IL164648A0 - Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation - Google Patents

Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation

Info

Publication number
IL164648A0
IL164648A0 IL16464802A IL16464802A IL164648A0 IL 164648 A0 IL164648 A0 IL 164648A0 IL 16464802 A IL16464802 A IL 16464802A IL 16464802 A IL16464802 A IL 16464802A IL 164648 A0 IL164648 A0 IL 164648A0
Authority
IL
Israel
Prior art keywords
preparation
polymorphic forms
novel crystalline
crystalline polymorphic
lercanidipine hydrochloride
Prior art date
Application number
IL16464802A
Other languages
English (en)
Original Assignee
Recordati Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11448245&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL164648(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Recordati Ireland Ltd filed Critical Recordati Ireland Ltd
Publication of IL164648A0 publication Critical patent/IL164648A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
IL16464802A 2001-08-06 2002-08-05 Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation IL164648A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001MI001726A ITMI20011726A1 (it) 2001-08-06 2001-08-06 Forme polimorfe della lercanidipina cloridrato
PCT/EP2002/008699 WO2003014084A1 (en) 2001-08-06 2002-08-05 Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation

Publications (1)

Publication Number Publication Date
IL164648A0 true IL164648A0 (en) 2005-12-18

Family

ID=11448245

Family Applications (3)

Application Number Title Priority Date Filing Date
IL16464802A IL164648A0 (en) 2001-08-06 2002-08-05 Novel crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation
IL15391702A IL153917A (en) 2001-08-06 2002-08-05 Crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation
IL164648A IL164648A (en) 2001-08-06 2004-10-17 Crystalline forms of recanidipine hydrochloride, a process for their formation and pharmaceutical preparations containing them

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL15391702A IL153917A (en) 2001-08-06 2002-08-05 Crystalline polymorphic forms of lercanidipine hydrochloride and process for their preparation
IL164648A IL164648A (en) 2001-08-06 2004-10-17 Crystalline forms of recanidipine hydrochloride, a process for their formation and pharmaceutical preparations containing them

Country Status (36)

Country Link
EP (4) EP1600441B1 (it)
JP (1) JP2005504045A (it)
KR (3) KR100667687B1 (it)
CN (2) CN101475524B (it)
AP (1) AP1766A (it)
AR (1) AR037139A1 (it)
AT (2) ATE307114T1 (it)
AU (1) AU2002327924C1 (it)
BR (1) BR0211739A (it)
CY (2) CY1109711T1 (it)
DE (2) DE60234961D1 (it)
DK (3) DK2157083T3 (it)
EA (1) EA005673B1 (it)
EC (1) ECSP044973A (it)
ES (3) ES2212759T3 (it)
HK (3) HK1067123A1 (it)
HR (1) HRP20040156B1 (it)
HU (1) HU229563B1 (it)
IL (3) IL164648A0 (it)
IT (1) ITMI20011726A1 (it)
MA (1) MA27133A1 (it)
ME (2) MEP2908A (it)
MX (1) MXPA04001069A (it)
NO (2) NO325541B1 (it)
NZ (2) NZ541341A (it)
OA (1) OA12648A (it)
PE (1) PE20030328A1 (it)
PL (1) PL216066B1 (it)
PT (2) PT1600441E (it)
RS (1) RS52161B (it)
SI (3) SI2157083T1 (it)
TN (1) TNSN04024A1 (it)
UA (1) UA82988C2 (it)
UY (1) UY27410A1 (it)
WO (1) WO2003014084A1 (it)
ZA (1) ZA200401806B (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20011726A1 (it) 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Forme polimorfe della lercanidipina cloridrato
AR043395A1 (es) * 2003-02-28 2005-07-27 Recordati Ireland Ltd Terapia de combinacion para la hipertension utilizando lercanidipina y un bloqueante de los receptores de angiotensina ii
WO2005053689A2 (en) * 2003-12-01 2005-06-16 Lifecycle Pharma A/S Pharmaceutical compositions comprising lercanidipine
AR052918A1 (es) 2005-02-25 2007-04-11 Recordati Ireland Ltd Clorhidrato de lercanidipina amorfo
BRPI0616169B8 (pt) 2005-09-16 2021-05-25 Glenmark Pharmaceuticals Ltd cloridrato de lercanidipina na forma polimorfa v, composição farmacêutica compreendendo dito composto e processos para preparação de cloridrato de lercanidipina
KR100821165B1 (ko) * 2006-03-10 2008-04-14 동우신테크 주식회사 레르카니디핀 염산염의 제조 방법
WO2008082041A1 (en) * 2006-12-29 2008-07-10 Dongwoo Syntech Co., Ltd Process for preparing lercanidipine hydrochloride
CN101868442A (zh) * 2007-03-05 2010-10-20 阿克塔维什集团Ptc公司 盐酸乐卡地平多晶型物和1,1,n-三甲基-n-(3,3-二苯基丙基)-2-氨基乙酰醋酸乙酯的改进制法
SI2585051T2 (sl) 2010-06-23 2020-07-31 Krka, D.D., Novo Mesto Farmacevtske oralne odmerne oblike,ki obsegajo lerkanidipin in enalapril in njune farmacevtsko sprejemljive soli
EP2444394A1 (en) 2010-10-21 2012-04-25 Alembic Pharmaceuticals Limited Process for the preparation of amorphous form of lercanidipine HCI
WO2012085249A2 (en) 2010-12-24 2012-06-28 Krka, D.D., Novo Mesto Homogenous pharmaceutical oral dosage forms comprising lercanidipine and enalapril or their pharmaceutically acceptable salts
EP2700632A4 (en) * 2011-04-18 2014-09-03 Hefei Beini Medical Technology Company Ltd METHOD FOR CLEANING DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKERS AND PRODUCING NANOPARTICLES THEREFOR
CN102531999B (zh) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 无定形盐酸乐卡地平及其制备方法
CN102558032B (zh) * 2011-12-16 2014-02-26 华润赛科药业有限责任公司 一种无定形盐酸乐卡地平及其制备方法
CN102584682A (zh) * 2011-12-31 2012-07-18 苏州二叶制药有限公司 盐酸乐卡地平的制备方法
CN103497075B (zh) * 2013-09-25 2016-03-23 山西北化关铝化工有限公司 水悬浮延期药造型粉
CN109232389B (zh) * 2018-05-15 2021-10-08 迪嘉药业集团有限公司 一种小粒度硝苯地平的结晶制备方法
CN115353485B (zh) * 2022-07-26 2024-04-19 山西双雁药业有限公司 从硝苯地平母液中回收硝苯地平的方法及应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US596139A (en) * 1897-12-28 Process of generating acetylene gas
GB8403866D0 (en) 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters
IT1275532B (it) * 1995-07-14 1997-08-07 Recordati Chem Pharm Uso di derivati 1,4-diidropiridinici per la prevenzione e la terapia della degenerazione aterosclerotica della parete arteriosa
US5767136A (en) 1995-05-12 1998-06-16 Recordati, S.A. Chemical And Pharmaceutical Company 1,4-Dihydropyridines useful for prevention or reduction of atherosclerotic lesions on arterial walls
US5696139A (en) * 1995-05-12 1997-12-09 Recordati S.A., Chemical And Pharmaceutical Company Use of S-enantiomers of 1,4-dihydropyridine derivatives for treating heart failure
IT1274480B (it) * 1995-05-12 1997-07-17 Recordati Chem Pharm Procedimento migliorato per la preparazione della lercanidipina cloridrato
DE60114153T2 (de) 2000-02-16 2006-07-06 Neurogen Corp., Branford Substituierte arylpyrazine
ITMI20011726A1 (it) 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Forme polimorfe della lercanidipina cloridrato
US20040198789A1 (en) 2003-02-28 2004-10-07 Recordati Ireland Limited Lercanidipine/ARB/diuretic therapeutic combinations

Also Published As

Publication number Publication date
NO20040266L (no) 2004-03-24
DE60234961D1 (de) 2010-02-11
ATE307114T1 (de) 2005-11-15
RS11304A (en) 2007-02-05
PT1600441E (pt) 2010-01-20
AP2004002989A0 (en) 2004-03-31
EP2036890A1 (en) 2009-03-18
SI1432683T1 (sl) 2006-04-30
IL153917A0 (en) 2003-07-31
EP2157083A3 (en) 2010-03-24
NO325541B1 (no) 2008-06-16
HK1067123A1 (en) 2005-04-01
ES2212759T3 (es) 2006-04-16
HRP20040156B1 (en) 2012-03-31
IL153917A (en) 2005-11-20
NO20082330L (no) 2004-03-24
MEP2908A (en) 2010-10-10
ATE453624T1 (de) 2010-01-15
SI2157083T1 (sl) 2016-01-29
CN1538957A (zh) 2004-10-20
KR20040030903A (ko) 2004-04-09
ZA200401806B (en) 2005-06-29
EP1432683A1 (en) 2004-06-30
DE60206787D1 (de) 2006-03-02
HU229563B1 (en) 2014-02-28
HK1140487A1 (en) 2010-10-15
RS52161B (en) 2012-08-31
ES2212759T1 (es) 2004-08-01
PL216066B1 (pl) 2014-02-28
UA82988C2 (uk) 2008-06-10
EA200400280A1 (ru) 2004-08-26
KR100667687B1 (ko) 2007-01-12
OA12648A (en) 2006-06-16
DK1600441T3 (da) 2010-02-08
CN101475524B (zh) 2012-08-29
HK1086263A1 (en) 2006-09-15
NZ541341A (en) 2007-02-23
PE20030328A1 (es) 2003-05-09
ITMI20011726A1 (it) 2003-02-06
EA005673B1 (ru) 2005-04-28
ES2334678T3 (es) 2010-03-15
HUP0401163A2 (hu) 2004-09-28
DK2157083T3 (en) 2015-11-02
EP1432683B9 (en) 2006-01-18
TNSN04024A1 (en) 2006-06-01
EP2157083A2 (en) 2010-02-24
DK1432683T3 (da) 2006-03-06
NO335651B1 (no) 2015-01-19
PT2157083E (pt) 2016-01-22
KR20050111799A (ko) 2005-11-28
AU2002327924B2 (en) 2008-04-24
AP1766A (en) 2007-08-10
MXPA04001069A (es) 2005-02-17
CN100448847C (zh) 2009-01-07
CN101475524A (zh) 2009-07-08
ES2555213T3 (es) 2015-12-29
JP2005504045A (ja) 2005-02-10
AU2002327924C1 (en) 2009-12-10
HUP0401163A3 (en) 2009-04-28
CY1117051T1 (el) 2017-04-05
IL164648A (en) 2007-02-11
UY27410A1 (es) 2003-03-31
EP1600441B1 (en) 2009-12-30
ITMI20011726A0 (it) 2001-08-06
PL369522A1 (en) 2005-05-02
EP1600441A2 (en) 2005-11-30
EP1600441A3 (en) 2005-12-07
EP2157083B1 (en) 2015-09-30
MA27133A1 (fr) 2005-01-03
KR100626819B1 (ko) 2006-09-20
DE60206787T2 (de) 2006-07-13
KR20050043992A (ko) 2005-05-11
HRP20040156A2 (en) 2004-08-31
WO2003014084A1 (en) 2003-02-20
ECSP044973A (es) 2004-06-28
SI1600441T1 (sl) 2010-02-26
NZ531558A (en) 2005-12-23
ME01525B (me) 2011-02-10
CY1109711T1 (el) 2014-08-13
AR037139A1 (es) 2004-10-27
BR0211739A (pt) 2004-09-28
EP1432683B1 (en) 2005-10-19

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