ATE260240T1 - Aminocyclohexylverbindungen und deren verwendung - Google Patents
Aminocyclohexylverbindungen und deren verwendungInfo
- Publication number
- ATE260240T1 ATE260240T1 AT99911550T AT99911550T ATE260240T1 AT E260240 T1 ATE260240 T1 AT E260240T1 AT 99911550 T AT99911550 T AT 99911550T AT 99911550 T AT99911550 T AT 99911550T AT E260240 T1 ATE260240 T1 AT E260240T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- compositions
- formula
- present
- aminocyclohexyl
- Prior art date
Links
- -1 AMINOCYCLOHEXYL COMPOUNDS Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- MHWUUEBDNXLKJI-UHFFFAOYSA-N 1-(1-aminocyclohexyl)oxycyclohexan-1-amine Chemical class C1CCCCC1(N)OC1(N)CCCCC1 MHWUUEBDNXLKJI-UHFFFAOYSA-N 0.000 abstract 1
- 230000036592 analgesia Effects 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000002690 local anesthesia Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US8034798P | 1998-04-01 | 1998-04-01 | |
| US11895499P | 1999-02-05 | 1999-02-05 | |
| PCT/CA1999/000280 WO1999050225A1 (en) | 1998-04-01 | 1999-04-01 | Aminocyclohexyl ether compounds and uses thereof |
Publications (1)
| Publication Number | Publication Date |
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| ATE260240T1 true ATE260240T1 (de) | 2004-03-15 |
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| AT99911550T ATE260240T1 (de) | 1998-04-01 | 1999-04-01 | Aminocyclohexylverbindungen und deren verwendung |
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| US (5) | US7101877B2 (de) |
| EP (2) | EP1087934B1 (de) |
| JP (2) | JP4334766B2 (de) |
| KR (1) | KR100631299B1 (de) |
| CN (1) | CN1217918C (de) |
| AT (1) | ATE260240T1 (de) |
| AU (1) | AU751772C (de) |
| BE (1) | BE2011C002I2 (de) |
| BR (1) | BRPI9909282B8 (de) |
| CA (1) | CA2326777C (de) |
| CY (1) | CY2010018I2 (de) |
| CZ (1) | CZ302147B6 (de) |
| DE (2) | DE69915063T2 (de) |
| DK (1) | DK1087934T3 (de) |
| EE (1) | EE04548B1 (de) |
| ES (1) | ES2217742T3 (de) |
| FR (1) | FR10C0057I2 (de) |
| HU (1) | HU229993B1 (de) |
| ID (1) | ID27178A (de) |
| IL (1) | IL138719A0 (de) |
| IS (1) | IS2648B (de) |
| LU (1) | LU91761I2 (de) |
| MX (1) | MXPA00009593A (de) |
| NO (2) | NO321130B1 (de) |
| NZ (1) | NZ507169A (de) |
| PL (1) | PL197293B1 (de) |
| PT (1) | PT1087934E (de) |
| RO (1) | RO121028B1 (de) |
| RU (1) | RU2252933C2 (de) |
| SK (1) | SK285908B6 (de) |
| TR (1) | TR200002796T2 (de) |
| WO (1) | WO1999050225A1 (de) |
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| DE10213051B4 (de) * | 2002-03-23 | 2013-03-07 | Grünenthal GmbH | Substituierte 4-Aminocyclohexanole |
| WO2003105756A2 (en) * | 2002-06-14 | 2003-12-24 | Johnson Matthey Pharmaceutical Materials, Inc. | Stereoselective synthesis of 1,2-disubstituted cycloalkyls |
| CN100441568C (zh) * | 2003-05-02 | 2008-12-10 | 卡迪欧梅制药公司 | 氨基环己基醚化合物和它们的用途 |
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| ATE529401T1 (de) | 2003-05-02 | 2011-11-15 | Cardiome Pharma Corp | Aminocyclohexylether-verbindungen und deren verwendung |
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| US7345087B2 (en) | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| WO2005097869A1 (en) * | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Polymers comprising ion channel modulating compounds and uses thereof |
| WO2005097203A2 (en) * | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Serum protein conjugates of ion channel modulating compounds and uses thereof |
| US8058304B2 (en) | 2004-04-01 | 2011-11-15 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| WO2005113011A2 (en) | 2004-04-01 | 2005-12-01 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
| EP1729814A2 (de) * | 2004-04-01 | 2006-12-13 | Cardiome Pharma Corp. | Pegylierte ionenkanalmodulatoren |
| US7705036B2 (en) | 2004-04-01 | 2010-04-27 | Cardiome Pharma Corp. | Deuterated aminocyclohexyl ether compounds and processes for preparing same |
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| EP1828099B1 (de) | 2004-11-18 | 2020-01-22 | Correvio International Sàrl | Syntheseverfahren für aminocyclohexyl-ether-verbindungen |
| MY144968A (en) | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| MY145694A (en) * | 2005-04-11 | 2012-03-30 | Xenon Pharmaceuticals Inc | Spiroheterocyclic compounds and their uses as therapeutic agents |
| GB0510164D0 (en) * | 2005-04-28 | 2005-06-22 | Paradigm Therapeutics Ltd | Ion channel |
| BRPI0612138B8 (pt) | 2005-06-15 | 2021-05-25 | Cardiome Pharma Corp | compostos éter aminocicloexílicos e método para fazer os mesmos |
| WO2007055180A1 (ja) * | 2005-11-09 | 2007-05-18 | Toray Fine Chemicals Co., Ltd. | 光学活性トランス-2-アミノシクロヘキサノールおよびその誘導体の製造方法 |
| ATE545416T1 (de) | 2006-10-12 | 2012-03-15 | Xenon Pharmaceuticals Inc | Verwendung von spiro-oxindol-verbindungen als therapeutika |
| WO2008046087A2 (en) * | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Spiro compounds and their uses as therapeutic agents |
| EA200971025A1 (ru) * | 2007-05-04 | 2010-04-30 | Кардиом Фарма Корп. | Пероральные композиции с регулируемым высвобождением соединений, модулирующих ионные каналы, и связанные с ними способы предупреждения аритмии |
| WO2010045197A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals, Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| CN103664973B (zh) | 2008-10-17 | 2017-04-19 | 泽农医药公司 | 螺羟吲哚化合物及其作为治疗剂的用途 |
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| EP2605772B1 (de) | 2010-08-16 | 2016-06-22 | Cardiome International AG | Verfahren zur herstellung von aminocyclohexyl-etherverbindungen |
| US9681836B2 (en) | 2012-04-23 | 2017-06-20 | Cyberonics, Inc. | Methods, systems and apparatuses for detecting seizure and non-seizure states |
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| KR102829709B1 (ko) | 2018-09-03 | 2025-07-04 | 에프. 호프만-라 로슈 아게 | 바이사이클릭 헤테로아릴 유도체 |
| EP3894411B1 (de) | 2018-12-13 | 2024-06-19 | F. Hoffmann-La Roche AG | 7-phenoxy-n-(3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazol-2-amin-derivate und ähnliche verbindungen als gamma-secretase-modulatoren zur behandlung von alzheimer's erkrankung |
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- 1999-04-01 DE DE69915063T patent/DE69915063T2/de not_active Expired - Lifetime
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- 1999-04-01 KR KR1020007010894A patent/KR100631299B1/ko not_active Expired - Lifetime
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- 1999-04-01 JP JP2000541135A patent/JP4334766B2/ja not_active Expired - Lifetime
- 1999-04-01 EP EP99911550A patent/EP1087934B1/de not_active Expired - Lifetime
- 1999-04-01 EP EP04002165A patent/EP1422217A3/de not_active Withdrawn
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- 1999-04-01 DE DE122010000052C patent/DE122010000052I1/de active Pending
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