HUT68961A - Tetrahydrocarbozone derivatives an their use as 5 ht1 receptor agonists - Google Patents

Tetrahydrocarbozone derivatives an their use as 5 ht1 receptor agonists

Info

Publication number
HUT68961A
HUT68961A HU9303731A HU9303731A HUT68961A HU T68961 A HUT68961 A HU T68961A HU 9303731 A HU9303731 A HU 9303731A HU 9303731 A HU9303731 A HU 9303731A HU T68961 A HUT68961 A HU T68961A
Authority
HU
Hungary
Prior art keywords
tetrahydrocarbozone
derivatives
receptor agonists
agonists
receptor
Prior art date
Application number
HU9303731A
Other languages
English (en)
Other versions
HU218907B (hu
Inventor
Francis David King
Laramie Mary Gaster
Alberto Julio Kaumann
Rodney Christopher Young
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUT68961(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of HUT68961A publication Critical patent/HUT68961A/hu
Publication of HU218907B publication Critical patent/HU218907B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HU9303731A 1991-06-26 1992-06-17 Eljárás hatóanyagként tetrahidrokarbazol-származékokat tartalmazó gyógyszerkészítmények előállítására, és eljárás a hatóanyagok egy csoportjának előállítására HU218907B (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919113802A GB9113802D0 (en) 1991-06-26 1991-06-26 Medicaments
US08/167,846 US5464864A (en) 1991-06-26 1992-06-17 Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists

Publications (2)

Publication Number Publication Date
HUT68961A true HUT68961A (en) 1995-08-28
HU218907B HU218907B (hu) 2000-12-28

Family

ID=10697363

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9303731A HU218907B (hu) 1991-06-26 1992-06-17 Eljárás hatóanyagként tetrahidrokarbazol-származékokat tartalmazó gyógyszerkészítmények előállítására, és eljárás a hatóanyagok egy csoportjának előállítására

Country Status (35)

Country Link
US (2) US5464864A (hu)
EP (1) EP0591280B1 (hu)
JP (1) JP3261502B2 (hu)
KR (1) KR100251571B1 (hu)
CN (1) CN1034072C (hu)
AP (1) AP344A (hu)
AT (1) ATE170746T1 (hu)
BR (2) BR9206237A (hu)
CA (1) CA2113726C (hu)
CZ (3) CZ150696A3 (hu)
DE (2) DE69226953T2 (hu)
DK (1) DK0591280T3 (hu)
FI (1) FI103967B (hu)
GB (1) GB9113802D0 (hu)
HK (1) HK1014669A1 (hu)
HU (1) HU218907B (hu)
IE (1) IE922062A1 (hu)
IL (4) IL117105A (hu)
LU (1) LU90939I2 (hu)
MA (1) MA22563A1 (hu)
MX (1) MX9203444A (hu)
NL (1) NL300103I2 (hu)
NO (2) NO304774B1 (hu)
NZ (1) NZ243288A (hu)
PL (3) PL169410B1 (hu)
PT (1) PT100620B (hu)
RU (1) RU2137474C1 (hu)
SA (1) SA92130141B1 (hu)
SG (1) SG47877A1 (hu)
SI (1) SI9200125B (hu)
SK (3) SK280905B6 (hu)
TW (1) TW214544B (hu)
UA (1) UA41254C2 (hu)
WO (1) WO1993000086A1 (hu)
ZA (1) ZA924658B (hu)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
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GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
US5616603A (en) * 1995-05-26 1997-04-01 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-HT1 -like agonists
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5618948A (en) * 1995-05-26 1997-04-08 Smithkline Beecham P.L.C. Process for preparing an enantiomer of a carbazole derivative
DE69610793T2 (de) * 1995-06-23 2001-05-03 Eli Lilly And Co., Indianapolis 6-Subsitituierte-1,2,3,4-tetrahydro-9H-Carbazole und 7-substituierte-1OH-Cyclohepta(7,6-B)-Indole
US5917054A (en) * 1995-07-18 1999-06-29 Smithkline Beecham P.L.C. Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9723061D0 (en) * 1997-10-31 1998-01-07 Vanguard Medica Ltd Medicaments
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
GB9808069D0 (en) * 1998-04-16 1998-06-17 Vanguard Medica Ltd Novel processes
GB9817911D0 (en) * 1998-08-17 1998-10-14 Vanguard Medica Ltd New use
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
AU2003249582B2 (en) 2002-06-21 2006-08-03 Suven Life Sciences Limited Tetracyclic arylsulfonyl indoles having serotonin receptor affinity
BR0312175A (pt) 2002-06-21 2005-04-05 Suven Life Sciences Ltd Composto, composição farmacêutica, uso de um composto, método para o tratamento e método para reduzir a morbidez e a mortalidade associadas com o excesso de peso
KR100776118B1 (ko) 2002-11-28 2007-11-15 수벤 라이프 사이언시스 리미티드 엔-아릴술포닐-3-아미노알콕시인돌
ES2310243T3 (es) 2002-11-28 2009-01-01 Suven Life Sciences Limited Indoles n-aril-3-sulfonil sustituidos que tienen afinidad por receptores de serotonina, proceso para su preparacion y composicion farmaceutica que los contiene.
JP4571507B2 (ja) 2002-12-18 2010-10-27 スベン ライフ サイエンシズ リミティド セロトニン受容体親和性を有する四環系３−置換インドール
CN101500996B (zh) * 2006-08-07 2012-07-04 埃科特莱茵药品有限公司 (3-胺基-1,2,3,4-四氢-9h-咔唑-9-基)-乙酸衍生物
SI2124556T1 (sl) 2006-10-09 2015-01-30 Charleston Laboratories, Inc. Farmacevtske sestave
ES2691033T3 (es) 2007-02-11 2018-11-23 Map Pharmaceuticals Inc. Método de administración terapéutica de DHE para activar el alivio rápido de la migraña a la vez que se reduce al mínimo el perfil de los efectos secundarios
US20090069399A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched frovatriptan
US8124126B2 (en) 2008-01-09 2012-02-28 Charleston Laboratories, Inc. Pharmaceutical compositions
WO2010073253A1 (en) * 2008-12-22 2010-07-01 Natco Pharma Limited Method for preparing an optically active frovatriptan
EP2451274B1 (en) 2009-07-08 2017-10-04 Charleston Laboratories, Inc. Pharmaceutical compositions
US10098674B2 (en) 2009-10-22 2018-10-16 Nuvasive, Inc. System and method for posterior cervical fusion
WO2011050140A1 (en) 2009-10-22 2011-04-28 Blue Fury Consulting, L.L.C. Posterior cervical fusion system and techniques
PL2734634T3 (pl) 2011-07-22 2020-03-31 The University Of Chicago Igf-1 do zastosowania do leczenia migreny
AU2013361337A1 (en) 2012-12-21 2015-07-09 Map Pharmaceuticals, Inc. 8'-Hydroxy-Dihydroergotamine compounds and compositions
EP2816030A1 (en) 2013-06-20 2014-12-24 Duke Chem, S. A. Process for the preparation of frovatriptan and its enantiomer
GB201312768D0 (en) * 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
JP2019507181A (ja) 2016-03-04 2019-03-14 チャールストン ラボラトリーズ，インコーポレイテッド 医薬組成物
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
US3959309A (en) * 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
US4062864A (en) * 1968-01-24 1977-12-13 Sterling Drug Inc. 3-Hydroxy carbazole derivatives
US3592824A (en) * 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
BE787537A (fr) * 1971-08-16 1973-02-14 Sterling Drug Inc Tetrahydrocarbazoles
US4172834A (en) * 1971-08-16 1979-10-30 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
US4257952A (en) * 1977-06-06 1981-03-24 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
US4254134A (en) * 1978-03-17 1981-03-03 Endo Laboratories, Inc. Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles
EP0115607A1 (de) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Tetrahydrocarbazolderivate

Also Published As

Publication number Publication date
TW214544B (hu) 1993-10-11
AU1977592A (en) 1993-01-25
US5464864A (en) 1995-11-07
IL117105A0 (en) 1996-06-18
ZA924658B (en) 1993-12-24
SG47877A1 (en) 1998-04-17
DE10299042I2 (de) 2005-02-03
FI935842A0 (fi) 1993-12-23
HU218907B (hu) 2000-12-28
BR9206237A (pt) 1995-04-11
MX9203444A (es) 1993-12-01
SI9200125B (en) 2001-12-31
CZ286193A3 (en) 1994-07-13
SA92130141B1 (ar) 2005-12-18
CN1069726A (zh) 1993-03-10
WO1993000086A1 (en) 1993-01-07
GB9113802D0 (en) 1991-08-14
AP344A (en) 1994-07-05
EP0591280A1 (en) 1994-04-13
CZ282327B6 (cs) 1997-06-11
DE10299042I1 (de) 2003-02-20
CZ282061B6 (cs) 1997-05-14
CA2113726A1 (en) 1993-01-07
NO304774B1 (no) 1999-02-15
SK280907B6 (sk) 2000-09-12
PL169392B1 (pl) 1996-07-31
PL171034B1 (en) 1997-02-28
NO934800D0 (no) 1993-12-23
PL169410B1 (pl) 1996-07-31
BR1100460A (pt) 2000-07-18
SK280905B6 (sk) 2000-09-12
DE69226953D1 (de) 1998-10-15
UA41254C2 (uk) 2001-09-17
NZ243288A (en) 1994-09-27
NO2005011I1 (no) 2005-05-18
IE922062A1 (en) 1992-12-30
CA2113726C (en) 2008-02-19
JPH06508827A (ja) 1994-10-06
DE69226953T2 (de) 1999-05-12
FI103967B1 (fi) 1999-10-29
EP0591280B1 (en) 1998-09-09
NO2005011I2 (no) 2008-02-11
CN1034072C (zh) 1997-02-19
US5637611A (en) 1997-06-10
MA22563A1 (fr) 1992-12-31
PT100620B (pt) 1999-01-29
IL117104A0 (en) 1996-06-18
FI103967B (fi) 1999-10-29
AP9200403A0 (en) 1992-07-31
CZ150596A3 (en) 1997-05-14
IL102322A0 (en) 1993-01-14
IL117105A (en) 1998-01-04
FI935842A (fi) 1993-12-23
ATE170746T1 (de) 1998-09-15
DK0591280T3 (da) 1999-02-15
SK280906B6 (sk) 2000-09-12
CZ282083B6 (cs) 1997-05-14
NL300103I1 (nl) 2002-12-02
PT100620A (pt) 1993-09-30
HK1014669A1 (en) 1999-09-30
AU652842B2 (en) 1994-09-08
RU2137474C1 (ru) 1999-09-20
NO934800L (no) 1993-12-23
JP3261502B2 (ja) 2002-03-04
SK131993A3 (en) 1994-06-08
IL117104A (en) 1997-09-30
KR100251571B1 (ko) 2000-07-01
IL102322A (en) 1997-09-30
CZ150696A3 (en) 1997-06-11
NL300103I2 (nl) 2003-02-03
LU90939I2 (fr) 2002-09-24
SI9200125A (en) 1992-12-31

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Legal Events

Date Code Title Description
DFD9 Temporary protection cancelled due to non-payment of fee
DNF4 Restoration of lapsed final protection
HPC4 Succession in title of patentee

Owner name: VERNALIS LIMITED, GB