX2019008773A (es) * 2017-01-24 2019-09-18 Pfizer Derivados de caliqueamicina y conjugados anticuerpo-farmaco de los mismos.
JP2022520106A (ja) * 2019-02-15 2022-03-28 ユニバーシティ オブ サザン カリフォルニア Ｌｙｍ－１およびｌｙｍ－２抗体組成物ならびに改善されたｃａｒ構築物
WO2022085762A1 (ja) * 2020-10-22 2022-04-28 富士フイルム株式会社 皮膚感作性測定試薬、化合物、及び皮膚感作性の測定方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2430943A1 (fr) * 1978-07-13 1980-02-08 Toyo Jozo Kk Nouveaux derives disulfures
DE3175151D1 (en) * 1980-05-21 1986-09-25 Teijin Ltd Reactive polymer and process for the preparation thereof
US4530835A (en) * 1983-07-08 1985-07-23 Warner-Lambert Company CL-1577 Antibiotic compounds and their production
CA1314245C (en) * 1984-05-23 1993-03-09 Franz Jansen Process for the preparation of conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, which are useful as immunotoxin potentiators
EP0182152B1 (de) * 1984-11-16 1999-05-26 American Cyanamid Company Antitumorale Antibiotika (Komplex LL-E-33288)
EP0330874A3 (de) * 1988-02-29 1989-10-18 American Cyanamid Company Antibakterielle und Antitumor-Mittel LL-E33288 epsilon-I und LL-E33288-epsilon-Br, deren Herstellungen und Zwischenprodukte
EP0342341A3 (de) * 1988-05-17 1991-07-24 American Cyanamid Company Verfahren zur Herstellung von Antitumor-Antibiotika LL-E33288 Gamma 2

Also Published As

Publication number Publication date
AU618763B2 (en) 1992-01-09
IL87946A0 (en) 1989-03-31
DK602588A (da) 1989-05-01
DK602588D0 (da) 1988-10-28
NO884833D0 (no) 1988-10-28
AR246083A1 (es) 1994-03-30
NO176480B (no) 1995-01-02
KR890006245A (ko) 1989-06-12
BR1100939A (pt) 1999-08-31
DK602488A (da) 1989-05-01
AU2448988A (en) 1989-05-04
KR970011385B1 (ko) 1997-07-10
EP0313874B1 (de) 1994-04-13
PT88882B (pt) 1993-01-29
EP0313874A3 (en) 1990-05-09
DE3851682D1 (de) 1994-11-03
JP2820256B2 (ja) 1998-11-05
NO884834L (no) 1989-05-02
IL87947A (en) 1995-05-26
AU612714B2 (en) 1991-07-18
ZA888127B (en) 1989-07-26
FI95204C (fi) 1996-01-10
DE3889063D1 (de) 1994-05-19
ZA888123B (en) 1989-07-26
ATE112172T1 (de) 1994-10-15
NZ226726A (en) 1991-08-27
KR0133130B1 (ko) 1998-04-17
HK131997A (en) 1997-10-03
FI884983A0 (fi) 1988-10-28
DE3889063T2 (de) 1994-12-01
FI884983L (fi) 1989-05-01
NZ226727A (en) 1991-12-23
JPH01193282A (ja) 1989-08-03
EP0313873B1 (de) 1994-09-28
IE883262L (en) 1989-04-30
ES2061586T3 (es) 1994-12-16
DK602488D0 (da) 1988-10-28
HK131897A (en) 1997-10-03
FI884984A7 (fi) 1989-05-01
NO176480C (no) 1995-04-12
AU2449488A (en) 1989-05-04
DE3851682T2 (de) 1995-05-04
JPH0296599A (ja) 1990-04-09
FI884984A0 (fi) 1988-10-28
DK174739B1 (da) 2003-10-13
IE65989B1 (en) 1995-11-29
PT88881B (pt) 1993-01-29
NO884834D0 (no) 1988-10-28
EP0313873A1 (de) 1989-05-03
JP2720933B2 (ja) 1998-03-04
CA1321582C (en) 1993-08-24
IE883261L (en) 1989-04-30
NO173506C (no) 1993-12-22
FI91262B (fi) 1994-02-28
ES2059464T3 (es) 1994-11-16
IE65053B1 (en) 1995-10-04
NO884833L (no) 1989-05-02
NO173506B (no) 1993-09-13
IL87947A0 (en) 1989-03-31
FI95204B (fi) 1995-09-29
EP0313874A2 (de) 1989-05-03
FI91262C (fi) 1994-06-10
ATE104309T1 (de) 1994-04-15
KR890006244A (ko) 1989-06-12

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