IL124563A - 5-phenyl-3-(substituted oximino) pyrrolo [3, 2-h] isoquinoline-2-one derivatives pharmaceutical compositions containing them and their preparation - Google Patents

5-phenyl-3-(substituted oximino) pyrrolo [3, 2-h] isoquinoline-2-one derivatives pharmaceutical compositions containing them and their preparation

Info

Publication number
IL124563A
IL124563A IL12456397A IL12456397A IL124563A IL 124563 A IL124563 A IL 124563A IL 12456397 A IL12456397 A IL 12456397A IL 12456397 A IL12456397 A IL 12456397A IL 124563 A IL124563 A IL 124563A
Authority
IL
Israel
Prior art keywords
het
phenyl
pyrrolo
isoquinoline
preparation
Prior art date
Application number
IL12456397A
Other languages
English (en)
Other versions
IL124563A0 (en
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of IL124563A0 publication Critical patent/IL124563A0/xx
Publication of IL124563A publication Critical patent/IL124563A/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL12456397A 1996-10-01 1997-10-01 5-phenyl-3-(substituted oximino) pyrrolo [3, 2-h] isoquinoline-2-one derivatives pharmaceutical compositions containing them and their preparation IL124563A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK106996 1996-10-01
DK127796 1996-11-13
PCT/DK1997/000418 WO1998014447A1 (en) 1996-10-01 1997-10-01 Novel indole-2,3-dione-3-oxime derivatives

Publications (2)

Publication Number Publication Date
IL124563A0 IL124563A0 (en) 1998-12-06
IL124563A true IL124563A (en) 2005-05-17

Family

ID=26065167

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12456397A IL124563A (en) 1996-10-01 1997-10-01 5-phenyl-3-(substituted oximino) pyrrolo [3, 2-h] isoquinoline-2-one derivatives pharmaceutical compositions containing them and their preparation

Country Status (29)

Country Link
US (3) USRE38200E1 (ru)
EP (1) EP0869958B1 (ru)
JP (1) JP3319762B2 (ru)
KR (1) KR100492052B1 (ru)
CN (1) CN1093859C (ru)
AT (1) ATE286052T1 (ru)
AU (1) AU716435B2 (ru)
BG (1) BG63874B1 (ru)
BR (1) BR9706765A (ru)
CA (1) CA2238410C (ru)
CZ (1) CZ297938B6 (ru)
DE (1) DE69732090T2 (ru)
DK (1) DK0869958T3 (ru)
EE (1) EE9800144A (ru)
ES (1) ES2235253T3 (ru)
HK (1) HK1017682A1 (ru)
HU (1) HU225145B1 (ru)
IL (1) IL124563A (ru)
IS (1) IS2123B (ru)
NO (1) NO310722B1 (ru)
NZ (1) NZ330456A (ru)
PL (1) PL193041B1 (ru)
PT (1) PT869958E (ru)
RU (1) RU2190612C2 (ru)
SI (1) SI0869958T1 (ru)
SK (1) SK282729B6 (ru)
TR (1) TR199800956T1 (ru)
UA (1) UA54403C2 (ru)
WO (1) WO1998014447A1 (ru)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA54403C2 (ru) * 1996-10-01 2003-03-17 Н'Юросерч А/С Производные индол-2,3-дион-3-оксима, фармацевтическая композиция, способ лечения расстройства или заболевания млекопитающих, в том числе человека и способ получения производных индол-2,3-дион-3-оксима
EP1066037B1 (en) * 1998-03-31 2004-12-29 Neurosearch A/S Use of indole-2,3-dione-3-oxime derivatives as ampa antagonists
WO2000071102A2 (en) * 1999-05-19 2000-11-30 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
ES2266214T3 (es) 2000-01-24 2007-03-01 Neurosearch A/S Derivados de isatina con actividad neurotrofica.
IT1318636B1 (it) * 2000-07-21 2003-08-27 Roberto Pellicciari Derivati dell'acido 2- o 3- tenoico ad attivita' antagonista deirecettori del glutammato.
US20040063742A1 (en) * 2001-02-15 2004-04-01 Dan Peters Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity
DE60206762T2 (de) 2001-07-13 2006-07-13 Pharmacia & Upjohn Co. Llc, Kalamazoo Hexahydroazepino(4,5-g)indole und -indoline als 5-ht rezeptor-liganden
MXPA05002056A (es) * 2002-08-22 2005-06-08 Neurosearch As Metodo para la preparacion de enantiomeros de derivados de indol-2,3-diona-3-oxima.
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
JP2009516712A (ja) * 2005-11-23 2009-04-23 ペインセプター ファーマ コーポレーション 依存性イオンチャネルを調節するための組成物および方法
US20080004306A1 (en) * 2006-04-10 2008-01-03 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
US20080021034A1 (en) * 2006-04-10 2008-01-24 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
WO2008031831A2 (en) * 2006-09-12 2008-03-20 Neurosearch A/S Pharmaceutical compositions comprising combinations of an ampa/kainate antagonistic compound and an inhibitor of a multidrug resistance protein
US20080108622A1 (en) * 2006-10-19 2008-05-08 Eisenach James C Combination therapy for the treatment of pain
US20080108603A1 (en) * 2006-10-19 2008-05-08 Eisenach James C Combination therapy for the treatment of pain
WO2010104324A2 (ko) * 2009-03-10 2010-09-16 한국과학기술연구원 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도
CN102653538A (zh) * 2011-03-04 2012-09-05 爱斯医药科技(南京)有限公司 Spd-502的制备方法
AU2016255431B2 (en) 2015-04-29 2020-05-07 Janssen Pharmaceutica Nv Imidazopyrazines and pyrazolopyrimidines and their use as AMPA receptor modulators
BR112017023147B1 (pt) 2015-04-29 2024-04-30 Rapport Therapeutics, Inc Derivados de azabenzimidazóis, seus usos como moduladores do receptor de ampa e composições farmacêuticas
BR112017023080A2 (pt) 2015-04-29 2018-07-10 Janssen Pharmaceutica Nv compostos benzimidazolona e benzotiazolona e uso dos mesmos como moduladores do receptor de ampa
MX369806B (es) 2015-04-29 2019-11-21 Janssen Pharmaceutica Nv Compuestos de indolona y su uso como moduladores del receptor ampa.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9204914A (es) * 1991-08-28 1993-07-01 Frank Watjen Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende.
US5721230A (en) 1993-05-10 1998-02-24 Hoffmann-La Roche Inc. Substituted pyrroles
DE69407407T2 (de) * 1993-05-13 1998-04-09 Neurosearch As Ampa antagonisten und behandlungsmethode
DK81593D0 (da) * 1993-07-07 1993-07-07 Neurosearch As Nye isatinoximderivater, deres fremstilling og anvendelse
CA2199614C (en) * 1994-09-14 2000-02-22 Peter Moldt Fused indole and quinoxaline derivatives, their preparation and use
AU687255B2 (en) * 1994-09-14 1998-02-19 Neurosearch A/S Indole-2,3-dione-3-oxime derivatives, their preparation and use
UA54403C2 (ru) * 1996-10-01 2003-03-17 Н'Юросерч А/С Производные индол-2,3-дион-3-оксима, фармацевтическая композиция, способ лечения расстройства или заболевания млекопитающих, в том числе человека и способ получения производных индол-2,3-дион-3-оксима

Also Published As

Publication number Publication date
PL193041B1 (pl) 2007-01-31
EP0869958A1 (en) 1998-10-14
USRE38200E1 (en) 2003-07-22
US6124285A (en) 2000-09-26
NO982466D0 (no) 1998-05-29
SK67698A3 (en) 1998-11-04
DK0869958T3 (da) 2005-04-18
EP0869958B1 (en) 2004-12-29
ATE286052T1 (de) 2005-01-15
IS4748A (is) 1998-05-18
CZ297938B6 (cs) 2007-05-02
BR9706765A (pt) 1999-09-14
CN1207100A (zh) 1999-02-03
BG63874B1 (bg) 2003-04-30
CA2238410A1 (en) 1998-04-09
US6693111B1 (en) 2004-02-17
CN1093859C (zh) 2002-11-06
WO1998014447A1 (en) 1998-04-09
MX9804365A (es) 1998-10-31
EE9800144A (et) 1998-10-15
NZ330456A (en) 1998-11-25
NO982466L (no) 1998-07-31
AU716435B2 (en) 2000-02-24
BG102489A (en) 1999-04-30
CA2238410C (en) 2007-06-12
ES2235253T3 (es) 2005-07-01
SK282729B6 (sk) 2002-11-06
SI0869958T1 (en) 2005-06-30
KR100492052B1 (ko) 2005-09-30
PL327073A1 (en) 1998-11-23
JP2000501432A (ja) 2000-02-08
IS2123B (is) 2006-07-14
NO310722B1 (no) 2001-08-20
PT869958E (pt) 2005-05-31
HUP9901630A3 (en) 2001-11-28
CZ160698A3 (cs) 1998-10-14
DE69732090T2 (de) 2005-12-29
JP3319762B2 (ja) 2002-09-03
KR19990071823A (ko) 1999-09-27
TR199800956T1 (xx) 1998-12-21
UA54403C2 (ru) 2003-03-17
AU4376897A (en) 1998-04-24
HU225145B1 (en) 2006-07-28
HK1017682A1 (en) 1999-11-26
DE69732090D1 (de) 2005-02-03
RU2190612C2 (ru) 2002-10-10
HUP9901630A2 (hu) 1999-08-30
IL124563A0 (en) 1998-12-06

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