IL142181A - Crystal of diuridine tetraphosphate or salt thereof and method for preparing the same and method forproducing said compound - Google Patents

Crystal of diuridine tetraphosphate or salt thereof and method for preparing the same and method forproducing said compound

Info

Publication number
IL142181A
IL142181A IL14218199A IL14218199A IL142181A IL 142181 A IL142181 A IL 142181A IL 14218199 A IL14218199 A IL 14218199A IL 14218199 A IL14218199 A IL 14218199A IL 142181 A IL142181 A IL 142181A
Authority
IL
Israel
Prior art keywords
salt
ump
ppi
dpp
producing
Prior art date
Application number
IL14218199A
Other languages
English (en)
Other versions
IL142181A0 (en
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Publication of IL142181A0 publication Critical patent/IL142181A0/xx
Publication of IL142181A publication Critical patent/IL142181A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL14218199A 1998-10-02 1999-10-01 Crystal of diuridine tetraphosphate or salt thereof and method for preparing the same and method forproducing said compound IL142181A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP28166398 1998-10-02
JP17068199 1999-06-17
PCT/JP1999/005415 WO2000020430A1 (fr) 1998-10-02 1999-10-01 Cristal de diuridine tetraphosphate ou sel correspondant et procede de fabrication

Publications (2)

Publication Number Publication Date
IL142181A0 IL142181A0 (en) 2002-03-10
IL142181A true IL142181A (en) 2005-12-18

Family

ID=26493605

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14218199A IL142181A (en) 1998-10-02 1999-10-01 Crystal of diuridine tetraphosphate or salt thereof and method for preparing the same and method forproducing said compound

Country Status (21)

Country Link
US (2) US6458946B1 (ko)
EP (1) EP1043329B1 (ko)
JP (2) JP3247685B2 (ko)
KR (1) KR100475008B1 (ko)
CN (2) CN1151166C (ko)
AT (1) ATE222920T1 (ko)
AU (1) AU747096C (ko)
BR (2) BR9914453A (ko)
CA (1) CA2345624C (ko)
CZ (1) CZ300402B6 (ko)
DE (1) DE69902624T2 (ko)
EA (2) EA003167B1 (ko)
ES (1) ES2183650T3 (ko)
HU (1) HU228681B1 (ko)
IL (1) IL142181A (ko)
MX (1) MXPA01003377A (ko)
NO (1) NO317305B1 (ko)
NZ (1) NZ510748A (ko)
PL (1) PL199434B1 (ko)
SK (1) SK283729B6 (ko)
WO (1) WO2000020430A1 (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7078391B2 (en) * 1997-02-10 2006-07-18 Inspire Pharmaceuticals, Inc. Method of treating edematous retinal disorders
US6818629B2 (en) 1997-02-10 2004-11-16 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate
US7223744B2 (en) 1997-02-10 2007-05-29 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
US6872710B2 (en) 1997-07-25 2005-03-29 Inspire Pharmaceuticals, Inc. Di(uridine 5′)-tetraphosphate and salts thereof
AU767136B2 (en) * 1999-06-30 2003-10-30 Merck Sharp & Dohme Corp. Dinucleotide crystals
US6867199B2 (en) 2000-08-21 2005-03-15 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapeutic use
CN100363376C (zh) * 2006-06-12 2008-01-23 南京工业大学 一种5’-核苷三磷酸钠盐的结晶方法
JPWO2017002827A1 (ja) * 2015-06-29 2018-04-26 ヤマサ醤油株式会社 Ｐ１，ｐ４−ビス（５’−ウリジル）テトラホスフェート結晶の保管方法
EP3546472B1 (en) 2016-10-25 2021-06-16 Yamasa Corporation Method for purifying p1,p4-di(uridine 5'-)tetraphosphate
KR20180091689A (ko) 2017-11-06 2018-08-16 주식회사 종근당 무정형 디뉴클레오사이드 폴리포스페이트 화합물의 제조방법
CN109021049B (zh) * 2018-06-14 2020-12-08 扬子江药业集团北京海燕药业有限公司 一种尿苷5′-二磷酸-苯并咪唑二钠的合成方法
KR20210110055A (ko) * 2020-02-28 2021-09-07 주식회사 종근당바이오 P1, p4-디(우리딘 5'-)테트라포스페이트 나트륨염 4 수화물 결정형 a의 제조방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6423694B1 (en) * 1996-02-21 2002-07-23 Inspire Pharmaceuticals, Inc. Method of treating otitis media with uridine triphosphates and related compounds
CN1229114C (zh) * 1996-03-27 2005-11-30 印斯拜尔药品股份有限公司 用三磷酸尿苷和相关化合物治疗纤毛运动障碍的方法
US6319908B1 (en) * 1996-07-03 2001-11-20 Inspire Pharmaceuticals, Inc. Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof
US5763447C1 (en) * 1996-07-23 2002-05-07 Inspire Pharmaceuticals Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds
PT1012154E (pt) * 1997-07-25 2004-08-31 Inspire Pharmaceuticals Inc Sais de di(5'-tetrafosfato de uridina), metodo para a sua preparacao, e suas utilizacoes

Also Published As

Publication number Publication date
CN1502622A (zh) 2004-06-09
KR20020013471A (ko) 2002-02-20
CN1151166C (zh) 2004-05-26
EA004513B1 (ru) 2004-04-29
ES2183650T3 (es) 2003-03-16
US6780988B2 (en) 2004-08-24
CZ20011028A3 (cs) 2001-08-15
US20020156269A1 (en) 2002-10-24
NO20011634L (no) 2001-05-30
DE69902624D1 (de) 2002-10-02
AU747096B2 (en) 2002-05-09
KR100475008B1 (ko) 2005-03-08
EP1043329B1 (en) 2002-08-28
JP3247685B2 (ja) 2002-01-21
CA2345624C (en) 2006-12-05
MXPA01003377A (es) 2003-06-24
PL347070A1 (en) 2002-03-11
JP3824894B2 (ja) 2006-09-20
SK4402001A3 (en) 2001-11-06
EA003167B1 (ru) 2003-02-27
EP1043329A1 (en) 2000-10-11
HU228681B1 (en) 2013-05-28
CA2345624A1 (en) 2000-04-13
BRPI9917911B1 (pt) 2016-08-23
EP1043329A4 (en) 2001-03-14
US6458946B1 (en) 2002-10-01
SK283729B6 (sk) 2003-12-02
PL199434B1 (pl) 2008-09-30
DE69902624T2 (de) 2003-04-03
HUP0103754A3 (en) 2003-01-28
CZ300402B6 (cs) 2009-05-13
AU6000899A (en) 2000-04-26
EA200100407A1 (ru) 2001-10-22
NO20011634D0 (no) 2001-03-30
CN1321163A (zh) 2001-11-07
EA200200695A1 (ru) 2002-10-31
BR9914453A (pt) 2001-05-22
HUP0103754A2 (hu) 2002-04-29
JP2002053590A (ja) 2002-02-19
ATE222920T1 (de) 2002-09-15
AU747096C (en) 2003-01-23
NZ510748A (en) 2002-10-25
NO317305B1 (no) 2004-10-04
IL142181A0 (en) 2002-03-10
WO2000020430A1 (fr) 2000-04-13
CN100396692C (zh) 2008-06-25

Similar Documents

Publication Publication Date Title
AP1668A (en) Method for separating hemicelluloses from a biomass containing hemicelluloses and biomass and hemicelluloses obtained by said method.
IL142181A (en) Crystal of diuridine tetraphosphate or salt thereof and method for preparing the same and method forproducing said compound
BG105547A (en) Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof
EP0908523A3 (en) Process for producing high-purity erythritol crystal
PL352363A1 (en) Dinucleotide crystal
JPH06157440A (ja) Ｎ−長鎖アシルアミノ酸の分離法及び精製法
EP1447409A4 (en) CRYSTAL OF OXIDIZED GLUTATHION AND METHOD FOR THE PRODUCTION THEREOF
MY107160A (en) N-aryl-3-aryl-4-substituted-4,5-dihydro-1h-pyrazole-1- carboxamides and processes for their production.
EP1460065A4 (en) METHOD FOR THE PRODUCTION OF CYCLIC DIAMINO COMPOUNDS BZW. THE SALTS
BG105426A (bg) Метод за пречистване на амониев сулфат
IL144976A0 (en) A process for the preparation of paclitaxel
DE69629661D1 (de) VERFAHREN ZUR HERSTELLUNG VON N-(D-alpha-METHYL-beta-MERCAPTOPROPIONYL)-L-PROLIN UND INTERMEDIATEN DAVON
WO2001096278A3 (en) A novel process for preparing salmeterol
CA2096675A1 (en) Process for preparing methylolhydantoins
JPH08268995A (ja) アミノアルキルスルホン酸類の製造方法
CA2361565A1 (en) Synthesis of ethyleneimine dimer
IL166696A (en) Process for producing gamma-ketoacetal compounds
Takeuchi et al. Stereospecific addition of singlet phenylnitrenium ion to some alkenes. Reactions of phenyl azide with alkenes in the presence of trifluoroacetic acid
RU92010801A (ru) Способ получения n-карбэтоксиметилпирролидона-2
YU25099A (sh) Postupak za sintezu 1,4-dihidropiridinskih derivata
RU94035156A (ru) Способ получения карбида титана
JPS63203673A (ja) Ｄｌ−パントラクトンの光学分割法
JPH06321979A (ja) ラクツロースの製造方法

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired