IL111188A - Asymmetric synthesis of (s)-(+)-n, n-dimethyl-3- (1-naphthalenyloxy)-3- (2-thienyl) propanamine - Google Patents

Asymmetric synthesis of (s)-(+)-n, n-dimethyl-3- (1-naphthalenyloxy)-3- (2-thienyl) propanamine

Info

Publication number
IL111188A
IL111188A IL111188A IL11118894A IL111188A IL 111188 A IL111188 A IL 111188A IL 111188 A IL111188 A IL 111188A IL 11118894 A IL11118894 A IL 11118894A IL 111188 A IL111188 A IL 111188A
Authority
IL
Israel
Prior art keywords
added
thienyl
dimethyl
stirred
mixture
Prior art date
Application number
IL111188A
Other languages
English (en)
Other versions
IL111188A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL111188A0 publication Critical patent/IL111188A0/xx
Publication of IL111188A publication Critical patent/IL111188A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL111188A 1993-10-12 1994-10-06 Asymmetric synthesis of (s)-(+)-n, n-dimethyl-3- (1-naphthalenyloxy)-3- (2-thienyl) propanamine IL111188A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/135,032 US5362886A (en) 1993-10-12 1993-10-12 Asymmetric synthesis

Publications (2)

Publication Number Publication Date
IL111188A0 IL111188A0 (en) 1994-12-29
IL111188A true IL111188A (en) 1998-06-15

Family

ID=22466186

Family Applications (1)

Application Number Title Priority Date Filing Date
IL111188A IL111188A (en) 1993-10-12 1994-10-06 Asymmetric synthesis of (s)-(+)-n, n-dimethyl-3- (1-naphthalenyloxy)-3- (2-thienyl) propanamine

Country Status (30)

Country Link
US (2) US5362886A (cs)
EP (1) EP0650965B1 (cs)
JP (1) JP3644986B2 (cs)
KR (1) KR100334585B1 (cs)
CN (1) CN1067681C (cs)
AT (1) ATE199084T1 (cs)
AU (1) AU685494B2 (cs)
BR (1) BR9404045A (cs)
CA (1) CA2133899C (cs)
CO (1) CO4290349A1 (cs)
CZ (1) CZ286122B6 (cs)
DE (1) DE69426663T2 (cs)
DK (1) DK0650965T3 (cs)
ES (1) ES2153850T3 (cs)
FI (1) FI944773L (cs)
GR (1) GR3035715T3 (cs)
HU (2) HU68943D0 (cs)
IL (1) IL111188A (cs)
MY (1) MY112254A (cs)
NO (1) NO301758B1 (cs)
NZ (1) NZ264633A (cs)
PE (1) PE18595A1 (cs)
PH (1) PH31595A (cs)
PL (1) PL179600B1 (cs)
PT (1) PT650965E (cs)
RU (1) RU2127269C1 (cs)
SI (1) SI0650965T1 (cs)
TW (1) TW381090B (cs)
YU (1) YU49027B (cs)
ZA (1) ZA947839B (cs)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508276A (en) * 1994-07-18 1996-04-16 Eli Lilly And Company Duloxetine enteric pellets
US5910319A (en) 1997-05-29 1999-06-08 Eli Lilly And Company Fluoxetine enteric pellets and methods for their preparation and use
US6199021B1 (en) 1997-10-15 2001-03-06 Cc Kinetics, Inc. Method and apparatus for measuring power output of one powering a chain driven vehicle
US6541668B1 (en) 1999-04-09 2003-04-01 Eli Lilly And Company Methods for preparing 3-arloxy-3-arylpropylamines and intermediates thereof
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
JP2005053781A (ja) * 2001-08-27 2005-03-03 Nagase & Co Ltd 光学活性な３−（ｎ−メチルアミノ）−１−（２−チエニル）−プロパン−１−オールの製造方法
WO2003062219A1 (en) * 2002-01-24 2003-07-31 Eli Lilly And Company Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine
WO2003078418A1 (fr) * 2002-03-19 2003-09-25 Mitsubishi Chemical Corporation Compose de 3-hydroxy-3-(2-thienyl)propionamide, procede de fabrication correspondant, et procede de fabrication d'un compose de 3-amino-1-(2-thienly)1-propanol a partir de ce dernier
US7659409B2 (en) 2002-03-19 2010-02-09 Mitsubishi Chemical Corporation 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same
DE10212301A1 (de) * 2002-03-20 2003-10-02 Bayer Ag Verfahren zur Herstellung von Aryl-aminopropanolen
WO2003097632A1 (fr) * 2002-05-20 2003-11-27 Mitsubishi Rayon Co., Ltd. Derives de propanolamine, procede de preparation de 3-n-methylamino-1-(2-thienyl)-1-propanols et procede de preparation de derives de propanolamine
FR2841899A1 (fr) * 2002-07-05 2004-01-09 Ppg Sipsy Procede de resolution asymetrique d'un racemique faisant intervenir l'acide diprogulique et utilisation dudit acide comme agent de resolution asymetrique
CN103058986A (zh) * 2002-07-09 2013-04-24 隆萨股份公司 N-单取代β-氨基醇的制备方法
WO2004005307A1 (en) * 2002-07-09 2004-01-15 Lonza Ag Process for the preparation of optically active 3-n-methylamino-1-(2-thienyl)-1-propanol
EP1852415B1 (en) * 2002-07-09 2009-10-07 Lonza Ag Process for the preparation of N-monosubstituted beta-amino alcohols
DE10235206A1 (de) * 2002-08-01 2004-02-19 Basf Ag Verfahren zur Herstellung von (S)-3-Methylmino-1-(thien-2-yl)propan-1-ol
EP1541569B1 (en) * 2002-08-06 2010-05-12 Sumitomo Seika Chemicals Co., Ltd. Process for producing n-monoalkyl-3-hydroxy-3-(2-thienyl)propanamine and intermediate
DE10237246B3 (de) * 2002-08-14 2004-01-22 Consortium für elektrochemische Industrie GmbH (S)-3-Methylamino-1-(2-thienyl)-1-propanol-(-)-2,3,4,6-Di-O-isopropyliden-2-keto-L-gulonsäuresalz, Verfahren zu dessen Herstellung, dessen Verwendung sowie ein Verfahren zur Enantiomerenanreicherung von (S)-3-Methylamino-1-(2-thienyl)-1-propanol
JP4589724B2 (ja) * 2002-08-27 2010-12-01 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング アミノアルコールのエナンチオ選択的水素化法
GB0221438D0 (en) * 2002-09-16 2002-10-23 Avecia Ltd Processes and compounds
WO2004031168A2 (en) * 2002-10-07 2004-04-15 Lonza Ag Processes and intermediates for the preparation of optically active 3-amino-1-(2-thienyl)-1-propanol derivatives
US20040235925A1 (en) * 2002-12-17 2004-11-25 Pharmacia Corporation Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of duloxetine, venlafaxine or atomoxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof
GB0229583D0 (en) * 2002-12-19 2003-01-22 Cipla Ltd A process for preparing duloxetine and intermediates for use therein
DE10302595A1 (de) * 2003-01-22 2004-07-29 Basf Ag 3-Methylamino-1-(2-thienyl)-1-proganon, seine Herstellung und Verwendung
WO2005019199A1 (en) * 2003-08-25 2005-03-03 Hetero Drugs Limited Amorphous duloxetine hydrochloride
DE10345772A1 (de) * 2003-10-01 2005-04-21 Basf Ag Verfahren zur Herstellung von 3-Methylamino-1-(thien-2-yl)-propan-1-ol
DE102004004719A1 (de) * 2004-01-29 2005-08-18 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Aminoalkoholen
SG135196A1 (en) * 2004-02-19 2007-09-28 Lonza Ag Process for the preparation of enantiomerically pure 1-substituted-3- aminoalcohols
US20050197503A1 (en) * 2004-03-05 2005-09-08 Boehringer Ingelheim International Gmbh Process for the preparation of N-alkyl-N-methyl-3-hydroxy-3-(2-thienyl)-propylamines
CN1300137C (zh) * 2004-03-31 2007-02-14 上海医药工业研究院 (s)－(+)－n,n－二甲基－3－(1－萘氧基)－3－(2－噻吩基)丙胺的制备方法
DE102004022686A1 (de) 2004-05-05 2005-11-24 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
GB0410470D0 (en) * 2004-05-11 2004-06-16 Cipla Ltd Pharmaceutical compound and polymorphs thereof
CZ297555B6 (cs) * 2004-10-26 2007-02-07 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (duloxetinu)
CZ297560B6 (cs) * 2004-10-26 2007-02-07 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (duloxetinu)
US20060194869A1 (en) * 2004-12-23 2006-08-31 Santiago Ini Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof
US20060270859A1 (en) * 2005-01-27 2006-11-30 Santiago Ini Duloxetine HCl polymorphs
MX2007010931A (es) * 2005-03-08 2007-10-16 Teva Pharma Formas cristalinas de (s)-(+)-n,n-dimetil-3-(1-naftaleniloxi)-3-(2 -tienil)propanamina oxalato y la preparacion ellas.
WO2006099459A1 (en) * 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Process for the preparation of optically active (s)-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine
WO2006126213A1 (en) * 2005-05-24 2006-11-30 Matrix Laboratories Ltd An improved process for the preparation of duloxetine
CN100364986C (zh) * 2005-07-14 2008-01-30 上海艾力斯医药科技有限公司 S－(+)－n,n－二甲基－3－(1－萘基氧基)－3－(2－噻吩基)丙胺的制备方法
WO2007020797A1 (ja) 2005-08-19 2007-02-22 Sumitomo Seika Chemicals Co., Ltd. （ｅ）－ｎ－モノアルキル－３－オキソ－３－（２－チエニル）プロペンアミンおよびその製造方法、ならびに（ｅ，ｚ）－ｎ－モノアルキル－３－オキソ－３－（２－チエニル）プロペンアミンの製造方法
US7842717B2 (en) * 2005-09-22 2010-11-30 Teva Pharmaceutical Industries Ltd. DNT-maleate and methods of preparation thereof
US20080207923A1 (en) * 2005-09-22 2008-08-28 Santiago Ini Pure DNT-maleate and methods of preparation thereof
CA2624788C (en) 2005-10-12 2011-04-19 Unimed Pharmaceuticals, Llc Improved testosterone gel and method of use
EP1863782A1 (en) * 2005-12-05 2007-12-12 Teva Pharmaceutical Industries Ltd. 2-(n-methyl-propanamine)-3-(2-naphtol) thiophene, an imputity of duloxetine hydrochloride
US20090182156A1 (en) * 2005-12-12 2009-07-16 Stephen Benedict David Winter Synthesis and preparations of duloxetine salts
CN1304360C (zh) * 2005-12-12 2007-03-14 天津大学 N,n－二甲基－3－羟基－3－芳基丙胺的制备方法
DE102005062661A1 (de) * 2005-12-23 2007-08-16 Basf Ag Verfahren zur Herstellung von optisch aktivem (1S)-3-Chlor-(-thien-2-yl)-propan-1-ol
DE102005062662A1 (de) 2005-12-23 2007-06-28 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
CZ299270B6 (cs) * 2006-01-04 2008-06-04 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
US8362279B2 (en) 2006-01-06 2013-01-29 Msn Laboratories Limited Process for pure duloxetine hydrochloride
US7538232B2 (en) 2006-01-19 2009-05-26 Eli Lilly And Company Process for the asymmetric synthesis of duloxetine
MX2007011727A (es) * 2006-01-23 2007-11-15 Teva Pharma Dnt-succinato y metodos de preparacion de el.
EP1844034A1 (en) * 2006-01-23 2007-10-17 Teva Pharmaceutical Industries Ltd Dnt-fumarate and methods of preparation thereof
US20070173540A1 (en) * 2006-01-23 2007-07-26 Santiago Ini DNT-benzenesulfonate and methods of preparation thereof
MX2007014131A (es) * 2006-02-13 2008-01-11 Teva Pharma Un proceso para la preparacion de (s)-(+)-n,n-dimetil-3-(1- naftale niloxi)-3-(2-tienil)propanamina un intermedio de duloxetina.
EP1820800A1 (en) 2006-02-17 2007-08-22 KRKA, tovarna zdravil, d.d., Novo mesto Crystalline forms of duloxetine hydrochloride and processes for their preparation
EP1888554A2 (en) * 2006-02-21 2008-02-20 Teva Pharmaceutical Industries Ltd Process for the preparation of (s)-(-)-n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamine, a duloxetine intermediate
EP1826204A1 (en) 2006-02-28 2007-08-29 Laboratorios Del Dr. Esteve, S.A. Process for obtaining enantiomers of duloxetine precursors
WO2007123900A2 (en) * 2006-04-17 2007-11-01 Teva Pharmaceutical Industries Ltd. Enantiomers of n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamine borane as intermediates in the synthesis of duloxetine
PT1857451E (pt) * 2006-05-05 2010-10-25 Fidia Farmaceutici Processo para a preparação de uma substância intermédia útil para a síntese assimétrica da (+)duloxetina
WO2007134168A2 (en) * 2006-05-10 2007-11-22 Dr. Reddy's Laboratories Ltd. Process for preparing duloxetine
ITMI20060984A1 (it) * 2006-05-18 2007-11-19 Dipharma Spa Procedimento per la preparazione di arilossipropilammine
WO2007139984A2 (en) * 2006-05-23 2007-12-06 Teva Pharmaceutical Industries Ltd. Duloxetine hcl polymorphs
EP1976846A2 (en) * 2006-05-31 2008-10-08 Teva Pharmaceutical Industries Ltd Process for preparing duloxetine and intermediates thereof
GB0612506D0 (en) * 2006-06-23 2006-08-02 Arrow Int Ltd Crystalline duloxetine hydrochloride
GB0612509D0 (en) * 2006-06-23 2006-08-02 Arrow Int Ltd Crystalline duloxetine hydrochloride
GB0612508D0 (en) * 2006-06-23 2006-08-02 Arrow Int Ltd Crystalline duloxetine hydrochloride
WO2008004191A2 (en) 2006-07-03 2008-01-10 Ranbaxy Laboratories Limited Process for the preparation of enantiomerically pure salts of n-methyl-3- ( 1-naphthaleneoxy) -3- (2-thienyl) propanamine
US20100261775A1 (en) * 2006-07-03 2010-10-14 Sujoy Biswas Polymorphic form of duloxetine hydrochloride
CZ300116B6 (cs) * 2006-12-05 2009-02-11 Zentiva, A. S. Zpusob cištení hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
WO2008077645A1 (en) * 2006-12-22 2008-07-03 Synthon B.V. Process for making duloxetine and related compounds
WO2008081476A2 (en) * 2006-12-29 2008-07-10 Cadila Healthcare Limited Process for preparing duloxetine hydrochloride
WO2008093360A2 (en) * 2007-01-31 2008-08-07 Usv Limited A process for preparation of (s)-(+)-n-methyl-3(1-naphthyloxy)-3(2-thienyl)propylamine hydrochloride
WO2008107911A2 (en) * 2007-03-05 2008-09-12 Lupin Limited Novel process for preparation of duloxetine hydrochloride
KR20100028559A (ko) * 2007-05-18 2010-03-12 시플라 리미티드 데스메틸시탈로프람을 경유한 에스시탈로프람의 제조방법, 상기 ｓ-이성체의 광학분리 및 메틸화
WO2009010238A2 (en) * 2007-07-13 2009-01-22 Synthon B.V. Duloxetine formulations
EP2060559A1 (en) 2007-11-19 2009-05-20 Cadila Pharmaceuticals Limited Process for the preparation of enantiomerically pure 3-hydroxy-3-arylpropylamines and their optical stereoisomers
WO2009087463A2 (en) * 2007-12-26 2009-07-16 Orchid Chemicals & Pharmaceuticals Limited A method for the preparation of duloxetine hydrochloride
WO2009092129A1 (en) * 2008-01-25 2009-07-30 Alpharma Pty Ltd Delayed release pharmaceutical composition of duloxetine
US8278463B2 (en) * 2008-04-04 2012-10-02 Ranbaxy Laboratories Limited Process for the preparation of pure duloxetine hydrochloride
KR101680385B1 (ko) * 2008-04-11 2016-11-28 넥타르 테라퓨틱스 올리고머-아릴옥시-치환된 프로판아민 컨쥬게이트
WO2009130708A2 (en) * 2008-04-22 2009-10-29 Shodhana Laboratories Limited Preparation of duloxetine and its salts
US20110230666A1 (en) * 2008-06-03 2011-09-22 Shodhana Laboratories Limited process for the separation of enantiomerically pure compounds
EP2133072A1 (en) 2008-06-13 2009-12-16 KRKA, D.D., Novo Mesto Gastro-resistant pharmaceutical oral compositions comprising duloxetine or its pharmaceutically acceptable derivatives
WO2010025287A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
EP2329013B1 (en) 2008-08-27 2015-10-28 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
CA2758736A1 (en) * 2009-01-06 2010-07-15 Alembic Pharmaceuticals Limited An improved process for the reparation of duloxetine and salts thereof
CA2754141A1 (en) * 2009-03-13 2010-09-16 Alembic Pharmaceuticals Limited A process for the preparation of duloxetine hydrochloride
CZ304602B6 (cs) 2009-09-02 2014-07-30 Zentiva, K. S. Způsob krystalizace hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (hydrochloridu duloxetinu)
WO2011033366A2 (en) 2009-09-16 2011-03-24 Jubilant Life Sciences Limited Process for the preparation of duloxetine hydrochloride and its precursors
WO2011077443A1 (en) * 2009-12-22 2011-06-30 Biocon Limited An improved process for the preparation of duloxetine hydrochloride
SI2558455T1 (sl) * 2010-04-13 2017-12-29 Krka, D.D., Novo Mesto Sinteza duloksetina in/ali njegovih farmacevtsko sprejemljivih soli
WO2011145102A1 (en) 2010-05-18 2011-11-24 Arch Pharmalabs Limited A process for the preparation of n-methyl-o-aryloxy-propanamine derivatives and pharmaceutically acceptable salt thereof
US9859510B2 (en) 2015-05-15 2018-01-02 Universal Display Corporation Organic electroluminescent materials and devices
US11011709B2 (en) 2016-10-07 2021-05-18 Universal Display Corporation Organic electroluminescent materials and devices
ES2754280A1 (es) 2018-10-11 2020-04-16 Laboratoris Sanifit S L Pautas posológicas de IP y análogos de IP para el tratamiento de calcificaciones ectópicas
EP4015494A1 (en) 2020-12-15 2022-06-22 Sanifit Therapeutics S.A. Processes for the preparation of soluble salts of inositol phosphates
CN114163415B (zh) * 2021-12-01 2023-03-03 珠海润都制药股份有限公司 一种盐酸度洛西汀中间体的制备方法
CN115286613B (zh) * 2022-10-08 2023-01-31 潍坊市海欣药业有限公司 一种盐酸度洛西汀的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4558164A (en) * 1984-08-06 1985-12-10 E. I. Du Pont De Nemours And Company Production of dinitrodiphenyl ether
KR880007433A (ko) * 1986-12-22 1988-08-27 메리 앤 터커 3-아릴옥시-3-치환된 프로판아민
US4956388A (en) * 1986-12-22 1990-09-11 Eli Lilly And Company 3-aryloxy-3-substituted propanamines
JPS6416778A (en) * 1987-07-09 1989-01-20 Tanabe Seiyaku Co Thiophene derivative
JPH02145581A (ja) * 1988-10-11 1990-06-05 Lonza Ag 置換チエニルエチルアミンとその製造方法
FI81083C (fi) * 1989-03-03 1990-09-10 Orion Yhtymae Oy Ett foerbaettrat foerfarande foer framstaellning av n-metyl-3-(p-trifluormetylfenoxi)-3-fenylpropylamin hydroklorid.
JP2707148B2 (ja) * 1990-04-20 1998-01-28 チッソ株式会社 光学活性フルオキセチンの製造方法とこの方法に使用する化合物
US5068451A (en) * 1990-05-04 1991-11-26 National Science Council Production of 3-phenoxy propanal derivatives
FI912280A7 (fi) * 1990-05-17 1991-11-18 Lilly Co Eli 1-aryyli-3-aminopropan-1-olien kiraalinen synteesi
CA2053997A1 (en) * 1991-03-15 1992-09-16 Jeffrey S. Stults Method for ether formation
DE4123253A1 (de) * 1991-07-15 1993-01-21 Schneider Manfred Prof Dr Verfahren zur enzymatischen racematspaltung halogenierter arylalkanole
HU9202128D0 (en) * 1992-06-26 1992-10-28 Richter Gedeon Vegyeszet Method for producing n-methyl-(3-phenyl-3-(4-[trifluoro-methyl])-phenooxi-)-amine

Also Published As

Publication number Publication date
AU7572094A (en) 1995-05-04
FI944773A7 (fi) 1995-04-13
CN1109470A (zh) 1995-10-04
SI0650965T1 (en) 2001-06-30
JPH07188065A (ja) 1995-07-25
AU685494B2 (en) 1998-01-22
KR100334585B1 (ko) 2005-07-28
NZ264633A (en) 1997-09-22
ZA947839B (en) 1996-04-09
DK0650965T3 (da) 2001-02-26
TW381090B (en) 2000-02-01
PH31595A (en) 1998-11-03
IL111188A0 (en) 1994-12-29
NO943825L (no) 1995-04-18
RU94035996A (ru) 1996-08-20
PL305326A1 (en) 1995-04-18
CZ286122B6 (cs) 2000-01-12
HU9402936D0 (en) 1995-01-30
PT650965E (pt) 2001-05-31
DE69426663T2 (de) 2001-06-21
PL179600B1 (pl) 2000-09-29
ES2153850T3 (es) 2001-03-16
US5491243A (en) 1996-02-13
CN1067681C (zh) 2001-06-27
YU49027B (sh) 2003-07-07
RU2127269C1 (ru) 1999-03-10
PE18595A1 (es) 1995-07-13
NO943825D0 (no) 1994-10-10
HUT68943A (en) 1995-08-28
KR950011434A (ko) 1995-05-15
FI944773L (fi) 1995-04-13
YU59194A (sh) 1997-03-07
CZ246594A3 (en) 1995-05-17
EP0650965B1 (en) 2001-02-07
CA2133899C (en) 2007-02-13
FI944773A0 (fi) 1994-10-11
NO301758B1 (no) 1997-12-08
BR9404045A (pt) 1995-06-13
DE69426663D1 (de) 2001-03-15
HU220673B1 (hu) 2002-04-29
HU68943D0 (en) 2000-04-28
ATE199084T1 (de) 2001-02-15
EP0650965A1 (en) 1995-05-03
CO4290349A1 (es) 1996-04-17
JP3644986B2 (ja) 2005-05-11
CA2133899A1 (en) 1995-04-13
MY112254A (en) 2001-05-31
US5362886A (en) 1994-11-08
GR3035715T3 (en) 2001-07-31

Similar Documents

Publication Publication Date Title
US5491243A (en) Intermediate useful for the asymmetric synthesis of duloxetine
EP1971592B1 (en) Improved synthesis and preparations of duloxetine salts
US7534900B2 (en) Process for the purification of duloxetine hydrochloride
JPH04226948A (ja) １−アリール−３−アミノプロパン−１−オール類のキラル合成
WO2003062219A1 (en) Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine
US20050171360A1 (en) Preparation of n-methyl-3-hydroxy- 3-(2-thienyl)propylamine via novel thiophene derivatives containing carbamate groups as intermediates
US20070281989A1 (en) Process for preparing duloxetine and intermediates thereof
CA2626500A1 (en) Process for the preparation of duloxetine
EP1539673B1 (en) Process for the preparation of n -monosubstituted beta-amino alcohols
JP3937489B2 (ja) プロパルギルアミン化合物の製造方法
US7560573B2 (en) Process for the preparation of (S)-(-)-N,N-dimethyl-3-(2-thienyl)-3-hydroxypropananine, a duloxetine intermediate
KR101675450B1 (ko) 중간체로서 광학 활성 3-아미노-1-프로판올 유도체의 제조방법 및 상기 중간체를 이용한 (s)-둘록세틴의 제조방법
KR101675440B1 (ko) 광학 활성 3-클로로-1-아릴프로판-1-올 유도체로부터 3-아미노-1-아릴프로판-1-올 유도체의 제조방법
CN113429380A (zh) 一种度洛西汀的制备方法
MX2007013043A (en) Process for the preparation of (s)-(-)-n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamine, a duloxetine intermediate
WO2011077443A1 (en) An improved process for the preparation of duloxetine hydrochloride
CS216168B2 (cs) Způsob výroby N-substituovaných N-2-furylethylaminů

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees