WO2000047547A3 - Cycloalkyl amine compounds and uses thereof - Google Patents

Cycloalkyl amine compounds and uses thereof Download PDF

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Publication number
WO2000047547A3
WO2000047547A3 PCT/CA2000/000117 CA0000117W WO0047547A3 WO 2000047547 A3 WO2000047547 A3 WO 2000047547A3 CA 0000117 W CA0000117 W CA 0000117W WO 0047547 A3 WO0047547 A3 WO 0047547A3
Authority
WO
WIPO (PCT)
Prior art keywords
amine compounds
compounds
cycloalkyl amine
compositions
present
Prior art date
Application number
PCT/CA2000/000117
Other languages
French (fr)
Other versions
WO2000047547A2 (en
Inventor
Gregory N Beatch
Bertrand M C Plouvier
Michael J A Walker
Richard A Wall
Alexander B Zolotoy
Original Assignee
Nortran Pharmaceuticals Inc
Gregory N Beatch
Bertrand M C Plouvier
Michael J A Walker
Richard A Wall
Alexander B Zolotoy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nortran Pharmaceuticals Inc, Gregory N Beatch, Bertrand M C Plouvier, Michael J A Walker, Richard A Wall, Alexander B Zolotoy filed Critical Nortran Pharmaceuticals Inc
Priority to AU25289/00A priority Critical patent/AU2528900A/en
Priority to US09/913,373 priority patent/US6979685B1/en
Publication of WO2000047547A2 publication Critical patent/WO2000047547A2/en
Publication of WO2000047547A3 publication Critical patent/WO2000047547A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Aminocycloalkyl compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of local analgesia and anesthesia.
PCT/CA2000/000117 1999-02-12 2000-02-10 Cycloalkyl amine compounds and uses thereof WO2000047547A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU25289/00A AU2528900A (en) 1999-02-12 2000-02-10 Cycloalkyl amine compounds and uses thereof
US09/913,373 US6979685B1 (en) 1999-02-12 2000-02-10 Cycloalkyl amine compounds and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11988799P 1999-02-12 1999-02-12
US60/119,887 1999-02-12

Publications (2)

Publication Number Publication Date
WO2000047547A2 WO2000047547A2 (en) 2000-08-17
WO2000047547A3 true WO2000047547A3 (en) 2000-12-14

Family

ID=22387012

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/000117 WO2000047547A2 (en) 1999-02-12 2000-02-10 Cycloalkyl amine compounds and uses thereof

Country Status (2)

Country Link
AU (1) AU2528900A (en)
WO (1) WO2000047547A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU751772C (en) 1998-04-01 2006-09-07 Correvio International Sàrl Aminocyclohexyl ether compounds and uses thereof
US7507545B2 (en) 1999-03-31 2009-03-24 Cardiome Pharma Corp. Ion channel modulating activity method
US7524879B2 (en) 2000-10-06 2009-04-28 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US7057053B2 (en) 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US20070099983A1 (en) 2003-05-02 2007-05-03 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
US7345086B2 (en) 2003-05-02 2008-03-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
WO2005018635A2 (en) 2003-08-07 2005-03-03 Cardiome Pharma Corp. Ion channel modulating activity i
US7345087B2 (en) 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
US8058304B2 (en) 2004-04-01 2011-11-15 Cardiome Pharma Corp. Merged ion channel modulating compounds and uses thereof
WO2005113011A2 (en) 2004-04-01 2005-12-01 Cardiome Pharma Corp. Prodrugs of ion channel modulating compounds and uses thereof
JP4991037B2 (en) 2004-04-01 2012-08-01 カーディオム ファーマ コーポレイション Drug conjugates comprising ion channel modulating compounds
EP1868598B1 (en) 2004-11-08 2014-04-23 Cardiome Pharma Corp. A new dosing regimen for ion channel modulating compounds for treating acute atrial fibrillation in a human

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2259260A1 (en) * 1972-12-04 1974-06-06 Merck Patent Gmbh 2-Pentyloxy-3-heptylamino-dialkoxy-cyclopentanes - from corresp. 1,4-substd. cpds. by hydrogenolysis or 2-R-pentyloxy-cpds. by oxidn. or thermolysis
DE3517901A1 (en) * 1984-05-18 1985-12-12 Glaxo Group Ltd., London AMINOCYCLOPENTYL ETHER, THEIR PRODUCTION AND PHARMACEUTICAL FORMULATION
JPH02270864A (en) * 1989-04-12 1990-11-05 Asahi Glass Co Ltd Fluorocarbacyclic nucleoside and production thereof
WO1994014435A1 (en) * 1992-12-29 1994-07-07 Rhone-Poulenc Rorer Pharmaceuticals Inc. Cycloalkyl amine bis-aryl squalene synthase inhibitors
WO1996023894A1 (en) * 1995-02-03 1996-08-08 Basf Aktiengesellschaft Racemate separation of primary and secondary heteroatom-substituted amine by enzyme-catalysed acylation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2259260A1 (en) * 1972-12-04 1974-06-06 Merck Patent Gmbh 2-Pentyloxy-3-heptylamino-dialkoxy-cyclopentanes - from corresp. 1,4-substd. cpds. by hydrogenolysis or 2-R-pentyloxy-cpds. by oxidn. or thermolysis
DE3517901A1 (en) * 1984-05-18 1985-12-12 Glaxo Group Ltd., London AMINOCYCLOPENTYL ETHER, THEIR PRODUCTION AND PHARMACEUTICAL FORMULATION
JPH02270864A (en) * 1989-04-12 1990-11-05 Asahi Glass Co Ltd Fluorocarbacyclic nucleoside and production thereof
WO1994014435A1 (en) * 1992-12-29 1994-07-07 Rhone-Poulenc Rorer Pharmaceuticals Inc. Cycloalkyl amine bis-aryl squalene synthase inhibitors
WO1996023894A1 (en) * 1995-02-03 1996-08-08 Basf Aktiengesellschaft Racemate separation of primary and secondary heteroatom-substituted amine by enzyme-catalysed acylation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 115, no. 5, 5 August 1991, Columbus, Ohio, US; abstract no. 50215n, MORISAWA Y ET AL: "Preparation of fluorocarbocyclic nucleosides as antitumor agents" page 904; column 2; XP002901046 *
CHEMICAL ABSTRACTS, vol. 129, no. 17, 26 October 1998, Columbus, Ohio, US; abstract no. 216472k, CROTTI P ET AL: "Regiochemical control of the ring-opening of epoxides by means of chelating processes. Part 13. Syntheses and ring-opening reactions of the diastereoisomeric cis- and transepoxides derived from 3-(benzyloxy)cyclopentene and 2-(benzyloxy)-2,5-dihydrofuran" page 662; column 2; XP002901045 *
CHEMICAL ABSTRACTS, vol. 89, no. 15, 9 October 1978, Columbus, Ohio, US; abstract no. 129113f, ORTH D ET AL: "Cyclopentane-1-amines" page 555; column 1; XP002901044 *
DE 2 658 401 A (MERCK PATENT GMBH) *
EUR.J.ORG.CHEM., no. 8, 1998, pages 1675 - 1686 *

Also Published As

Publication number Publication date
WO2000047547A2 (en) 2000-08-17
AU2528900A (en) 2000-08-29

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