CA3017411C - Combinations of lsd1 inhibitors for use in the treatment of solid tumors - Google Patents

Combinations of lsd1 inhibitors for use in the treatment of solid tumors Download PDF

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Publication number
CA3017411C
CA3017411C CA3017411A CA3017411A CA3017411C CA 3017411 C CA3017411 C CA 3017411C CA 3017411 A CA3017411 A CA 3017411A CA 3017411 A CA3017411 A CA 3017411A CA 3017411 C CA3017411 C CA 3017411C
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Prior art keywords
inhibitor
pharmaceutically acceptable
acceptable salt
use according
trans
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CA3017411A
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English (en)
French (fr)
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CA3017411A1 (en
Inventor
Mark DEMARIO
William Pierceall
Fiona MACK
Tamara Maes
Serena LUNARDI
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Oryzon Genomics SA
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Oryzon Genomics SA
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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CA3017411A 2016-03-15 2017-03-13 Combinations of lsd1 inhibitors for use in the treatment of solid tumors Active CA3017411C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662308529P 2016-03-15 2016-03-15
US62/308,529 2016-03-15
PCT/EP2017/055784 WO2017157825A1 (en) 2016-03-15 2017-03-13 Combinations of lsd1 inhibitors for use in the treatment of solid tumors

Publications (2)

Publication Number Publication Date
CA3017411A1 CA3017411A1 (en) 2017-09-21
CA3017411C true CA3017411C (en) 2024-06-25

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CA3017411A Active CA3017411C (en) 2016-03-15 2017-03-13 Combinations of lsd1 inhibitors for use in the treatment of solid tumors

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US (2) US10265279B2 (enExample)
EP (1) EP3429571B1 (enExample)
JP (2) JP7158023B2 (enExample)
KR (2) KR102511024B1 (enExample)
CN (2) CN120661674A (enExample)
AR (1) AR107871A1 (enExample)
AU (2) AU2017233898B2 (enExample)
CA (1) CA3017411C (enExample)
EA (1) EA201892075A1 (enExample)
IL (1) IL261721B (enExample)
MX (2) MX381890B (enExample)
MY (1) MY199967A (enExample)
SG (2) SG10201913331VA (enExample)
WO (1) WO2017157825A1 (enExample)

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EP3090998A1 (en) 2015-05-06 2016-11-09 F. Hoffmann-La Roche AG Solid forms
EP3307267B1 (en) 2016-06-10 2019-04-10 Oryzon Genomics, S.A. Multiple sclerosis treatment
AU2017233898B2 (en) 2016-03-15 2022-12-15 Oryzon Genomics, S.A. Combinations of LSD1 inhibitors for use in the treatment of solid tumors
KR102646126B1 (ko) * 2016-03-15 2024-03-11 오리존 지노믹스 에스.에이. 혈액 악성 종양의 치료를 위한 lsd1 억제제의 조합물
US11685782B2 (en) 2017-10-23 2023-06-27 Children's Medical Center Corporation Methods of treating cancer using LSD1 inhibitors in combination with immunotherapy
MA50564A (fr) 2017-11-06 2020-09-16 Hutchinson Fred Cancer Res Association d'une thérapie cellulaire et d'un inhibiteur de gamma secrétase
WO2019108789A1 (en) * 2017-11-29 2019-06-06 The Trustees Of Columbia University In The City Of New York Combination therapy of lymphoma
KR20210006426A (ko) * 2018-05-04 2021-01-18 오리존 지노믹스 에스.에이. 안정한 약제학적 제제
MX2020011826A (es) 2018-05-06 2021-01-15 Ayala Pharmaceuticals Inc Composiciones de combinacion que comprenden compuestos de bisfluoroalquil-1,4-benzodiazepinona y metodos de uso de las mismas.
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