IL117105A0 - Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them - Google Patents
Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL117105A0 IL117105A0 IL11710596A IL11710596A IL117105A0 IL 117105 A0 IL117105 A0 IL 117105A0 IL 11710596 A IL11710596 A IL 11710596A IL 11710596 A IL11710596 A IL 11710596A IL 117105 A0 IL117105 A0 IL 117105A0
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- tetrahydrocarbazole derivatives
- derivatives process
- Prior art date
Links
- XKLNOVWDVMWTOB-UHFFFAOYSA-N 2,3,4,9-tetrahydro-1h-carbazole Chemical class N1C2=CC=CC=C2C2=C1CCCC2 XKLNOVWDVMWTOB-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919113802A GB9113802D0 (en) | 1991-06-26 | 1991-06-26 | Medicaments |
US08/167,846 US5464864A (en) | 1991-06-26 | 1992-06-17 | Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists |
IL102322A IL102322A (en) | 1991-06-26 | 1992-06-25 | Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
IL117105A0 true IL117105A0 (en) | 1996-06-18 |
Family
ID=10697363
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11710596A IL117105A0 (en) | 1991-06-26 | 1992-06-25 | Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them |
IL117104A IL117104A (en) | 1991-06-26 | 1992-06-25 | Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them |
IL117105A IL117105A (en) | 1991-06-26 | 1992-06-25 | Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them |
IL102322A IL102322A (en) | 1991-06-26 | 1992-06-25 | Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL117104A IL117104A (en) | 1991-06-26 | 1992-06-25 | Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them |
IL117105A IL117105A (en) | 1991-06-26 | 1992-06-25 | Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them |
IL102322A IL102322A (en) | 1991-06-26 | 1992-06-25 | Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments |
Country Status (34)
Country | Link |
---|---|
US (2) | US5464864A (cs) |
EP (1) | EP0591280B1 (cs) |
JP (1) | JP3261502B2 (cs) |
KR (1) | KR100251571B1 (cs) |
CN (1) | CN1034072C (cs) |
AP (1) | AP344A (cs) |
AT (1) | ATE170746T1 (cs) |
BR (2) | BR9206237A (cs) |
CA (1) | CA2113726C (cs) |
CZ (3) | CZ150596A3 (cs) |
DE (2) | DE69226953T2 (cs) |
DK (1) | DK0591280T3 (cs) |
FI (1) | FI103967B (cs) |
GB (1) | GB9113802D0 (cs) |
HU (1) | HU218907B (cs) |
IE (1) | IE922062A1 (cs) |
IL (4) | IL117105A0 (cs) |
LU (1) | LU90939I2 (cs) |
MA (1) | MA22563A1 (cs) |
MX (1) | MX9203444A (cs) |
NL (1) | NL300103I2 (cs) |
NO (2) | NO304774B1 (cs) |
NZ (1) | NZ243288A (cs) |
PL (3) | PL169392B1 (cs) |
PT (1) | PT100620B (cs) |
RU (1) | RU2137474C1 (cs) |
SA (1) | SA92130141B1 (cs) |
SG (1) | SG47877A1 (cs) |
SI (1) | SI9200125B (cs) |
SK (3) | SK280907B6 (cs) |
TW (1) | TW214544B (cs) |
UA (1) | UA41254C2 (cs) |
WO (1) | WO1993000086A1 (cs) |
ZA (1) | ZA924658B (cs) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
GB9226566D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
US5616603A (en) * | 1995-05-26 | 1997-04-01 | Smithkline Beecham Plc | Enantiomers of carbazole derivatives as 5-HT1 -like agonists |
GB9226530D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
US5618948A (en) * | 1995-05-26 | 1997-04-08 | Smithkline Beecham P.L.C. | Process for preparing an enantiomer of a carbazole derivative |
ES2151993T3 (es) * | 1995-06-23 | 2001-01-16 | Lilly Co Eli | 1,2,3,4-tetrahidro-9h-carbazoles 6-sustituidos y 10h-ciclohepta(7,6-b)indoles 7-sustituidos. |
US5917054A (en) * | 1995-07-18 | 1999-06-29 | Smithkline Beecham P.L.C. | Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists |
US5708187A (en) * | 1996-06-27 | 1998-01-13 | Eli Lilly And Company | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists |
US5891885A (en) * | 1996-10-09 | 1999-04-06 | Algos Pharmaceutical Corporation | Method for treating migraine |
GB9723061D0 (en) * | 1997-10-31 | 1998-01-07 | Vanguard Medica Ltd | Medicaments |
US6066092A (en) * | 1997-11-06 | 2000-05-23 | Cady; Roger K. | Preemptive prophylaxis of migraine device and method |
US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
GB9808069D0 (en) * | 1998-04-16 | 1998-06-17 | Vanguard Medica Ltd | Novel processes |
GB9817911D0 (en) * | 1998-08-17 | 1998-10-14 | Vanguard Medica Ltd | New use |
US20030017175A1 (en) * | 2001-07-05 | 2003-01-23 | R.T. Alamo Ventures I, Inc. | Sublingual administration of dihydroergotamine for the treatment of migraine |
US20030198669A1 (en) * | 2001-07-05 | 2003-10-23 | R.T. Alamo Ventures I, Llc | Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine |
US6685951B2 (en) | 2001-07-05 | 2004-02-03 | R. T. Alamo Ventures I, Inc. | Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine |
CA2460486A1 (en) * | 2001-09-28 | 2003-04-10 | F. Hoffmann-La Roche Ag | Pseudopolymorphic forms of carvedilol |
MXPA04012834A (es) | 2002-06-21 | 2005-04-25 | Suven Life Sciences Ltd | Arilalquil indoles novedosos que tienen afinidad por el receptor de la serotonina, utiles como agentes terapeuticos, proceso para su preparacion y composiciones farmaceuticas que los contienen. |
CA2490254C (en) | 2002-06-21 | 2011-11-01 | Suven Life Sciences Limited | Novel tetracyclic arylsulfonyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them |
BRPI0315959C1 (pt) | 2002-11-28 | 2021-05-25 | Suven Life Sciences Ltd | composto, composição farmacêutica, uso do composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso e processo para a preparação do composto |
PT1567492E (pt) | 2002-11-28 | 2013-07-22 | Suven Life Sciences Ltd | N-arilsulfonil-3-aminoalcoxi-indóis |
NZ540841A (en) | 2002-12-18 | 2008-08-29 | Suven Life Sciences Ltd | Tetracyclic 3-substituted indoles having serotonin receptor affinity |
RU2430088C2 (ru) * | 2004-07-14 | 2011-09-27 | Центарис Гмбх | Производные тетрагидрокарбазола и фармацевтическая композиция на их основе |
US7601856B2 (en) | 2006-07-27 | 2009-10-13 | Wyeth | Benzofurans as potassium ion channel modulators |
CA2658986C (en) * | 2006-08-07 | 2014-11-25 | Actelion Pharmaceuticals Ltd | (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives |
EP2813144A1 (en) | 2006-10-09 | 2014-12-17 | Charleston Laboratories, Inc. | Analgesic compositions comprising an antihistamine |
US8148377B2 (en) | 2007-02-11 | 2012-04-03 | Map Pharmaceuticals, Inc. | Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile |
US20090069399A1 (en) * | 2007-09-12 | 2009-03-12 | Protia, Llc | Deuterium-enriched frovatriptan |
CA2905541C (en) | 2008-01-09 | 2020-02-11 | Charleston Laboratories, Inc. | Pharmaceutical compositions comprising an antiemetic and an opioid analgesic |
WO2010073253A1 (en) * | 2008-12-22 | 2010-07-01 | Natco Pharma Limited | Method for preparing an optically active frovatriptan |
CA2767576C (en) | 2009-07-08 | 2020-03-10 | Charleston Laboratories Inc. | Pharmaceutical compositions comprising an antiemetic and an opioid analgesic |
US9204906B2 (en) | 2009-10-22 | 2015-12-08 | Nuvasive, Inc. | Posterior cervical fusion system and techniques |
US10098674B2 (en) | 2009-10-22 | 2018-10-16 | Nuvasive, Inc. | System and method for posterior cervical fusion |
AU2012287120B2 (en) | 2011-07-22 | 2017-02-23 | The University Of Chicago | Treatments for migraine and related disorders |
AU2013361337A1 (en) | 2012-12-21 | 2015-07-09 | Map Pharmaceuticals, Inc. | 8'-Hydroxy-Dihydroergotamine compounds and compositions |
EP2816030A1 (en) | 2013-06-20 | 2014-12-24 | Duke Chem, S. A. | Process for the preparation of frovatriptan and its enantiomer |
GB201312768D0 (en) | 2013-07-17 | 2013-08-28 | Ge Healthcare Ltd | Work-up procedure |
JP2019507181A (ja) | 2016-03-04 | 2019-03-14 | チャールストン ラボラトリーズ,インコーポレイテッド | 医薬組成物 |
EP3766483A1 (en) | 2019-07-19 | 2021-01-20 | BioPharma Synergies, S. L. | Orodispersible powder composition comprising a triptan |
WO2025038666A2 (en) * | 2023-08-13 | 2025-02-20 | GATC Health Corp | Compounds and methods for treating addiction |
CN119499195A (zh) * | 2024-11-26 | 2025-02-25 | 青岛国信制药有限公司 | 一种快速吸收琥珀酸呋罗曲坦片及其制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3642816A (en) * | 1967-08-10 | 1972-02-15 | Sterling Drug Inc | 3-acetamido-1 2 3 4-tetrahydrocarbazole |
US4062864A (en) * | 1968-01-24 | 1977-12-13 | Sterling Drug Inc. | 3-Hydroxy carbazole derivatives |
US3959309A (en) * | 1968-01-24 | 1976-05-25 | Sterling Drug Inc. | 3-Amido-1,2,3,4-tetrahydrocarbazoles |
US3592824A (en) * | 1970-03-12 | 1971-07-13 | Miles Lab | 3-substituted amino-1,2,3,4-tetrahydrocarbazoles |
BE787537A (fr) * | 1971-08-16 | 1973-02-14 | Sterling Drug Inc | Tetrahydrocarbazoles |
US4172834A (en) | 1971-08-16 | 1979-10-30 | Sterling Drug Inc. | 3-Amino-tetrahydrocarbazoles |
DE2815926A1 (de) * | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US4257952A (en) * | 1977-06-06 | 1981-03-24 | Sterling Drug Inc. | 3-Amino-tetrahydrocarbazoles |
US4254134A (en) * | 1978-03-17 | 1981-03-03 | Endo Laboratories, Inc. | Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles |
EP0115607A1 (de) * | 1983-01-04 | 1984-08-15 | MERCK PATENT GmbH | Tetrahydrocarbazolderivate |
-
1991
- 1991-06-26 GB GB919113802A patent/GB9113802D0/en active Pending
-
1992
- 1992-06-17 UA UA93002251A patent/UA41254C2/uk unknown
- 1992-06-17 CZ CZ961505A patent/CZ150596A3/cs not_active IP Right Cessation
- 1992-06-17 JP JP51108692A patent/JP3261502B2/ja not_active Expired - Lifetime
- 1992-06-17 SK SK1685-98A patent/SK280907B6/sk not_active IP Right Cessation
- 1992-06-17 HU HU9303731A patent/HU218907B/hu active IP Right Revival
- 1992-06-17 EP EP92912379A patent/EP0591280B1/en not_active Expired - Lifetime
- 1992-06-17 DK DK92912379T patent/DK0591280T3/da active
- 1992-06-17 SK SK1319-93A patent/SK280905B6/sk not_active IP Right Cessation
- 1992-06-17 CZ CZ961506A patent/CZ282327B6/cs not_active IP Right Cessation
- 1992-06-17 DE DE69226953T patent/DE69226953T2/de not_active Expired - Lifetime
- 1992-06-17 SK SK1054-98A patent/SK280906B6/sk not_active IP Right Cessation
- 1992-06-17 KR KR1019930704055A patent/KR100251571B1/ko not_active Expired - Lifetime
- 1992-06-17 BR BR9206237A patent/BR9206237A/pt not_active Application Discontinuation
- 1992-06-17 PL PL92301883A patent/PL169392B1/pl unknown
- 1992-06-17 CZ CS932861A patent/CZ282083B6/cs not_active IP Right Cessation
- 1992-06-17 DE DE2002199042 patent/DE10299042I2/de active Active
- 1992-06-17 PL PL92307118A patent/PL169410B1/pl unknown
- 1992-06-17 SG SG1996004938A patent/SG47877A1/en unknown
- 1992-06-17 US US08/167,846 patent/US5464864A/en not_active Expired - Lifetime
- 1992-06-17 CA CA002113726A patent/CA2113726C/en not_active Expired - Lifetime
- 1992-06-17 PL PL92311304A patent/PL171034B1/pl unknown
- 1992-06-17 RU RU93058534A patent/RU2137474C1/ru active Protection Beyond IP Right Term
- 1992-06-17 AT AT92912379T patent/ATE170746T1/de active
- 1992-06-17 WO PCT/GB1992/001082 patent/WO1993000086A1/en active IP Right Grant
- 1992-06-24 ZA ZA924658A patent/ZA924658B/xx unknown
- 1992-06-24 MA MA22853A patent/MA22563A1/fr unknown
- 1992-06-24 NZ NZ243288A patent/NZ243288A/en not_active IP Right Cessation
- 1992-06-24 PT PT100620A patent/PT100620B/pt not_active IP Right Cessation
- 1992-06-25 IL IL11710596A patent/IL117105A0/xx unknown
- 1992-06-25 IL IL117104A patent/IL117104A/xx not_active IP Right Cessation
- 1992-06-25 IL IL117105A patent/IL117105A/en not_active IP Right Cessation
- 1992-06-25 TW TW081104991A patent/TW214544B/zh not_active IP Right Cessation
- 1992-06-25 AP APAP/P/1992/000403A patent/AP344A/en active
- 1992-06-25 IL IL102322A patent/IL102322A/xx not_active IP Right Cessation
- 1992-06-25 CN CN92108831A patent/CN1034072C/zh not_active Expired - Lifetime
- 1992-06-26 MX MX9203444A patent/MX9203444A/es unknown
- 1992-06-26 SI SI9200125A patent/SI9200125B/sl unknown
- 1992-07-01 IE IE206292A patent/IE922062A1/en not_active IP Right Cessation
- 1992-10-04 SA SA92130141A patent/SA92130141B1/ar unknown
-
1993
- 1993-12-23 NO NO934759A patent/NO304774B1/no not_active IP Right Cessation
- 1993-12-23 FI FI935842A patent/FI103967B/fi not_active IP Right Cessation
-
1995
- 1995-05-15 US US08/442,719 patent/US5637611A/en not_active Expired - Lifetime
-
1997
- 1997-05-06 BR BR1100460-6A patent/BR1100460A/pt active IP Right Grant
-
2002
- 2002-07-24 LU LU90939C patent/LU90939I2/fr unknown
- 2002-10-14 NL NL300103C patent/NL300103I2/nl unknown
-
2005
- 2005-05-03 NO NO2005011C patent/NO2005011I2/no unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL117104A0 (en) | Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them | |
SG52322A1 (en) | 3-Amidopyrazole derivatives process for preparing these and pharmaceutical compositions containing them | |
HU9401844D0 (en) | Isatin derivatives process for the preparation thereof and pharmaceutical compositions comprising the same | |
IL103126A (en) | 5-amino-4-hydroxyhexanoic acid derivatives, process for their preparation and pharmaceutical compositions containing them | |
HUT72639A (en) | Substituted thiazolidinedione derivatives, pharmaceutical compositions containing them and process for their preparation | |
IL105412A0 (en) | Indole derivatives,their preparation and pharmaceutical compositions containing them | |
IL101864A0 (en) | Thiopyranopyrrole derivatives,their preparation and pharmaceutical compositions containing them | |
IL96385A0 (en) | Indole derivatives,their preparation and pharmaceutical compositions containing them | |
ZA927994B (en) | Heterobiaryl derivatives pharmaceutical compositions containing these compounds and processes for preparing them | |
IL86877A (en) | Carbazole derivatives,their preparation and pharmaceutical compositions containing them | |
IL100262A0 (en) | Alpha-oxoacetamide derivatives,their preparation and pharmaceutical compositions containing them | |
IL102175A0 (en) | Imidazodiazepine derivatives,their preparation and pharmaceutical compositions containing them | |
IL109703A0 (en) | Substituted carbazole derivatives, processes for their preparation and pharmaceutical compositions containing them | |
IL97050A0 (en) | 4-isoxazolecarboxamide derivatives,pharmaceutical compositions containing them and their preparation | |
HUT69712A (en) | Process for preparing benzimidazole derivatives and pharmaceutical compositions containing them | |
IL98542A0 (en) | Benzoquinazoline derivatives,their preparation and pharmaceutical compositions containing them | |
HUT67014A (en) | Benzofuran derivatives, pharmaceutical compositions containing them and process for the preparation of thereof | |
AU1256792A (en) | Indole derivatives and pharmaceutical compositions containing them | |
IL100850A0 (en) | Indole derivatives and pharmaceutical compositions containing them | |
IL102500A0 (en) | 3-deoxy-mannosamine derivatives,their preparation and pharmaceutical compositions containing them | |
IL98812A0 (en) | Purine derivatives,process for their preparation and pharmaceutical compositions containing them | |
HUT56345A (en) | Process for producing indole derivatives and pharmaceutical compositions comprising such compounds | |
IL102116A (en) | Hetaryloxy-beta-carboline derivatives processes for the preparation thereof and pharmaceutical compositions containing the same | |
HU903016D0 (en) | Process for the preparation of indole derivatives and pharmaceutical compositions containing them | |
IL99469A0 (en) | Imidazoline derivatives,process for their preparation and pharmaceutical compositions containing them |