HUP0500183A2 - Benzimidazol-származékok az ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

Benzimidazol-származékok az ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

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Publication number
HUP0500183A2
HUP0500183A2 HU0500183A HUP0500183A HUP0500183A2 HU P0500183 A2 HUP0500183 A2 HU P0500183A2 HU 0500183 A HU0500183 A HU 0500183A HU P0500183 A HUP0500183 A HU P0500183A HU P0500183 A2 HUP0500183 A2 HU P0500183A2
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group
alkyl
heterocycloalkyl
compounds
formula
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HU0500183A
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English (en)
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Lydie Poitout
Valérie Brault
Eric Ferrandis
Christophe Thurieau
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Société de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.)
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Publication of HUP0500183A2 publication Critical patent/HUP0500183A2/hu
Publication of HU228339B1 publication Critical patent/HU228339B1/hu

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Abstract

A találmány tárgyát az (I) általános képletű vegyületek és azokattartalmazó gyógyszerkészítmények képezik, ahol a képletben A jelentése-CH2- vagy -C(O)-; Y jelentése -S- vagy -NH-, R1 és R2 jelentésehidrogénatom, alkil-, bicikloalkilcsoport, amely adott esetbenalkilcsoporttal helyettesített, vagy -(CH2)n-X képletű csoport, ahol Xjelentése például adott esetben alkilszubsztituált amino-, adamantil-,heterocikloalkil-, aril-, aril-karbonil- vagy heteroarilcsoport, vagyR1 és R2 együtt a kapcsolódó nitrogénatommal együtt például egyheterocikloalkil- vagy heterobicikloalkil-csoportot alkot, R3jelentése -(CH2)p-W3-(CH2)p'-Z3 csoport, W3 jelentése kovalens kötés,-CH(OH)- vagy -C(O)-, Z3 jelentése például alkil-, adamantil-, aril-vagy heteroarilcsoport, p és p' jelentése 0-4 egész szám, R4 jelentése-(CH2)s-R"4 csoport, ahol R"4 jelentése például heterocikloalkil- vagyheteroarilcsoport; amely legalább egy nitrogénatomot tartalmaz, és sjelentése 0-6 értékű egész szám, vagy a vegyületek gyógyászatilagelfogadható sói. A találmány szerinti vegyületek GnRJ-antagonistahatásúak. Ó
HU0500183A 2001-12-21 2002-12-20 Benzimidazole derivatives pharmaceutical compositions containing them and their use HU228339B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0116647A FR2833948B1 (fr) 2001-12-21 2001-12-21 Nouveaux derives de benzimidazole et leur utilisation en tant que medicament
PCT/FR2002/004477 WO2003053939A1 (fr) 2001-12-21 2002-12-20 Derives de benzimidazole et leur utilisation comme antagonistes de gnrh

Publications (2)

Publication Number Publication Date
HUP0500183A2 true HUP0500183A2 (hu) 2005-05-30
HU228339B1 HU228339B1 (en) 2013-03-28

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HU0500183A HU228339B1 (en) 2001-12-21 2002-12-20 Benzimidazole derivatives pharmaceutical compositions containing them and their use

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US (2) US7495110B2 (hu)
EP (1) EP1467974B1 (hu)
JP (1) JP4418679B2 (hu)
KR (1) KR100927500B1 (hu)
CN (1) CN100334077C (hu)
AT (1) ATE370126T1 (hu)
AU (1) AU2002365016B2 (hu)
CA (1) CA2471044C (hu)
CZ (1) CZ2004819A3 (hu)
DE (1) DE60221901T2 (hu)
ES (1) ES2291544T3 (hu)
FR (1) FR2833948B1 (hu)
HK (1) HK1070359A1 (hu)
HU (1) HU228339B1 (hu)
NO (1) NO327105B1 (hu)
NZ (1) NZ533558A (hu)
PL (1) PL212986B1 (hu)
RU (1) RU2294326C2 (hu)
WO (1) WO2003053939A1 (hu)

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EP1467974A1 (fr) 2004-10-20
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