HUT64049A - Process for producing (4r-cis)-(1,1-dimethylethyl)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetate, the compound and its intermediates - Google Patents

Process for producing (4r-cis)-(1,1-dimethylethyl)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetate, the compound and its intermediates

Info

Publication number
HUT64049A
HUT64049A HU931122A HU9301122A HUT64049A HU T64049 A HUT64049 A HU T64049A HU 931122 A HU931122 A HU 931122A HU 9301122 A HU9301122 A HU 9301122A HU T64049 A HUT64049 A HU T64049A
Authority
HU
Hungary
Prior art keywords
cyanomethyl
dimethylethyl
dioxane
cis
dimethyl
Prior art date
Application number
HU931122A
Other languages
English (en)
Other versions
HU9301122D0 (en
HU213731B (en
Inventor
Alan Millar
Donald Eugene Butler
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Priority to HU9701183A priority Critical patent/HU219237B/hu
Publication of HU9301122D0 publication Critical patent/HU9301122D0/hu
Publication of HUT64049A publication Critical patent/HUT64049A/hu
Publication of HU213731B publication Critical patent/HU213731B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
HU9301122A 1990-10-17 1991-09-11 Process for producing (4r-cis)-(1,1-dimethylethyl)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetate HU213731B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU9701183A HU219237B (en) 1990-10-17 1991-09-11 (4r-cis)-[(1,1-dimethyl-ethyl)]-6-[substituted]-2,2-dimethyl-1,3-dioxane-4-acetate intermediates and process for producing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/599,521 US5103024A (en) 1990-10-17 1990-10-17 Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate

Publications (3)

Publication Number Publication Date
HU9301122D0 HU9301122D0 (en) 1993-08-30
HUT64049A true HUT64049A (en) 1993-11-29
HU213731B HU213731B (en) 1997-09-29

Family

ID=24399962

Family Applications (2)

Application Number Title Priority Date Filing Date
HU9301122A HU213731B (en) 1990-10-17 1991-09-11 Process for producing (4r-cis)-(1,1-dimethylethyl)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetate
HU9701183A HU219237B (en) 1990-10-17 1991-09-11 (4r-cis)-[(1,1-dimethyl-ethyl)]-6-[substituted]-2,2-dimethyl-1,3-dioxane-4-acetate intermediates and process for producing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU9701183A HU219237B (en) 1990-10-17 1991-09-11 (4r-cis)-[(1,1-dimethyl-ethyl)]-6-[substituted]-2,2-dimethyl-1,3-dioxane-4-acetate intermediates and process for producing them

Country Status (20)

Country Link
US (1) US5103024A (hu)
EP (1) EP0553213B1 (hu)
JP (1) JP3105923B2 (hu)
KR (1) KR0166385B1 (hu)
AT (1) ATE118772T1 (hu)
AU (1) AU646311B2 (hu)
CA (1) CA2092997C (hu)
CZ (5) CZ124697A3 (hu)
DE (1) DE69107622T2 (hu)
DK (1) DK0553213T3 (hu)
ES (1) ES2070519T3 (hu)
FI (1) FI108539B (hu)
HK (1) HK1005026A1 (hu)
HU (2) HU213731B (hu)
IE (1) IE62940B1 (hu)
NO (1) NO301588B1 (hu)
PT (1) PT99244B (hu)
RU (1) RU2067580C1 (hu)
SK (5) SK280941B6 (hu)
WO (1) WO1992006968A1 (hu)

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US5298627A (en) * 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
HRP960312B1 (en) 1995-07-17 2001-10-31 Warner Lambert Co NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1)
US6087511A (en) * 1996-07-16 2000-07-11 Warner-Lambert Company Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1)
WO1999057109A1 (fr) * 1998-04-30 1999-11-11 Kaneka Corporation Procede de production de derives d'acide acetique 6-cyanomethyl-1,3-dioxane-4
HU227840B1 (en) * 1999-05-06 2012-05-02 Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag Intermediates of atorvastatin synthesis and process for producing them
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SI20848A (sl) 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
GEP20053546B (en) 2001-06-29 2005-06-10 Warner Lambert Co Crystalline Forms of 'R-(R*,R*)!-2-(4- Fluorophenyl)-Beta, Delta-Dihydroxy-5-(1-Methylethyl)-3-Phenyl-4-'Phenylamino) Carbonyl!-1H-Pyrrole-1-Heptanoic Acid Calcium Salt (2:1) (Atorvastatin)
GB0116212D0 (en) * 2001-07-03 2001-08-29 Avecia Ltd Process
CN100471836C (zh) 2001-07-30 2009-03-25 雷迪实验室有限公司 托伐他汀钙晶型vi和vii
PE20030324A1 (es) * 2001-07-31 2003-04-03 Warner Lambert Co Composiciones farmaceuticas de amlodipina y atorvastatina
EP1572638A4 (en) * 2001-08-31 2010-05-05 Morepen Lab Ltd IMPROVED PROCESS FOR THE PREPARATION OF AMORPHOUS CALCIUM ATORVASTATIN SALT (2: 1)
HU227124B1 (en) * 2001-09-14 2010-07-28 Egis Gyogyszergyar Nyilvanosan Polymorphs of 1-pyrrole derivative, intermediate for the preparation of atorvastatin
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
CZ296967B6 (cs) * 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
DE10212492B4 (de) * 2002-03-21 2012-02-02 Daimler Ag Kolbenpumpe
US7932064B2 (en) 2002-06-13 2011-04-26 Verenium Corporation Processes for making (R)-ethyl 4-cyano-3-hydroxybutyric acid
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HRP20020885B1 (en) * 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
US20060205804A1 (en) * 2003-04-14 2006-09-14 Nelson James D Process for preparing 5-(4-fluorophenyl)-1-[2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl) ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
US20040248972A1 (en) * 2003-05-16 2004-12-09 Ambit Biosciences Corporation Compounds and uses thereof
EP1626713A2 (en) * 2003-05-16 2006-02-22 Ambit Biosciences Corporation Heterocyclic compounds and uses thereof
US20050182125A1 (en) * 2003-05-16 2005-08-18 Ambit Biosciences Corporation Pyrrole compounds and uses thereof
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
JP4820965B2 (ja) * 2003-07-25 2011-11-24 ブラッドフォード・ファーマ・リミテッド スタチン、特にアトルバスタチンの調製において有用な方法および中間体化合物
MXPA06003003A (es) * 2003-09-17 2006-06-23 Warner Lambert Co Formas cristalinas de acido [r-(r*, r*)]-2-(4- fluorofenil)-(, (-dihidroxi -5-(1- metiletil)-3 -fenil-4 -[(fenilamino) -carbonil]- 1h-pirrol -1-heptanoico.
CA2456430A1 (en) * 2004-01-28 2005-07-28 Brantford Chemicals Inc. Improved process for the preparation of amorphous atorvastatin calcium
CN1942439B (zh) 2004-03-17 2011-12-21 兰贝克赛实验室有限公司 无定形形式的阿托伐他汀钙的制备方法
RU2330840C1 (ru) * 2004-04-16 2008-08-10 Пфайзер Продактс Инк. Способ получения аморфного кальций аторвастатина
CA2649054A1 (en) 2004-05-05 2005-11-10 Pfizer Products Inc. Salt forms of [r-(r*,r*)]-2-(4-fluorophenyl)-.beta., .delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid
CA2833770A1 (en) * 2004-07-16 2006-01-26 Lek Pharmaceuticals D.D Oxidative degradation products of atorvastatin calcium
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JP2008510798A (ja) * 2004-08-27 2008-04-10 バイオコン・リミテッド 非晶質アトルバスタチンカルシウムのための方法
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US4647576A (en) * 1984-09-24 1987-03-03 Warner-Lambert Company Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
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Also Published As

Publication number Publication date
AU8848091A (en) 1992-05-20
HK1005026A1 (en) 1998-12-18
SK280940B6 (sk) 2000-09-12
CZ209495A3 (en) 1997-12-17
CA2092997C (en) 2002-05-14
DK0553213T3 (da) 1995-07-17
ATE118772T1 (de) 1995-03-15
US5103024A (en) 1992-04-07
CZ282993B6 (cs) 1997-12-17
CZ282922B6 (cs) 1997-11-12
SK280938B6 (sk) 2000-09-12
KR0166385B1 (en) 1999-01-15
DE69107622D1 (de) 1995-03-30
HU9701183D0 (en) 1997-09-29
SK33993A3 (en) 1993-10-06
RU2067580C1 (ru) 1996-10-10
DE69107622T2 (de) 1995-07-06
NO301588B1 (no) 1997-11-17
SK280942B6 (sk) 2000-09-12
EP0553213A1 (en) 1993-08-04
CZ282992B6 (cs) 1997-12-17
CZ124797A3 (en) 1997-12-17
IE62940B1 (en) 1995-03-08
HU9301122D0 (en) 1993-08-30
HU213731B (en) 1997-09-29
SK280939B6 (sk) 2000-09-12
JP3105923B2 (ja) 2000-11-06
WO1992006968A1 (en) 1992-04-30
JPH06502162A (ja) 1994-03-10
FI931680A (fi) 1993-04-14
FI108539B (fi) 2002-02-15
SK280941B6 (sk) 2000-09-12
AU646311B2 (en) 1994-02-17
NO931421D0 (no) 1993-04-16
CZ282994B6 (cs) 1997-12-17
NO931421L (no) 1993-06-16
FI931680A0 (fi) 1993-04-14
CZ124697A3 (en) 1997-12-17
KR930702328A (ko) 1993-09-08
PT99244A (pt) 1992-09-30
CZ124597A3 (en) 1997-12-17
CA2092997A1 (en) 1992-04-18
HU219237B (en) 2001-03-28
IE913629A1 (en) 1992-04-22
CZ283003B6 (cs) 1997-12-17
ES2070519T3 (es) 1995-06-01
EP0553213B1 (en) 1995-02-22
PT99244B (pt) 1999-04-30
CZ61493A3 (en) 1994-02-16

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