GB9317987D0
(en)
*
|
1993-08-26 |
1993-10-13 |
Glaxo Group Ltd |
Chemical compounds
|
IS4208A
(is)
*
|
1993-09-22 |
1995-03-23 |
Glaxo Group Limited |
3-(tetrazólýl-benzyl)amínó-piperadidín afleiður
|
WO1996021661A1
(en)
*
|
1995-01-12 |
1996-07-18 |
Glaxo Group Limited |
Piperidine derivatives having tachykinin antagonist activity
|
GB9505692D0
(en)
*
|
1995-03-21 |
1995-05-10 |
Glaxo Group Ltd |
Chemical compounds
|
GB9513117D0
(en)
*
|
1995-06-28 |
1995-08-30 |
Merck Sharp & Dohme |
Therapeutic agents
|
TW458774B
(en)
|
1995-10-20 |
2001-10-11 |
Pfizer |
Antiemetic pharmaceutical compositions
|
US6211199B1
(en)
|
1995-11-17 |
2001-04-03 |
Aventis Pharmaceuticals Inc. |
Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
|
GB9525296D0
(en)
*
|
1995-12-11 |
1996-02-07 |
Merck Sharp & Dohme |
Therapeutic agents
|
US5998439A
(en)
|
1996-02-21 |
1999-12-07 |
Hoescht Marion Roussel, Inc. |
Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
|
US5932571A
(en)
*
|
1996-02-21 |
1999-08-03 |
Hoechst Marion Roussel, Inc. |
Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
|
US5922737A
(en)
*
|
1996-02-21 |
1999-07-13 |
Hoechst Marion Roussel, Inc. |
Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
|
JP2000514047A
(ja)
*
|
1996-06-26 |
2000-10-24 |
ワーナー―ランバート・コンパニー |
催吐の処置用医薬の製造のためのタキキニンアンタゴニストの使用
|
MX9706196A
(es)
*
|
1996-08-14 |
1998-02-28 |
Pfizer |
Compuestos triciclicos de piperidinilamino como antagonistas de la sustancia p.
|
MX9706944A
(es)
*
|
1996-09-12 |
1998-08-30 |
Pfizer |
Quinuclidinas sustituidas con tetrazolilo como antagonistas de la sustancia p.
|
US6117855A
(en)
*
|
1996-10-07 |
2000-09-12 |
Merck Sharp & Dohme Ltd. |
Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent
|
EP0941092B1
(en)
*
|
1996-12-02 |
2004-12-29 |
MERCK SHARP & DOHME LTD. |
Use of nk-1 receptor antagonists for treating major depressive disorders
|
EP0942731B1
(en)
*
|
1996-12-02 |
2004-11-17 |
MERCK SHARP & DOHME LTD. |
Use of nk-1 receptor antagonists for treating substance use disorders
|
ATE293975T1
(de)
*
|
1996-12-02 |
2005-05-15 |
Merck Sharp & Dohme |
Die verwendung von nk-1 rezeptor antagonisten für die behandlung von kognitiven störungen
|
DE69732492T2
(de)
*
|
1996-12-02 |
2006-03-30 |
Merck Sharp & Dohme Ltd., Hoddesdon |
Verwendung von nk-1 rezeptorantagonisten zur behandlung von schweren depressionen, die von angstzuständen begleitet werden
|
US5977104A
(en)
*
|
1996-12-02 |
1999-11-02 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptor antagonists for treating bipolar disorders
|
ATE282417T1
(de)
*
|
1996-12-02 |
2004-12-15 |
Merck Sharp & Dohme |
Die verwendung von nk-1 rezeptor antagonisten für die behandlung von bewegungsstörungen
|
CA2273807A1
(en)
*
|
1996-12-02 |
1998-06-11 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating schizophrenic disorders
|
ATE274908T1
(de)
*
|
1996-12-02 |
2004-09-15 |
Merck Sharp & Dohme |
Die verwendung von nk-1 rezeptor antagonisten für die behandlungen von stress störungen
|
JP2001504848A
(ja)
*
|
1996-12-02 |
2001-04-10 |
メルク シヤープ エンド ドーム リミテツド |
重症不安障害の治療のためのnk−1受容体拮抗薬の使用
|
JP2001504851A
(ja)
*
|
1996-12-02 |
2001-04-10 |
メルク シヤープ エンド ドーム リミテツド |
性的機能不全の治療のためのnk−1受容体拮抗薬の使用
|
US6613765B1
(en)
|
1996-12-02 |
2003-09-02 |
Merck Sharp & Dohme Limited |
Use of NK-1 receptor antagonists for treating major depressive disorders
|
US6100256A
(en)
*
|
1996-12-02 |
2000-08-08 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptors antagonists for treating schizophrenic disorders
|
US6114315A
(en)
*
|
1996-12-02 |
2000-09-05 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptor antagonists for treating major depressive disorders with anxiety
|
CA2273856A1
(en)
*
|
1996-12-02 |
1998-06-11 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating bipolar disorders
|
US5861417A
(en)
*
|
1996-12-19 |
1999-01-19 |
Hoechst Marion Roussel, Inc. |
Heterocyclic substituted pyrrolidine amide derivatives
|
AU744261B2
(en)
*
|
1997-04-24 |
2002-02-21 |
Merck Sharp & Dohme Limited |
Use of NK-1 receptor antagonists for treating eating disorders
|
JP2002506459A
(ja)
|
1997-06-27 |
2002-02-26 |
メルク シヤープ エンド ドーム リミテツド |
置換された3−(ベンジルアミノ)ピペリジン誘導体およびその治療薬としての使用
|
CA2298779A1
(en)
*
|
1997-08-04 |
1999-02-18 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating aggressive behaviour disorders
|
GB9716457D0
(en)
*
|
1997-08-04 |
1997-10-08 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9716463D0
(en)
*
|
1997-08-04 |
1997-10-08 |
Merck Sharp & Dohme |
Therapeutic agents
|
WO1999007376A1
(en)
*
|
1997-08-04 |
1999-02-18 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating mania
|
GB9723544D0
(en)
*
|
1997-11-07 |
1998-01-07 |
Merck Sharp & Dohme |
Therapeutic agents
|
US6087348A
(en)
*
|
1997-12-01 |
2000-07-11 |
Merck Sharp & Dohme Ltd. |
Use of NK-1 receptor antagonists for treating stress disorders
|
US6271230B1
(en)
|
1997-12-01 |
2001-08-07 |
Merck Sharp & Dohme Limited |
Use of NK-1 receptor antagonists for treating cognitive disorders
|
US6156749A
(en)
*
|
1997-12-01 |
2000-12-05 |
Merck Sharp & Dohme Limited |
Use of NK-1 receptor antagonists for treating movement disorders
|
GB9816897D0
(en)
*
|
1998-08-04 |
1998-09-30 |
Merck Sharp & Dohme |
Therapeutic use
|
EP1152761B1
(en)
*
|
1999-02-18 |
2009-06-24 |
Novasearch AG |
Use of 5-ht3 receptor antagonists for treating musculoeskeletal diseases
|
JP2001039954A
(ja)
*
|
1999-05-24 |
2001-02-13 |
Tomono Agrica Co Ltd |
ヘテロ環誘導体
|
US7163949B1
(en)
|
1999-11-03 |
2007-01-16 |
Amr Technology, Inc. |
4-phenyl substituted tetrahydroisoquinolines and use thereof
|
MXPA02004330A
(es)
|
1999-11-03 |
2004-07-30 |
Albany Molecular Res Inc |
Tetrahidroisoquinolinas aril-y heteroaril-sustituidas y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina..
|
WO2002004455A2
(en)
|
2000-07-11 |
2002-01-17 |
Albany Molecular Research, Inc |
4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
|
WO2002028853A1
(fr)
*
|
2000-10-02 |
2002-04-11 |
Tanabe Seiyaku Co., Ltd. |
Compose de benzylamine, son procede de production et produit intermediaire correspondant
|
WO2002064022A2
(en)
*
|
2001-02-14 |
2002-08-22 |
Duke University |
Therapy for cerebral vasospasm
|
US20040142929A1
(en)
*
|
2001-07-06 |
2004-07-22 |
Ramon Merce-Vidal |
Derivatives of aryl (or heteroaryl) azolylcarbinoles for the treatment of urinary incontinence
|
US20030083345A1
(en)
*
|
2001-07-10 |
2003-05-01 |
Torsten Hoffmann |
Method of treatment and/or prevention of brain, spinal or nerve injury
|
US7491737B2
(en)
*
|
2002-10-30 |
2009-02-17 |
Merck & Co., Inc. |
Heterarylpiperidine modulators of chemokine receptor activity
|
GB0308968D0
(en)
*
|
2003-04-17 |
2003-05-28 |
Glaxo Group Ltd |
Medicaments
|
WO2005012267A1
(ja)
*
|
2003-08-01 |
2005-02-10 |
Toyo Kasei Kogyo Company Limited |
アルコキシ-テトラゾール-1-イル-ベンズアルデヒド化合物およびその製造方法
|
CN1580283A
(zh)
*
|
2003-08-13 |
2005-02-16 |
清华大学 |
一种检测核酸分子的方法
|
ES2347152T3
(es)
*
|
2003-11-26 |
2010-10-26 |
Pfizer Products Inc. |
Derivados de aminopirazol como inhibidores de gsk-3.
|
GB0409098D0
(en)
*
|
2004-04-23 |
2004-05-26 |
Glaxo Group Ltd |
Medicament
|
ZA200701232B
(en)
|
2004-07-15 |
2008-08-27 |
Amr Technology Inc |
Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
|
JP2006137691A
(ja)
*
|
2004-11-11 |
2006-06-01 |
Toyo Kasei Kogyo Co Ltd |
2−アルコキシ−5−テトラゾリル−ベンズアルデヒド化合物の製造方法
|
ATE550019T1
(de)
|
2005-05-17 |
2012-04-15 |
Merck Sharp & Dohme |
Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
|
BRPI0613403A2
(pt)
|
2005-07-15 |
2009-02-10 |
Amr Technology Inc |
tetrahidrobenzodiazepinas aril- e heteroarila-substituÍdas e uso das mesmas para bloquear a recaptaÇço de norepinefrina, dopamina e serotonina
|
RU2008116844A
(ru)
|
2005-09-29 |
2009-11-10 |
Мерк энд Ко., Инк. (US) |
Ацилированные производные спиропиперидина как модуляторы рецептора меланокортина-4
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
CA2664113C
(en)
|
2006-09-22 |
2013-05-28 |
Merck & Co., Inc. |
Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
CL2008000046A1
(es)
|
2007-01-10 |
2008-05-09 |
Angeletti P Ist Richerche Bio |
Compuestos derivados de 2-(4-piperidin-3-il-fenil)-7-amido-2,7a-dihidro-1h-indazol; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar o prevenir el cancer, enfermedades inflamatorias, lesiones por reperfusion, afeccione
|
EP2117538A1
(en)
|
2007-01-24 |
2009-11-18 |
Glaxo Group Limited |
Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)
|
US8106086B2
(en)
|
2007-04-02 |
2012-01-31 |
Msd K.K. |
Indoledione derivative
|
EP2520561B1
(en)
*
|
2007-06-08 |
2016-02-10 |
MannKind Corporation |
IRE-1A Inhibitors
|
EP2170076B1
(en)
|
2007-06-27 |
2016-05-18 |
Merck Sharp & Dohme Corp. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
US8598184B2
(en)
|
2008-03-03 |
2013-12-03 |
Tiger Pharmatech |
Protein kinase inhibitors
|
US9156812B2
(en)
|
2008-06-04 |
2015-10-13 |
Bristol-Myers Squibb Company |
Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
|
WO2010008894A1
(en)
*
|
2008-06-24 |
2010-01-21 |
Valeant Pharmaceuticals International |
Benzyloxy anilide derivatives useful as potassium channel modulators
|
US8691825B2
(en)
|
2009-04-01 |
2014-04-08 |
Merck Sharp & Dohme Corp. |
Inhibitors of AKT activity
|
KR20120034644A
(ko)
|
2009-05-12 |
2012-04-12 |
알바니 몰레큘라 리써치, 인크. |
아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도
|
AU2010247735B2
(en)
|
2009-05-12 |
2015-07-16 |
Albany Molecular Research, Inc. |
Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof
|
ES2662072T3
(es)
|
2009-05-12 |
2018-04-05 |
Albany Molecular Research, Inc. |
7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y uso de la misma
|
MX2012004377A
(es)
|
2009-10-14 |
2012-06-01 |
Merck Sharp & Dohme |
Piperidinas sustituidas que aumentan la actividad de p53 y sus usos.
|
WO2011163330A1
(en)
|
2010-06-24 |
2011-12-29 |
Merck Sharp & Dohme Corp. |
Novel heterocyclic compounds as erk inhibitors
|
AU2011285909B2
(en)
|
2010-08-02 |
2016-11-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
|
EP4079856A1
(en)
|
2010-08-17 |
2022-10-26 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina)
|
EP2608669B1
(en)
|
2010-08-23 |
2016-06-22 |
Merck Sharp & Dohme Corp. |
NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
|
WO2012030685A2
(en)
|
2010-09-01 |
2012-03-08 |
Schering Corporation |
Indazole derivatives useful as erk inhibitors
|
WO2012036997A1
(en)
|
2010-09-16 |
2012-03-22 |
Schering Corporation |
Fused pyrazole derivatives as novel erk inhibitors
|
EP3766975A1
(en)
|
2010-10-29 |
2021-01-20 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
|
WO2012087772A1
(en)
|
2010-12-21 |
2012-06-28 |
Schering Corporation |
Indazole derivatives useful as erk inhibitors
|
AU2012245971A1
(en)
|
2011-04-21 |
2013-10-17 |
Piramal Enterprises Limited |
A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
|
NO2729147T3
(cs)
|
2011-07-04 |
2018-02-03 |
|
|
EP2770987B1
(en)
|
2011-10-27 |
2018-04-04 |
Merck Sharp & Dohme Corp. |
Novel compounds that are erk inhibitors
|
EP2844261B1
(en)
|
2012-05-02 |
2018-10-17 |
Sirna Therapeutics, Inc. |
SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
|
WO2014052563A2
(en)
|
2012-09-28 |
2014-04-03 |
Merck Sharp & Dohme Corp. |
Novel compounds that are erk inhibitors
|
DK2925888T3
(en)
|
2012-11-28 |
2017-12-18 |
Merck Sharp & Dohme |
COMPOSITIONS AND METHODS OF CANCER TREATMENT
|
KR102196882B1
(ko)
|
2012-12-20 |
2020-12-30 |
머크 샤프 앤드 돔 코포레이션 |
Hdm2 억제제로서의 치환된 이미다조피리딘
|
WO2014120748A1
(en)
|
2013-01-30 |
2014-08-07 |
Merck Sharp & Dohme Corp. |
2,6,7,8 substituted purines as hdm2 inhibitors
|
US20160194368A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
EP3525785B1
(en)
|
2016-10-12 |
2025-08-27 |
Merck Sharp & Dohme LLC |
Kdm5 inhibitors
|
KR20250069704A
(ko)
|
2017-06-30 |
2025-05-19 |
체이스 테라퓨틱스 코포레이션 |
우울증을 치료하기 위한 nk-1 길항제 조성물 및 우울증 치료에 사용하는 방법
|
US10947234B2
(en)
|
2017-11-08 |
2021-03-16 |
Merck Sharp & Dohme Corp. |
PRMT5 inhibitors
|
WO2019094312A1
(en)
|
2017-11-08 |
2019-05-16 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
CA3091944A1
(en)
|
2018-02-26 |
2019-08-29 |
Ospedale San Raffaele S.R.L. |
Nk-1 antagonists for use in the treatment of ocular pain
|
EP3833668B1
(en)
|
2018-08-07 |
2025-03-19 |
Merck Sharp & Dohme LLC |
Prmt5 inhibitors
|
WO2020033284A1
(en)
|
2018-08-07 |
2020-02-13 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
CN112805006B
(zh)
|
2018-08-07 |
2024-09-24 |
默沙东有限责任公司 |
Prmt5抑制剂
|
EP4117673A1
(en)
|
2020-03-11 |
2023-01-18 |
Ospedale San Raffaele S.r.l. |
Treatment of stem cell deficiency
|
CN117623228A
(zh)
*
|
2023-12-07 |
2024-03-01 |
江西赣锋锂业集团股份有限公司 |
一种四氢铝锂的制备方法
|
WO2025168119A1
(zh)
*
|
2024-02-08 |
2025-08-14 |
上海数因信科智能科技有限公司 |
四唑类化合物、其药物组合物及其应用
|