IL83235A - N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof - Google Patents

N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof

Info

Publication number
IL83235A
IL83235A IL83235A IL8323587A IL83235A IL 83235 A IL83235 A IL 83235A IL 83235 A IL83235 A IL 83235A IL 8323587 A IL8323587 A IL 8323587A IL 83235 A IL83235 A IL 83235A
Authority
IL
Israel
Prior art keywords
phosphonylmethoxyalkyl
purines
pyrimidines
therapeutic application
derivatives
Prior art date
Application number
IL83235A
Other languages
English (en)
Other versions
IL83235A0 (en
Original Assignee
Stichting Rega V Z W
Ceskoslovenska Akademie Ved
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Rega V Z W, Ceskoslovenska Akademie Ved filed Critical Stichting Rega V Z W
Publication of IL83235A0 publication Critical patent/IL83235A0/xx
Publication of IL83235A publication Critical patent/IL83235A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
IL83235A 1986-07-18 1987-07-17 N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof IL83235A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS865469A CS264222B1 (en) 1986-07-18 1986-07-18 N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them

Publications (2)

Publication Number Publication Date
IL83235A0 IL83235A0 (en) 1987-12-31
IL83235A true IL83235A (en) 1992-11-15

Family

ID=5399635

Family Applications (1)

Application Number Title Priority Date Filing Date
IL83235A IL83235A (en) 1986-07-18 1987-07-17 N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof

Country Status (21)

Country Link
US (3) US5142051A (el)
EP (1) EP0253412B1 (el)
JP (1) JPH0822866B2 (el)
KR (1) KR950004179B1 (el)
AT (1) ATE57932T1 (el)
AU (1) AU600002B2 (el)
CA (1) CA1340856C (el)
CS (1) CS264222B1 (el)
DE (2) DE19775085I2 (el)
DK (1) DK170646B1 (el)
EG (1) EG18273A (el)
ES (1) ES2036194T3 (el)
FI (1) FI86856C (el)
GR (1) GR3002534T3 (el)
IE (1) IE60117B1 (el)
IL (1) IL83235A (el)
LU (1) LU90155I2 (el)
NL (1) NL970036I2 (el)
NZ (1) NZ221100A (el)
PT (1) PT85354B (el)
ZA (1) ZA875283B (el)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
US5650510A (en) * 1986-11-18 1997-07-22 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
AU613592B2 (en) * 1986-11-18 1991-08-08 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosophonomethoxy-alkyene purine and pyrimide derivatives
JPH0217199A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−アデノシンの製造方法
US5688778A (en) * 1989-05-15 1997-11-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nucleoside analogs
US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
FI911875A (fi) * 1990-04-20 1991-10-21 Bristol Myers Squibb Co Kirala 2-(fosfonometoxi) propylguaniner som antivirala aemnen.
SK280313B6 (sk) * 1990-04-24 1999-11-08 �Stav Organick� Chemie A Biochemie Av �R N-(3-fluór-2-fosfonylmetoxypropyl)deriváty purínov
CS276072B6 (en) * 1990-08-06 1992-03-18 Ustav Organicke Chemie A Bioch (2R)-2-/DI(2-PROPYL)PHOSPHONYLMETHOXY/-3-p-TOLUENESULFONYLOXY -1- TRIMETHYLACETOXYPROPANE AND PROCESS FOR PREPARING THEREOF
CA2088363C (en) * 1990-08-10 2002-05-28 Purushotham Vemishetti Process for the preparation of nucleotides
DK0481214T3 (da) * 1990-09-14 1999-02-22 Acad Of Science Czech Republic Prolægemidler af phosphonater
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
CZ287745B6 (cs) * 1991-10-11 2001-01-17 Ústav organické chemie a biochemie AV ČR Acyklické fosfonomethoxyalkylsubstituované alkenylové a alkinylové deriváty purinu a pyrimidinu
US6057305A (en) * 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US5817647A (en) * 1993-04-01 1998-10-06 Merrell Pharmaceuticals Inc. Unsaturated acetylene phosphonate derivatives of purines
US5514798A (en) * 1993-06-02 1996-05-07 Gilead Sciences, Inc. Method and cyclic carbonates for nucleotide analogues
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US5656745A (en) * 1993-09-17 1997-08-12 Gilead Sciences, Inc. Nucleotide analogs
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CA2171868A1 (en) * 1993-09-17 1995-03-23 Petr Alexander Method for dosing therapeutic compounds
NZ283658A (en) * 1994-04-04 1999-09-29 William R Freeman Compositions and treatment of increased intraocular pressure with phosphonyl-alkyloxy-pyrimidines/purines (nucleosides)
US5468752A (en) * 1994-04-04 1995-11-21 Freeman; William R. Treatment of conditions of abnormally increased intraocular pressure by administration of HPMPC and related phosphonylmethoxyalkylcytosines
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EP1244668B1 (en) * 2000-01-07 2006-04-05 Universitaire Instelling Antwerpen Purine derivatives, process for their preparation and use thereof
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Family Cites Families (15)

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US4287188A (en) * 1977-02-24 1981-09-01 Burroughs Wellcome Co. Purine derivatives
AU521577B2 (en) * 1977-02-24 1982-04-22 Wellcome Foundation Limited, The 9-hydroxyethoxymethyl guanine phosphates
DE2909709A1 (de) * 1979-03-12 1980-09-25 Kailash Kumar Dr Gauri Verfahren zur herstellung von nucleotidderivaten, neue nucleotidderivate und daraus hergestellte arzneimittel
NZ205802A (en) * 1982-09-30 1986-10-08 Syntex Inc Phosphate ester derivatives of guanine as antiviral agents
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
IL72173A0 (en) * 1983-06-24 1984-10-31 Merck & Co Inc Guanine derivatives,their preparation and pharmaceutical compositions containing them
US4670424A (en) * 1983-09-19 1987-06-02 Merck & Co., Inc. Cyclic pyrophosphates of purine and pyrimidine acyclonucleosides
US4590269A (en) * 1984-03-29 1986-05-20 Syntex (U.S.A.) Inc. Process for preparing the cyclic phosphate ester of substituted 9-(1,3-dihydroxy-2-propoxymethyl)purines
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
CS263952B1 (en) * 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
AU613592B2 (en) * 1986-11-18 1991-08-08 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosophonomethoxy-alkyene purine and pyrimide derivatives
CA1330794C (en) * 1987-03-27 1994-07-19 Phillip Frost Anti-viral compounds, dosage forms and methods

Also Published As

Publication number Publication date
FI873165A (fi) 1988-01-19
FI86856B (fi) 1992-07-15
GR3002534T3 (en) 1993-01-25
DK373487A (da) 1988-01-19
DE3765864D1 (de) 1990-12-06
ZA875283B (en) 1988-03-30
CA1340856C (en) 1999-12-21
IE871944L (en) 1988-01-18
AU7575987A (en) 1988-01-21
ES2036194T3 (es) 1993-05-16
PT85354A (en) 1987-08-01
FI873165A0 (fi) 1987-07-17
AU600002B2 (en) 1990-08-02
EP0253412A3 (en) 1989-04-26
KR950004179B1 (en) 1995-04-27
US5641763A (en) 1997-06-24
DK373487D0 (da) 1987-07-17
DE19775085I2 (de) 2004-01-15
IL83235A0 (en) 1987-12-31
EP0253412B1 (en) 1990-10-31
NZ221100A (en) 1991-09-25
US5142051A (en) 1992-08-25
CS546986A1 (en) 1988-08-16
IE60117B1 (en) 1994-06-01
DK170646B1 (da) 1995-11-20
JPH0822866B2 (ja) 1996-03-06
JPS6345289A (ja) 1988-02-26
EP0253412A2 (en) 1988-01-20
CS264222B1 (en) 1989-06-13
NL970036I1 (nl) 1997-12-01
LU90155I2 (fr) 1997-12-22
US5869467A (en) 1999-02-09
NL970036I2 (nl) 1998-03-02
PT85354B (pt) 1990-04-30
KR880001688A (ko) 1988-04-26
EG18273A (en) 1992-12-30
ATE57932T1 (de) 1990-11-15
FI86856C (fi) 1992-10-26

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