HUT73495A - Preparation of stable zinc insulin analog crystals - Google Patents

Preparation of stable zinc insulin analog crystals Download PDF

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Publication number
HUT73495A
HUT73495A HU9501715A HU9501715A HUT73495A HU T73495 A HUT73495 A HU T73495A HU 9501715 A HU9501715 A HU 9501715A HU 9501715 A HU9501715 A HU 9501715A HU T73495 A HUT73495 A HU T73495A
Authority
HU
Hungary
Prior art keywords
pro
lys
solution
zinc
approx
Prior art date
Application number
HU9501715A
Other languages
English (en)
Hungarian (hu)
Other versions
HU9501715D0 (en
Inventor
Jeffrey Clayton Baker
Nancy Delores Carter
Bruce Hill Frank
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22990041&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUT73495(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HU9501715D0 publication Critical patent/HU9501715D0/hu
Publication of HUT73495A publication Critical patent/HUT73495A/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
HU9501715A 1994-06-16 1995-06-13 Preparation of stable zinc insulin analog crystals HUT73495A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/260,647 US5504188A (en) 1994-06-16 1994-06-16 Preparation of stable zinc insulin analog crystals

Publications (2)

Publication Number Publication Date
HU9501715D0 HU9501715D0 (en) 1995-08-28
HUT73495A true HUT73495A (en) 1996-08-28

Family

ID=22990041

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9501715A HUT73495A (en) 1994-06-16 1995-06-13 Preparation of stable zinc insulin analog crystals

Country Status (29)

Country Link
US (1) US5504188A (en, 2012)
EP (1) EP0692489B1 (en, 2012)
JP (1) JP3595607B2 (en, 2012)
KR (1) KR100369951B1 (en, 2012)
CN (1) CN1184234C (en, 2012)
AT (1) ATE233278T1 (en, 2012)
AU (1) AU697794B2 (en, 2012)
BR (1) BR9502798A (en, 2012)
CA (1) CA2151563C (en, 2012)
CO (1) CO4410205A1 (en, 2012)
CZ (1) CZ286066B6 (en, 2012)
DE (1) DE69529708T2 (en, 2012)
DK (1) DK0692489T3 (en, 2012)
ES (1) ES2188637T3 (en, 2012)
FI (1) FI952930A7 (en, 2012)
HU (1) HUT73495A (en, 2012)
IL (1) IL114152A (en, 2012)
IN (1) IN178919B (en, 2012)
MY (1) MY130551A (en, 2012)
NO (1) NO952334L (en, 2012)
NZ (1) NZ272358A (en, 2012)
PE (1) PE21896A1 (en, 2012)
PL (1) PL180968B1 (en, 2012)
RO (1) RO113529B1 (en, 2012)
RU (1) RU2156257C2 (en, 2012)
SI (1) SI0692489T1 (en, 2012)
TW (1) TW379228B (en, 2012)
YU (1) YU39595A (en, 2012)
ZA (1) ZA954942B (en, 2012)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
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RU2205188C2 (ru) 1998-06-30 2003-05-27 Ново Нордиск А/С Затравочные кристаллы для получения пептидов или протеинов
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ATE218364T1 (de) * 1998-10-16 2002-06-15 Novo Nordisk As Stabile konzentrierte insulin präparationen zur pulmonaren verabreichung
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US20040214747A1 (en) * 1999-01-06 2004-10-28 Dimarchi Richard Dennis Method for administering monomeric insulin
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US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7196059B2 (en) * 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
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US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
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CN106117345B (zh) * 2015-05-05 2020-11-24 宜昌东阳光长江药业股份有限公司 一种制备甘精胰岛素结晶的方法
CN104892749B (zh) * 2015-06-16 2019-02-05 珠海联邦制药股份有限公司 一种德谷胰岛素结晶的制备方法及应用
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Also Published As

Publication number Publication date
RU2156257C2 (ru) 2000-09-20
SI0692489T1 (en) 2003-06-30
HU9501715D0 (en) 1995-08-28
TW379228B (en) 2000-01-11
DE69529708T2 (de) 2003-10-16
MY130551A (en) 2007-06-29
AU697794B2 (en) 1998-10-15
NZ272358A (en) 1996-12-20
YU39595A (sh) 1997-08-22
KR960000922A (ko) 1996-01-25
RO113529B1 (ro) 1998-08-28
US5504188A (en) 1996-04-02
FI952930A0 (fi) 1995-06-14
FI952930L (fi) 1995-12-17
RU95110107A (ru) 1997-05-10
CN1128271A (zh) 1996-08-07
ATE233278T1 (de) 2003-03-15
CZ154195A3 (en) 1996-02-14
ES2188637T3 (es) 2003-07-01
CO4410205A1 (es) 1997-01-09
CA2151563A1 (en) 1995-12-17
FI952930A7 (fi) 1995-12-17
EP0692489A1 (en) 1996-01-17
ZA954942B (en) 1996-12-17
JPH08169899A (ja) 1996-07-02
NO952334D0 (no) 1995-06-13
IN178919B (en, 2012) 1997-07-19
AU2168195A (en) 1996-01-04
DK0692489T3 (da) 2003-03-31
CA2151563C (en) 2007-08-07
CN1184234C (zh) 2005-01-12
JP3595607B2 (ja) 2004-12-02
IL114152A (en) 1999-12-31
PL309099A1 (en) 1995-12-27
PE21896A1 (es) 1996-06-15
IL114152A0 (en) 1995-10-31
CZ286066B6 (cs) 2000-01-12
BR9502798A (pt) 1996-06-04
PL180968B1 (pl) 2001-05-31
EP0692489B1 (en) 2003-02-26
KR100369951B1 (ko) 2003-03-28
DE69529708D1 (de) 2003-04-03
NO952334L (no) 1995-12-18

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