BE2011C002I2 - Aminocyclohexyl ether compounds and uses thereof - Google Patents

Aminocyclohexyl ether compounds and uses thereof

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Publication number
BE2011C002I2
BE2011C002I2 BE2011C002C BE2011C002C BE2011C002I2 BE 2011C002 I2 BE2011C002 I2 BE 2011C002I2 BE 2011C002 C BE2011C002 C BE 2011C002C BE 2011C002 C BE2011C002 C BE 2011C002C BE 2011C002 I2 BE2011C002 I2 BE 2011C002I2
Authority
BE
Belgium
Prior art keywords
ether compounds
compounds
aminocyclohexyl ether
compositions
formula
Prior art date
Application number
BE2011C002C
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English (en)
Original Assignee
Cardiome Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Cardiome Pharma Corp filed Critical Cardiome Pharma Corp
Publication of BE2011C002I2 publication Critical patent/BE2011C002I2/fr

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    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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BE2011C002C 1998-04-01 2011-01-20 Aminocyclohexyl ether compounds and uses thereof BE2011C002I2 (en)

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US8034798P 1998-04-01 1998-04-01
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PCT/CA1999/000280 WO1999050225A1 (fr) 1998-04-01 1999-04-01 Composes d'aminocyclohexyl ether et leurs applications
EP99911550A EP1087934B1 (fr) 1998-04-01 1999-04-01 Composes d'aminocyclohexyl ether et leurs applications

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Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU751772C (en) 1998-04-01 2006-09-07 Correvio International Sàrl Aminocyclohexyl ether compounds and uses thereof
US7507545B2 (en) 1999-03-31 2009-03-24 Cardiome Pharma Corp. Ion channel modulating activity method
DE10049481A1 (de) 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte C-Cyclohexylmethylamin-Derivate
US7057053B2 (en) 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US7524879B2 (en) * 2000-10-06 2009-04-28 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
DE10213051B4 (de) * 2002-03-23 2013-03-07 Grünenthal GmbH Substituierte 4-Aminocyclohexanole
WO2003105756A2 (fr) * 2002-06-14 2003-12-24 Johnson Matthey Pharmaceutical Materials, Inc. Synthese stereoselective de cycloalkyles substitues en positions 1 et 2
US7345086B2 (en) 2003-05-02 2008-03-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
US20090041841A1 (en) * 2003-05-02 2009-02-12 Cardiome Pharma Corp. Controlled release tablet formulations for the prevention of arrhythmias
US20080063707A1 (en) * 2003-05-02 2008-03-13 Cardiome Pharma Corp. Controlled release tablet formulations for the prevention of arrhythmias
PL227937B1 (pl) 2003-05-02 2018-01-31 Cardiome Pharma Corp Sposób wytwarzania związku typu eteru aminocykloheksylowego, związek typu eteru aminocykloheksylowego, jego kompozycja, sposób modulowania aktywności kanałów jonowych, oraz zastosowanie związku typu eteru aminocykloheksylowego do wytwarzania leku
CN100441568C (zh) * 2003-05-02 2008-12-10 卡迪欧梅制药公司 氨基环己基醚化合物和它们的用途
US20060094880A9 (en) * 2003-06-04 2006-05-04 Barrett Anthony G M Synthetic process for trans-aminocyclohexyl ether compounds
WO2005018635A2 (fr) * 2003-08-07 2005-03-03 Cardiome Pharma Corp. Activite i modulant des canaux ioniques
US7345087B2 (en) 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
WO2005097203A2 (fr) * 2004-04-01 2005-10-20 Cardiome Pharma Corp. Conjugues de proteine serique de composes de modulation du canal ionique, utilisations de ces derniers
WO2005097869A1 (fr) * 2004-04-01 2005-10-20 Cardiome Pharma Corp. Polymeres comprenant des composes modulateurs de canaux ioniques et utilisations de ceux-ci
WO2005094897A2 (fr) * 2004-04-01 2005-10-13 Cardiome Pharma Corp. Derives de composes de modulation des canaux ioniques, compositions pharmaceutiques et utilisations
US7705036B2 (en) 2004-04-01 2010-04-27 Cardiome Pharma Corp. Deuterated aminocyclohexyl ether compounds and processes for preparing same
US8058304B2 (en) 2004-04-01 2011-11-15 Cardiome Pharma Corp. Merged ion channel modulating compounds and uses thereof
US7977373B2 (en) 2004-04-01 2011-07-12 Cardiome Pharma Corp. Prodrugs of ion channel modulating compounds and uses thereof
CA2586918C (fr) 2004-11-08 2021-01-19 Cardiome Pharma Corp. Utilisations de composes modulant les canaux ioniques pour le traitement de la fibrillation auriculaire aigue chez l'humain
US8692002B2 (en) * 2004-11-18 2014-04-08 Cardiome Pharma Corp. Synthetic process for aminocyclohexyl ether compounds
AR053710A1 (es) * 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
AR056968A1 (es) 2005-04-11 2007-11-07 Xenon Pharmaceuticals Inc Compuestos espiro-oxindol y composiciones farmacéuticas
GB0510164D0 (en) * 2005-04-28 2005-06-22 Paradigm Therapeutics Ltd Ion channel
MX346530B (es) 2005-06-15 2017-03-22 Cardiome Pharma Corp Procedimiento sintético para la preparación de compuestos de éter aminociclohexílico.
JPWO2007055180A1 (ja) * 2005-11-09 2009-04-30 東レ・ファインケミカル株式会社 光学活性トランス−2−アミノシクロヘキサノールおよびその誘導体の製造方法
TW200833695A (en) 2006-10-12 2008-08-16 Xenon Pharmaceuticals Inc Use of spiro-oxindole compounds as therapeutic agents
WO2008046087A2 (fr) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Composés spiro et leurs utilisations en tant qu'agents thérapeutiques
NZ581351A (en) * 2007-05-04 2012-07-27 Cardiome Pharma Corp Controlled release oral formulations of vernakalant hydrochloride and related methods for preventing arrhythmia
RU2011119626A (ru) 2008-10-17 2012-11-27 Ксенон Фармасьютикалз Инк. Спирооксиндольные соединения и их применение в качестве терапевтичеких средств
US8101647B2 (en) 2008-10-17 2012-01-24 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
EP2488531B1 (fr) 2009-10-14 2014-03-26 Xenon Pharmaceuticals Inc. Procédés de synthèse pour des composés spiro-oxindoles
WO2011106729A2 (fr) 2010-02-26 2011-09-01 Xenon Pharmaceuticals Inc. Compositions pharmaceutiques de composé spiro-oxindole pour administration topique et leur utilisation en tant qu'agents thérapeutiques.
EP2605772B1 (fr) 2010-08-16 2016-06-22 Cardiome International AG Procédé de préparation de composés d'éther d'aminocyclohexyle
US9681836B2 (en) 2012-04-23 2017-06-20 Cyberonics, Inc. Methods, systems and apparatuses for detecting seizure and non-seizure states
WO2016127068A1 (fr) 2015-02-05 2016-08-11 Teva Pharmaceuticals International Gmbh Procédés de traitement d'une névralgie post-herpétique à l'aide d'une formule topique d'un composé de spiro-oxindole
CN114031535B (zh) * 2021-11-30 2023-08-25 上海旭东海普药业有限公司 一种改进的盐酸维纳卡兰的合成方法

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2954380A (en) 1958-11-26 1960-09-27 Us Vitamin Pharm Corp Piperazinocyclohexyl esters
US3218328A (en) 1963-02-18 1965-11-16 U S Vitamin & Pharmacentical C Heterocyclic amino phenoxyacetic acids, acid addition salts and quaternary ammonium salts thereof
DE2259260A1 (de) 1972-12-04 1974-06-06 Merck Patent Gmbh Neue amine
US4179501A (en) 1976-11-12 1979-12-18 The Upjohn Company Analgesic N-(2-aminocycloaliphatic)azidobenzamides
US4145435A (en) 1976-11-12 1979-03-20 The Upjohn Company 2-aminocycloaliphatic amide compounds
DE2658401A1 (de) 1976-12-23 1978-07-06 Merck Patent Gmbh Cyclopentan-1-amine, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
US4598087A (en) 1983-12-06 1986-07-01 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
US4656182A (en) 1983-12-06 1987-04-07 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
SE8502455L (sv) 1984-05-18 1985-11-19 Glaxo Group Ltd Aminocyklopentyletrar och deras framstellning samt farmaceutisk beredning
US4663343A (en) 1985-07-19 1987-05-05 Warner-Lambert Company Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds
EP0248824B1 (fr) 1985-10-25 1990-01-17 The Upjohn Company L'usage de l'acetamide et de la Benzamide de CIS N- (2-Aminocycloaliphatique) Benzene pour la fabrication des anti-convulsifs
US5059620A (en) 1985-12-27 1991-10-22 The Du Pont Merck Pharmaceutical Company Aryl substituted aminomethyl benzene derivatives
US4855316A (en) 1988-02-18 1989-08-08 Warner-Lambert Company 1,2-diamino-4,5-dimethoxycyclohexyl amide analgesic compounds
US5051428A (en) 1988-12-06 1991-09-24 Warner-Lambert Company 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics
AU626949B2 (en) 1988-12-06 1992-08-13 Warner-Lambert Company 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics
US4906655A (en) 1989-01-24 1990-03-06 Warner-Lambert Company Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents
JPH02270864A (ja) 1989-04-12 1990-11-05 Asahi Glass Co Ltd フルオロカルバサイクリックヌクレオシドおよびその製造法
ZA929008B (en) 1991-12-13 1993-05-21 Bristol Myers Squibb Co Piperazinyl- and piperidinyl-cyclohexanols.
CA2058502A1 (fr) 1991-12-27 1993-06-28 David C. Horwell 2-aminomonomethoxycyclohexanecarboxamides, utiles comme analgesiques
EP0552386A1 (fr) 1992-01-13 1993-07-28 Warner-Lambert Company Dérivés 2-amino-3 ou 6-méthoxy cyclohexyl-amides
US5506257A (en) 1992-03-26 1996-04-09 University Of British Columbia Aminocyclohexylamides for antiarrhythmic and anaesthetic uses
EP0632806B1 (fr) * 1992-03-26 1997-07-02 The University Of British Columbia Aminocyclohexylamides destines a des utilisations antiarythmiques et anesthesiques
GB9220286D0 (en) 1992-09-25 1992-11-11 Merck Sharp & Dohme Therapeutic agents
US5451596A (en) * 1992-12-29 1995-09-19 Rhone Poulenc Rorer Pharmaceuticals Inc. Cycloalkyl amine bis-aryl squalene synthase inhibitors
US5747278A (en) 1993-05-21 1998-05-05 California Institute Of Technology DNA encoding inward rectifier, G-protein activated, mammalian, potassium KGA channel and uses thereof
US5492825A (en) 1993-08-06 1996-02-20 The Regents Of The University Of California Mammalian inward rectifier potassium channel cDNA, IRK1, corresponding vectors, and transformed cells
DE69429524T2 (de) 1993-09-24 2002-08-08 Univ British Columbia Aminocyclohexylester und ihre anwendung
GB9406043D0 (en) 1994-03-26 1994-05-18 Smithkline Beecham Plc Compounds
US5441946A (en) 1994-04-14 1995-08-15 Rhone-Poulenc-Rorer Pharmaceuticals, Inc. Phosphonate derivatives of lipophilic amines
ES2167457T3 (es) 1994-09-19 2002-05-16 Fujisawa Pharmaceutical Co Nuevo uso medicinal de un antagonista de 5ht3.
US5556990A (en) 1994-12-16 1996-09-17 Rhone-Poulenc Rorer Pharmaceuticals Inc. Polyarylcarbamoylaza- and -carbamoylalkanedioic acids
EP0801683B1 (fr) 1995-02-03 2002-05-02 Basf Aktiengesellschaft Separation des racemates d'amines primaires et secondaires substituees par des heteroatomes par acylation catalysee par des enzymes
PL328199A1 (en) 1996-01-25 1999-01-18 Schering Ag Improved concentrated intravascular injection and infusion solutions
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5646151A (en) 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
KR20000022274A (ko) 1996-06-27 2000-04-25 스튜어트 알. 수터, 스티븐 베네티아너, 피터 존 기딩스 Il-8 수용체 길항제
US5935945A (en) 1996-10-31 1999-08-10 Merck & Co., Inc. Methods of treating or preventing cardiac arrhythmia
US6180632B1 (en) 1997-05-28 2001-01-30 Aventis Pharmaceuticals Products Inc. Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
US6399618B1 (en) 1997-07-09 2002-06-04 Cardiome Pharma Corp Compositions and methods for modulating sexual activity
TW536401B (en) 1997-09-03 2003-06-11 Cardiome Pharma Corp A pharmaceutical composition of N,N-bis(phenylcarbamoylmethyl)dimethylammomum chloride and derivatives for the treatment of pain
CN1278166A (zh) 1997-09-26 2000-12-27 诺特兰药品公司 局部麻醉或抗心律不齐同时产生止痛的氨基环己酰胺的对映体混合物
JP3773644B2 (ja) 1998-01-06 2006-05-10 芝府エンジニアリング株式会社 接点材料
US6013830A (en) 1998-03-30 2000-01-11 Sepracor Inc. Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols
AU751772C (en) * 1998-04-01 2006-09-07 Correvio International Sàrl Aminocyclohexyl ether compounds and uses thereof
GB9819466D0 (en) * 1998-09-08 1998-10-28 Boudriau Pierre Automated turning module for rudderless for personal watercraft
US6979685B1 (en) 1999-02-12 2005-12-27 Cardiome Pharma Corp. Cycloalkyl amine compounds and uses thereof
WO2000047547A2 (fr) 1999-02-12 2000-08-17 Nortran Pharmaceuticals Inc. Composes d'amines cycloalkyles et utilisation de ceux-ci
WO2000051981A1 (fr) 1999-03-04 2000-09-08 Nortran Pharmaceuticals Inc. Composes d'aminocycloakyl-cinnamide destines a l'arythmie et utiles en tant qu'analgesiques et anesthesiants
US7507545B2 (en) 1999-03-31 2009-03-24 Cardiome Pharma Corp. Ion channel modulating activity method
CA2268590A1 (fr) 1999-04-12 2000-10-12 Nortran Pharmaceuticals Inc. Composes de regulation des canaux ioniques et utilisations de ces produits
ES2225553T3 (es) 2000-04-20 2005-03-16 F. Hoffmann-La Roche Ag Derivados de pirrolidina y piperidina y su empleo para el tratamiento de trastornos neurodegenerativos.
CA2311483A1 (fr) 2000-06-12 2001-12-12 Gregory N Beatch Ethers imidazo [1,2-a] pyridiniques et leurs utilisations
US6521619B2 (en) 2000-06-29 2003-02-18 Icos Corporation Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents
US6498170B2 (en) 2000-07-17 2002-12-24 Wyeth Cyclamine sulfonamides as β-3 adrenergic receptor agonists
US7057053B2 (en) 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
WO2003105756A2 (fr) 2002-06-14 2003-12-24 Johnson Matthey Pharmaceutical Materials, Inc. Synthese stereoselective de cycloalkyles substitues en positions 1 et 2
US20060167226A1 (en) 2002-07-12 2006-07-27 Cardiome Pharma Corp. Mutations of voltage-gated ion channnels that allow them to express a voltage-independent phenotype and an improved method to use the same
WO2004098525A2 (fr) 2003-05-02 2004-11-18 Cardiome Pharma Corp. Utilisations de composes modulant les canaux ioniques
PL227937B1 (pl) 2003-05-02 2018-01-31 Cardiome Pharma Corp Sposób wytwarzania związku typu eteru aminocykloheksylowego, związek typu eteru aminocykloheksylowego, jego kompozycja, sposób modulowania aktywności kanałów jonowych, oraz zastosowanie związku typu eteru aminocykloheksylowego do wytwarzania leku
US7345086B2 (en) 2003-05-02 2008-03-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
US20060094880A9 (en) 2003-06-04 2006-05-04 Barrett Anthony G M Synthetic process for trans-aminocyclohexyl ether compounds
WO2005018635A2 (fr) 2003-08-07 2005-03-03 Cardiome Pharma Corp. Activite i modulant des canaux ioniques
US20070197632A1 (en) 2003-10-31 2007-08-23 Cardiome Pharma Corp Aminocyclohexyl ether compounds and uses thereof
US7345087B2 (en) 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
US7789873B2 (en) * 2004-08-02 2010-09-07 Coloplast A/S Urinary catheter assembly

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US20080070911A1 (en) 2008-03-20
AU3021599A (en) 1999-10-18
EE04548B1 (et) 2005-10-17
JP2002509908A (ja) 2002-04-02
ATE260240T1 (de) 2004-03-15
CZ20003485A3 (cs) 2001-03-14
BRPI9909282B1 (pt) 2011-07-26
RO121028B1 (ro) 2006-11-30
IL138719A0 (en) 2001-10-31
US20110207730A1 (en) 2011-08-25
CN1303364A (zh) 2001-07-11
US20050020481A1 (en) 2005-01-27
JP2006306878A (ja) 2006-11-09
NO20004897L (no) 2000-11-13
CA2326777A1 (fr) 1999-10-07
ID27178A (id) 2001-03-08
ES2217742T3 (es) 2004-11-01
NO321130B1 (no) 2006-03-20
CA2326777C (fr) 2011-12-20
DE69915063T2 (de) 2004-10-14
RU2252933C2 (ru) 2005-05-27
IS2648B (is) 2010-08-15
EP1087934B1 (fr) 2004-02-25
US7534790B2 (en) 2009-05-19
US20070004718A1 (en) 2007-01-04
NO2010023I1 (no) 2010-12-14
DK1087934T3 (da) 2004-06-28
SK14372000A3 (sk) 2001-07-10
KR100631299B1 (ko) 2006-10-09
CY2010018I1 (el) 2012-01-25
PT1087934E (pt) 2004-07-30
FR10C0057I1 (fr) 2011-02-18
HK1038345A1 (en) 2002-03-15
IS5632A (is) 2000-09-20
MXPA00009593A (es) 2004-03-10
EP1087934A1 (fr) 2001-04-04
JP4334766B2 (ja) 2009-09-30
CY2010018I2 (el) 2012-01-25
FR10C0057I2 (fr) 2011-11-25
AU751772C (en) 2006-09-07
HUP0102613A3 (en) 2002-05-28
PL343425A1 (en) 2001-08-13
DE122010000052I1 (de) 2011-05-05
NO2010023I2 (no) 2011-10-17
EE200000583A (et) 2002-02-15
US20100029639A1 (en) 2010-02-04
WO1999050225A1 (fr) 1999-10-07
KR20010042334A (ko) 2001-05-25
EP1422217A3 (fr) 2004-06-16
US20050192208A2 (en) 2005-09-01
SK285908B6 (sk) 2007-10-04
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