HUP0102613A2 - Amino-ciklohexil-éter-származékok és ezek alkalmazása - Google Patents

Amino-ciklohexil-éter-származékok és ezek alkalmazása

Info

Publication number
HUP0102613A2
HUP0102613A2 HU0102613A HUP0102613A HUP0102613A2 HU P0102613 A2 HUP0102613 A2 HU P0102613A2 HU 0102613 A HU0102613 A HU 0102613A HU P0102613 A HUP0102613 A HU P0102613A HU P0102613 A2 HUP0102613 A2 HU P0102613A2
Authority
HU
Hungary
Prior art keywords
group
atom
ring
azabicyclo
independently
Prior art date
Application number
HU0102613A
Other languages
English (en)
Inventor
Allen I. Bain
Gregory N. Beatch
Cindy J. Longley
Bertrand M. C. Plouvier
Tao Sheng
Michael J. A. Walker
Richard A. Wall
Sandro L. Yong
Jiqun Zhu
Alexander B. Zolotoy
Original Assignee
Nortran Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nortran Pharmaceuticals Inc. filed Critical Nortran Pharmaceuticals Inc.
Publication of HUP0102613A2 publication Critical patent/HUP0102613A2/hu
Publication of HUP0102613A3 publication Critical patent/HUP0102613A3/hu
Publication of HU229993B1 publication Critical patent/HU229993B1/hu

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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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Abstract

A tal lm ny szerinti vegyületek (I) ltal nos képletében X jelentések"zvetlen k"tés vagy -C(R6R14)-Y- vagy -C(R13)=CH- ltal nos képletűcsoport, R1 és R2 jelentése egym stól függetlenül hidrogénatom,alkilcsoport, alkoxialkilcsoport, hidroxialkilcsoport vagyaralkilcsoport vagy R1 és R2 jelentése a kapcsolódó nitrogénatommalegyütt (II) ltal nos képletű gyűrű, amely a nitrogénatom mellett 3-9tov bbi gyűrűatomot tartalmazhat egym stól függetlenül a szénatom,nitrogénatom, oxigénatom és kénatom k"zül megv lasztva, R1 és R2jelentése a kapcsolódó nitrogénatommal együtt 3-azabiciklo[3.2.2]nonn-3-il-csoport, 2-azabiciklo[2.2.2]okt n-2-il-csoport, 3-azabiciklo[3.1.0]hex n-3-il-csoport és 3-azabiciklo[3.2.0.]hept n-3-il-csoport k"zül megv lasztott biciklusos gyűrűrendszert képez, R3 ésR4 jelentése egym stól függetlenül a ciklohex n gyűrűh"z 3-, 4-, 5-vagy 6-helyzetben kapcsolódó szubsztituens, amely egym stólfüggetlenül hidrogénatom, hidroxilcsoport, alkilcsoport vagyalkoxicsoport, vagy R3 és R4 a ciklohex ngyűrű azonos atomj hozkapcsolódik, és együtt spiro "t- vagy hattagú heterociklusos gyűrűtképez, amely egy vagy két heteroatomként oxigénatomot és/vagykénatomot tartalmaz, A jelentése alkilcsoport, karbociklusos gyűrűvagy (III), (IV), (V), (VI), (VII) vagy (VIII) ltal nos képletűgyűrűrendszer, Z jelentése CH, CH2, O, N vagy S. A tal lm ny szerintivegyületek gyógyszer hatóanyagként alkalmazhatók kül"nb"ző betegségek,péld ul szívarrhytmia kezelésére. Ó
HU0102613A 1998-04-01 1999-04-01 Aminocyclohexyl ether compounds and uses thereof HU229993B1 (en)

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