IL131047A0 - Use of il-18 inhibitors - Google Patents

Use of il-18 inhibitors

Info

Publication number
IL131047A0
IL131047A0 IL13104799A IL13104799A IL131047A0 IL 131047 A0 IL131047 A0 IL 131047A0 IL 13104799 A IL13104799 A IL 13104799A IL 13104799 A IL13104799 A IL 13104799A IL 131047 A0 IL131047 A0 IL 131047A0
Authority
IL
Israel
Prior art keywords
inhibitors
Prior art date
Application number
IL13104799A
Other languages
English (en)
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Priority to IL13104799A priority Critical patent/IL131047A0/xx
Priority to PL353732A priority patent/PL202477B1/pl
Priority to CA2380216A priority patent/CA2380216C/en
Priority to NZ516535A priority patent/NZ516535A/en
Priority to PT00944201T priority patent/PT1206274E/pt
Priority to IL14767500A priority patent/IL147675A0/xx
Priority to BR0012675-6A priority patent/BR0012675A/pt
Priority to CZ20020195A priority patent/CZ302114B6/cs
Priority to JP2001512563A priority patent/JP4827352B2/ja
Priority to CNB008106894A priority patent/CN1173736C/zh
Priority to EP00944201A priority patent/EP1206274B1/en
Priority to PCT/IL2000/000419 priority patent/WO2001007480A2/en
Priority to DK00944201T priority patent/DK1206274T3/da
Priority to AT00944201T priority patent/ATE363288T1/de
Priority to KR1020027000682A priority patent/KR100682219B1/ko
Priority to SI200030956T priority patent/SI1206274T1/sl
Priority to DE60035049T priority patent/DE60035049T2/de
Priority to SK88-2002A priority patent/SK287522B6/sk
Priority to UA2002021472A priority patent/UA73745C2/uk
Priority to TR2002/00169T priority patent/TR200200169T2/
Priority to AU58432/00A priority patent/AU782478B2/en
Priority to MXPA02000838A priority patent/MXPA02000838A/es
Priority to EA200200189A priority patent/EA005419B1/ru
Priority to EEP200200032A priority patent/EE04838B1/xx
Priority to DE1206274T priority patent/DE1206274T1/de
Priority to ES00944201T priority patent/ES2186596T3/es
Priority to HU0202107A priority patent/HU228780B1/hu
Priority to ARP000103786A priority patent/AR024907A1/es
Publication of IL131047A0 publication Critical patent/IL131047A0/xx
Priority to NO20020153A priority patent/NO329827B1/no
Priority to ZA200200390A priority patent/ZA200200390B/xx
Priority to BG106311A priority patent/BG65800B1/bg
Priority to IL147675A priority patent/IL147675A/en
Priority to HK02108154.3A priority patent/HK1048248B/zh
Priority to US11/825,548 priority patent/US7741276B2/en
Priority to CY20071100938T priority patent/CY1107932T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL13104799A 1999-07-22 1999-07-22 Use of il-18 inhibitors IL131047A0 (en)

Priority Applications (35)

Application Number Priority Date Filing Date Title
IL13104799A IL131047A0 (en) 1999-07-22 1999-07-22 Use of il-18 inhibitors
SK88-2002A SK287522B6 (sk) 1999-07-22 2000-07-17 Použitie inhibítorov produkcie a/alebo účinku IL-18
UA2002021472A UA73745C2 (en) 1999-07-22 2000-07-17 Use of il-18 inhibitors for preparing pharmaceutical composition inhibiting tumor metastasis
NZ516535A NZ516535A (en) 1999-07-22 2000-07-17 Use of Interleukin-18 binding protein (IL-18BP) as an inhibitor for medicaments suitable to treat tumor metastasis
CA2380216A CA2380216C (en) 1999-07-22 2000-07-17 Use of interleukin-18 inhibitors to inhibit tumor metastasis
IL14767500A IL147675A0 (en) 1999-07-22 2000-07-17 Use of il-18 inhibitors
TR2002/00169T TR200200169T2 (tr) 1999-07-22 2000-07-17 IL-18 inhibitörlerinin kullanımı.
CZ20020195A CZ302114B6 (cs) 1999-07-22 2000-07-17 Farmaceutický prostredek pro inhibici produkce IL-18
JP2001512563A JP4827352B2 (ja) 1999-07-22 2000-07-17 Ｉｌ−１８阻害剤の用途
CNB008106894A CN1173736C (zh) 1999-07-22 2000-07-17 白细胞介素-18抑制剂抑制肿瘤转移的用途
EP00944201A EP1206274B1 (en) 1999-07-22 2000-07-17 Use of interleukin-18 inhibitors to inhibit tumor metastasis
PCT/IL2000/000419 WO2001007480A2 (en) 1999-07-22 2000-07-17 Use of interleukin-18 inhibitors to inhibit tumor metastasis
DK00944201T DK1206274T3 (da) 1999-07-22 2000-07-17 Anvendelse af interleukin-18-inhibitorer til hæmning af tumormetastase
AT00944201T ATE363288T1 (de) 1999-07-22 2000-07-17 Verwendung von interleukin-18-inhibitoren zur hemmung von tumormetastasierung
KR1020027000682A KR100682219B1 (ko) 1999-07-22 2000-07-17 종양 전이를 저해하는 인터루킨-18 저해물질의 용도
SI200030956T SI1206274T1 (sl) 1999-07-22 2000-07-17 Uporaba zaviralcev interlevkina-18 za zaviranje tumorske metastaze
DE60035049T DE60035049T2 (de) 1999-07-22 2000-07-17 Verwendung von interleukin-18-inhibitoren zur hemmung von tumormetastasierung
PL353732A PL202477B1 (pl) 1999-07-22 2000-07-17 Zastosowanie inhibitorów działania IL-18
PT00944201T PT1206274E (pt) 1999-07-22 2000-07-17 Utilização de inibidores de interleucina-18 para inibir a metástase de tumores.
BR0012675-6A BR0012675A (pt) 1999-07-22 2000-07-17 Uso de inibidores de il-18
AU58432/00A AU782478B2 (en) 1999-07-22 2000-07-17 Use of IL-18 inhibitors
MXPA02000838A MXPA02000838A (es) 1999-07-22 2000-07-17 Uso de inhibidores de interleucina-18 para inhibir metastasis tumoral.
EA200200189A EA005419B1 (ru) 1999-07-22 2000-07-17 Применение ингибиторов интерлейкина-18 для приготовления лекарственного средства для подавления метастазов опухолей
EEP200200032A EE04838B1 (et) 1999-07-22 2000-07-17 Interleukiin-18 inhibiitorite kasutamine kasvaja metastaaside pärssimiseks sobivate ravimite valmistamiseks ning selliseid inhibiitoreid sisaldav farmatseutiline kompositsioon
DE1206274T DE1206274T1 (de) 1999-07-22 2000-07-17 Verwendung von interleukin-18-inhibitoren zur hemmung von tumormetastasierung
ES00944201T ES2186596T3 (es) 1999-07-22 2000-07-17 Uso de inhibidores de la interleucina-18 para inhibir metastasis tumorales.
HU0202107A HU228780B1 (en) 1999-07-22 2000-07-17 Use of interleukin-18 inhibitors to inhibit tumor metastasis
ARP000103786A AR024907A1 (es) 1999-07-22 2000-07-21 Uso de inhibidores de la produccion y/o accion de la il-18 y composiciones farmaceuticas formuladas con dichos inhibidores para el tratamiento demetastasis de tumores.
NO20020153A NO329827B1 (no) 1999-07-22 2002-01-11 Anvendelse av inhibitorer av IL-18 produksjon og/eller dets virkning ved fremstilling av medikamenter for a hemme metastase av melanom, og anvendelse av en ekspresjonsvektor som koder for en inhibitor for IL-18 produksjon og deller dets virkning ved fremstillingen av medikamenter for a hemme metastase av melanom
ZA200200390A ZA200200390B (en) 1999-07-22 2002-01-16 Use of interleukin-18 inhibitors to inhibit tumor metastasis.
BG106311A BG65800B1 (bg) 1999-07-22 2002-01-16 Използване на инхибитори на интерлевкин-18 за потискане на туморни метастази
IL147675A IL147675A (en) 1999-07-22 2002-01-17 Use of IL-81 inhibitors for drug preparation
HK02108154.3A HK1048248B (zh) 1999-07-22 2002-11-11 白細胞介素-18抑制劑抑制腫瘤轉移的用途
US11/825,548 US7741276B2 (en) 1999-07-22 2007-07-06 Use of interleukin-18 inhibitors to inhibit tumor metastasis
CY20071100938T CY1107932T1 (el) 1999-07-22 2007-07-13 Χρηση αναστολεων ιντερλευκινης-18 για αναστολη μεταστασης ογκων

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL13104799A IL131047A0 (en) 1999-07-22 1999-07-22 Use of il-18 inhibitors

Publications (1)

Publication Number Publication Date
IL131047A0 true IL131047A0 (en) 2001-01-28

Family

ID=11073044

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13104799A IL131047A0 (en) 1999-07-22 1999-07-22 Use of il-18 inhibitors
IL147675A IL147675A (en) 1999-07-22 2002-01-17 Use of IL-81 inhibitors for drug preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL147675A IL147675A (en) 1999-07-22 2002-01-17 Use of IL-81 inhibitors for drug preparation

Country Status (31)

Country Link
US (1) US7741276B2 (bg)
EP (1) EP1206274B1 (bg)
JP (1) JP4827352B2 (bg)
KR (1) KR100682219B1 (bg)
CN (1) CN1173736C (bg)
AR (1) AR024907A1 (bg)
AT (1) ATE363288T1 (bg)
AU (1) AU782478B2 (bg)
BG (1) BG65800B1 (bg)
BR (1) BR0012675A (bg)
CA (1) CA2380216C (bg)
CY (1) CY1107932T1 (bg)
CZ (1) CZ302114B6 (bg)
DE (2) DE60035049T2 (bg)
DK (1) DK1206274T3 (bg)
EA (1) EA005419B1 (bg)
EE (1) EE04838B1 (bg)
ES (1) ES2186596T3 (bg)
HK (1) HK1048248B (bg)
HU (1) HU228780B1 (bg)
IL (2) IL131047A0 (bg)
MX (1) MXPA02000838A (bg)
NO (1) NO329827B1 (bg)
NZ (1) NZ516535A (bg)
PL (1) PL202477B1 (bg)
PT (1) PT1206274E (bg)
SK (1) SK287522B6 (bg)
TR (1) TR200200169T2 (bg)
UA (1) UA73745C2 (bg)
WO (1) WO2001007480A2 (bg)
ZA (1) ZA200200390B (bg)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101111103B1 (ko) 2000-02-10 2012-02-13 아보트 러보러터리즈 사람 인터류킨-18에 결합하는 항체 및 이를 제조하고 사용하는 방법
EP1331943A4 (en) 2000-10-11 2005-01-26 Viron Therapeutics Inc NUCLEIC ACID MOLECULES AND POLYPEPTIDES FOR IMMUNOMODULATION
US7718368B2 (en) 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
ES2416510T3 (es) * 2002-10-08 2013-08-01 Ares Trading S.A. Uso de una citocina capaz de unirse a IL 18BP y de inhibir la actividad de una segunda citocina
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
US7691611B2 (en) 2005-06-03 2010-04-06 Ares Trading S.A. Production of recombinant IL-18 binding protein
JP5091127B2 (ja) 2005-06-10 2012-12-05 アレス トレーディング ソシエテ アノニム Ｉｌ−１８結合タンパク質の精製のための方法
CL2008002153A1 (es) 2007-07-24 2009-06-05 Amgen Inc Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r.
US9812033B2 (en) * 2013-03-06 2017-11-07 Venkatesh R. Chari Tactile graphic display
AU2023236289A1 (en) 2022-03-15 2024-08-15 Compugen Ltd. Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994005333A1 (en) * 1992-09-02 1994-03-17 Isis Pharmaceuticals, Inc. Oligonucleotide modulation of cell adhesion
US7141393B2 (en) * 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
SK122199A3 (en) * 1997-03-18 2000-12-11 Basf Ag Methods and compositions for modulating responsiveness to corticosteroids
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use

Also Published As

Publication number Publication date
TR200200169T2 (tr) 2002-06-21
DE60035049T2 (de) 2007-09-27
IL147675A (en) 2009-05-04
US7741276B2 (en) 2010-06-22
KR20020027493A (ko) 2002-04-13
MXPA02000838A (es) 2002-07-30
WO2001007480A3 (en) 2001-05-10
DE60035049D1 (de) 2007-07-12
CY1107932T1 (el) 2013-09-04
JP4827352B2 (ja) 2011-11-30
EA005419B1 (ru) 2005-02-24
UA73745C2 (en) 2005-09-15
PL202477B1 (pl) 2009-06-30
CA2380216A1 (en) 2001-02-01
BRPI0012675B8 (bg) 2021-05-25
EP1206274A2 (en) 2002-05-22
HU228780B1 (en) 2013-05-28
PL353732A1 (en) 2003-12-01
HUP0202107A3 (en) 2005-01-28
WO2001007480A2 (en) 2001-02-01
JP2003505472A (ja) 2003-02-12
EA200200189A1 (ru) 2002-12-26
BRPI0012675B1 (pt) 2001-02-01
NO329827B1 (no) 2011-01-03
CA2380216C (en) 2012-01-31
BG65800B1 (bg) 2009-12-31
BG106311A (bg) 2002-08-30
ZA200200390B (en) 2003-04-30
DE1206274T1 (de) 2002-11-14
NZ516535A (en) 2004-04-30
AU782478B2 (en) 2005-08-04
AR024907A1 (es) 2002-10-30
NO20020153L (no) 2002-03-11
CN1173736C (zh) 2004-11-03
BR0012675A (pt) 2002-04-09
KR100682219B1 (ko) 2007-02-12
CZ2002195A3 (cs) 2002-06-12
AU5843200A (en) 2001-02-13
ES2186596T3 (es) 2007-11-16
EP1206274B1 (en) 2007-05-30
CN1364086A (zh) 2002-08-14
SK882002A3 (en) 2002-07-02
EE04838B1 (et) 2007-06-15
ATE363288T1 (de) 2007-06-15
HUP0202107A2 (en) 2002-10-28
NO20020153D0 (no) 2002-01-11
PT1206274E (pt) 2007-07-06
HK1048248B (zh) 2005-04-22
DK1206274T3 (da) 2007-08-13
SK287522B6 (sk) 2011-01-04
EE200200032A (et) 2003-02-17
CZ302114B6 (cs) 2010-10-20
ES2186596T1 (es) 2003-05-16
US20080003216A1 (en) 2008-01-03
HK1048248A1 (en) 2003-03-28

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