HUP0105406A2 - Imidazo[1,2-a]kinolinszármazékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények, valamint intermedierek - Google Patents

Imidazo[1,2-a]kinolinszármazékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények, valamint intermedierek

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Publication number
HUP0105406A2
HUP0105406A2 HU0105406A HUP0105406A HUP0105406A2 HU P0105406 A2 HUP0105406 A2 HU P0105406A2 HU 0105406 A HU0105406 A HU 0105406A HU P0105406 A HUP0105406 A HU P0105406A HU P0105406 A2 HUP0105406 A2 HU P0105406A2
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HU
Hungary
Prior art keywords
group
atom
alkyl
hydrogen atom
optionally
Prior art date
Application number
HU0105406A
Other languages
English (en)
Inventor
Kinga Boér
Géza Tímári
Mária Balogh
Zoltán Kapui
Endre Mikus
Katalin Urbán-Szabó
Péter Arányi
Sándor Bátori
László Balázs
NAGY Lajos T.
Katalin Gerber
Judit Szeredi
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Priority to HU0105406A priority Critical patent/HUP0105406A3/hu
Publication of HUP0105406D0 publication Critical patent/HUP0105406D0/hu
Priority to CNB02825645XA priority patent/CN1307174C/zh
Priority to EP02788261A priority patent/EP1456205A1/en
Priority to MXPA04006115A priority patent/MXPA04006115A/es
Priority to BR0215272-0A priority patent/BR0215272A/pt
Priority to UA20040706065A priority patent/UA78745C2/uk
Priority to JP2003554685A priority patent/JP4530663B2/ja
Priority to IL16244302A priority patent/IL162443A0/xx
Priority to KR1020047009788A priority patent/KR100725298B1/ko
Priority to PCT/HU2002/000144 priority patent/WO2003053969A1/en
Priority to AU2002353241A priority patent/AU2002353241B2/en
Priority to MEP-189/08A priority patent/MEP18908A/xx
Priority to KR1020077004953A priority patent/KR20070034136A/ko
Priority to PL02370761A priority patent/PL370761A1/xx
Priority to HU0402424A priority patent/HUP0402424A3/hu
Priority to US10/499,251 priority patent/US7176213B2/en
Priority to EA200400847A priority patent/EA007226B1/ru
Priority to CA2470067A priority patent/CA2470067C/en
Priority to YU56104A priority patent/RS56104A/sr
Priority to NZ534015A priority patent/NZ534015A/en
Publication of HUP0105406A2 publication Critical patent/HUP0105406A2/hu
Publication of HUP0105406A3 publication Critical patent/HUP0105406A3/hu
Priority to MA27725A priority patent/MA27240A1/fr
Priority to TNP2004000105A priority patent/TNSN04105A1/en
Priority to IL162443A priority patent/IL162443A/en
Priority to IS7317A priority patent/IS7317A/is
Priority to ZA200404807A priority patent/ZA200404807B/xx
Priority to HR20040671A priority patent/HRP20040671A2/xx
Priority to NO20043117A priority patent/NO329743B1/no

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    • C—CHEMISTRY; METALLURGY
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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Abstract

A találmány (I) általános képletű vegyületekre, ahol R1 jelentésehidrogénatom, vagy alkilcsoport; R2 jelentése hidrogénatom, vagyalkilcsoport; R3 jelentése hidrogénatom, alkilcsoport,cikloalkilcsoport, adott esetben egy vagy több alkilcsoporttal,alkoxicsoporttal, vagy halogénatommal szubsztituált fenil-, tienil-,vagy furilcsoport, adott esetben egy vagy több alkilcsoporttal,alkoxicsoporttal, vagy halogénatommal szubsztituált, egy vagy két vagyhárom nitrogénatomot tartalmazó 5 vagy 6 tagú heteroaromás gyűrű, vagyegy nitrogénatomot és egy oxigénatomot, vagy egy nitrogénatomot és egykénatomot tartalmazó 5 tagú heteroaromás gyűrű; R4, R5, R6 és R7 jelentése egymástól függetlenül hidrogénatom,alkilcsoport, alkoxicsoport, hidroxicsoport, vagy halogénatom, vagy R4és R7 jelentése hidrogénatom és R5 és R6 együttesenmetiléndioxicsoportot képeznek; R8 jelentése hidrogénatom,cianocsoport, aminokarbonilcsoport, alkoxikarbonilcsoport, vagykarboxicsoport; R9 és R10 jelentése egymástól függetlenülhidrogénatom, alkilcsoport, cikloalkilcsoport, adott esetbenmetiléndioxi-csoprttal, vagy egy szubsztituált fenil-, fenil-(C1-4)alkil-, tienil-(C1-4)alkil-, vagy furil-(C1-4)alkilcsoport, vagyadott esetben egy szubsztituált, egy vagy két vagy háromnitrogénatomot tartalmazó 5 vagy 6 tagú heteroaromás gyűrű, vagy egynitrogénatomot és egy oxigénatomot vagy egy nitrogénatomot és egykénatomot tartalmazó 5 tagú heteroaromás gyűrű, vagy -(CH2)m -OH vagy-(CH2)o -NR12N13 csoport, vagy R9 és R10 együttesen a nitrogénatommal3-7 tagú, adott esetben 1-4 szénatomos alkilcsoporttal helyetesitettheterociklikus csoportot képez, X jelentése -CH2- csoport, -NH-csoport, -NR11- csoport, vagy kénatom, vagy oxigénatom, vagyszulfocsoport vagy szulfoxicsoport - ahol R11 jelentése 1-4 szénatomosegyenes vagy elágazó szénláncú alkilcsoport, vagy 3-6 szénatomoscikloalkilcsoport-; n értéke nulla, 1 vagy 2; m értéke 1, 2, 3 vagy 4,és o értéke 0, 1, 2, 3 vagy 4, valamint sóikra, szolvátjaikra,optikailag aktív izomerjeikre és ezek sóira és szolvátjaira,előállítási eljárásukra, alkalmazásukra és az (I) általános képletűvegyületeket tartalmazó gyógyászati készítményekre vonatkozik,valamint a vegyületek előállításakor alkalmazott bizonyosintermedierekre. Ó
HU0105406A 2001-12-21 2001-12-21 Imidazo[1,2-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates HUP0105406A3 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
HU0105406A HUP0105406A3 (en) 2001-12-21 2001-12-21 Imidazo[1,2-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
NZ534015A NZ534015A (en) 2001-12-21 2002-12-17 Imidazoquinoline derivatives
KR1020077004953A KR20070034136A (ko) 2001-12-21 2002-12-17 이미다조퀴놀린 유도체
HU0402424A HUP0402424A3 (en) 2001-12-21 2002-12-17 Imidazoquinoline derivatives, process for their preparation and pharmaceutical compositions containing the same
MXPA04006115A MXPA04006115A (es) 2001-12-21 2002-12-17 Derivados de imidazoquinolina.
BR0215272-0A BR0215272A (pt) 2001-12-21 2002-12-17 Derivados imidazoquinolina
UA20040706065A UA78745C2 (en) 2001-12-21 2002-12-17 Imidazoquinoline derivatives
JP2003554685A JP4530663B2 (ja) 2001-12-21 2002-12-17 イミダゾキノリン誘導体
IL16244302A IL162443A0 (en) 2001-12-21 2002-12-17 Imidazoquinoline derivatives
KR1020047009788A KR100725298B1 (ko) 2001-12-21 2002-12-17 이미다조퀴놀린 유도체
PCT/HU2002/000144 WO2003053969A1 (en) 2001-12-21 2002-12-17 Imidazoquinoline derivatives
AU2002353241A AU2002353241B2 (en) 2001-12-21 2002-12-17 Imidazoquinoline derivatives
MEP-189/08A MEP18908A (en) 2001-12-21 2002-12-17 Imidazoquinoline derivatives
CNB02825645XA CN1307174C (zh) 2001-12-21 2002-12-17 咪唑并喹啉衍生物
PL02370761A PL370761A1 (en) 2001-12-21 2002-12-17 Imidazoquinoline derivatives
EP02788261A EP1456205A1 (en) 2001-12-21 2002-12-17 Imidazoquinoline derivatives
US10/499,251 US7176213B2 (en) 2001-12-21 2002-12-17 Imidazoquinoline derivatives and their use as adenosine A3 ligands
EA200400847A EA007226B1 (ru) 2001-12-21 2002-12-17 Производные имидазохинолина
CA2470067A CA2470067C (en) 2001-12-21 2002-12-17 Imidazoquinoline derivatives
YU56104A RS56104A (en) 2001-12-21 2002-12-17 Imidazoquinoline derivatives
MA27725A MA27240A1 (fr) 2001-12-21 2004-06-07 Derives d'imidazoquinoleine
TNP2004000105A TNSN04105A1 (en) 2001-12-21 2004-06-08 Imidazoquinoline derivatives
IL162443A IL162443A (en) 2001-12-21 2004-06-10 Imidazoquinoline derivatives
IS7317A IS7317A (is) 2001-12-21 2004-06-16 Imídasókínólínafleiður
ZA200404807A ZA200404807B (en) 2001-12-21 2004-06-17 Imidazoquinoline derivatives.
HR20040671A HRP20040671A2 (en) 2001-12-21 2004-07-20 Imidazoquinoline derivatives
NO20043117A NO329743B1 (no) 2001-12-21 2004-07-20 Imidazokinolinderivater, fremgangsmate for fremstilling derav, mellomprodukter i fremgangsmaten for fremstilling av forbindelsene, farmasoytiske preparater inneholdende forbindelsene og anvendelse av forbindelsene til fremstilling av farmasoytiske preparater

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0105406A HUP0105406A3 (en) 2001-12-21 2001-12-21 Imidazo[1,2-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates

Publications (3)

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HUP0105406D0 HUP0105406D0 (en) 2002-03-28
HUP0105406A2 true HUP0105406A2 (hu) 2003-10-28
HUP0105406A3 HUP0105406A3 (en) 2003-12-29

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HU0105406A HUP0105406A3 (en) 2001-12-21 2001-12-21 Imidazo[1,2-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates

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Country Link
US (1) US7176213B2 (hu)
EP (1) EP1456205A1 (hu)
JP (1) JP4530663B2 (hu)
KR (2) KR100725298B1 (hu)
CN (1) CN1307174C (hu)
AU (1) AU2002353241B2 (hu)
BR (1) BR0215272A (hu)
CA (1) CA2470067C (hu)
EA (1) EA007226B1 (hu)
HR (1) HRP20040671A2 (hu)
HU (1) HUP0105406A3 (hu)
IL (2) IL162443A0 (hu)
IS (1) IS7317A (hu)
MA (1) MA27240A1 (hu)
MX (1) MXPA04006115A (hu)
NO (1) NO329743B1 (hu)
NZ (1) NZ534015A (hu)
PL (1) PL370761A1 (hu)
RS (1) RS56104A (hu)
TN (1) TNSN04105A1 (hu)
UA (1) UA78745C2 (hu)
WO (1) WO2003053969A1 (hu)
ZA (1) ZA200404807B (hu)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1430032A2 (en) * 2001-09-24 2004-06-23 Elan Pharmaceuticals, Inc. Substituted amides for the treatment of neurological disorders
HUP0203976A3 (en) * 2002-11-15 2004-08-30 Sanofi Aventis Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them
HUP0400812A2 (en) * 2004-04-19 2006-02-28 Sanofi Aventis Crystalline forms of 2-amino-3-cyano-quinoline derivatives, process for their preparation and pharmaceutical compositions containing them
WO2006091591A1 (en) * 2005-02-22 2006-08-31 The Regents Of The University Of California Methods of treating gastrointestinal inflammation
HUP0700395A2 (en) * 2007-06-07 2009-03-02 Sanofi Aventis Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates
US8357132B1 (en) 2009-10-21 2013-01-22 Lekweuwa Agatha N Urine capturing assembly
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KR20040072670A (ko) 2004-08-18
HRP20040671A2 (en) 2005-08-31
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KR20070034136A (ko) 2007-03-27
TNSN04105A1 (en) 2006-06-01
CN1606555A (zh) 2005-04-13
WO2003053969A1 (en) 2003-07-03
CN1307174C (zh) 2007-03-28
HUP0105406D0 (en) 2002-03-28
EA200400847A1 (ru) 2004-12-30
JP4530663B2 (ja) 2010-08-25
RS56104A (en) 2006-10-27
IL162443A0 (en) 2005-11-20
BR0215272A (pt) 2004-12-14
NO329743B1 (no) 2010-12-13
EP1456205A1 (en) 2004-09-15
US20050070566A1 (en) 2005-03-31
JP2005516956A (ja) 2005-06-09
KR100725298B1 (ko) 2007-06-07
IL162443A (en) 2010-05-17
EA007226B1 (ru) 2006-08-25
US7176213B2 (en) 2007-02-13
UA78745C2 (en) 2007-04-25
AU2002353241A1 (en) 2003-07-09
CA2470067A1 (en) 2003-07-03
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MXPA04006115A (es) 2005-06-08
PL370761A1 (en) 2005-05-30
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