IL261721B - Combinations of lsd1 inhibitors for use in the treatment of solid tumors - Google Patents

Combinations of lsd1 inhibitors for use in the treatment of solid tumors

Info

Publication number
IL261721B
IL261721B IL261721A IL26172118A IL261721B IL 261721 B IL261721 B IL 261721B IL 261721 A IL261721 A IL 261721A IL 26172118 A IL26172118 A IL 26172118A IL 261721 B IL261721 B IL 261721B
Authority
IL
Israel
Prior art keywords
cancer
pharmaceutically acceptable
acceptable salt
inhibitor
diamine
Prior art date
Application number
IL261721A
Other languages
English (en)
Hebrew (he)
Other versions
IL261721A (en
Original Assignee
Oryzon Genomics Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oryzon Genomics Sa filed Critical Oryzon Genomics Sa
Publication of IL261721A publication Critical patent/IL261721A/en
Publication of IL261721B publication Critical patent/IL261721B/en

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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Molecular Biology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Oncology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Inorganic Chemistry (AREA)
IL261721A 2016-03-15 2017-03-13 Combinations of lsd1 inhibitors for use in the treatment of solid tumors IL261721B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662308529P 2016-03-15 2016-03-15
PCT/EP2017/055784 WO2017157825A1 (en) 2016-03-15 2017-03-13 Combinations of lsd1 inhibitors for use in the treatment of solid tumors

Publications (2)

Publication Number Publication Date
IL261721A IL261721A (en) 2018-10-31
IL261721B true IL261721B (en) 2022-07-01

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IL261721A IL261721B (en) 2016-03-15 2017-03-13 Combinations of lsd1 inhibitors for use in the treatment of solid tumors

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US (2) US10265279B2 (enExample)
EP (1) EP3429571B1 (enExample)
JP (2) JP7158023B2 (enExample)
KR (2) KR102511024B1 (enExample)
CN (2) CN120661674A (enExample)
AR (1) AR107871A1 (enExample)
AU (2) AU2017233898B2 (enExample)
CA (1) CA3017411C (enExample)
EA (1) EA201892075A1 (enExample)
IL (1) IL261721B (enExample)
MX (2) MX381890B (enExample)
MY (1) MY199967A (enExample)
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EP3307267B1 (en) 2016-06-10 2019-04-10 Oryzon Genomics, S.A. Multiple sclerosis treatment
AU2017233898B2 (en) 2016-03-15 2022-12-15 Oryzon Genomics, S.A. Combinations of LSD1 inhibitors for use in the treatment of solid tumors
KR102646126B1 (ko) * 2016-03-15 2024-03-11 오리존 지노믹스 에스.에이. 혈액 악성 종양의 치료를 위한 lsd1 억제제의 조합물
US11685782B2 (en) 2017-10-23 2023-06-27 Children's Medical Center Corporation Methods of treating cancer using LSD1 inhibitors in combination with immunotherapy
MA50564A (fr) 2017-11-06 2020-09-16 Hutchinson Fred Cancer Res Association d'une thérapie cellulaire et d'un inhibiteur de gamma secrétase
WO2019108789A1 (en) * 2017-11-29 2019-06-06 The Trustees Of Columbia University In The City Of New York Combination therapy of lymphoma
KR20210006426A (ko) * 2018-05-04 2021-01-18 오리존 지노믹스 에스.에이. 안정한 약제학적 제제
MX2020011826A (es) 2018-05-06 2021-01-15 Ayala Pharmaceuticals Inc Composiciones de combinacion que comprenden compuestos de bisfluoroalquil-1,4-benzodiazepinona y metodos de uso de las mismas.
CN109265462B (zh) * 2018-10-31 2020-06-02 郑州大学 嘧啶并1,2,4-三氮唑类化合物及其制备方法和应用
SG11202109025XA (en) * 2019-03-25 2021-09-29 Oryzon Genomics Sa Combinations of iadademstat for cancer therapy
JP2022546908A (ja) * 2019-07-05 2022-11-10 オリゾン・ゲノミクス・ソシエダッド・アノニマ Ｋｄｍ１ａ阻害剤を使用した小細胞肺がんの個別化された処置のためのバイオマーカーおよび方法
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AU2017233898A1 (en) 2018-11-01
MX381890B (es) 2025-03-13
KR20230042756A (ko) 2023-03-29
IL261721A (en) 2018-10-31
US20220378722A1 (en) 2022-12-01
US10265279B2 (en) 2019-04-23
EA201892075A1 (ru) 2019-04-30
AU2023201580A1 (en) 2023-04-13

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