MX346473B - Procesos cromatograficos y compuestos purificados de los mismos. - Google Patents

Procesos cromatograficos y compuestos purificados de los mismos.

Info

Publication number
MX346473B
MX346473B MX2012001824A MX2012001824A MX346473B MX 346473 B MX346473 B MX 346473B MX 2012001824 A MX2012001824 A MX 2012001824A MX 2012001824 A MX2012001824 A MX 2012001824A MX 346473 B MX346473 B MX 346473B
Authority
MX
Mexico
Prior art keywords
ion
purified compounds
pairing agents
chromatographic processes
preparative
Prior art date
Application number
MX2012001824A
Other languages
English (en)
Other versions
MX2012001824A (es
Inventor
Dave Nitesh
Shankar Sundaresh
Iyer Harish
Chaitanya Gulla Krishana
Original Assignee
Biocon Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Ltd filed Critical Biocon Ltd
Publication of MX2012001824A publication Critical patent/MX2012001824A/es
Publication of MX346473B publication Critical patent/MX346473B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a la utilidad de los agentes de apareamiento jónico en la escala preparativa de purificación. Más particularmente, la descripción se refiere al uso de agentes de apareamiento jónico en cromatografía lineal preparativa RP permitiendo alta pureza del producto final deseado. La descripción muestra que los agentes de apareamiento iónico tienen un efecto dramático en la pureza deseada de polipéptidos.
MX2012001824A 2009-08-11 2010-08-09 Procesos cromatograficos y compuestos purificados de los mismos. MX346473B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1908CH2009 2009-08-11
PCT/IB2010/053589 WO2011018745A1 (en) 2009-08-11 2010-08-09 Chromatographic processes and purified compounds thereof

Publications (2)

Publication Number Publication Date
MX2012001824A MX2012001824A (es) 2012-03-07
MX346473B true MX346473B (es) 2017-03-22

Family

ID=43585994

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012001824A MX346473B (es) 2009-08-11 2010-08-09 Procesos cromatograficos y compuestos purificados de los mismos.

Country Status (15)

Country Link
US (1) US20120178900A1 (es)
EP (1) EP2464655B1 (es)
JP (1) JP6169354B2 (es)
KR (1) KR20120055653A (es)
CN (1) CN102471368A (es)
BR (1) BR112012002934B1 (es)
ES (1) ES2625125T3 (es)
IL (1) IL217999B (es)
MX (1) MX346473B (es)
MY (1) MY186089A (es)
PL (1) PL2464655T3 (es)
PT (1) PT2464655T (es)
RU (1) RU2508294C2 (es)
SG (1) SG178306A1 (es)
WO (1) WO2011018745A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102471367A (zh) * 2009-07-09 2012-05-23 拜康有限公司 一种制备非线性梯度色谱法及其纯化的产物
CN102584953B (zh) * 2012-02-09 2014-01-01 深圳翰宇药业股份有限公司 一种阿托西班的纯化方法
CN102702321A (zh) * 2012-06-14 2012-10-03 吉尔生化（上海）有限公司 一种纯化依非巴特的方法
US9534029B2 (en) 2012-10-03 2017-01-03 Csl Behring Ag Method of purifying proteins
CN112717125A (zh) * 2012-10-03 2021-04-30 瑞士杰特贝林生物制品有限公司 一种纯化蛋白质的方法
TWI659209B (zh) 2013-06-17 2019-05-11 地平線罕見醫學製藥有限責任公司 分析半胱胺組合物的方法
CN103980350B (zh) * 2013-09-10 2018-01-09 杭州阿诺生物医药科技股份有限公司 一种固环合成阿托西班的方法
JP6709024B2 (ja) * 2015-07-03 2020-06-10 国立研究開発法人医薬基盤・健康・栄養研究所 ペプチド又はタンパク質の分画方法
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN107312072A (zh) * 2017-06-20 2017-11-03 浙江湃肽生物有限公司 一种纯化分离阿托西班的方法
EP3841106A4 (en) 2018-08-20 2022-08-10 Biocon Biologics Limited CHROMATOGRAPHY METHOD FOR PURIFYING INSULIN ANALOGS
JP6564539B1 (ja) * 2018-09-14 2019-08-21 長瀬産業株式会社 スルホン酸化合物によるペプチド精製方法
CN109942686B (zh) * 2019-05-06 2021-06-25 上海上药第一生化药业有限公司 一种加压素乙酰化杂质的精制方法
CN110016070B (zh) * 2019-05-06 2021-07-20 上海上药第一生化药业有限公司 一种加压素[+Gly]杂质的精制方法
CN110028556B (zh) * 2019-05-07 2021-04-13 上海上药第一生化药业有限公司 一种缩宫素[-nh2]杂质的精制方法
CN110078796B (zh) * 2019-05-07 2021-04-13 上海上药第一生化药业有限公司 一种缩宫素[4-Glu,5-Asp]杂质的精制方法
CN110066319B (zh) * 2019-05-07 2021-04-06 上海上药第一生化药业有限公司 一种缩宫素乙酰化杂质的精制方法
CN110078797B (zh) * 2019-05-07 2021-04-13 上海上药第一生化药业有限公司 一种缩宫素[4-Glu]杂质的精制方法
CN110041405B (zh) * 2019-05-07 2021-04-13 上海上药第一生化药业有限公司 一种缩宫素[5-Asp]杂质的精制方法
CN110041406B (zh) * 2019-05-07 2021-04-13 上海上药第一生化药业有限公司 一种缩宫素[+Gly]杂质的精制方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4028120C2 (de) * 1990-09-05 1996-09-19 Hoechst Ag Verfahren zur Reinigung von Insulin und/oder Insulinderivaten
US5208041A (en) * 1991-05-23 1993-05-04 Allelix Biopharmaceuticals Inc. Essentially pure human parathyroid hormone
US5290920A (en) * 1992-04-16 1994-03-01 Allelix Biopharmaceuticals Inc. Method of purifying human epidermal growth factor
US5504188A (en) * 1994-06-16 1996-04-02 Eli Lilly And Company Preparation of stable zinc insulin analog crystals
ES2242270T3 (es) * 1997-02-07 2005-11-01 Novo Nordisk A/S Cristalizacion de proteinas.
HUP0000547A3 (en) * 1997-03-20 2002-11-28 Novo Nordisk As Zinc free insulin crystals for use in pulmonary compositions
ATE464390T1 (de) * 2001-11-19 2010-04-15 Novo Nordisk As Verfahren zur herstellung von insulinverbindungen
KR20040070237A (ko) * 2001-12-20 2004-08-06 일라이 릴리 앤드 캄파니 연장된 작용 시간을 갖는 인슐린 분자
DE10235168A1 (de) * 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
PT1511761E (pt) * 2003-04-07 2006-11-30 Novetide Ltd Processo para produção peptídeos cíclicos
JP2007513192A (ja) * 2004-10-04 2007-05-24 ノベタイド，リミティド ペプチド用の対イオン交換法
JP2008534628A (ja) * 2005-05-03 2008-08-28 ノベタイド，リミティド ペプチド誘導体の製造のための方法
US8067533B2 (en) * 2006-02-23 2011-11-29 Fibrex Medical Research & Development Gmbh Peptides and peptide derivatives, the production thereof as well as their use for preparing a therapeutically and/or preventively active pharmaceutical composition
KR101257330B1 (ko) * 2008-02-06 2013-04-23 바이오콘 리미티드 펩타이드 정제 방법

Also Published As

Publication number Publication date
JP6169354B2 (ja) 2017-07-26
ES2625125T3 (es) 2017-07-18
MX2012001824A (es) 2012-03-07
MY186089A (en) 2021-06-21
CN102471368A (zh) 2012-05-23
BR112012002934A2 (pt) 2016-04-05
BR112012002934B1 (pt) 2021-12-21
IL217999A0 (en) 2012-04-30
EP2464655A4 (en) 2013-04-24
KR20120055653A (ko) 2012-05-31
WO2011018745A1 (en) 2011-02-17
US20120178900A1 (en) 2012-07-12
SG178306A1 (en) 2012-03-29
RU2508294C2 (ru) 2014-02-27
RU2012108039A (ru) 2013-09-20
IL217999B (en) 2018-01-31
EP2464655A1 (en) 2012-06-20
EP2464655B1 (en) 2017-02-15
JP2013501773A (ja) 2013-01-17
PL2464655T3 (pl) 2017-08-31
PT2464655T (pt) 2017-05-25

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