MY130551A - Preparation of stable zinc insulin analog crystals - Google Patents
Preparation of stable zinc insulin analog crystalsInfo
- Publication number
- MY130551A MY130551A MYPI95001263A MYPI9501263A MY130551A MY 130551 A MY130551 A MY 130551A MY PI95001263 A MYPI95001263 A MY PI95001263A MY PI9501263 A MYPI9501263 A MY PI9501263A MY 130551 A MY130551 A MY 130551A
- Authority
- MY
- Malaysia
- Prior art keywords
- preparation
- insulin analog
- zinc insulin
- stable zinc
- analog crystals
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/260,647 US5504188A (en) | 1994-06-16 | 1994-06-16 | Preparation of stable zinc insulin analog crystals |
Publications (1)
Publication Number | Publication Date |
---|---|
MY130551A true MY130551A (en) | 2007-06-29 |
Family
ID=22990041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MYPI95001263A MY130551A (en) | 1994-06-16 | 1995-05-12 | Preparation of stable zinc insulin analog crystals |
Country Status (29)
Country | Link |
---|---|
US (1) | US5504188A (en, 2012) |
EP (1) | EP0692489B1 (en, 2012) |
JP (1) | JP3595607B2 (en, 2012) |
KR (1) | KR100369951B1 (en, 2012) |
CN (1) | CN1184234C (en, 2012) |
AT (1) | ATE233278T1 (en, 2012) |
AU (1) | AU697794B2 (en, 2012) |
BR (1) | BR9502798A (en, 2012) |
CA (1) | CA2151563C (en, 2012) |
CO (1) | CO4410205A1 (en, 2012) |
CZ (1) | CZ286066B6 (en, 2012) |
DE (1) | DE69529708T2 (en, 2012) |
DK (1) | DK0692489T3 (en, 2012) |
ES (1) | ES2188637T3 (en, 2012) |
FI (1) | FI952930L (en, 2012) |
HU (1) | HUT73495A (en, 2012) |
IL (1) | IL114152A (en, 2012) |
IN (1) | IN178919B (en, 2012) |
MY (1) | MY130551A (en, 2012) |
NO (1) | NO952334L (en, 2012) |
NZ (1) | NZ272358A (en, 2012) |
PE (1) | PE21896A1 (en, 2012) |
PL (1) | PL180968B1 (en, 2012) |
RO (1) | RO113529B1 (en, 2012) |
RU (1) | RU2156257C2 (en, 2012) |
SI (1) | SI0692489T1 (en, 2012) |
TW (1) | TW379228B (en, 2012) |
YU (1) | YU39595A (en, 2012) |
ZA (1) | ZA954942B (en, 2012) |
Families Citing this family (85)
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US5504188A (en) * | 1994-06-16 | 1996-04-02 | Eli Lilly And Company | Preparation of stable zinc insulin analog crystals |
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US5869604A (en) * | 1995-11-09 | 1999-02-09 | Georgia Institute Of Technology | Crystallization and purification of polypeptides |
US6043214A (en) * | 1997-03-20 | 2000-03-28 | Novo Nordisk A/S | Method for producing powder formulation comprising an insulin |
DE69806582T2 (de) * | 1997-03-20 | 2003-02-13 | Novo Nordisk A/S, Bagsvaerd | Verfahren zur herstellung eines therapeutischen puders durch copräzipitation von insulin und einem absorptionsverstärker |
CA2309955A1 (en) * | 1997-11-12 | 1999-05-20 | Alza Corporation | Method for decreasing self-association of polypeptides |
RU2205188C2 (ru) | 1998-06-30 | 2003-05-27 | Ново Нордиск А/С | Затравочные кристаллы для получения пептидов или протеинов |
US6956021B1 (en) * | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
DE69901726T2 (de) * | 1998-10-16 | 2002-12-19 | Novo Nordisk As | Stabile konzentrierte insulin präparationen zur pulmonaren verabreichung |
US6635617B1 (en) | 1998-10-16 | 2003-10-21 | Novo Nordisk A/S | Insulin preparations for pulmonary delivery containing menthol |
US6211144B1 (en) | 1998-10-16 | 2001-04-03 | Novo Nordisk A/S | Stable concentrated insulin preparations for pulmonary delivery |
CA2346884A1 (en) * | 1998-10-16 | 2000-04-27 | Novo Nordisk A/S | Insulin preparations for pulmonary delivery containing menthol |
US20040214747A1 (en) * | 1999-01-06 | 2004-10-28 | Dimarchi Richard Dennis | Method for administering monomeric insulin |
US7169889B1 (en) * | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
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US6867183B2 (en) * | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US7060675B2 (en) * | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
US6835802B2 (en) * | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
US6828305B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6858580B2 (en) * | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6828297B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US7713932B2 (en) * | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
US6713452B2 (en) * | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6913903B2 (en) * | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US6770625B2 (en) | 2001-09-07 | 2004-08-03 | Nobex Corporation | Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith |
US7196059B2 (en) * | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US7030082B2 (en) * | 2001-09-07 | 2006-04-18 | Nobex Corporation | Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith |
US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US7166571B2 (en) * | 2001-09-07 | 2007-01-23 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US20030068361A1 (en) * | 2001-10-09 | 2003-04-10 | Rimona Margalit | Liposome-encapsulated insulin formulations |
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US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
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US8106090B2 (en) | 2005-07-20 | 2012-01-31 | Eli Lilly And Company | 1-amino linked compounds |
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US20090054305A1 (en) | 2006-03-15 | 2009-02-26 | Novo Nordisk A/S | Mixtures of Amylin and Insulin |
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ES2744384T3 (es) * | 2007-06-13 | 2020-02-24 | Novo Nordisk As | Formulación farmacéutica que comprende un derivado de insulina |
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US20090271021A1 (en) * | 2008-04-28 | 2009-10-29 | Popp Shane M | Execution system for the monitoring and execution of insulin manufacture |
EP2337563B1 (en) | 2008-09-08 | 2014-04-09 | The Board of Trustees of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase activity and methods of use thereof |
WO2010062308A1 (en) | 2008-10-28 | 2010-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase and methods of use thereof |
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CA2750252A1 (en) | 2009-01-28 | 2010-08-05 | Smartcells, Inc. | Synthetic conjugates and uses thereof |
JP2012520879A (ja) | 2009-03-20 | 2012-09-10 | スマートセルズ・インコーポレイテツド | 末端官能基化コンジュゲートおよびその用途 |
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EP2670368A4 (en) | 2011-02-03 | 2015-04-15 | Pharmedica Ltd | NEW ORAL DISSOLUTION FILMS FOR INSULIN DELIVERY FOR THE TREATMENT OF DIABETES |
WO2012115641A1 (en) | 2011-02-23 | 2012-08-30 | Elona Biotechnologies | Lis-pro proinsulin compositions and methods of producing lis-pro insulin analogs therefrom |
US10457659B2 (en) | 2011-04-29 | 2019-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
CN102219851B (zh) * | 2011-05-09 | 2012-05-30 | 甘李药业有限公司 | 甘精胰岛素结晶的制备方法 |
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KR20150135332A (ko) | 2013-03-14 | 2015-12-02 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법 |
CN103342746B (zh) * | 2013-07-26 | 2014-07-30 | 珠海联邦制药股份有限公司 | 一种制备稳定的门冬胰岛素结晶的方法 |
WO2015084694A2 (en) | 2013-12-04 | 2015-06-11 | Merck Sharp & Dohme Corp. | Method for preparing crystalline insulin |
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CN104193819B (zh) * | 2014-09-03 | 2017-05-17 | 韩飞 | 胰岛素二聚体晶体的合成和保存方法 |
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CN104892749B (zh) * | 2015-06-16 | 2019-02-05 | 珠海联邦制药股份有限公司 | 一种德谷胰岛素结晶的制备方法及应用 |
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EP3740212A4 (en) | 2017-12-18 | 2021-10-27 | Merck Sharp & Dohme Corp. | CONJUGATE-BASED SYSTEMS FOR CONTROLLED INSULIN DELIVERY |
EP3727424A4 (en) | 2017-12-18 | 2021-10-27 | Merck Sharp & Dohme Corp. | CONJUGATE-BASED SYSTEMS FOR CONTROLLED INSULIN DELIVERY |
CR20220555A (es) | 2020-03-31 | 2023-01-23 | Protomer Tech Inc | Conjugados para reactividad selectiva a dioles vecinales |
PE20231948A1 (es) | 2020-11-19 | 2023-12-05 | Protomer Tech Inc | Compuestos aromaticos que contienen boro y analogos de insulina |
CN113896784B (zh) * | 2021-10-18 | 2024-04-16 | 合肥天麦生物科技发展有限公司 | 一种胰岛素结晶的制备方法及其产品 |
KR20250004935A (ko) | 2022-05-18 | 2025-01-08 | 프로토머 테크놀로지스 인크. | 방향족 붕소-함유 화합물 및 관련 인슐린 유사체 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE533252A (en, 2012) * | ||||
BE533298A (en, 2012) * | ||||
BE515508A (en, 2012) * | ||||
US2143590A (en) * | 1936-09-26 | 1939-01-10 | Univ Alberta | Insulin preparation and process of producing crystals of insulin |
US2626228A (en) * | 1945-05-17 | 1953-01-20 | Novo Terapeutisk Labor As | Method of producing crystalline insulin |
DK78069C (da) * | 1952-06-23 | 1954-09-06 | Novo Terapeutisk Labor As | Fremgangsmåde til fremstilling af krystallinsk insulin. |
US2920104A (en) | 1958-07-01 | 1960-01-05 | Vanderbilt Co R T | Stabilized solutions of a dithiocarbamate |
US3719655A (en) * | 1969-12-05 | 1973-03-06 | Lilly Co Eli | Process for the crystallization of the ammonium and alkali metal salts in insulin |
DE2933946A1 (de) * | 1979-08-22 | 1981-03-12 | Hoechst Ag, 6000 Frankfurt | Insulinkristallsuspension und verfahren zu ihrer herstellung. |
DE3326472A1 (de) * | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
DE3327709A1 (de) * | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
PH25772A (en) * | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
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DE3717370A1 (de) * | 1987-05-22 | 1988-12-01 | Hoechst Ag | Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus |
US5149777A (en) * | 1988-07-20 | 1992-09-22 | Novo Nordisk A/S | Human insulin analogs and preparations containing them |
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US5504188A (en) * | 1994-06-16 | 1996-04-02 | Eli Lilly And Company | Preparation of stable zinc insulin analog crystals |
US5597893A (en) * | 1994-10-31 | 1997-01-28 | Eli Lilly And Company | Preparation of stable insulin analog crystals |
YU18596A (sh) * | 1995-03-31 | 1998-07-10 | Eli Lilly And Company | Analogne formulacije monomernog insulina |
-
1994
- 1994-06-16 US US08/260,647 patent/US5504188A/en not_active Expired - Lifetime
- 1994-06-29 TW TW083105905A patent/TW379228B/zh not_active IP Right Cessation
-
1995
- 1995-05-12 MY MYPI95001263A patent/MY130551A/en unknown
- 1995-06-12 CA CA002151563A patent/CA2151563C/en not_active Expired - Lifetime
- 1995-06-13 NO NO952334A patent/NO952334L/no not_active Application Discontinuation
- 1995-06-13 HU HU9501715A patent/HUT73495A/hu unknown
- 1995-06-13 YU YU39595A patent/YU39595A/sh unknown
- 1995-06-14 DK DK95304098T patent/DK0692489T3/da active
- 1995-06-14 RU RU95110107/04A patent/RU2156257C2/ru active
- 1995-06-14 PL PL95309099A patent/PL180968B1/pl unknown
- 1995-06-14 RO RO95-01139A patent/RO113529B1/ro unknown
- 1995-06-14 IN IN674CA1995 patent/IN178919B/en unknown
- 1995-06-14 KR KR1019950015780A patent/KR100369951B1/ko not_active Expired - Lifetime
- 1995-06-14 FI FI952930A patent/FI952930L/fi unknown
- 1995-06-14 CZ CZ19951541A patent/CZ286066B6/cs not_active IP Right Cessation
- 1995-06-14 AU AU21681/95A patent/AU697794B2/en not_active Ceased
- 1995-06-14 PE PE1995271264A patent/PE21896A1/es not_active Application Discontinuation
- 1995-06-14 AT AT95304098T patent/ATE233278T1/de not_active IP Right Cessation
- 1995-06-14 NZ NZ272358A patent/NZ272358A/en unknown
- 1995-06-14 BR BR9502798A patent/BR9502798A/pt not_active Application Discontinuation
- 1995-06-14 DE DE69529708T patent/DE69529708T2/de not_active Expired - Lifetime
- 1995-06-14 JP JP14732095A patent/JP3595607B2/ja not_active Expired - Lifetime
- 1995-06-14 IL IL11415295A patent/IL114152A/xx not_active IP Right Cessation
- 1995-06-14 CN CNB951065556A patent/CN1184234C/zh not_active Expired - Lifetime
- 1995-06-14 ES ES95304098T patent/ES2188637T3/es not_active Expired - Lifetime
- 1995-06-14 CO CO95026237A patent/CO4410205A1/es unknown
- 1995-06-14 SI SI9530647T patent/SI0692489T1/xx unknown
- 1995-06-14 EP EP95304098A patent/EP0692489B1/en not_active Expired - Lifetime
- 1995-06-14 ZA ZA954942A patent/ZA954942B/xx unknown
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