IL162554A0 - Microneedle devices and methods of manufacture - Google Patents

Microneedle devices and methods of manufacture

Info

Publication number
IL162554A0
IL162554A0 IL16255402A IL16255402A IL162554A0 IL 162554 A0 IL162554 A0 IL 162554A0 IL 16255402 A IL16255402 A IL 16255402A IL 16255402 A IL16255402 A IL 16255402A IL 162554 A0 IL162554 A0 IL 162554A0
Authority
IL
Israel
Prior art keywords
microneedle
methods
microneedles
microneedle devices
cover
Prior art date
Application number
IL16255402A
Other languages
English (en)
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of IL162554A0 publication Critical patent/IL162554A0/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150015Source of blood
    • A61B5/150022Source of blood for capillary blood or interstitial fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150206Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274Manufacture or production processes or steps for blood sampling devices
    • A61B5/150282Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150572Pierceable protectors, e.g. shields, caps, sleeves or films, e.g. for hygienic purposes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150694Procedure for removing protection means at the time of piercing
    • A61B5/150717Procedure for removing protection means at the time of piercing manually removed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150969Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150977Arrays of piercing elements for simultaneous piercing
    • A61B5/150984Microneedles or microblades
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/157Devices characterised by integrated means for measuring characteristics of blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046Solid microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Manufacturing & Machinery (AREA)
  • Optics & Photonics (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL16255402A 2002-01-15 2002-11-26 Microneedle devices and methods of manufacture IL162554A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/051,745 US6908453B2 (en) 2002-01-15 2002-01-15 Microneedle devices and methods of manufacture
PCT/US2002/037920 WO2003059431A1 (en) 2002-01-15 2002-11-26 Microneedle devices and methods of manufacture

Publications (1)

Publication Number Publication Date
IL162554A0 true IL162554A0 (en) 2005-11-20

Family

ID=21973131

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16255402A IL162554A0 (en) 2002-01-15 2002-11-26 Microneedle devices and methods of manufacture

Country Status (8)

Country Link
US (2) US6908453B2 (ja)
EP (1) EP1465698B1 (ja)
JP (1) JP4382492B2 (ja)
AT (1) ATE384549T1 (ja)
AU (1) AU2002359490A1 (ja)
DE (1) DE60224842T2 (ja)
IL (1) IL162554A0 (ja)
WO (1) WO2003059431A1 (ja)

Families Citing this family (219)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
CN1691969A (zh) 2002-07-19 2005-11-02 3M创新有限公司 微针装置和微针施用设备
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
CA2536249A1 (en) * 2003-08-25 2005-03-10 3M Innovative Properties Company Delivery of immune response modifier compounds
CA2536443A1 (en) * 2003-08-26 2005-03-03 Alza Corporation Device and method for intradermal cell implantation
US7378451B2 (en) * 2003-10-17 2008-05-27 3M Innovative Properties Co Surfactant composition having stable hydrophilic character
CN100478040C (zh) * 2003-11-10 2009-04-15 新加坡科技研究局 微型针以及微型针的制造
US7753888B2 (en) * 2003-11-21 2010-07-13 The Regents Of The University Of California Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles
US7361182B2 (en) 2003-12-19 2008-04-22 Lightnix, Inc. Medical lancet
CA2552385C (en) * 2003-12-29 2013-07-23 3M Innovative Properties Company Medical devices and kits including same
US7150726B2 (en) * 2004-01-23 2006-12-19 Norfolk Medical Device for subcutaneous infusion of fluids
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2005082593A1 (en) * 2004-02-17 2005-09-09 Avery Dennison Corporation Method of making microneedles
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
EP1732640A4 (en) * 2004-03-12 2010-09-01 Agency Science Tech & Res METHOD AND FORMS FOR USE IN THE MANUFACTURE OF MICRONED NEEDLES WITH SIDE OPENINGS
CA2562643A1 (en) * 2004-04-12 2005-11-24 Allergan, Inc. Multi-site injection system
EP1773444B1 (en) * 2004-06-10 2017-09-20 3M Innovative Properties Company Patch application device and kit
US7560036B2 (en) * 2004-08-05 2009-07-14 Apogee Technology, Inc. System and method for drug delivery and microfluidic applications using microneedles
US8696619B2 (en) * 2004-08-10 2014-04-15 Robert P. Schnall Drug delivery devices
US20070250018A1 (en) * 2004-08-12 2007-10-25 Hirotoshi Adachi Transdermal Drug Administration System with Microneedles
WO2006018642A1 (en) 2004-08-16 2006-02-23 Functional Microstructures Limited Method of producing a microneedle or microimplant
AR050608A1 (es) * 2004-08-19 2006-11-08 Alza Corp Aparato y metodo para administracion transdermica de factores de crecimiento endotelial vascular
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
JP2008520369A (ja) 2004-11-18 2008-06-19 スリーエム イノベイティブ プロパティズ カンパニー 目立たないマイクロニードルアレイアプリケーター
EP1827715B1 (en) 2004-11-18 2013-07-17 3M Innovative Properties Company Method of contact coating a microneedle array
CA2588080C (en) * 2004-11-18 2013-01-08 3M Innovative Properties Company Masking method for coating a microneedle array
EP1838383B1 (en) 2004-11-18 2011-04-06 3M Innovative Properties Company Microneedle array applicator and retainer
US20080009801A1 (en) * 2004-12-02 2008-01-10 Nickel Janice H Method for dispensing material into a drug delivery device
EP2067599B1 (en) * 2004-12-07 2016-10-26 3M Innovative Properties Company Method of molding a microneedle
AU2005314289A1 (en) 2004-12-10 2006-06-15 3M Innovative Properties Company Medical device
JP4793806B2 (ja) * 2005-03-22 2011-10-12 Tti・エルビュー株式会社 イオントフォレーシス装置
EP1898807A1 (en) * 2005-03-28 2008-03-19 Alza Corporation Microprojections with capillary control features and method
CA2602259A1 (en) 2005-03-29 2006-10-05 Arkal Medical, Inc. Devices, systems, methods and tools for continuous glucose monitoring
JP5301985B2 (ja) 2005-04-07 2013-09-25 スリーエム イノベイティブ プロパティズ カンパニー ツールフィードバック感知のためのシステム及び方法
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
US7442029B2 (en) 2005-05-16 2008-10-28 Asml Netherlands B.V. Imprint lithography
US20080195035A1 (en) 2005-06-24 2008-08-14 Frederickson Franklyn L Collapsible Patch and Method of Application
ATE477833T1 (de) * 2005-06-27 2010-09-15 3M Innovative Properties Co Mikronadelkartuschenanordnung
CA2613111C (en) 2005-06-27 2015-05-26 3M Innovative Properties Company Microneedle array applicator device and method of array application
US20070004989A1 (en) * 2005-06-29 2007-01-04 Parvinder Dhillon Device for transdermal sampling
US7890164B2 (en) 2005-09-15 2011-02-15 Tti Ellebeau, Inc. Iontophoresis device
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070073212A1 (en) * 2005-09-28 2007-03-29 Takehiko Matsumura Iontophoresis apparatus and method to deliver active agents to biological interfaces
US20070078374A1 (en) * 2005-09-30 2007-04-05 Transcutaneous Technologies Inc. Iontophoretic delivery of vesicle-encapsulated active agents
US7574256B2 (en) * 2005-09-30 2009-08-11 Tti Ellebeau, Inc. Iontophoretic device and method of delivery of active agents to biological interface
US20070093789A1 (en) * 2005-09-30 2007-04-26 Transcutaneous Technologies Inc. Iontophoresis apparatus and method for delivery of angiogenic factors to enhance healing of injured tissue
US8900180B2 (en) * 2005-11-18 2014-12-02 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
US20080319404A1 (en) * 2005-12-21 2008-12-25 Pekurovsky Mikhail L Microneedle Devices
EP1965856A2 (en) * 2005-12-30 2008-09-10 Tti Ellebeau, Inc. Iontophoretic systems, devices, and methods of delivery of active agents to biological interface
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
EP1992386B1 (en) * 2006-02-10 2011-11-09 Hisamitsu Pharmaceutical Co., Inc. Transdermal drug administration apparatus having microneedles
EP1820441A1 (de) * 2006-02-16 2007-08-22 Roche Diagnostics GmbH Mikronadelanordnung mit Sensor basierend auf der abgeschwächten Totalreflexion (ATR)
US7699819B2 (en) 2006-02-21 2010-04-20 The Hong Kong University Of Science And Technology Molecular sieve and zeolite microneedles and preparation thereof
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
US20080004564A1 (en) * 2006-03-30 2008-01-03 Transcutaneous Technologies Inc. Controlled release membrane and methods of use
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
DE102006028782A1 (de) * 2006-06-23 2007-12-27 Robert Bosch Gmbh Vorrichtung zur Aufbewahrung und Transport von Mikronadeln und ein Verfahren zur Verabreichung von Wirkstoffen mittels einer solchen Vorrichtung
US8250729B2 (en) * 2006-07-12 2012-08-28 University Of Utah Research Foundation 3D fabrication of needle tip geometry and knife blade
US20090326441A1 (en) * 2006-08-01 2009-12-31 Agency For Science ,Technology And Research Ultrasonic Enhanced Microneedles
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
ES2380226T3 (es) * 2006-09-04 2012-05-09 F. Hoffmann-La Roche Ag Embalaje para instrumentos médicos hidrófilos
US20080097352A1 (en) * 2006-09-12 2008-04-24 Beck Patricia A Methods of fabricating microneedles with bio-sensory functionality
US20090181078A1 (en) * 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
ES2673046T3 (es) * 2006-09-26 2018-06-19 Infectious Disease Research Institute Composición de vacuna que contiene un adyuvante sintético
JP4954656B2 (ja) * 2006-09-28 2012-06-20 凸版印刷株式会社 針状体および針状体の製造方法
WO2008042902A2 (en) 2006-10-02 2008-04-10 Emkinetics, Inc. Method and apparatus for magnetic induction therapy
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
EP2090331A4 (en) * 2006-11-22 2012-04-18 Toppan Printing Co Ltd MICRONADEL ARRANGEMENT AND MANUFACTURING METHOD THEREFOR
WO2008070524A2 (en) 2006-12-01 2008-06-12 Tti Ellebeau, Inc. Systems, devices, and methods for powering and/or controlling devices, for instance transdermal delivery devices
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
JP5297595B2 (ja) * 2007-03-20 2013-09-25 凸版印刷株式会社 針状体および針状体製造方法
US8439861B2 (en) * 2007-04-24 2013-05-14 Velcro Industries B.V. Skin penetrating touch fasteners
TW200841866A (en) * 2007-04-25 2008-11-01 Micro Base Technology Corp Cosmetic or medical patch structure
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
US20090053673A1 (en) * 2007-08-23 2009-02-26 Zimmer, Inc. Method for localized treatment of periodontal tissue
WO2009040548A1 (en) * 2007-09-28 2009-04-02 The Queen's University Of Belfast Delivery device and method
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
US9220678B2 (en) 2007-12-24 2015-12-29 The University Of Queensland Coating method
CA2749347C (en) * 2008-02-07 2018-03-27 The University Of Queensland Patch production
US20090234322A1 (en) * 2008-03-12 2009-09-17 Ultradent Products, Inc. Method of dental tissue injection using an array of micro-needles
US20090259176A1 (en) * 2008-04-09 2009-10-15 Los Gatos Research, Inc. Transdermal patch system
US8012329B2 (en) 2008-05-09 2011-09-06 3M Innovative Properties Company Dimensional control in electroforms
WO2009140735A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection by microneedle patch with analyte selective reagents.
EP2328530A4 (en) * 2008-08-22 2012-09-12 Us Worldmeds Llc TRANSDERMAL ADMINISTRATION OF APOMORPHINE USING MICROARRAYS
JP2012509106A (ja) * 2008-11-18 2012-04-19 スリーエム イノベイティブ プロパティズ カンパニー 中空のマイクロニードルアレイ及び方法
HUE049678T2 (hu) 2008-12-02 2020-10-28 Allergan Inc Injekciós eszköz
JP5563652B2 (ja) 2009-03-17 2014-07-30 カーディオスライヴ インコーポレイテッド 体外除細動器
US8781576B2 (en) 2009-03-17 2014-07-15 Cardiothrive, Inc. Device and method for reducing patient transthoracic impedance for the purpose of delivering a therapeutic current
KR101033514B1 (ko) * 2009-06-02 2011-05-09 (주)마이티시스템 유연한 미세바늘 패치 시스템 및 그 제작방법
CN105131051B (zh) 2009-06-05 2020-07-10 传染性疾病研究院 合成的吡喃葡萄糖脂佐剂
US8062568B2 (en) * 2009-08-27 2011-11-22 Korea University Research And Business Foundation Nano pattern writer
US20110319742A1 (en) * 2009-09-08 2011-12-29 SensiVida Medical Technologies, Inc. Spatial imaging methods for biomedical monitoring and systems thereof
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
EP2493551A4 (en) 2009-10-26 2013-04-17 Emkinetics Inc METHOD AND APPARATUS FOR ELECTROMAGNETIC STIMULATION OF NERVE, MUSCLE, AND ORGANIC TISSUES
DE102009046581A1 (de) 2009-11-10 2011-05-12 Robert Bosch Gmbh Herstellungsverfahren für eine poröse Mikronadelanordnung und entsprechende poröse Mikronadelanordnung und entsprechender Substratverbund
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
US20110172638A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including multi-functional cover
GB2478363A (en) * 2010-03-05 2011-09-07 Ndm Technologies Ltd Microneedle patch and method of manufacture
JP5423522B2 (ja) * 2010-03-25 2014-02-19 日本電気株式会社 モジュール及びモジュール製造方法
PT2563453T (pt) 2010-04-28 2017-03-15 Kimberly Clark Co Dispositivo medicinal possuindo uma nanoforma com melhor interacção celular e um método para a sua formação
CN102985131B (zh) 2010-04-28 2016-06-29 金伯利-克拉克环球有限公司 用于递送siRNA的医疗装置
CA2796965C (en) 2010-04-28 2019-04-16 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
FR2959599B1 (fr) * 2010-04-28 2013-12-20 Commissariat Energie Atomique Dispositif et procede de texturation mecanique d'une plaquette de silicium destinee a constituer une cellule photovoltaique, plaquette de silicium obtenue
JP5860032B2 (ja) 2010-04-28 2016-02-16 キンバリー クラーク ワールドワイド インコーポレイテッド 関節リウマチ薬の送達のためのデバイス
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
US20120089118A1 (en) * 2010-10-08 2012-04-12 A Nevada Corporation Delivery of bisphosphonates by microinjection systems
WO2012061556A1 (en) 2010-11-03 2012-05-10 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
EA027236B1 (ru) 2011-04-08 2017-07-31 Иммьюн Дизайн Корп. Иммуногенные композиции и способы применения таких композиций для индукции гуморального и клеточного иммунного ответа
US8636696B2 (en) * 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
JP2014236758A (ja) * 2011-09-30 2014-12-18 テルモ株式会社 センサ
US11179553B2 (en) 2011-10-12 2021-11-23 Vaxxas Pty Limited Delivery device
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
KR102145638B1 (ko) 2011-10-27 2020-08-18 소렌토 쎄라퓨틱스, 인코포레이티드 고점도 생체활성 제제의 경피 전달 방법
HUE044841T2 (hu) 2012-02-07 2019-11-28 Infectious Disease Res Inst TLR4 agonistákat tartalmazó javított adjuváns készítmények és azok alkalmazási eljárásai
IN2014DN10161A (ja) 2012-05-01 2015-08-21 Univ Pittsburgh
US9895435B2 (en) 2012-05-16 2018-02-20 Immune Design Corp. Vaccines for HSV-2
JP5903016B2 (ja) * 2012-06-27 2016-04-13 コスメディ製薬株式会社 マイクロニードルパッチの保護離型シート
KR102560618B1 (ko) * 2012-07-06 2023-07-26 더 제너럴 하스피탈 코포레이션 피부과 치료를 위한 방법 및 장치
WO2014120129A1 (en) 2013-01-29 2014-08-07 Hewlett-Packard Development Company, L.P. Apparatus having surface-enhanced spectroscopy elements on an exterior surface
CN103157178B (zh) * 2013-02-05 2014-12-31 北京化工大学 精确控制微针插入长度的印章式工具
EP4039236A1 (en) 2013-02-20 2022-08-10 Cytrellis Biosystems, Inc. System for tightening a region of skin
ITMI20130586A1 (it) * 2013-04-11 2014-10-12 Azienda Ospedaliero Universitaria P Isana Microago e matrice di microaghi per uso medicale, e processo di produzione di detta matrice
AU2014253791B2 (en) 2013-04-18 2019-05-02 Immune Design Corp. GLA monotherapy for use in cancer treatment
US20140350516A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Mechanical syringe accessory
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
BR112015031162A2 (pt) * 2013-06-13 2017-07-25 Microdermics Inc microagulhas metálicas
US9656094B2 (en) 2013-06-14 2017-05-23 Cardiothrive, Inc. Biphasic or multiphasic pulse generator and method
US9907970B2 (en) 2013-06-14 2018-03-06 Cardiothrive, Inc. Therapeutic system and method using biphasic or multiphasic pulse waveform
US9833630B2 (en) 2013-06-14 2017-12-05 Cardiothrive, Inc. Biphasic or multiphasic pulse waveform and method
US9616243B2 (en) 2013-06-14 2017-04-11 Cardiothrive, Inc. Dynamically adjustable multiphasic defibrillator pulse system and method
US10279189B2 (en) 2013-06-14 2019-05-07 Cardiothrive, Inc. Wearable multiphasic cardioverter defibrillator system and method
US10149973B2 (en) 2013-06-14 2018-12-11 Cardiothrive, Inc. Multipart non-uniform patient contact interface and method of use
US10555754B2 (en) 2013-08-09 2020-02-11 Cytrellis Biosystems, Inc. Methods and apparatuses for skin treatment using non-thermal tissue ablation
KR101511850B1 (ko) * 2013-10-10 2015-04-16 (주)엠큐어 멀티니들허브를 갖는 피부재생기
WO2015095675A1 (en) 2013-12-19 2015-06-25 Cytrellis Biosystems, Inc. Methods and devices for manipulating subdermal fat
MA39228A1 (fr) 2014-01-21 2017-06-30 Immune Design Corp Compositions à utiliser pour le traitement d'états allergiques
JP5884954B2 (ja) 2014-02-27 2016-03-15 凸版印刷株式会社 マイクロニードルユニット、および、マイクロニードル用容器
US20170101242A1 (en) * 2014-03-26 2017-04-13 Nissha Printing Co., Ltd. Conical-projections-sheet packaging body and a method of manufacturing the same
WO2015168214A1 (en) * 2014-04-30 2015-11-05 Kimberly-Clark Worldwide, Inc. Draped microneedle array
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
US9987427B1 (en) 2014-06-24 2018-06-05 National Technology & Engineering Solutions Of Sandia, Llc Diagnostic/drug delivery “sense-respond” devices, systems, and uses thereof
US10321858B2 (en) 2014-08-18 2019-06-18 Proteadx, Inc. Apparatus and methods for transdermal sensing of analytes in interstitial fluid and associated data transmission systems
US9933387B1 (en) 2014-09-07 2018-04-03 Biolinq, Inc. Miniaturized sub-nanoampere sensitivity low-noise potentiostat system
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
BR112017009805A2 (pt) 2014-11-14 2017-12-26 Cytrellis Biosystems Inc dispositivos e métodos para ablação da pele
JP6906885B2 (ja) 2014-11-14 2021-07-21 ロレアル しわを減少させるためのマイクロニードルシート
WO2016121499A1 (ja) * 2015-01-27 2016-08-04 凸版印刷株式会社 経皮投与デバイス
CA3204959A1 (en) 2015-02-02 2016-08-11 Vaxxas Pty Limited Microprojection array applicator and method
CA2976544A1 (en) 2015-03-10 2016-09-15 Allergan Pharmaceuticals Holdings (Ireland) Unlimited Company Multiple needle injector
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
WO2016175164A1 (ja) * 2015-04-27 2016-11-03 株式会社クオリーメン シート状小片、その小片を含む発毛促進用シート、並びに、その小片を含む美白及び皺改善剤
JP6646985B2 (ja) * 2015-09-08 2020-02-14 花王株式会社 微細突起具の製造方法
US11103259B2 (en) 2015-09-18 2021-08-31 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
EP3355981A4 (en) 2015-09-28 2019-05-22 Vaxxas Pty Limited MICROPROJECTION ARRANGEMENTS WITH IMPROVED SKIN-IMPROPER PROPERTIES AND METHOD THEREFOR
JP6461761B2 (ja) * 2015-10-06 2019-01-30 富士フイルム株式会社 経皮吸収シートの製造方法
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
ES2865489T3 (es) 2015-12-04 2021-10-15 Ascilion Ab Una microaguja y un chip
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
KR102561605B1 (ko) 2016-03-29 2023-08-01 사이트렐리스 바이오시스템즈, 인크. 미용 피부 리설페이싱용 디바이스 및 방법
EP4406569A2 (en) 2016-04-08 2024-07-31 Allergan, Inc. Aspiration and injection device
US11147485B2 (en) 2016-05-04 2021-10-19 Midge Medical Gmbh Body fluid extraction device
US10092207B1 (en) 2016-05-15 2018-10-09 Biolinq, Inc. Tissue-penetrating electrochemical sensor featuring a co-electrodeposited thin film comprised of polymer and bio-recognition element
KR102392974B1 (ko) 2016-05-16 2022-05-02 인펙셔스 디지즈 리서치 인스티튜트 (아이디알아이) Tlr 작용제를 함유하는 제제 및 사용 방법
CA3023672A1 (en) 2016-05-16 2017-11-23 Infectious Disease Research Institute Pegylated liposomes and methods of use
JP7140684B2 (ja) 2016-06-01 2022-09-21 アクセス ツー アドバンスト ヘルス インスティチュート サイジング剤含有ナノアラム粒子
JP6300864B2 (ja) * 2016-08-09 2018-03-28 ヒューレット−パッカード デベロップメント カンパニー エル.ピー.Hewlett‐Packard Development Company, L.P. 外面に表面増感分光法要素を有する装置
JP2019529043A (ja) 2016-09-21 2019-10-17 サイトレリス バイオシステムズ,インコーポレーテッド 美容スキンリサーフェシング装置及び方法
MX2019005833A (es) 2016-11-21 2019-10-30 Eirion Therapeutics Inc Administracion transdermica de agentes grandes.
EP3544586A1 (en) * 2016-11-23 2019-10-02 University Medical Pharmaceuticals Corporation Microneedle delivery system and method
JP6977258B2 (ja) * 2016-12-20 2021-12-08 株式会社リコー 中空構造体
EP3338832A1 (en) * 2016-12-23 2018-06-27 Sanofi-Aventis Deutschland GmbH Medicament delivery device
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
ES2960937T3 (es) 2017-03-31 2024-03-07 Vaxxas Pty Ltd Dispositivo y método para recubrir superficies
US11045142B1 (en) 2017-04-29 2021-06-29 Biolinq, Inc. Heterogeneous integration of silicon-fabricated solid microneedle sensors and CMOS circuitry
WO2018231706A1 (en) 2017-06-11 2018-12-20 Molecular Express, Inc. Methods and compositions for substance use disorder vaccine formulations and uses thereof
CA3065371A1 (en) 2017-06-13 2018-12-20 Vaxxas Pty Limited Quality control of substrate coatings
JP6931222B2 (ja) * 2017-07-18 2021-09-01 コスメディ製薬株式会社 マイクロニードルアレイの発泡支持体シート
US11464957B2 (en) 2017-08-04 2022-10-11 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
US11766203B2 (en) 2017-09-13 2023-09-26 National Technology & Engineering Solutions Of Sandia, Llc Coaxial microneedle assemblies and methods thereof
TWI667016B (zh) 2017-11-20 2019-08-01 研能科技股份有限公司 血糖監測控制系統
WO2019126735A1 (en) 2017-12-21 2019-06-27 Georgia Tech Research Corporation Methods and systems for improved collection of interstitial fluid
US10828500B2 (en) 2017-12-22 2020-11-10 Cardiothrive, Inc. External defibrillator
SG10201800072YA (en) * 2018-01-03 2019-08-27 Micropoint Tech Pte Ltd Microneedle Patches Comprising Corticosteroid
US10918839B2 (en) * 2018-03-13 2021-02-16 II Jaro Mayda Balloon catheter
CN111801135B (zh) * 2018-03-30 2023-06-27 富士胶片株式会社 微针阵列的制造方法
USD875254S1 (en) 2018-06-08 2020-02-11 Biolinq, Inc. Intradermal biosensor
KR20210057140A (ko) 2018-09-13 2021-05-20 에이리온 테라퓨틱스, 인코포레이티드 플라즈미노겐 활성인자 억제제 1 (pai-1) 억제제의 용도
BR112021004542A2 (pt) 2018-09-13 2021-06-08 Eirion Therapeutics, Inc. inibidores do inibidor de ativador de plasminogênio 1 (pai-1) e usos para os mesmos
US20210338158A1 (en) 2018-10-02 2021-11-04 WearOptimo Pty Ltd Measurement system
WO2020069567A1 (en) 2018-10-02 2020-04-09 WearOptimo Pty Ltd Electrode arrangement
BR112021009554A2 (pt) 2018-12-03 2021-08-17 Eirion Therapeutics, Inc. aplicação melhorada de agentes grandes
MX2021012739A (es) 2019-05-14 2021-11-17 Eirion Therapeutics Inc Retrasar el efecto pico y/o prolongar la duracion de la respuesta.
TWI687247B (zh) * 2019-05-15 2020-03-11 微邦科技股份有限公司 微針結構及其生物可降解微針
CN111939452A (zh) * 2019-05-15 2020-11-17 微邦科技股份有限公司 微针结构及其生物可降解微针
EP3772331A1 (fr) * 2019-08-08 2021-02-10 PKvitality Systeme de surveillance corporelle comprenant une microaiguille
CN110711312B (zh) * 2019-11-07 2021-07-30 河南大学 基于微机电系统的强促渗透皮释药微系统及其制造方法
EP4048152B1 (en) 2020-07-29 2023-12-20 Biolinq Incorporated Continuous analyte monitoring system with microneedle array
WO2022118859A1 (ja) * 2020-12-01 2022-06-09 三井化学株式会社 マイクロニードルアレイ、マイクロニードルアレイアセンブリ、及び検査チップ
AU2021406131A1 (en) 2020-12-23 2023-08-03 Access To Advanced Health Institute Solanesol vaccine adjuvants and methods of preparing same
CN112858430B (zh) * 2021-01-08 2021-11-26 中山大学 一种检测植物活性小分子的传感器和制备方法
USD988160S1 (en) * 2021-03-16 2023-06-06 Biolinq Incorporated Wearable dermal sensor
KR20240005085A (ko) 2021-05-08 2024-01-11 바이오링크 인코포레이티드 미세 바늘 어레이 기반 지속 분석물 모니터링 장치의 고장 감지
CN113499537A (zh) * 2021-09-03 2021-10-15 河南佳普医药科技有限公司 一种微针透皮给药装置
JP7141625B1 (ja) 2021-09-17 2022-09-26 リンテック株式会社 マイクロニードルパッチ及びマイクロニードル構造体
USD996999S1 (en) * 2021-11-16 2023-08-29 Biolinq Incorporated Wearable sensor
USD1013544S1 (en) * 2022-04-29 2024-02-06 Biolinq Incorporated Wearable sensor
USD1012744S1 (en) * 2022-05-16 2024-01-30 Biolinq Incorporated Wearable sensor with illuminated display
WO2024129424A1 (en) * 2022-12-16 2024-06-20 Kindeva Drug Delivery L.P. Drug delivery device
USD1035004S1 (en) 2023-02-28 2024-07-09 Biolinq Incorporated Wearable sensor

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123212A (en) * 1964-03-03 Multiple disposable intracutaneous injector package
BE542424A (ja) * 1954-04-27
US3034507A (en) * 1960-05-10 1962-05-15 American Cyanamid Co Intracutaneous injection device
US3074403A (en) * 1960-05-17 1963-01-22 American Cyanamid Co Intracutaneous injector with capillary gap
US3136314A (en) * 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3246647A (en) * 1962-07-23 1966-04-19 American Cyanamid Co Disposable intracutaneous injector
US3466131A (en) * 1967-09-07 1969-09-09 Becton Dickinson Co Dispensing applicator package
US3675766A (en) * 1970-02-04 1972-07-11 Sol Roy Rosenthal Multiple puncture injector device
US3688764A (en) * 1970-08-20 1972-09-05 Bard Hamilton Co Inc Intracutaneous injection system
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) * 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
DE2250293A1 (de) * 1972-10-13 1974-04-25 Bayern Freistaat Impfstempel zur cutanen pockenimpfung mittels trockenimpfstoff
OA05448A (fr) * 1975-10-16 1981-03-31 Manufrance Manufacture Francai Dispositif vaccinateur multipénétrant.
US4473083A (en) * 1981-12-14 1984-09-25 Maganias Nicholas H Device and method for allergy testing
US4921475A (en) * 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
GB2221394B (en) 1988-08-05 1992-03-04 Eilert Eilertsen An injection device
US6090790A (en) * 1989-12-14 2000-07-18 Eriksson; Elof Gene delivery by microneedle injection
US5402798A (en) * 1991-07-18 1995-04-04 Swierczek; Remi Disposable skin perforator and blood testing device
US5342737A (en) * 1992-04-27 1994-08-30 The United States Of America As Represented By The Secretary Of The Navy High aspect ratio metal microstructures and method for preparing the same
DE69333951D1 (de) * 1992-06-18 2006-02-02 Us Gov Health & Human Serv Rekombinantes pseudomonas exotoxin mit gesteigerter aktivität
JP3211525B2 (ja) 1993-04-22 2001-09-25 オムロン株式会社 薄材メッシュ、その製造方法及びその製造装置
US5620095A (en) 1993-06-11 1997-04-15 Minnesota Mining And Manufacturing Company Orthopedic casting material and hermetic package
JP2551742B2 (ja) * 1994-05-23 1996-11-06 三星電機株式会社 医薬品投与用皮膚傷形成装置
DE69637994D1 (de) 1995-04-26 2009-09-24 Minnesota Mining & Mfg Ablationsverfahren durch laser-darstellung
WO1996037155A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
AU5869796A (en) * 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
JP2725637B2 (ja) * 1995-05-31 1998-03-11 日本電気株式会社 電子回路装置およびその製造方法
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US5658515A (en) * 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
US5657516A (en) * 1995-10-12 1997-08-19 Minnesota Mining And Manufacturing Company Dual structured fastener elements
ZA975326B (en) * 1996-06-18 1998-01-14 Alza Corp Device and method for enhancing transdermal flux of agents being delivered or sampled.
EP0921840B1 (en) * 1996-07-03 2003-05-28 Altea Therapeutics Corporation Multiple mechanical microporation of skin or mucosa
US6797276B1 (en) * 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
CA2271167C (en) 1996-12-20 2007-01-09 Alza Corporation Device and method for enhancing transdermal agent flux
US6605332B2 (en) * 1997-07-29 2003-08-12 3M Innovative Properties Company Unitary polymer substrate having napped surface of frayed end microfibers
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
EP1037686B1 (en) * 1997-12-11 2005-08-17 Alza Corporation Device for enhancing transdermal agent flux
CA2313458C (en) * 1997-12-11 2007-04-17 Alza Corporation Device for enhancing transdermal agent flux
US6099682A (en) 1998-02-09 2000-08-08 3M Innovative Properties Company Corporation Of Delaware Cold seal package and method for making the same
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
JP2002517300A (ja) * 1998-06-10 2002-06-18 ジョージア テック リサーチ コーポレイション 微小針デバイスおよび製造方法ならびにそれらの使用
GB9815819D0 (en) * 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
GB9815820D0 (en) 1998-07-22 1998-09-16 Secr Defence Improvements relating to micro-machining
US6532386B2 (en) * 1998-08-31 2003-03-11 Johnson & Johnson Consumer Companies, Inc. Electrotransort device comprising blades
WO2000035530A1 (en) * 1998-12-18 2000-06-22 Minimed Inc. Insertion sets with micro-piercing members for use with medical devices and methods of using the same
US6713291B2 (en) * 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
JP4499295B2 (ja) * 1999-01-28 2010-07-07 サイト パルス サイエンシズ、インコーポレイテッド 細胞内への巨大分子の送達
US6611707B1 (en) * 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
AU5461300A (en) 1999-06-04 2000-12-28 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
AU2573801A (en) * 1999-11-02 2001-05-14 University Of Hawaii Method for fabricating arrays of micro-needles
CN1390148A (zh) * 1999-11-15 2003-01-08 维尔克鲁工业公司 皮肤附着件
EP1276426A4 (en) 2000-03-09 2008-03-19 Nanopass Ltd SYSTEMS AND METHODS FOR TRANSPORTING FLUIDS THROUGH A BIOLOGICAL BARRIER AND TECHNIQUES FOR PRODUCING SUCH SYSTEMS
US6558361B1 (en) * 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
AU2001275138A1 (en) * 2000-06-02 2001-12-17 The University Of Utah Research Foundation Active needle devices with integrated functionality
US6537242B1 (en) * 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6589202B1 (en) * 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US6440096B1 (en) * 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6749575B2 (en) * 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
IL154811A0 (en) * 2000-09-08 2003-10-31 Alza Corp Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure
ES2317940T3 (es) * 2000-10-13 2009-05-01 Alza Corporation Dispositivo de retencion para un elemento de microsalientes para aplicador de impactos.
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
HUP0302924A2 (en) * 2000-10-26 2003-12-29 Alza Corp Transdermal drug delivery devices having coated microprotrusions
WO2002064193A2 (en) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
WO2002050584A2 (en) * 2000-12-21 2002-06-27 Biovalve Technologies, Inc. Microneedle array systems
US20020099356A1 (en) * 2001-01-19 2002-07-25 Unger Evan C. Transmembrane transport apparatus and method
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6591124B2 (en) * 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
AU2002312315A1 (en) * 2001-06-08 2002-12-23 The Regents Of The University Of California Microfabricated surgical devices and methods of making the same
US6686299B2 (en) * 2001-06-21 2004-02-03 Carlo D. Montemagno Nanosyringe array and method
US6746590B2 (en) * 2001-09-05 2004-06-08 3M Innovative Properties Company Ultrasonically-enhanced electroplating apparatus and methods
US6881203B2 (en) * 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
AU2002327675A1 (en) * 2001-09-19 2003-04-01 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
EP1469903A2 (en) * 2001-09-28 2004-10-27 BioValve Technologies, Inc. Microneedle with membrane
US6689100B2 (en) * 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
ES2319625T3 (es) * 2001-10-29 2009-05-11 Becton, Dickinson And Company Dispositivo para la administracion de una sustancia.
ATE509272T1 (de) * 2001-11-09 2011-05-15 3Dbiosurfaces Technologies Llc Substrate mit hochliegendem oberflächenbereich für mikroarrays sowie verfahren zur herstellung davon
RU2314760C2 (ru) * 2001-12-20 2008-01-20 Алза Корпорейшн Микровыступы, пробивающие кожу, имеющие средство регулирования глубины пробивки
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US20040060902A1 (en) * 2002-02-05 2004-04-01 Evans John D. Microprotrusion array and methods of making a microprotrusion
US7392080B2 (en) * 2002-03-11 2008-06-24 Altea Therapeutics Corporation Transdermal drug delivery patch system, method of making same and method of using same
US6780171B2 (en) * 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US6899838B2 (en) * 2002-07-12 2005-05-31 Becton, Dickinson And Company Method of forming a mold and molding a micro-device
DK1523355T3 (en) * 2002-07-22 2019-04-23 Becton Dickinson Co PLASTER-LIKE INFUSION DEVICE
WO2004020015A2 (en) * 2002-08-29 2004-03-11 Becton Dickinson And Company Microprotrusion arrays and methods for using same to deliver substances into tissue
EP1590034B1 (en) * 2002-10-07 2014-05-14 Biovalve Technologies, Inc. Microneedle array patch
AU2004251699A1 (en) * 2003-06-04 2005-01-06 Georgia Tech Research Corporation Drilling microneedle device
AR044985A1 (es) * 2003-07-02 2005-10-12 Alza Corp Metodo y parche de inmunizacion por disposicion de microproyeccion
CA2534823A1 (en) * 2003-08-04 2005-02-24 Alza Corporation Method and device for enhancing transdermal agent flux
BR122020015610B8 (pt) * 2003-08-12 2023-11-14 Becton Dickinson Co Dispositivo para distribuir um medicamento para dentro do corpo de um paciente por injeção
CA2536443A1 (en) * 2003-08-26 2005-03-03 Alza Corporation Device and method for intradermal cell implantation
US8353861B2 (en) * 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
WO2005041871A2 (en) * 2003-10-24 2005-05-12 Alza Corporation Apparatus and method for enhancing transdermal drug delivery
AU2004285484A1 (en) * 2003-10-24 2005-05-12 Alza Corporation Pretreatment method and system for enhancing transdermal drug delivery
CA2543280A1 (en) * 2003-10-28 2005-05-19 Alza Corporation Delivery of polymer conjugates of therapeutic peptides and proteins via coated microporjections

Also Published As

Publication number Publication date
AU2002359490A1 (en) 2003-07-30
US20050187521A1 (en) 2005-08-25
DE60224842D1 (de) 2008-03-13
EP1465698A1 (en) 2004-10-13
WO2003059431A1 (en) 2003-07-24
JP2005514179A (ja) 2005-05-19
EP1465698B1 (en) 2008-01-23
US20030135161A1 (en) 2003-07-17
JP4382492B2 (ja) 2009-12-16
ATE384549T1 (de) 2008-02-15
US6908453B2 (en) 2005-06-21
DE60224842T2 (de) 2009-01-22

Similar Documents

Publication Publication Date Title
IL162554A0 (en) Microneedle devices and methods of manufacture
ES2612779T3 (es) Sistema de parches transdérmicos de administración de fármacos, método de fabricación del mismo y método de uso del mismo
ES2314995T3 (es) Dispositivo para mejorar el flujo de agentes tansdermicos.
US8579862B2 (en) Applicator for microneedle array
TW200613029A (en) System and method for drug delivery and microfluidic applications using microneedles
JP2012523265A (ja) 流体伝達を調節することができるマイクロニードルユニット
WO2002085447A3 (en) Microprojection array having a beneficial agent containing coating
DE60106261D1 (de) Abgabevorrichtung mit mikronadeln zur transdermalen verabreichung von einer substanz
WO2005000382A3 (en) Drilling microneedle device
ZA200705629B (en) Medical device
JP2005501615A5 (ja)
WO2005042054A3 (en) Pretreatment method and system for enhancing transdermal drug delivery
PL1684846T3 (pl) Urządzenie do transdermalnego podawania substancji czynnych
US20200230389A1 (en) Micropenetrator device for penetrating a biological barrier
CN105381536A (zh) 自行载药的长时透皮给药及取样装置
CN107913458B (zh) 一种液体定量储存系统
CN211461763U (zh) 一种方便按压的可溶性微针贴片
CN105944227A (zh) 一种局部止痛贴