BR112013019508A2 - purificação de insulina - Google Patents
purificação de insulinaInfo
- Publication number
- BR112013019508A2 BR112013019508A2 BR112013019508A BR112013019508A BR112013019508A2 BR 112013019508 A2 BR112013019508 A2 BR 112013019508A2 BR 112013019508 A BR112013019508 A BR 112013019508A BR 112013019508 A BR112013019508 A BR 112013019508A BR 112013019508 A2 BR112013019508 A2 BR 112013019508A2
- Authority
- BR
- Brazil
- Prior art keywords
- insulin peptide
- insulin
- protein
- column
- solid phase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11152910 | 2011-02-01 | ||
US201161439544P | 2011-02-04 | 2011-02-04 | |
PCT/EP2012/051662 WO2012104339A1 (en) | 2011-02-01 | 2012-02-01 | Purification of insulin |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013019508A2 true BR112013019508A2 (pt) | 2016-08-30 |
Family
ID=44514301
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013019508A BR112013019508A2 (pt) | 2011-02-01 | 2012-02-01 | purificação de insulina |
Country Status (10)
Country | Link |
---|---|
US (1) | US9447163B2 (pt) |
EP (1) | EP2670773A1 (pt) |
JP (1) | JP6110312B2 (pt) |
KR (1) | KR20140007377A (pt) |
CN (1) | CN103459417B (pt) |
AU (1) | AU2012213432B2 (pt) |
BR (1) | BR112013019508A2 (pt) |
MX (1) | MX342922B (pt) |
RU (1) | RU2603752C2 (pt) |
WO (1) | WO2012104339A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1969004E (pt) | 2005-12-28 | 2011-11-25 | Novo Nordisk As | Composições que compreendem uma insulina acilada e zinco e método para criar tais composições |
RU2013123515A (ru) | 2010-10-27 | 2014-12-10 | Ново Нордиск А/С | Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами |
JP6755175B2 (ja) * | 2013-03-20 | 2020-09-16 | ノヴォ ノルディスク アー/エス | インスリン投薬レジメン |
US10137172B2 (en) | 2013-04-30 | 2018-11-27 | Novo Nordisk A/S | Administration regime |
US10155799B2 (en) | 2014-07-21 | 2018-12-18 | Merck Sharp & Dohme Corp. | Chromatography process for purification of insulin and insulin analogs |
US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
CN108524539B (zh) * | 2018-07-03 | 2019-04-02 | 扬子江药业集团广州海瑞药业有限公司 | 一种平衡盐冲洗液的药物组合物 |
CN111500563B (zh) * | 2020-05-08 | 2023-10-13 | 华兰生物工程重庆有限公司 | 一种从人血浆中纯化人凝血因子ⅶ的方法 |
CN111518193B (zh) * | 2020-06-11 | 2023-09-26 | 南京赛诺生物制药有限公司 | 一种脂肪酸酰化胰岛素和glp-1多肽的纯化方法 |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2693434A (en) | 1950-04-05 | 1954-11-02 | Hoechst Ag | Crystallized insulin preparation and process of preparing same |
GB729670A (en) | 1951-11-15 | 1955-05-11 | Novo Terapeutisk Labor As | Improved process for the production of insulin in crystalline form and crystalline insulin produced thereby |
US3649456A (en) | 1969-09-08 | 1972-03-14 | Rohm & Haas | Separation of polypeptide substances with macroreticular resins |
US3907676A (en) | 1970-07-28 | 1975-09-23 | Novo Terapeutisk Labor As | Process for purifying insulin |
GB1581824A (en) | 1976-01-16 | 1980-12-31 | Leo Sa Lab | Preparation of insulin |
DE2629568C3 (de) | 1976-07-01 | 1981-09-10 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Reinigung von Insulin, seinen Analogen und Derivaten |
NL7713966A (nl) | 1976-12-27 | 1978-06-29 | Univ Minnesota | Werkwijze voor het behandelen van insuline. |
DE3511269A1 (de) | 1985-04-12 | 1986-10-09 | Veb Berlin-Chemie, Ddr 1199 Berlin | Verfahren zur reinigung von insulin |
PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
US4764592A (en) * | 1987-04-23 | 1988-08-16 | Eli Lilly And Company | Crystalline human proinsulin and process for its production |
US5122603A (en) | 1989-03-08 | 1992-06-16 | The University Of Virginia Alumni Patents Foundation | Purified insulin mediators and purification process for same |
US5278284A (en) | 1992-05-14 | 1994-01-11 | Miller Brewing Company | Protein purification method |
DE4406515C1 (de) | 1994-02-28 | 1995-10-19 | Immuno Ag | Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine |
US5504188A (en) | 1994-06-16 | 1996-04-02 | Eli Lilly And Company | Preparation of stable zinc insulin analog crystals |
WO1996040776A1 (en) * | 1995-06-07 | 1996-12-19 | Chiron Corporation | Methods for purifying authentic igf from yeast hosts |
AU5749198A (en) | 1997-02-07 | 1998-08-26 | Novo Nordisk A/S | Crystallisation of proteins |
RU2122549C1 (ru) | 1997-12-29 | 1998-11-27 | Закрытое акционерное общество "Фосфосорб" | Способ хроматографического выделения и очистки белков, пептидов и их комплексов |
ES2245824T3 (es) | 1998-04-15 | 2006-01-16 | Novo Nordisk A/S | Nuevo proceso de separacion de proteinas utilizando un eluyente que contiene ca++. |
US6451987B1 (en) | 1999-03-15 | 2002-09-17 | Novo Nordisk A/S | Ion exchange chromatography of proteins and peptides |
US20030216543A1 (en) | 2001-05-16 | 2003-11-20 | Wang Nien-Hwa Linda | Insulin purification using simulated moving bed technology |
DE10235168A1 (de) | 2002-08-01 | 2004-02-12 | Aventis Pharma Deutschland Gmbh | Verfahren zur Reinigung von Preproinsulin |
US7608583B2 (en) | 2002-12-05 | 2009-10-27 | Wockhardt Limited | Process for the extraction and isolation of insulin from recombinant sources |
RU2251426C1 (ru) * | 2003-09-18 | 2005-05-10 | Цыганков Владимир Владимирович | Способ получения инсулина из природного источника и инсулин |
ES2391776T3 (es) * | 2004-11-22 | 2012-11-29 | Novo Nordisk A/S | Formulaciones solubles, estables conteniendo insulina con una sal de protamina |
PT1969004E (pt) * | 2005-12-28 | 2011-11-25 | Novo Nordisk As | Composições que compreendem uma insulina acilada e zinco e método para criar tais composições |
US20100190210A1 (en) * | 2006-03-20 | 2010-07-29 | Medarex, Inc. | Protein Purification |
MX2008014061A (es) * | 2006-05-09 | 2008-11-14 | Novo Nordisk As | Derivado de insulina. |
RU2322504C1 (ru) | 2006-06-26 | 2008-04-20 | Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук | Способ получения генно-инженерного инсулина человека |
CN101173006B (zh) | 2006-10-30 | 2011-12-21 | 江苏万邦生化医药股份有限公司 | 一种重组人胰岛素的制备方法 |
CA2666607C (en) | 2006-11-01 | 2015-02-10 | Biogen Idec Ma Inc. | Method of isolating biomacromolecules using low ph and divalent cations |
JP5552046B2 (ja) * | 2007-06-13 | 2014-07-16 | ノボ・ノルデイスク・エー/エス | インスリン誘導体を含有する薬学的製剤 |
EP2027875A1 (en) * | 2007-08-23 | 2009-02-25 | Octapharma AG | A Process for Isolation and Purification of a Target Protein free of Prion Protein (PrPSC) |
JP5715418B2 (ja) * | 2007-11-08 | 2015-05-07 | ノボ・ノルデイスク・エー/エス | インスリン誘導体 |
-
2012
- 2012-02-01 RU RU2013137811/10A patent/RU2603752C2/ru not_active IP Right Cessation
- 2012-02-01 BR BR112013019508A patent/BR112013019508A2/pt not_active IP Right Cessation
- 2012-02-01 US US13/980,969 patent/US9447163B2/en not_active Expired - Fee Related
- 2012-02-01 MX MX2013008824A patent/MX342922B/es active IP Right Grant
- 2012-02-01 CN CN201280007328.5A patent/CN103459417B/zh not_active Expired - Fee Related
- 2012-02-01 EP EP12701534.5A patent/EP2670773A1/en not_active Withdrawn
- 2012-02-01 WO PCT/EP2012/051662 patent/WO2012104339A1/en active Application Filing
- 2012-02-01 JP JP2013552191A patent/JP6110312B2/ja not_active Expired - Fee Related
- 2012-02-01 KR KR1020137021460A patent/KR20140007377A/ko not_active Application Discontinuation
- 2012-02-01 AU AU2012213432A patent/AU2012213432B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
AU2012213432A1 (en) | 2013-07-11 |
CN103459417B (zh) | 2018-04-10 |
EP2670773A1 (en) | 2013-12-11 |
MX342922B (es) | 2016-10-19 |
AU2012213432B2 (en) | 2016-10-13 |
JP2014504621A (ja) | 2014-02-24 |
CN103459417A (zh) | 2013-12-18 |
JP6110312B2 (ja) | 2017-04-05 |
RU2013137811A (ru) | 2015-03-10 |
MX2013008824A (es) | 2013-10-07 |
WO2012104339A1 (en) | 2012-08-09 |
US20140073759A1 (en) | 2014-03-13 |
KR20140007377A (ko) | 2014-01-17 |
US9447163B2 (en) | 2016-09-20 |
RU2603752C2 (ru) | 2016-11-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS. |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2551 DE 26-11-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |