IL117105A0 - Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them - Google Patents

Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL117105A0
IL117105A0 IL11710596A IL11710596A IL117105A0 IL 117105 A0 IL117105 A0 IL 117105A0 IL 11710596 A IL11710596 A IL 11710596A IL 11710596 A IL11710596 A IL 11710596A IL 117105 A0 IL117105 A0 IL 117105A0
Authority
IL
Israel
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
tetrahydrocarbazole derivatives
derivatives process
Prior art date
Application number
IL11710596A
Other languages
English (en)
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL117105(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of IL117105A0 publication Critical patent/IL117105A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL11710596A 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them IL117105A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919113802A GB9113802D0 (en) 1991-06-26 1991-06-26 Medicaments
US08/167,846 US5464864A (en) 1991-06-26 1992-06-17 Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists
IL102322A IL102322A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments

Publications (1)

Publication Number Publication Date
IL117105A0 true IL117105A0 (en) 1996-06-18

Family

ID=10697363

Family Applications (4)

Application Number Title Priority Date Filing Date
IL11710596A IL117105A0 (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them
IL102322A IL102322A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments
IL117104A IL117104A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them
IL117105A IL117105A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL102322A IL102322A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments
IL117104A IL117104A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them
IL117105A IL117105A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them

Country Status (34)

Country Link
US (2) US5464864A (cs)
EP (1) EP0591280B1 (cs)
JP (1) JP3261502B2 (cs)
KR (1) KR100251571B1 (cs)
CN (1) CN1034072C (cs)
AP (1) AP344A (cs)
AT (1) ATE170746T1 (cs)
BR (2) BR9206237A (cs)
CA (1) CA2113726C (cs)
CZ (3) CZ282083B6 (cs)
DE (2) DE69226953T2 (cs)
DK (1) DK0591280T3 (cs)
FI (1) FI103967B (cs)
GB (1) GB9113802D0 (cs)
HU (1) HU218907B (cs)
IE (1) IE922062A1 (cs)
IL (4) IL117105A0 (cs)
LU (1) LU90939I2 (cs)
MA (1) MA22563A1 (cs)
MX (1) MX9203444A (cs)
NL (1) NL300103I2 (cs)
NO (2) NO304774B1 (cs)
NZ (1) NZ243288A (cs)
PL (3) PL169410B1 (cs)
PT (1) PT100620B (cs)
RU (1) RU2137474C1 (cs)
SA (1) SA92130141B1 (cs)
SG (1) SG47877A1 (cs)
SI (1) SI9200125B (cs)
SK (3) SK280907B6 (cs)
TW (1) TW214544B (cs)
UA (1) UA41254C2 (cs)
WO (1) WO1993000086A1 (cs)
ZA (1) ZA924658B (cs)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
US5616603A (en) * 1995-05-26 1997-04-01 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-HT1 -like agonists
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5618948A (en) * 1995-05-26 1997-04-08 Smithkline Beecham P.L.C. Process for preparing an enantiomer of a carbazole derivative
ES2151993T3 (es) * 1995-06-23 2001-01-16 Lilly Co Eli 1,2,3,4-tetrahidro-9h-carbazoles 6-sustituidos y 10h-ciclohepta(7,6-b)indoles 7-sustituidos.
US5917054A (en) * 1995-07-18 1999-06-29 Smithkline Beecham P.L.C. Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9723061D0 (en) * 1997-10-31 1998-01-07 Vanguard Medica Ltd Medicaments
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
GB9808069D0 (en) * 1998-04-16 1998-06-17 Vanguard Medica Ltd Novel processes
GB9817911D0 (en) * 1998-08-17 1998-10-14 Vanguard Medica Ltd New use
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
JP2005507899A (ja) * 2001-09-28 2005-03-24 エフ．ホフマン−ラ　ロシュ　アーゲー カルベジロールの疑似多形形態
DE60317333T2 (de) 2002-06-21 2008-08-28 Suven Life Sciences Ltd. Tetracyklische arylsulfonylindole mit affinität zum serotonin rezeptor
WO2004000845A1 (en) 2002-06-21 2003-12-31 Suven Life Sciences Limited Arylalkyl indoles having sertonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
CA2509982C (en) 2002-11-28 2011-11-08 Suven Life Sciences Limited N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them
EA009193B1 (ru) 2002-11-28 2007-12-28 Сувен Лайф Сайенсиз Лимитед N-арилсульфонил-3-аминоалкоксииндолы
KR100739987B1 (ko) 2002-12-18 2007-07-16 수벤 라이프 사이언시스 리미티드 세로토닌 수용체 친화력을 가지는 테트라사이클릭 3-치환인돌
RU2430088C2 (ru) * 2004-07-14 2011-09-27 Центарис Гмбх Производные тетрагидрокарбазола и фармацевтическая композиция на их основе
US7601856B2 (en) 2006-07-27 2009-10-13 Wyeth Benzofurans as potassium ion channel modulators
BRPI0715179A2 (pt) * 2006-08-07 2013-06-11 Actelion Pharmaceuticals Ltd composto, composiÇço farmacÊutica e uso de um composto
EP2124556B1 (en) 2006-10-09 2014-09-03 Charleston Laboratories, Inc. Pharmaceutical compositions
HUE026884T2 (en) 2007-02-11 2016-08-29 Map Pharmaceuticals Inc DHE is a therapeutic method of administration for the rapid relief of migraine while minimizing side effects
US20090069399A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched frovatriptan
CA2749273C (en) 2008-01-09 2018-09-04 Charleston Laboratories, Inc. Pharmaceutical oral dosage form comprising a triptan and an antiemetic
WO2010073253A1 (en) * 2008-12-22 2010-07-01 Natco Pharma Limited Method for preparing an optically active frovatriptan
EP2451274B1 (en) 2009-07-08 2017-10-04 Charleston Laboratories, Inc. Pharmaceutical compositions
WO2011050140A1 (en) 2009-10-22 2011-04-28 Blue Fury Consulting, L.L.C. Posterior cervical fusion system and techniques
US10098674B2 (en) 2009-10-22 2018-10-16 Nuvasive, Inc. System and method for posterior cervical fusion
WO2013016223A2 (en) 2011-07-22 2013-01-31 The University Of Chicago Treatments for migraine and related disorders
EP2935280A4 (en) 2012-12-21 2016-05-25 Map Pharmaceuticals Inc 8'-HYDROXY-DIHYDROERGOTAMINE COMPOUNDS AND COMPOSITIONS
EP2816030A1 (en) 2013-06-20 2014-12-24 Duke Chem, S. A. Process for the preparation of frovatriptan and its enantiomer
GB201312768D0 (en) 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
US10179109B2 (en) 2016-03-04 2019-01-15 Charleston Laboratories, Inc. Pharmaceutical compositions comprising 5HT receptor agonist and antiemetic particulates
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan
WO2025038666A2 (en) * 2023-08-13 2025-02-20 GATC Health Corp Compounds and methods for treating addiction
CN119499195A (zh) * 2024-11-26 2025-02-25 青岛国信制药有限公司 一种快速吸收琥珀酸呋罗曲坦片及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
US3959309A (en) 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
US4062864A (en) * 1968-01-24 1977-12-13 Sterling Drug Inc. 3-Hydroxy carbazole derivatives
US3592824A (en) * 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
US4172834A (en) * 1971-08-16 1979-10-30 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
BE787537A (fr) * 1971-08-16 1973-02-14 Sterling Drug Inc Tetrahydrocarbazoles
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4257952A (en) * 1977-06-06 1981-03-24 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
US4254134A (en) * 1978-03-17 1981-03-03 Endo Laboratories, Inc. Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles
EP0115607A1 (de) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Tetrahydrocarbazolderivate

Also Published As

Publication number Publication date
TW214544B (cs) 1993-10-11
NL300103I1 (nl) 2002-12-02
AU652842B2 (en) 1994-09-08
SA92130141B1 (ar) 2005-12-18
US5464864A (en) 1995-11-07
NO2005011I2 (no) 2008-02-11
GB9113802D0 (en) 1991-08-14
PT100620B (pt) 1999-01-29
SK280907B6 (sk) 2000-09-12
NZ243288A (en) 1994-09-27
CZ282327B6 (cs) 1997-06-11
JPH06508827A (ja) 1994-10-06
NO934800L (no) 1993-12-23
IL117104A (en) 1997-09-30
ZA924658B (en) 1993-12-24
DK0591280T3 (da) 1999-02-15
PT100620A (pt) 1993-09-30
SI9200125B (en) 2001-12-31
IL117105A (en) 1998-01-04
EP0591280B1 (en) 1998-09-09
HUT68961A (en) 1995-08-28
CA2113726A1 (en) 1993-01-07
CN1034072C (zh) 1997-02-19
JP3261502B2 (ja) 2002-03-04
FI103967B1 (fi) 1999-10-29
AP344A (en) 1994-07-05
WO1993000086A1 (en) 1993-01-07
PL169410B1 (pl) 1996-07-31
DE10299042I2 (de) 2005-02-03
NO2005011I1 (no) 2005-05-18
CA2113726C (en) 2008-02-19
LU90939I2 (fr) 2002-09-24
KR100251571B1 (ko) 2000-07-01
HU218907B (hu) 2000-12-28
IE922062A1 (en) 1992-12-30
SK280905B6 (sk) 2000-09-12
PL169392B1 (pl) 1996-07-31
FI935842A7 (fi) 1993-12-23
IL117104A0 (en) 1996-06-18
CZ150696A3 (en) 1997-06-11
SK280906B6 (sk) 2000-09-12
PL171034B1 (en) 1997-02-28
RU2137474C1 (ru) 1999-09-20
NL300103I2 (nl) 2003-02-03
CZ286193A3 (en) 1994-07-13
CZ282061B6 (cs) 1997-05-14
SI9200125A (en) 1992-12-31
UA41254C2 (uk) 2001-09-17
IL102322A0 (en) 1993-01-14
NO934800D0 (no) 1993-12-23
FI103967B (fi) 1999-10-29
SK131993A3 (en) 1994-06-08
FI935842A0 (fi) 1993-12-23
MA22563A1 (fr) 1992-12-31
SG47877A1 (en) 1998-04-17
US5637611A (en) 1997-06-10
CN1069726A (zh) 1993-03-10
NO304774B1 (no) 1999-02-15
AU1977592A (en) 1993-01-25
AP9200403A0 (en) 1992-07-31
CZ282083B6 (cs) 1997-05-14
HK1014669A1 (en) 1999-09-30
DE69226953D1 (de) 1998-10-15
DE69226953T2 (de) 1999-05-12
IL102322A (en) 1997-09-30
BR9206237A (pt) 1995-04-11
MX9203444A (es) 1993-12-01
CZ150596A3 (en) 1997-05-14
ATE170746T1 (de) 1998-09-15
BR1100460A (pt) 2000-07-18
EP0591280A1 (en) 1994-04-13
DE10299042I1 (de) 2003-02-20

Similar Documents

Publication Publication Date Title
IL117105A0 (en) Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them
SG52322A1 (en) 3-Amidopyrazole derivatives process for preparing these and pharmaceutical compositions containing them
HU9401844D0 (en) Isatin derivatives process for the preparation thereof and pharmaceutical compositions comprising the same
IL103126A (en) 5-amino-4-hydroxyhexanoic acid derivatives, process for their preparation and pharmaceutical compositions containing them
HUT72639A (en) Substituted thiazolidinedione derivatives, pharmaceutical compositions containing them and process for their preparation
IL105412A0 (en) Indole derivatives,their preparation and pharmaceutical compositions containing them
IL101864A0 (en) Thiopyranopyrrole derivatives,their preparation and pharmaceutical compositions containing them
IL96385A0 (en) Indole derivatives,their preparation and pharmaceutical compositions containing them
ZA927994B (en) Heterobiaryl derivatives pharmaceutical compositions containing these compounds and processes for preparing them
IL86877A (en) Carbazole derivatives,their preparation and pharmaceutical compositions containing them
IL100262A0 (en) Alpha-oxoacetamide derivatives,their preparation and pharmaceutical compositions containing them
IL102175A0 (en) Imidazodiazepine derivatives,their preparation and pharmaceutical compositions containing them
IL109703A0 (en) Substituted carbazole derivatives, processes for their preparation and pharmaceutical compositions containing them
IL97050A0 (en) 4-isoxazolecarboxamide derivatives,pharmaceutical compositions containing them and their preparation
HUT69712A (en) Process for preparing benzimidazole derivatives and pharmaceutical compositions containing them
IL98542A0 (en) Benzoquinazoline derivatives,their preparation and pharmaceutical compositions containing them
HUT67014A (en) Benzofuran derivatives, pharmaceutical compositions containing them and process for the preparation of thereof
AU1256792A (en) Indole derivatives and pharmaceutical compositions containing them
IL100850A0 (en) Indole derivatives and pharmaceutical compositions containing them
IL102500A0 (en) 3-deoxy-mannosamine derivatives,their preparation and pharmaceutical compositions containing them
IL98812A0 (en) Purine derivatives,process for their preparation and pharmaceutical compositions containing them
HUT56345A (en) Process for producing indole derivatives and pharmaceutical compositions comprising such compounds
IL102116A (en) Hetaryloxy-beta-carboline derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
HU903016D0 (en) Process for the preparation of indole derivatives and pharmaceutical compositions containing them
IL99469A0 (en) Imidazoline derivatives,process for their preparation and pharmaceutical compositions containing them