ZA875283B - N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof - Google Patents

N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof

Info

Publication number
ZA875283B
ZA875283B ZA875283A ZA875283A ZA875283B ZA 875283 B ZA875283 B ZA 875283B ZA 875283 A ZA875283 A ZA 875283A ZA 875283 A ZA875283 A ZA 875283A ZA 875283 B ZA875283 B ZA 875283B
Authority
ZA
South Africa
Prior art keywords
phosphonylmethoxyalkyl
purines
pyrimidines
therapeutic application
derivatives
Prior art date
Application number
ZA875283A
Other languages
English (en)
Inventor
Antonin Holy
Holy Antonin
Ivan Rosenberg
Rosenberg Ivan
Erik De Clercq
De Clercq Erik
Original Assignee
Stichting Rega V Z W
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Rega V Z W filed Critical Stichting Rega V Z W
Publication of ZA875283B publication Critical patent/ZA875283B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA875283A 1986-07-18 1987-07-17 N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof ZA875283B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS865469A CS264222B1 (en) 1986-07-18 1986-07-18 N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them

Publications (1)

Publication Number Publication Date
ZA875283B true ZA875283B (en) 1988-03-30

Family

ID=5399635

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA875283A ZA875283B (en) 1986-07-18 1987-07-17 N-phosphonylmethoxyalkyl pyrimidines and purines and therapeutic application thereof

Country Status (21)

Country Link
US (3) US5142051A (el)
EP (1) EP0253412B1 (el)
JP (1) JPH0822866B2 (el)
KR (1) KR950004179B1 (el)
AT (1) ATE57932T1 (el)
AU (1) AU600002B2 (el)
CA (1) CA1340856C (el)
CS (1) CS264222B1 (el)
DE (2) DE19775085I2 (el)
DK (1) DK170646B1 (el)
EG (1) EG18273A (el)
ES (1) ES2036194T3 (el)
FI (1) FI86856C (el)
GR (1) GR3002534T3 (el)
IE (1) IE60117B1 (el)
IL (1) IL83235A (el)
LU (1) LU90155I2 (el)
NL (1) NL970036I2 (el)
NZ (1) NZ221100A (el)
PT (1) PT85354B (el)
ZA (1) ZA875283B (el)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
IL84477A (en) * 1986-11-18 1995-12-08 Bristol Myers Squibb Co History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
US5650510A (en) * 1986-11-18 1997-07-22 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
JPH0217199A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−アデノシンの製造方法
US5688778A (en) * 1989-05-15 1997-11-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nucleoside analogs
US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
DE69110528T2 (de) * 1990-04-20 1996-03-14 Inst Of Organic Chemistry And Chirale 2-(Phosphonomethoxy)propyl-Guanine als antivirale Agentien.
CZ285420B6 (cs) * 1990-04-24 1999-08-11 Ústav Organické Chemie A Biochemie Avčr N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití
CS276072B6 (en) * 1990-08-06 1992-03-18 Ustav Organicke Chemie A Bioch (2R)-2-/DI(2-PROPYL)PHOSPHONYLMETHOXY/-3-p-TOLUENESULFONYLOXY -1- TRIMETHYLACETOXYPROPANE AND PROCESS FOR PREPARING THEREOF
JP3116079B2 (ja) * 1990-08-10 2000-12-11 インスティチュート オブ オーガニック ケミストリ アンド バイオケミストリ アカデミー オブ サイエンス オブ ザ チェコ リパブリック ヌクレオチドの新規な製法
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US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
CZ287745B6 (cs) * 1991-10-11 2001-01-17 Ústav organické chemie a biochemie AV ČR Acyklické fosfonomethoxyalkylsubstituované alkenylové a alkinylové deriváty purinu a pyrimidinu
US6057305A (en) * 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US5817647A (en) * 1993-04-01 1998-10-06 Merrell Pharmaceuticals Inc. Unsaturated acetylene phosphonate derivatives of purines
US5514798A (en) * 1993-06-02 1996-05-07 Gilead Sciences, Inc. Method and cyclic carbonates for nucleotide analogues
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AU521577B2 (en) * 1977-02-24 1982-04-22 Wellcome Foundation Limited, The 9-hydroxyethoxymethyl guanine phosphates
US4287188A (en) * 1977-02-24 1981-09-01 Burroughs Wellcome Co. Purine derivatives
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NZ205802A (en) * 1982-09-30 1986-10-08 Syntex Inc Phosphate ester derivatives of guanine as antiviral agents
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
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CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
IL84477A (en) * 1986-11-18 1995-12-08 Bristol Myers Squibb Co History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
CA1330794C (en) * 1987-03-27 1994-07-19 Phillip Frost Anti-viral compounds, dosage forms and methods

Also Published As

Publication number Publication date
ES2036194T3 (es) 1993-05-16
NL970036I1 (nl) 1997-12-01
AU600002B2 (en) 1990-08-02
NL970036I2 (nl) 1998-03-02
KR880001688A (ko) 1988-04-26
DE19775085I2 (de) 2004-01-15
US5142051A (en) 1992-08-25
FI873165A (fi) 1988-01-19
DK373487A (da) 1988-01-19
IE60117B1 (en) 1994-06-01
AU7575987A (en) 1988-01-21
ATE57932T1 (de) 1990-11-15
GR3002534T3 (en) 1993-01-25
NZ221100A (en) 1991-09-25
DK373487D0 (da) 1987-07-17
EP0253412A2 (en) 1988-01-20
CS264222B1 (en) 1989-06-13
LU90155I2 (fr) 1997-12-22
EG18273A (en) 1992-12-30
JPH0822866B2 (ja) 1996-03-06
FI873165A0 (fi) 1987-07-17
EP0253412A3 (en) 1989-04-26
JPS6345289A (ja) 1988-02-26
IL83235A0 (en) 1987-12-31
IL83235A (en) 1992-11-15
CS546986A1 (en) 1988-08-16
KR950004179B1 (en) 1995-04-27
FI86856C (fi) 1992-10-26
EP0253412B1 (en) 1990-10-31
US5869467A (en) 1999-02-09
IE871944L (en) 1988-01-18
CA1340856C (en) 1999-12-21
DE3765864D1 (de) 1990-12-06
PT85354A (en) 1987-08-01
PT85354B (pt) 1990-04-30
FI86856B (fi) 1992-07-15
DK170646B1 (da) 1995-11-20
US5641763A (en) 1997-06-24

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