ZA947839B - Asymmetric synthesis - Google Patents

Asymmetric synthesis

Info

Publication number
ZA947839B
ZA947839B ZA947839A ZA947839A ZA947839B ZA 947839 B ZA947839 B ZA 947839B ZA 947839 A ZA947839 A ZA 947839A ZA 947839 A ZA947839 A ZA 947839A ZA 947839 B ZA947839 B ZA 947839B
Authority
ZA
South Africa
Prior art keywords
equiv
stirring
iii
potassium
solvent
Prior art date
Application number
ZA947839A
Other languages
English (en)
Inventor
Richard Alan Berglund
Original Assignee
Eli Lilly And Comany
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Comany filed Critical Eli Lilly And Comany
Publication of ZA947839B publication Critical patent/ZA947839B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA947839A 1993-10-12 1994-10-06 Asymmetric synthesis ZA947839B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/135,032 US5362886A (en) 1993-10-12 1993-10-12 Asymmetric synthesis

Publications (1)

Publication Number Publication Date
ZA947839B true ZA947839B (en) 1996-04-09

Family

ID=22466186

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA947839A ZA947839B (en) 1993-10-12 1994-10-06 Asymmetric synthesis

Country Status (30)

Country Link
US (2) US5362886A (cs)
EP (1) EP0650965B1 (cs)
JP (1) JP3644986B2 (cs)
KR (1) KR100334585B1 (cs)
CN (1) CN1067681C (cs)
AT (1) ATE199084T1 (cs)
AU (1) AU685494B2 (cs)
BR (1) BR9404045A (cs)
CA (1) CA2133899C (cs)
CO (1) CO4290349A1 (cs)
CZ (1) CZ286122B6 (cs)
DE (1) DE69426663T2 (cs)
DK (1) DK0650965T3 (cs)
ES (1) ES2153850T3 (cs)
FI (1) FI944773L (cs)
GR (1) GR3035715T3 (cs)
HU (2) HU220673B1 (cs)
IL (1) IL111188A (cs)
MY (1) MY112254A (cs)
NO (1) NO301758B1 (cs)
NZ (1) NZ264633A (cs)
PE (1) PE18595A1 (cs)
PH (1) PH31595A (cs)
PL (1) PL179600B1 (cs)
PT (1) PT650965E (cs)
RU (1) RU2127269C1 (cs)
SI (1) SI0650965T1 (cs)
TW (1) TW381090B (cs)
YU (1) YU49027B (cs)
ZA (1) ZA947839B (cs)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508276A (en) * 1994-07-18 1996-04-16 Eli Lilly And Company Duloxetine enteric pellets
US5910319A (en) 1997-05-29 1999-06-08 Eli Lilly And Company Fluoxetine enteric pellets and methods for their preparation and use
US6199021B1 (en) 1997-10-15 2001-03-06 Cc Kinetics, Inc. Method and apparatus for measuring power output of one powering a chain driven vehicle
AU3877500A (en) * 1999-04-09 2000-11-14 Eli Lilly And Company Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
JP2005053781A (ja) * 2001-08-27 2005-03-03 Nagase & Co Ltd 光学活性な３−（ｎ−メチルアミノ）−１−（２−チエニル）−プロパン−１−オールの製造方法
WO2003062219A1 (en) * 2002-01-24 2003-07-31 Eli Lilly And Company Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine
US7659409B2 (en) 2002-03-19 2010-02-09 Mitsubishi Chemical Corporation 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same
EP1486493A4 (en) * 2002-03-19 2007-04-04 Mitsubishi Chem Corp 3-HYDROXY-3- (2-THIENYL) PROPIONIC ACID AMID COMPOUND, METHOD FOR THE PRODUCTION THEREOF AND METHOD FOR PRODUCING A 3-AMINO-1- (2-THIENYL) -1-PROPANOL COMPOUND THEREFOR
DE10212301A1 (de) 2002-03-20 2003-10-02 Bayer Ag Verfahren zur Herstellung von Aryl-aminopropanolen
EP1506965A4 (en) * 2002-05-20 2010-11-03 Mitsubishi Rayon Co PROPANOLAMINE DERIVATIVES, PROCESS FOR PREPARING 3-N-METHYLAMINO-1- (2-THIENYL) -1-PROPANOLS AND METHOD FOR PRODUCING PROPANOLAMINE DERIVATIVES
US20050256318A1 (en) * 2002-07-09 2005-11-17 Dominique Michel Process for the preparation of n-monosubstituted beta-amino alcohols
FR2841899A1 (fr) * 2002-07-05 2004-01-09 Ppg Sipsy Procede de resolution asymetrique d'un racemique faisant intervenir l'acide diprogulique et utilisation dudit acide comme agent de resolution asymetrique
NZ537567A (en) 2002-07-09 2006-11-30 Lonza Ag Process for the preparation of N-monosubstituted beta-amino alcohols
WO2004005307A1 (en) * 2002-07-09 2004-01-15 Lonza Ag Process for the preparation of optically active 3-n-methylamino-1-(2-thienyl)-1-propanol
DE10235206A1 (de) * 2002-08-01 2004-02-19 Basf Ag Verfahren zur Herstellung von (S)-3-Methylmino-1-(thien-2-yl)propan-1-ol
CN1332958C (zh) * 2002-08-06 2007-08-22 住友精化株式会社 N－单烷基－3－羟基－3－(2－噻吩基)丙胺的制造方法及制造中间体
DE10237246B3 (de) * 2002-08-14 2004-01-22 Consortium für elektrochemische Industrie GmbH (S)-3-Methylamino-1-(2-thienyl)-1-propanol-(-)-2,3,4,6-Di-O-isopropyliden-2-keto-L-gulonsäuresalz, Verfahren zu dessen Herstellung, dessen Verwendung sowie ein Verfahren zur Enantiomerenanreicherung von (S)-3-Methylamino-1-(2-thienyl)-1-propanol
KR101017884B1 (ko) * 2002-08-27 2011-03-04 메르크 파텐트 게엠베하 아미노 알콜의 거울상이성질 선택성 수소화 반응을 위한 제조방법
GB0221438D0 (en) * 2002-09-16 2002-10-23 Avecia Ltd Processes and compounds
AU2003276066A1 (en) * 2002-10-07 2004-04-23 Lonza Ag Processes and intermediates for the preparation of optically active 3-amino-1-(2-thienyl)-1-propanol derivatives
US20040235925A1 (en) * 2002-12-17 2004-11-25 Pharmacia Corporation Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of duloxetine, venlafaxine or atomoxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof
GB0229583D0 (en) * 2002-12-19 2003-01-22 Cipla Ltd A process for preparing duloxetine and intermediates for use therein
DE10302595A1 (de) * 2003-01-22 2004-07-29 Basf Ag 3-Methylamino-1-(2-thienyl)-1-proganon, seine Herstellung und Verwendung
AU2003263585A1 (en) * 2003-08-25 2005-03-10 Hetero Drugs Limited Amorphous duloxetine hydrochloride
DE10345772A1 (de) * 2003-10-01 2005-04-21 Basf Ag Verfahren zur Herstellung von 3-Methylamino-1-(thien-2-yl)-propan-1-ol
DE102004004719A1 (de) * 2004-01-29 2005-08-18 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Aminoalkoholen
EP1720852B1 (en) * 2004-02-19 2012-07-11 Lonza AG Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
US20050197503A1 (en) * 2004-03-05 2005-09-08 Boehringer Ingelheim International Gmbh Process for the preparation of N-alkyl-N-methyl-3-hydroxy-3-(2-thienyl)-propylamines
CN1300137C (zh) * 2004-03-31 2007-02-14 上海医药工业研究院 (s)－(+)－n,n－二甲基－3－(1－萘氧基)－3－(2－噻吩基)丙胺的制备方法
DE102004022686A1 (de) 2004-05-05 2005-11-24 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
GB0410470D0 (en) * 2004-05-11 2004-06-16 Cipla Ltd Pharmaceutical compound and polymorphs thereof
CZ297555B6 (cs) * 2004-10-26 2007-02-07 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (duloxetinu)
CZ297560B6 (cs) * 2004-10-26 2007-02-07 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (duloxetinu)
US20060194869A1 (en) * 2004-12-23 2006-08-31 Santiago Ini Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof
WO2006081515A2 (en) * 2005-01-27 2006-08-03 Teva Pharmaceutical Industries Ltd. Duloxetine hydrochloride polymorphs
US7399871B2 (en) * 2005-03-08 2008-07-15 Teva Pharmaceutical Industries Ltd. Crystal forms of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine oxalate and the preparation thereof
CA2599475A1 (en) * 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Pure duloxetine hydrochloride
WO2006126213A1 (en) * 2005-05-24 2006-11-30 Matrix Laboratories Ltd An improved process for the preparation of duloxetine
CN100364986C (zh) * 2005-07-14 2008-01-30 上海艾力斯医药科技有限公司 S－(+)－n,n－二甲基－3－(1－萘基氧基)－3－(2－噻吩基)丙胺的制备方法
CA2616269C (en) 2005-08-19 2014-03-18 Sumitomo Seika Chemicals Co., Ltd. (e)-n-monoalkyl-3-oxo-3-(2-thienyl)propenamine and process for producing the same and process for producing (e,z)-n-monoalkyl-3-oxo-3-(2-thienyl) propenamine
US20070281989A1 (en) * 2006-05-31 2007-12-06 Santiago Ini Process for preparing duloxetine and intermediates thereof
US7842717B2 (en) * 2005-09-22 2010-11-30 Teva Pharmaceutical Industries Ltd. DNT-maleate and methods of preparation thereof
US20080207923A1 (en) * 2005-09-22 2008-08-28 Santiago Ini Pure DNT-maleate and methods of preparation thereof
PT2450041T (pt) 2005-10-12 2018-11-16 Unimed Pharmaceuticals Llc Gel de testosterona melhorado e método para a sua utilização
US7759500B2 (en) * 2005-12-05 2010-07-20 Teva Pharmaceutical Industries Ltd. 2-(N-methyl-propanamine)-3-(2-naphthol)thiophene, an impurity of duloxetine hydrochloride
CN1304360C (zh) * 2005-12-12 2007-03-14 天津大学 N,n－二甲基－3－羟基－3－芳基丙胺的制备方法
WO2007119116A2 (en) 2005-12-12 2007-10-25 Medichem, S.A. Improved synthesis and preparations of duloxetine salts
DE102005062661A1 (de) * 2005-12-23 2007-08-16 Basf Ag Verfahren zur Herstellung von optisch aktivem (1S)-3-Chlor-(-thien-2-yl)-propan-1-ol
DE102005062662A1 (de) 2005-12-23 2007-06-28 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
CZ299270B6 (cs) 2006-01-04 2008-06-04 Zentiva, A. S. Zpusob výroby hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
US8362279B2 (en) 2006-01-06 2013-01-29 Msn Laboratories Limited Process for pure duloxetine hydrochloride
US7538232B2 (en) 2006-01-19 2009-05-26 Eli Lilly And Company Process for the asymmetric synthesis of duloxetine
US20070173541A1 (en) * 2006-01-23 2007-07-26 Santiago Ini DNT-succinate and methods of preparation thereof
WO2007086948A1 (en) * 2006-01-23 2007-08-02 Teva Pharmaceutical Industries Ltd. Dnt-fumarate and methods of preparation thereof
EP1856088A1 (en) * 2006-01-23 2007-11-21 Teva Pharmaceutical Industries Ltd Dnt-benzenesulfonate and methods of preparation thereof
US20070238883A1 (en) * 2006-02-13 2007-10-11 Santiago Ini Process for the preparation of(s)-(+)-N,N-dimethyl-3-(1-Naphthalenyloxy)-3-(2-Thienyl)propanamine, A duloxetine intermediate
EP1820800A1 (en) 2006-02-17 2007-08-22 KRKA, tovarna zdravil, d.d., Novo mesto Crystalline forms of duloxetine hydrochloride and processes for their preparation
EP1888554A2 (en) * 2006-02-21 2008-02-20 Teva Pharmaceutical Industries Ltd Process for the preparation of (s)-(-)-n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamine, a duloxetine intermediate
EP1826204A1 (en) 2006-02-28 2007-08-29 Laboratorios Del Dr. Esteve, S.A. Process for obtaining enantiomers of duloxetine precursors
WO2007123900A2 (en) * 2006-04-17 2007-11-01 Teva Pharmaceutical Industries Ltd. Enantiomers of n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamine borane as intermediates in the synthesis of duloxetine
DK1857451T3 (da) * 2006-05-05 2010-10-11 Fidia Farmaceutici Fremgangsmåde til fremstilling af en intermediær nyttig til asymmetrisk syntese af (+)
WO2007134168A2 (en) * 2006-05-10 2007-11-22 Dr. Reddy's Laboratories Ltd. Process for preparing duloxetine
ITMI20060984A1 (it) * 2006-05-18 2007-11-19 Dipharma Spa Procedimento per la preparazione di arilossipropilammine
EP1934197A2 (en) * 2006-05-23 2008-06-25 Teva Pharmaceutical Industries Ltd Duloxetine hcl polymorphs
GB0612509D0 (en) * 2006-06-23 2006-08-02 Arrow Int Ltd Crystalline duloxetine hydrochloride
GB0612506D0 (en) * 2006-06-23 2006-08-02 Arrow Int Ltd Crystalline duloxetine hydrochloride
GB0612508D0 (en) * 2006-06-23 2006-08-02 Arrow Int Ltd Crystalline duloxetine hydrochloride
US20100280093A1 (en) * 2006-07-03 2010-11-04 Ranbaxy Laboratories Limited Process for the preparation enantiomerically pure salts of n-methyl-3-(1-naphthaleneoxy)-3-(2-thienyl)propanamine
EP2040697A2 (en) * 2006-07-03 2009-04-01 Ranbaxy Laboratories Limited Polymorphic form of duloxetine hydrochloride
CZ300116B6 (cs) * 2006-12-05 2009-02-11 Zentiva, A. S. Zpusob cištení hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu
ATE552250T1 (de) * 2006-12-22 2012-04-15 Synthon Bv Verfahren zur herstellung von duloxetin und verwandten verbindungen
WO2008081476A2 (en) * 2006-12-29 2008-07-10 Cadila Healthcare Limited Process for preparing duloxetine hydrochloride
WO2008093360A2 (en) * 2007-01-31 2008-08-07 Usv Limited A process for preparation of (s)-(+)-n-methyl-3(1-naphthyloxy)-3(2-thienyl)propylamine hydrochloride
US8269023B2 (en) * 2007-03-05 2012-09-18 Lupin Ltd. Process for preparation of duloxetine hydrochloride
US8288568B2 (en) * 2007-05-18 2012-10-16 Cipla Limited Process for the preparation of escitalopram
WO2009010238A2 (en) * 2007-07-13 2009-01-22 Synthon B.V. Duloxetine formulations
EP2060559A1 (en) 2007-11-19 2009-05-20 Cadila Pharmaceuticals Limited Process for the preparation of enantiomerically pure 3-hydroxy-3-arylpropylamines and their optical stereoisomers
WO2009087463A2 (en) * 2007-12-26 2009-07-16 Orchid Chemicals & Pharmaceuticals Limited A method for the preparation of duloxetine hydrochloride
US20110070299A1 (en) * 2008-01-25 2011-03-24 Alphapharm Pty Ltd. Delayed release pharmaceutical composition of duloxetine
US8278463B2 (en) * 2008-04-04 2012-10-02 Ranbaxy Laboratories Limited Process for the preparation of pure duloxetine hydrochloride
KR101680385B1 (ko) * 2008-04-11 2016-11-28 넥타르 테라퓨틱스 올리고머-아릴옥시-치환된 프로판아민 컨쥬게이트
WO2009130708A2 (en) * 2008-04-22 2009-10-29 Shodhana Laboratories Limited Preparation of duloxetine and its salts
WO2009147687A2 (en) * 2008-06-03 2009-12-10 Shodhana Laboratories Limited An improved process for the separation of enantiomerically pure compounds
EP2133072A1 (en) 2008-06-13 2009-12-16 KRKA, D.D., Novo Mesto Gastro-resistant pharmaceutical oral compositions comprising duloxetine or its pharmaceutically acceptable derivatives
WO2010025238A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2010025287A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US20110275836A1 (en) * 2009-01-06 2011-11-10 Alembic Pharmaceuticals Limited Process for the preparation of duloxetine and salts thereof
EP2393799A1 (en) * 2009-03-13 2011-12-14 Alembic Pharmaceuticals Limited A process for the preparation of duloxetine hydrochloride
CZ304602B6 (cs) 2009-09-02 2014-07-30 Zentiva, K. S. Způsob krystalizace hydrochloridu (S)-N-methyl-3-(1-naftyloxy)-3-(2-thienyl)propylaminu (hydrochloridu duloxetinu)
WO2011033366A2 (en) 2009-09-16 2011-03-24 Jubilant Life Sciences Limited Process for the preparation of duloxetine hydrochloride and its precursors
WO2011077443A1 (en) * 2009-12-22 2011-06-30 Biocon Limited An improved process for the preparation of duloxetine hydrochloride
EP2558455B1 (en) * 2010-04-13 2017-08-09 KRKA, D.D., Novo Mesto Synthesis of duloxetine and/or pharmaceutically acceptable salts thereof
US20130053579A1 (en) 2010-05-18 2013-02-28 Arch Pharmalabs Limited Process for the preparation of n-methyl-o-aryloxy propanamine derivatives and pharmaceutically acceptable salt thereof
US9859510B2 (en) 2015-05-15 2018-01-02 Universal Display Corporation Organic electroluminescent materials and devices
US11011709B2 (en) 2016-10-07 2021-05-18 Universal Display Corporation Organic electroluminescent materials and devices
AU2018445164B2 (en) 2018-10-11 2025-05-29 Vifor (International) Ltd. Inositol phosphates for the treatment of ectopic calcification
EP4015494A1 (en) 2020-12-15 2022-06-22 Sanifit Therapeutics S.A. Processes for the preparation of soluble salts of inositol phosphates
CN114163415B (zh) * 2021-12-01 2023-03-03 珠海润都制药股份有限公司 一种盐酸度洛西汀中间体的制备方法
CN115286613B (zh) * 2022-10-08 2023-01-31 潍坊市海欣药业有限公司 一种盐酸度洛西汀的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4558164A (en) * 1984-08-06 1985-12-10 E. I. Du Pont De Nemours And Company Production of dinitrodiphenyl ether
KR880007433A (ko) * 1986-12-22 1988-08-27 메리 앤 터커 3-아릴옥시-3-치환된 프로판아민
US4956388A (en) * 1986-12-22 1990-09-11 Eli Lilly And Company 3-aryloxy-3-substituted propanamines
JPS6416778A (en) * 1987-07-09 1989-01-20 Tanabe Seiyaku Co Thiophene derivative
JPH02145581A (ja) * 1988-10-11 1990-06-05 Lonza Ag 置換チエニルエチルアミンとその製造方法
FI81083C (fi) * 1989-03-03 1990-09-10 Orion Yhtymae Oy Ett foerbaettrat foerfarande foer framstaellning av n-metyl-3-(p-trifluormetylfenoxi)-3-fenylpropylamin hydroklorid.
JP2707148B2 (ja) * 1990-04-20 1998-01-28 チッソ株式会社 光学活性フルオキセチンの製造方法とこの方法に使用する化合物
US5068451A (en) * 1990-05-04 1991-11-26 National Science Council Production of 3-phenoxy propanal derivatives
IL98108A0 (en) * 1990-05-17 1992-06-21 Lilly Co Eli Chiral synthesis of 1-aryl-3-aminopropan-1-ols
CA2053997A1 (en) * 1991-03-15 1992-09-16 Jeffrey S. Stults Method for ether formation
DE4123253A1 (de) * 1991-07-15 1993-01-21 Schneider Manfred Prof Dr Verfahren zur enzymatischen racematspaltung halogenierter arylalkanole
HU9202128D0 (en) * 1992-06-26 1992-10-28 Richter Gedeon Vegyeszet Method for producing n-methyl-(3-phenyl-3-(4-[trifluoro-methyl])-phenooxi-)-amine

Also Published As

Publication number Publication date
NZ264633A (en) 1997-09-22
MY112254A (en) 2001-05-31
RU2127269C1 (ru) 1999-03-10
DE69426663T2 (de) 2001-06-21
JPH07188065A (ja) 1995-07-25
SI0650965T1 (en) 2001-06-30
PT650965E (pt) 2001-05-31
DK0650965T3 (da) 2001-02-26
ATE199084T1 (de) 2001-02-15
NO943825L (no) 1995-04-18
CO4290349A1 (es) 1996-04-17
US5362886A (en) 1994-11-08
NO301758B1 (no) 1997-12-08
IL111188A (en) 1998-06-15
RU94035996A (ru) 1996-08-20
BR9404045A (pt) 1995-06-13
EP0650965A1 (en) 1995-05-03
CA2133899A1 (en) 1995-04-13
CN1109470A (zh) 1995-10-04
PE18595A1 (es) 1995-07-13
US5491243A (en) 1996-02-13
EP0650965B1 (en) 2001-02-07
HU220673B1 (hu) 2002-04-29
KR950011434A (ko) 1995-05-15
NO943825D0 (no) 1994-10-10
YU49027B (sh) 2003-07-07
ES2153850T3 (es) 2001-03-16
AU685494B2 (en) 1998-01-22
IL111188A0 (en) 1994-12-29
AU7572094A (en) 1995-05-04
CA2133899C (en) 2007-02-13
PL179600B1 (pl) 2000-09-29
CN1067681C (zh) 2001-06-27
DE69426663D1 (de) 2001-03-15
HUT68943A (en) 1995-08-28
GR3035715T3 (en) 2001-07-31
KR100334585B1 (ko) 2005-07-28
HU9402936D0 (en) 1995-01-30
CZ286122B6 (cs) 2000-01-12
FI944773A7 (fi) 1995-04-13
HU68943D0 (en) 2000-04-28
YU59194A (sh) 1997-03-07
CZ246594A3 (en) 1995-05-17
PH31595A (en) 1998-11-03
TW381090B (en) 2000-02-01
PL305326A1 (en) 1995-04-18
FI944773A0 (fi) 1994-10-11
JP3644986B2 (ja) 2005-05-11
FI944773L (fi) 1995-04-13

Similar Documents

Publication Publication Date Title
IL111188A0 (en) Asymmetric synthesis
AU8794291A (en) New oxazolopyridine derivatives, processes for preparing these and pharmaceutical compositions containing them
AU3775685A (en) Xanthine derivatives
IL86837A (en) Repairing agent for cells and tissues containing as active ingredient an n-acetylneuraminic acid salt
CA2336412A1 (en) Medicament for treatment of diabetes
AU1400801A (en) Aralkyl-1,2-diamines having calcimimetic activity and preparation mode
EP0323757A3 (en) Alkylaminopyrimidine derivative, process for producing the same, and insecticide, acaricide and fungicide containing the same as active ingredient
MX9603004A (es) Guanididas sustituidas del acido cinamico, procedimiento para su preparacion, su empleo como medicamento o agente de diagnostico, asi como medicamento que las contiene.
HUT70531A (en) Arylmorpholine derivatives, pharmaceutical compositions containing them as active agent and process for preparing them
HUT54113A (en) Process for producing butenecarboxylic acid derivatives and pharmaceutical compositions comprising such compounds
ZA846425B (en) Benzoic acid derivatives process for preparation and application as drugs,disinfectants or preservatives
AU7971182A (en) Anthranilic acid derivatives
DE3261606D1 (en) Novel quinolinecarboxylic acid derivative, process for production thereof, and antibacterial agent containing said compound as active ingredient
EP0916656A3 (en) A method for production of pyrrolidinone derivatives
EP0476156A4 (en) Solid oral preparation containing catechol compound
IL69448A (en) Process for combating phytopathogenic fungi with azolylphenoxy-tetrahydrofuran-2-ylidene methane derivatives
WO1995006473A3 (en) Medical use of polysulfonic acid compound
GR3019568T3 (en) Cyclopentane ether derivatives, methods for preparing them and their use in pharmaceuticals
TH16646A (th) การสังเคาะห์แบบอสมมาตร
EP0392015A4 (en) Novel derivatives of physiologically active substance ml-236b and process for their preparation
ES546646A0 (es) Un procedimiento para preparar un compuesto relacionado con arfamenina
IE810944L (en) Imidazole derivatives