EA199800527A1 - Производнфе 2-амино-5,6-дихлорбензимидазола, обладающие противовирусной активностью - Google Patents

Производнфе 2-амино-5,6-дихлорбензимидазола, обладающие противовирусной активностью

Info

Publication number
EA199800527A1
EA199800527A1 EA199800527A EA199800527A EA199800527A1 EA 199800527 A1 EA199800527 A1 EA 199800527A1 EA 199800527 A EA199800527 A EA 199800527A EA 199800527 A EA199800527 A EA 199800527A EA 199800527 A1 EA199800527 A1 EA 199800527A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
dichlorobenzimidazole
owned
amino
production
Prior art date
Application number
EA199800527A
Other languages
English (en)
Inventor
Сьюзан Мэри Дэлюдж
Марк У. Андерсон
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of EA199800527A1 publication Critical patent/EA199800527A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к производным бензимидазола формулы (I), где: Rпредставляет собой Н, Салкил, Сциклоалкил; Rпредставляет собой Н, Салкил; или Rи Rвместе с азотом формируют 4 или 5 членное гетероциклическое кольцо; Rпредставляет собой BRили R, где В представляет собой мостиковую группу -C(O)NH-, -С(O)NCалкил или -С(O)O- и Rпредставляет собой Н, Салкил, Салкенил или галогеногруппу (предпочтительно фтор-); и каждое n является целым числом, независимо выбранным из 0, 1 или 2 (предпочтительно 0 или 1); и геометрическим изомерам или их смесям; и их физиологически функциональным производным, и их применению в медицинской терапии, в частности, для лечения или профилактики вирусных инфекций, таких как инфекции, вызванные вирусом герпеса. Изобретение также относится к их получению и фармацевтическим препаратам, содержащим их.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800527A 1996-01-05 1997-01-03 Производнфе 2-амино-5,6-дихлорбензимидазола, обладающие противовирусной активностью EA199800527A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9600142.5A GB9600142D0 (en) 1996-01-05 1996-01-05 Chemical compounds
PCT/EP1997/000018 WO1997025316A1 (en) 1996-01-05 1997-01-03 2-amino-5,6-dichlorobenzimidazole derivatives having antiviral activity

Publications (1)

Publication Number Publication Date
EA199800527A1 true EA199800527A1 (ru) 1999-02-25

Family

ID=10786609

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800527A EA199800527A1 (ru) 1996-01-05 1997-01-03 Производнфе 2-амино-5,6-дихлорбензимидазола, обладающие противовирусной активностью

Country Status (19)

Country Link
US (1) US5998398A (ru)
EP (1) EP0886635A1 (ru)
JP (1) JP2000503017A (ru)
KR (1) KR19990077040A (ru)
CN (1) CN1212683A (ru)
AP (1) AP9801287A0 (ru)
AU (1) AU1438997A (ru)
BR (1) BR9706938A (ru)
CA (1) CA2241893A1 (ru)
CZ (1) CZ212798A3 (ru)
EA (1) EA199800527A1 (ru)
GB (1) GB9600142D0 (ru)
HU (1) HUP9900580A3 (ru)
IS (1) IS4791A (ru)
NO (1) NO983089L (ru)
OA (1) OA10706A (ru)
PL (1) PL327686A1 (ru)
TR (1) TR199801290T2 (ru)
WO (1) WO1997025316A1 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872742B2 (en) 1996-08-28 2005-03-29 The Procter & Gamble Company Substituted cyclic amine metalloprotease inhibitors
AU6221998A (en) 1997-02-13 1998-09-08 Glaxo Group Limited Benzimidazole derivatives
US6455506B1 (en) 1997-07-30 2002-09-24 Smithkline Beecham Corporation Lyxofuranosyl benzimidazoles as antiviral agents
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
ID30204A (id) 1999-12-27 2001-11-15 Japan Tobacco Inc Senyawa-senyawa cincin terfusi dan penggunaannya sebagai obat
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
AR035543A1 (es) * 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
JP4445262B2 (ja) 2001-10-09 2010-04-07 アムジェン インコーポレイテッド 抗炎症剤としてのイミダゾール誘導体
AU2004261667A1 (en) 2003-08-01 2005-02-10 Genelabs Technologies, Inc. Bicyclic imidazol derivatives against Flaviviridae
JP5066514B2 (ja) * 2005-03-14 2012-11-07 ハイ ポイント ファーマシューティカルズ，エルエルシー ベンズアゾール誘導体、組成物及びβ−セクレターゼ阻害剤としての使用方法
GB201223265D0 (en) * 2012-12-21 2013-02-06 Selvita Sa Novel benzimidazole derivatives as kinase inhibitors

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4492708A (en) * 1982-09-27 1985-01-08 Eli Lilly And Company Antiviral benzimidazoles
US4996308A (en) * 1988-03-25 1991-02-26 Merrell Dow Pharmaceuticals Inc. Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group
ZA894534B (en) * 1988-06-20 1990-03-28 Merrell Dow Pharma Novel neplanocin derivatives
GB8826205D0 (en) * 1988-11-09 1988-12-14 Wellcome Found Heterocyclic compounds
GB8926417D0 (en) * 1989-11-22 1990-01-10 Wellcome Found Heterocyclic compounds
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
JPH03223264A (ja) * 1990-01-30 1991-10-02 Nippon Kayaku Co Ltd 新規なシクロペンタン誘導体及びその製造法
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
EP0521463A3 (en) * 1991-07-04 1993-04-14 Hoechst Aktiengesellschaft Substituted cyclic cycloalkyltriols, process, intermediates for their preparation and their use as antiviral and antiparasitic agents
JPH05141464A (ja) * 1991-11-15 1993-06-08 Kajima Corp 積層ゴム支承及び該積層ゴム支承を用いた構造物の振動制御装置
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
WO1994008456A1 (en) * 1992-10-21 1994-04-28 The Regents Of The University Of Michigan Polysubstituted benzimidazoles as antiviral agents
US5399580A (en) * 1993-03-08 1995-03-21 Burroughs Wellcome Co. Therapeutic nucleosides-uses
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
AU3692895A (en) * 1994-09-09 1996-03-27 Regents Of The University Of Michigan, The Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring

Also Published As

Publication number Publication date
PL327686A1 (en) 1998-12-21
TR199801290T2 (xx) 1998-09-21
CA2241893A1 (en) 1997-07-17
WO1997025316A1 (en) 1997-07-17
GB9600142D0 (en) 1996-03-06
US5998398A (en) 1999-12-07
BR9706938A (pt) 1999-04-06
NO983089L (no) 1998-09-01
KR19990077040A (ko) 1999-10-25
JP2000503017A (ja) 2000-03-14
HUP9900580A3 (en) 2000-01-28
EP0886635A1 (en) 1998-12-30
NO983089D0 (no) 1998-07-03
AU1438997A (en) 1997-08-01
HUP9900580A2 (hu) 1999-06-28
OA10706A (en) 2001-05-08
CZ212798A3 (cs) 1998-12-16
CN1212683A (zh) 1999-03-31
AP9801287A0 (en) 1998-09-30
IS4791A (is) 1998-06-30

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