HUP9900580A2 - Vírusölő hatású 2-amino-5,6-diklór-benzimidazol-származékok - Google Patents

Vírusölő hatású 2-amino-5,6-diklór-benzimidazol-származékok

Info

Publication number
HUP9900580A2
HUP9900580A2 HU9900580A HUP9900580A HUP9900580A2 HU P9900580 A2 HUP9900580 A2 HU P9900580A2 HU 9900580 A HU9900580 A HU 9900580A HU P9900580 A HUP9900580 A HU P9900580A HU P9900580 A2 HUP9900580 A2 HU P9900580A2
Authority
HU
Hungary
Prior art keywords
alkyl
ring
atom
carbon
compounds
Prior art date
Application number
HU9900580A
Other languages
English (en)
Inventor
Marc W. Anderson
Susan Mary Daluge
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of HUP9900580A2 publication Critical patent/HUP9900580A2/hu
Publication of HUP9900580A3 publication Critical patent/HUP9900580A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgya (I) általánős képletű benzimidazőlszármazékők, ahőlR1 jelentése hidrőgénatőm, 1-4 szénatőmős alkil- vagy 3-5 szénatőmősciklőalkilcsőpőrt, R2 jelentése hidrőgénatőm vagy 1-4 szénatőmősalkilcsőpőrt, vagy R1 és R2 a nitrőgénatőmmal együtt 4 vagy 5-tagúheterőciklűsős gyűrűt képez, R3 jelentése BR4 vagy R4, ahől Bjelentése -C(O)NH-, -C(O)N-(1-4 szénatőmős alkil)- vagy -C(O)O-hídcsőpőrt és R4 jelentése hidrőgénatőm, 1-4 szénatőmős alkil-, 2-6szénatőmős alkenilcsőpőrt, vagy halőgénatőm, előnyösen flűőratőm ésmindegyik n lehet 0, 1 vagy 2, előnyösen 0 vagy 1, és ezek geőmetriaiizőmerei és elegyei és fiziőlógiailag reakcióképes származékai. Atalálmány kiterjed a vegyületek gyógyászati alkalmazására, különösenherpeszvírűsők által őkőzőtt vírűsfertőzések kezelésére vagymegelőzésére. A találmány kiterjed a vegyületek előállítására és avegyületeket tartalmazó gyógyászati készítményekre is. ŕ
HU9900580A 1996-01-05 1997-01-03 2-amino-5,6-dichlorobenzimidazole derivatives having antiviral activity HUP9900580A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9600142.5A GB9600142D0 (en) 1996-01-05 1996-01-05 Chemical compounds

Publications (2)

Publication Number Publication Date
HUP9900580A2 true HUP9900580A2 (hu) 1999-06-28
HUP9900580A3 HUP9900580A3 (en) 2000-01-28

Family

ID=10786609

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900580A HUP9900580A3 (en) 1996-01-05 1997-01-03 2-amino-5,6-dichlorobenzimidazole derivatives having antiviral activity

Country Status (19)

Country Link
US (1) US5998398A (hu)
EP (1) EP0886635A1 (hu)
JP (1) JP2000503017A (hu)
KR (1) KR19990077040A (hu)
CN (1) CN1212683A (hu)
AP (1) AP9801287A0 (hu)
AU (1) AU1438997A (hu)
BR (1) BR9706938A (hu)
CA (1) CA2241893A1 (hu)
CZ (1) CZ212798A3 (hu)
EA (1) EA199800527A1 (hu)
GB (1) GB9600142D0 (hu)
HU (1) HUP9900580A3 (hu)
IS (1) IS4791A (hu)
NO (1) NO983089L (hu)
OA (1) OA10706A (hu)
PL (1) PL327686A1 (hu)
TR (1) TR199801290T2 (hu)
WO (1) WO1997025316A1 (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872742B2 (en) 1996-08-28 2005-03-29 The Procter & Gamble Company Substituted cyclic amine metalloprotease inhibitors
US6413938B1 (en) 1997-02-13 2002-07-02 The Regents Of The University Of Michigan Benzimidazole derivatives for the treatment of viral infections
CA2297076A1 (en) 1997-07-30 1999-02-11 The Regents Of The University Of Michigan Lyxofuranosyl benzimidazoles as antiviral agents
CZ20013424A3 (cs) 1999-12-27 2002-02-13 Japan Tobacco Inc. Sloučeniny s fúzovanými kruhy a jejich pouľití jako léčiva
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
AR035543A1 (es) * 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
WO2003030902A1 (en) 2001-10-09 2003-04-17 Tularik Inc. Imidazole derivates as anti-inflammatory agents
WO2005012288A1 (en) 2003-08-01 2005-02-10 Genelabs Technologies, Inc Bicyclic imidazol derivatives against flaviviridae
NZ561029A (en) * 2005-03-14 2011-03-31 High Point Pharmaceuticals Llc Benzazole dervatives, compositions, and method of use as beta-secretase inhibitors
GB201223265D0 (en) * 2012-12-21 2013-02-06 Selvita Sa Novel benzimidazole derivatives as kinase inhibitors

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4492708A (en) * 1982-09-27 1985-01-08 Eli Lilly And Company Antiviral benzimidazoles
US4996308A (en) * 1988-03-25 1991-02-26 Merrell Dow Pharmaceuticals Inc. Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group
ZA894534B (en) * 1988-06-20 1990-03-28 Merrell Dow Pharma Novel neplanocin derivatives
GB8826205D0 (en) * 1988-11-09 1988-12-14 Wellcome Found Heterocyclic compounds
GB8926417D0 (en) * 1989-11-22 1990-01-10 Wellcome Found Heterocyclic compounds
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
JPH03223264A (ja) * 1990-01-30 1991-10-02 Nippon Kayaku Co Ltd 新規なシクロペンタン誘導体及びその製造法
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
EP0521463A3 (en) * 1991-07-04 1993-04-14 Hoechst Aktiengesellschaft Substituted cyclic cycloalkyltriols, process, intermediates for their preparation and their use as antiviral and antiparasitic agents
JPH05141464A (ja) * 1991-11-15 1993-06-08 Kajima Corp 積層ゴム支承及び該積層ゴム支承を用いた構造物の振動制御装置
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
AU5447094A (en) * 1992-10-21 1994-05-09 Regents Of The University Of Michigan, The Polysubstituted benzimidazoles as antiviral agents
US5399580A (en) * 1993-03-08 1995-03-21 Burroughs Wellcome Co. Therapeutic nucleosides-uses
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
AP741A (en) * 1994-09-09 1999-04-26 The Wellcome Foundation Ltd Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring.

Also Published As

Publication number Publication date
AU1438997A (en) 1997-08-01
CZ212798A3 (cs) 1998-12-16
CA2241893A1 (en) 1997-07-17
NO983089D0 (no) 1998-07-03
KR19990077040A (ko) 1999-10-25
HUP9900580A3 (en) 2000-01-28
AP9801287A0 (en) 1998-09-30
PL327686A1 (en) 1998-12-21
WO1997025316A1 (en) 1997-07-17
EA199800527A1 (ru) 1999-02-25
IS4791A (is) 1998-06-30
US5998398A (en) 1999-12-07
NO983089L (no) 1998-09-01
JP2000503017A (ja) 2000-03-14
TR199801290T2 (xx) 1998-09-21
OA10706A (en) 2001-05-08
CN1212683A (zh) 1999-03-31
GB9600142D0 (en) 1996-03-06
BR9706938A (pt) 1999-04-06
EP0886635A1 (en) 1998-12-30

Similar Documents

Publication Publication Date Title
HUP0101999A2 (hu) 4-Hidroxi-kinolin-3-karboxamid- és -hidrazid-származékok, ezeket tartalmazó gyógyászati készítmények, valamint e vegyületek alkalmazása
HUP0203971A2 (hu) Imidazoimidazolok és -triazolok mint gyulladásellenes szerek és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
DE69817393D1 (de) Neue heterozyklische verbindungen
HUP0400710A2 (hu) Tioéter helyettesítővel helyettesített imidazokinolinszármazékok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
DK602988D0 (da) Nukleosidderivater med antiviral virkning og laegemiddelpraeparat indeholdende saadanne forbindelser
DE60140456D1 (de) Aza heterocyclische derivate und ihre therapeutische verwendung
LU90839I2 (fr) Kaletra-combinaison de lopinavir et de ritonavir et ses d-riv-s pharmaceutiquement acceptables
HUP0102613A2 (hu) Amino-ciklohexil-éter-származékok és ezek alkalmazása
EP0930310A4 (en) ISOCOUMARIN DERIVATIVES AND THE USE THEREOF IN MEDICINES
HUP0401083A2 (hu) 4-Amino-6-fenil-pirrolo[2,3-d]pirimidin-származékok, ezeket tartalmazó gyógyászati készítmények és eljárás a vegyületek előállítására
BR9815166A (pt) "método de inibição da replicação de vìrus, composto, método de inibição da replicação de citomegalovìrus, composto antiviral, utilização de um composto, composição farmacêutica, composição farmacêutica inibidora da replicação de vìrus e de citomegalovìrus e composição farmacêutica antiviral"
HUP0400837A2 (hu) 2-feniltiazol-származékok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
HUP0500831A2 (hu) Helyettesített tioacetamidok és alkalmazásuk, valamint ilyen tioacetamidszármazékokat tartalmazó gyógyszerkészítmények
HUP9900580A2 (hu) Vírusölő hatású 2-amino-5,6-diklór-benzimidazol-származékok
ES2010091A6 (es) Un metodo para preparar compuestos analogos a nucleosidos didesoxicarbociclicos.
EP0380048A3 (en) Use of benzoyl urea derivatives as antiviral agents
HUP9801356A2 (hu) Triciklusos (2-hidroxi-2-metil-3,3,3-trifluor-propanoil)-amino-benzoxepin-, -benzotiepin-, -benzocikloheptén-, -indén-származékok és az ezeket tartalmazó gyógyszerkészítmények
ATE211468T1 (de) Neuraminsäuredervate, ihre herstellung und medizinische verwendung
ATE233754T1 (de) Diphenyl-piperidin derivate
TW360652B (en) Acryloyl substituted disstamycin derivatives, process for preparing them, and pharmaceutical composition comprising them
DK0915894T3 (da) Nukleotidanaloger
HUP0104033A2 (hu) Benzoilpiridazin-származékok, a vegyületeket tartalmazó gyógyszerkészítmények, eljárás az előállításukra és alkalmazásuk
ATE56006T1 (de) Succinimide derivate, herstellung und anwendung.
NO304486B1 (no) Oksazolidonderivater og anvendelser derav, og midler og medisinske preparater omfattende slike oksazolidonderivater
HUP9702393A2 (hu) bisz(2-Halogén-etil)-amino-fenil szubsztituált distamycinszármazékok, tumorellenes és vírusellenes hatóanyagok