ES8801221A1 - Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina - Google Patents
Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidinaInfo
- Publication number
- ES8801221A1 ES8801221A1 ES557198A ES557198A ES8801221A1 ES 8801221 A1 ES8801221 A1 ES 8801221A1 ES 557198 A ES557198 A ES 557198A ES 557198 A ES557198 A ES 557198A ES 8801221 A1 ES8801221 A1 ES 8801221A1
- Authority
- ES
- Spain
- Prior art keywords
- cyclopenta
- preparation
- pyrimidine derivatives
- hydrogen
- acyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Dental Preparations (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Luminescent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Eyeglasses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Soil Working Implements (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE CICLOPENTADPIRIDINA, DE FORMULA GENERAL (I), Y SUS SALES ESTERES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R2 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO HIDROXIDO, UN GRUPO ALCOXI C1-4 O UN GRUPO ARILOXI; R3 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C1-4; Y R4 Y R5 REPRESENTAN GRUPOS ALQUILO C1-4, GRUPOS ALCOXI C1-4 O GRUPOS HIDROXI, CON TETRAACETATO DE PLOMO, PARA OBTENER UN COMPUESTO DE FORMULA GENERAL (III). EL COMPUESTO OBTENIDO DE FORMULA GENERAL (III), SE HIDROLIZA Y OPCIONALMENTE EL COMPUESTO HIDROLIZADO SE HACE REACCIONAR CON UN HALURO DE FORMULA: R7X, PARA OBTENER EL COMPUESTO DE FORMULA GENERAL BUSCADO. DE APLICACION EN EL TRATAMIENTO DE LA DEPRESION MENTAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4362685 | 1985-03-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES557198A0 ES557198A0 (es) | 1988-01-01 |
ES8801221A1 true ES8801221A1 (es) | 1988-01-01 |
Family
ID=12669058
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES552796A Expired ES8704905A1 (es) | 1985-03-07 | 1986-03-07 | Un procedimiento para la preparacion de nuevos derivados de ciclopenta (d) pirimidina. |
ES557198A Expired ES8801221A1 (es) | 1985-03-07 | 1986-11-14 | Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina |
ES557199A Expired ES8801222A1 (es) | 1985-03-07 | 1986-11-14 | Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES552796A Expired ES8704905A1 (es) | 1985-03-07 | 1986-03-07 | Un procedimiento para la preparacion de nuevos derivados de ciclopenta (d) pirimidina. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES557199A Expired ES8801222A1 (es) | 1985-03-07 | 1986-11-14 | Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina |
Country Status (15)
Country | Link |
---|---|
US (1) | US4749704A (es) |
EP (1) | EP0194161B1 (es) |
JP (1) | JPS6270A (es) |
KR (1) | KR890003839B1 (es) |
AT (1) | ATE106077T1 (es) |
AU (1) | AU580391B2 (es) |
CA (1) | CA1273632A (es) |
DE (1) | DE3689848T2 (es) |
DK (1) | DK165109C (es) |
ES (3) | ES8704905A1 (es) |
FI (1) | FI88717C (es) |
HK (1) | HK1005450A1 (es) |
IE (1) | IE64504B1 (es) |
NO (1) | NO168767C (es) |
ZA (1) | ZA861708B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5037980A (en) * | 1988-04-18 | 1991-08-06 | American Cyanamid Company | Phenyl imidazo[1,2-a]pyrimidines |
US5877178A (en) * | 1991-04-08 | 1999-03-02 | Duquesne University Of The Holy Ghost | Pyrimidine derivatives and methods of making and using these derivatives |
US5234936A (en) * | 1991-10-24 | 1993-08-10 | American Home Products Corporation | Pyrimidocycloalkanes as a ii antagonists |
EP1656354B1 (en) * | 2003-08-12 | 2007-09-26 | F.Hoffmann-La Roche Ag | Tetrahydroquinazoline derivatives as cfr antagonists |
US7568556B2 (en) | 2005-10-26 | 2009-08-04 | Mitsubishi Electric Corporation | Elevator group management control device |
SI2054418T1 (sl) | 2006-07-06 | 2012-02-29 | Array Biopharma Inc | Dihidrotieno pirimidini kot AKT protein kinazni inhibitorji |
US8329701B2 (en) | 2006-07-06 | 2012-12-11 | Array Biopharma Inc. | Dihydrofuro pyrimidines as AKT protein kinase inhibitors |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
KR20150041164A (ko) | 2006-07-06 | 2015-04-15 | 어레이 바이오파마 인크. | Akt 단백질 키나제 억제제로서의 시클로펜타〔d〕피리미딘 |
WO2008021456A2 (en) * | 2006-08-16 | 2008-02-21 | Cytovia, Inc. | N-aryl-5,7-dihydrofuro[3,4-d]pyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
BRPI0813993A2 (pt) | 2007-07-05 | 2015-06-16 | Array Biopharma Inc | Ciclopentanos de pirimidila como inibidores de proteína quinase akt |
US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
CN101801955B (zh) | 2007-07-05 | 2013-05-08 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的嘧啶基环戊烷 |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
CA2711699A1 (en) | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors |
JP5539225B2 (ja) | 2008-01-09 | 2014-07-02 | アレイ バイオファーマ、インコーポレイテッド | Aktタンパク質キナーゼ阻害剤としての水酸化されたピリミジルシクロペンタン |
CN102186757B (zh) | 2008-10-20 | 2013-10-30 | 三菱电机株式会社 | 电梯组群管理装置 |
EP2694073B1 (en) | 2011-04-01 | 2018-08-08 | Genentech, Inc. | Combinations of akt and mek inhibitors for treating cancer |
FI2694072T4 (fi) | 2011-04-01 | 2024-09-30 | Genentech Inc | Akt-inhibiittoriyhdisteen ja abirateronin yhdistelmä käytettäväksi terapeuttisissa hoidoissa |
GB201121127D0 (en) | 2011-12-08 | 2012-01-18 | Dow Corning | Treatment of filler with silane |
CN111303053B (zh) * | 2020-03-16 | 2023-01-17 | 中国海洋大学 | 环戊并[d]嘧啶类化合物及其药学上可接受的盐、溶剂合物或者前药以及应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3470182A (en) * | 1967-02-09 | 1969-09-30 | Sandoz Ag | 4-amino-substituted quinazolines |
US3980650A (en) * | 1972-05-05 | 1976-09-14 | N.V. Koninklijke Pharmaceutische Fabrieken V/H Brocades-Stheeman En Pharmacia | 4-Amino-pyrimidine derivatives |
US3915976A (en) * | 1972-09-01 | 1975-10-28 | Sandoz Ag | Substituted-4-phenyl-5h-cycloalkano(d)pyrimidines |
PH20344A (en) * | 1981-01-29 | 1986-12-04 | Sankyo Co | Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them |
JPS57203072A (en) * | 1981-06-05 | 1982-12-13 | Sankyo Co Ltd | 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient |
-
1986
- 1986-03-06 JP JP61049238A patent/JPS6270A/ja not_active Withdrawn
- 1986-03-06 US US06/837,079 patent/US4749704A/en not_active Expired - Lifetime
- 1986-03-07 EP EP86301660A patent/EP0194161B1/en not_active Expired - Lifetime
- 1986-03-07 DK DK106586A patent/DK165109C/da not_active IP Right Cessation
- 1986-03-07 DE DE3689848T patent/DE3689848T2/de not_active Expired - Fee Related
- 1986-03-07 ZA ZA861708A patent/ZA861708B/xx unknown
- 1986-03-07 KR KR1019860001624A patent/KR890003839B1/ko not_active IP Right Cessation
- 1986-03-07 AU AU54481/86A patent/AU580391B2/en not_active Ceased
- 1986-03-07 FI FI860969A patent/FI88717C/fi not_active IP Right Cessation
- 1986-03-07 CA CA000503571A patent/CA1273632A/en not_active Expired - Lifetime
- 1986-03-07 IE IE59786A patent/IE64504B1/en not_active IP Right Cessation
- 1986-03-07 NO NO860852A patent/NO168767C/no unknown
- 1986-03-07 AT AT86301660T patent/ATE106077T1/de not_active IP Right Cessation
- 1986-03-07 ES ES552796A patent/ES8704905A1/es not_active Expired
- 1986-11-14 ES ES557198A patent/ES8801221A1/es not_active Expired
- 1986-11-14 ES ES557199A patent/ES8801222A1/es not_active Expired
-
1998
- 1998-05-27 HK HK98104569A patent/HK1005450A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES552796A0 (es) | 1987-04-16 |
ES557198A0 (es) | 1988-01-01 |
ATE106077T1 (de) | 1994-06-15 |
AU580391B2 (en) | 1989-01-12 |
ES557199A0 (es) | 1988-01-01 |
ZA861708B (en) | 1986-11-26 |
EP0194161A2 (en) | 1986-09-10 |
NO168767C (no) | 1992-04-01 |
FI88717C (fi) | 1993-06-28 |
DK106586D0 (da) | 1986-03-07 |
NO168767B (no) | 1991-12-23 |
DE3689848T2 (de) | 1995-01-12 |
EP0194161A3 (en) | 1987-09-02 |
ES8801222A1 (es) | 1988-01-01 |
IE64504B1 (en) | 1995-08-09 |
DK165109C (da) | 1993-03-01 |
FI860969A (fi) | 1986-09-08 |
FI88717B (fi) | 1993-03-15 |
CA1273632A (en) | 1990-09-04 |
AU5448186A (en) | 1986-09-11 |
FI860969A0 (fi) | 1986-03-07 |
KR890003839B1 (ko) | 1989-10-05 |
KR860007221A (ko) | 1986-10-08 |
NO860852L (no) | 1986-09-08 |
HK1005450A1 (en) | 1999-01-08 |
DE3689848D1 (de) | 1994-06-30 |
DK106586A (da) | 1986-09-08 |
JPS6270A (ja) | 1987-01-06 |
DK165109B (da) | 1992-10-12 |
EP0194161B1 (en) | 1994-05-25 |
ES8704905A1 (es) | 1987-04-16 |
US4749704A (en) | 1988-06-07 |
IE860597L (en) | 1986-09-07 |
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