HUE058739T2 - Adipóz szövetbõl származó stromális õssejtek refrakter komplex perianális fisztulák kezelésében történõ alkalmazásra Crohn-betegségben - Google Patents

Adipóz szövetbõl származó stromális õssejtek refrakter komplex perianális fisztulák kezelésében történõ alkalmazásra Crohn-betegségben

Info

Publication number
HUE058739T2
HUE058739T2 HUE17160932A HUE17160932A HUE058739T2 HU E058739 T2 HUE058739 T2 HU E058739T2 HU E17160932 A HUE17160932 A HU E17160932A HU E17160932 A HUE17160932 A HU E17160932A HU E058739 T2 HUE058739 T2 HU E058739T2
Authority
HU
Hungary
Prior art keywords
crohn
disease
treatment
stem cells
adipose tissue
Prior art date
Application number
HUE17160932A
Other languages
English (en)
Hungarian (hu)
Inventor
Eduardo Bravo
Maria Pascual
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of HUE058739T2 publication Critical patent/HUE058739T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HUE17160932A 2016-03-14 2017-03-14 Adipóz szövetbõl származó stromális õssejtek refrakter komplex perianális fisztulák kezelésében történõ alkalmazásra Crohn-betegségben HUE058739T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1604304.4A GB201604304D0 (en) 2016-03-14 2016-03-14 Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease

Publications (1)

Publication Number Publication Date
HUE058739T2 true HUE058739T2 (hu) 2022-09-28

Family

ID=55952284

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE17160932A HUE058739T2 (hu) 2016-03-14 2017-03-14 Adipóz szövetbõl származó stromális õssejtek refrakter komplex perianális fisztulák kezelésében történõ alkalmazásra Crohn-betegségben

Country Status (27)

Country Link
US (3) US10357518B2 (enExample)
EP (2) EP3219321B1 (enExample)
JP (2) JP6931656B2 (enExample)
KR (1) KR102277789B1 (enExample)
CN (2) CN108883135B (enExample)
AU (1) AU2017232718B2 (enExample)
BE (1) BE1024781B1 (enExample)
CA (1) CA3017694C (enExample)
CY (1) CY1125513T1 (enExample)
DE (1) DE102017002458B4 (enExample)
DK (1) DK3219321T3 (enExample)
ES (2) ES2911718T3 (enExample)
FR (1) FR3048614B1 (enExample)
GB (2) GB201604304D0 (enExample)
HR (1) HRP20220539T1 (enExample)
HU (1) HUE058739T2 (enExample)
IL (2) IL261730B2 (enExample)
LT (1) LT3219321T (enExample)
MX (1) MX2018010699A (enExample)
NL (1) NL2018512B1 (enExample)
NO (1) NO345415B1 (enExample)
PL (1) PL3219321T3 (enExample)
RS (1) RS63163B1 (enExample)
RU (1) RU2742308C2 (enExample)
SG (2) SG11201807404XA (enExample)
SI (1) SI3219321T1 (enExample)
WO (1) WO2017158509A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
GB201604304D0 (en) * 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
CA3054947A1 (en) 2017-03-30 2018-10-04 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with live biotherapeutics
US20220202868A1 (en) * 2019-02-27 2022-06-30 Tigenix S.A.U. Improved stem cell populations for allogeneic therapy
BR112022017560A2 (pt) * 2020-03-11 2022-12-27 Mesoblast Int Sarl Método para tratar doença inflamatória intestinal i
CN115297875A (zh) * 2020-03-11 2022-11-04 迈索布拉斯特国际有限公司 治疗炎症性肠病的方法ii
CN111481573A (zh) * 2020-03-26 2020-08-04 卡替（上海）生物技术股份有限公司 牙髓间充质干细胞在制备克罗恩病治疗药物中的用途
JP2023551479A (ja) * 2020-11-25 2023-12-08 フラッグシップ パイオニアリング， インコーポレイテッド 脂肪生成細胞組成物及び方法
EP4531879A1 (en) * 2022-05-25 2025-04-09 Flagship Pioneering Innovations VI, LLC Compositions of secretory and/or catalytic cells and methods using the same

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5733542A (en) 1990-11-16 1998-03-31 Haynesworth; Stephen E. Enhancing bone marrow engraftment using MSCS
US6010696A (en) 1990-11-16 2000-01-04 Osiris Therapeutics, Inc. Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells
FR2680931B1 (fr) 1991-08-27 1997-08-14 Thomson Csf Procede de detection et de suivi d'objets en mouvement par analyse de sequences d'images.
DE69317439T2 (de) 1992-12-02 1998-07-02 Shell Int Research Azoxycyanbenzol-Derivate
US5578475A (en) 1993-07-12 1996-11-26 Life Technologies, Inc. Composition and methods for transfecting eukaryotic cells
US5472183A (en) 1994-03-17 1995-12-05 Nisca Corporation Sheet feeding device with multiple sheet stackers
JPH10505250A (ja) 1994-06-06 1998-05-26 ケース ウエスターン リザーブ ユニバーシティ 組織再生のためのバイオマトリックス
US6174333B1 (en) 1994-06-06 2001-01-16 Osiris Therapeutics, Inc. Biomatrix for soft tissue regeneration using mesenchymal stem cells
CA2222328C (en) 1995-06-07 2012-01-10 Inex Pharmaceuticals Corporation Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US6051429A (en) 1995-06-07 2000-04-18 Life Technologies, Inc. Peptide-enhanced cationic lipid transfections
US5744335A (en) 1995-09-19 1998-04-28 Mirus Corporation Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein
US6546106B2 (en) 1996-09-03 2003-04-08 New Transducers Limited Acoustic device
US5705308A (en) 1996-09-30 1998-01-06 Eastman Kodak Company Infrared-sensitive, negative-working diazonaphthoquinone imaging composition and element
US6391297B1 (en) 1997-12-02 2002-05-21 Artecel Sciences, Inc. Differentiation of adipose stromal cells into osteoblasts and uses thereof
US6368636B1 (en) 1998-03-18 2002-04-09 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
US9585916B2 (en) 1999-03-26 2017-03-07 Northern Therapeutics Inc. Cell based therapy for the pulmonary system
ES2205792T3 (es) 1998-04-03 2004-05-01 Osiris Therapeutics, Inc. Celulas madre mesenquimatosas como inmunosupresores.
US6546105B1 (en) 1998-10-30 2003-04-08 Matsushita Electric Industrial Co., Ltd. Sound image localization device and sound image localization method
US20030082152A1 (en) 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
US20050153442A1 (en) 1999-03-10 2005-07-14 Adam Katz Adipose-derived stem cells and lattices
IL145002A0 (en) 1999-03-10 2002-06-30 Univ Pittsburgh Adipose-derived stem cells and lattices
US6777231B1 (en) 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
CN1201268C (zh) 1999-06-30 2005-05-11 国际商业机器公司 实现运动模糊化的图像处理
US7670628B2 (en) 1999-07-07 2010-03-02 Angioblast Systems, Inc. Mesenchymal precursor cell
US6555374B1 (en) 1999-08-19 2003-04-29 Artecel Sciences, Inc. Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
US20020155096A1 (en) 2001-02-23 2002-10-24 Chancellor Michael B. Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair
US20030054331A1 (en) 2001-09-14 2003-03-20 Stemsource, Inc. Preservation of non embryonic cells from non hematopoietic tissues
EP1453954A4 (en) * 2001-11-09 2004-12-15 Artecel Sciences Inc Endocrine pancreas differentiation of adipose tissue-derived stromal cells and uses thereof
BR0214029A (pt) 2001-11-09 2005-04-19 Artecel Sciences Inc Métodos e composições para o uso de células estromais para suportar células tronco embriÈnicas e adultas
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
WO2003105908A2 (en) 2002-03-15 2003-12-24 Department Of Veterans Affairs, Rehabilitation R & D Service Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
EP1990350A1 (en) 2002-06-14 2008-11-12 Cartela R&D AB Marker for mesenchymal stem cells and its use
US20040101959A1 (en) 2002-11-21 2004-05-27 Olga Marko Treatment of tissue with undifferentiated mesenchymal cells
EP2263698A1 (en) 2003-04-01 2010-12-22 United States of America Dempartment of Veteran's Affairs Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure and renal dysfunction
ES2265199B1 (es) 2003-06-12 2008-02-01 Cellerix, S.L. Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones.
ES2564044T3 (es) 2003-06-27 2016-03-17 DePuy Synthes Products, Inc. Células posparto derivadas de tejido del cordón umbilical y métodos de preparación y uso de las mismas
US7645229B2 (en) 2003-09-26 2010-01-12 Armstrong David N Instrument and method for endoscopic visualization and treatment of anorectal fistula
WO2005035738A1 (en) 2003-10-07 2005-04-21 Biomaster Inc. Cell differentiation of adipose-derived precursor cells
DE602004030823D1 (de) 2003-11-04 2011-02-10 Biomaster Inc Verfahren und system zur herstellung von stammzellen aus fettgewebe
EP2298863B1 (en) 2004-03-22 2015-07-22 Mesoblast International Sàrl Mesenchymal stem cells and uses therefor
US20080095749A1 (en) 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
RU2252252C1 (ru) 2004-04-09 2005-05-20 Тепляшин Александр Сергеевич Способ выделения мезенхимальных стволовых клеток
ES2264862B8 (es) 2004-08-25 2017-01-20 Cellerix, S.L. Biomaterial para sutura.
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
ES2313805B1 (es) 2004-10-04 2009-12-23 Cellerix, S.L. Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
WO2006029347A2 (en) 2004-09-03 2006-03-16 University Of Maryland, Baltimore Integrin cd18 is a novel stromal stem cell marker and functions to promote osteogenesis
WO2006110582A1 (en) 2005-04-08 2006-10-19 Xcyte Therapies, Inc. Compositions and methods for the treatment of burns and sepsis
CA2623353C (en) 2005-09-23 2017-02-21 Cellerix, S.L. Cell populations having immunoregulatory activity, method for isolation and uses
EP1795588A1 (en) 2005-12-07 2007-06-13 Cellerix, S.L. Use of adipose tissue derived mesenchymal stem cells for the treatment of graft versus host disease
WO2008036374A2 (en) 2006-09-21 2008-03-27 Medistem Laboratories, Inc. Allogeneic stem cell transplants in non-conditioned recipients
US20110262402A1 (en) 2007-09-07 2011-10-27 Masahiko Kuroda Therapeutic and prophylactic agents for arthritis
KR101738323B1 (ko) 2007-09-19 2017-05-19 플루리스템 리미티드 지방 또는 태반 조직 유래의 부착 세포 및 이의 치료 용도
ES2595103T3 (es) 2007-10-17 2016-12-27 Txcell Células Tr1, células madre mesenquimales y usos de estas
GB0814249D0 (en) 2008-08-04 2008-09-10 Cellerix Sa Uses of mesenchymal stem cells
ES2345867B1 (es) * 2009-04-03 2011-07-28 Fundacion Instituto Mediterraneo Para La Biotecnologia Y La Investigacion Sanitaria (Imabis) Celulas madre multipotentes derivadas de estroma de mesenterio.
ES2479621T3 (es) * 2009-04-28 2014-07-24 Anterogen Co., Ltd. Composición de células madre estromales derivadas de tejido adiposo autólogo y alogénico destinada al tratamiento de fístulas
WO2011004264A1 (en) 2009-07-09 2011-01-13 Cellerix Sa Methods and compositions for use in cellular therapies
US20130324591A1 (en) * 2010-12-06 2013-12-05 Quark Pharmaceuticals, Inc. Double stranded oligonucleotide compounds comprising positional modifications
WO2012095743A2 (en) 2011-01-12 2012-07-19 Cellerix Sa Methods and compositions for use in intralymphatic cellular therapies
WO2012123401A1 (en) 2011-03-11 2012-09-20 Tigenix, S.A. Cell populations having immunoregulatory activity, method for isolation and uses
US20140134140A1 (en) 2012-11-09 2014-05-15 Case Western Reserve University Mesenchymal stem cell compositions for the treatment of microbial infections
EP3581932A1 (en) * 2013-03-15 2019-12-18 TiGenix, S.A.U. Lymphocyte biomarkers for determining the clinical response to cell therapy
US20160120910A1 (en) 2013-06-25 2016-05-05 Tigenix S.A.U. Cell populations having immunoregulatory activity, methods for the preparation and uses thereof
NZ727950A (en) * 2014-06-30 2022-07-01 Takeda Pharmaceuticals Co Mesenchymal stromal cells for treating sepsis
US11578306B2 (en) * 2015-09-24 2023-02-14 Cellect Biotherapeutics Ltd. Methods for propagating mesenchymal stem cells (MSC) for use in transplantation
GB201604304D0 (en) * 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
US10152822B2 (en) 2017-04-01 2018-12-11 Intel Corporation Motion biased foveated renderer
US10890966B2 (en) 2017-07-27 2021-01-12 Arm Limited Graphics processing systems
US10818080B2 (en) 2018-07-25 2020-10-27 Disney Enterprises, Inc. Piecewise-polynomial coupling layers for warp-predicting neural networks
US11109065B2 (en) 2018-09-26 2021-08-31 Google Llc Video encoding by providing geometric proxies

Also Published As

Publication number Publication date
FR3048614A1 (enExample) 2017-09-15
SI3219321T1 (sl) 2022-05-31
HRP20220539T1 (hr) 2022-06-10
FR3048614B1 (fr) 2020-02-21
CN108883135A (zh) 2018-11-23
US20170258851A1 (en) 2017-09-14
US10357518B2 (en) 2019-07-23
IL261730B1 (en) 2024-01-01
AU2017232718A1 (en) 2018-10-04
US20220249574A1 (en) 2022-08-11
NL2018512B1 (en) 2017-09-07
IL298107B1 (en) 2023-10-01
KR102277789B1 (ko) 2021-07-15
NO345415B1 (en) 2021-01-18
BE1024781A1 (de) 2018-06-27
BR112018068493A2 (pt) 2019-01-22
SG11201807404XA (en) 2018-09-27
GB2548490B (en) 2020-09-02
DE102017002458A1 (de) 2017-09-14
GB2548490A (en) 2017-09-20
RS63163B1 (sr) 2022-05-31
ES2681774B1 (es) 2019-12-26
DK3219321T3 (da) 2022-04-25
GB201604304D0 (en) 2016-04-27
MX2018010699A (es) 2019-01-14
NL2018512A (en) 2017-03-30
BE1024781B1 (de) 2018-07-02
CA3017694C (en) 2024-02-27
EP3219321A1 (en) 2017-09-20
JP2021119789A (ja) 2021-08-19
US11273182B2 (en) 2022-03-15
US12213998B2 (en) 2025-02-04
CN108883135B (zh) 2022-11-04
RU2018131519A (ru) 2020-04-15
IL261730B2 (en) 2024-05-01
ES2681774A1 (es) 2018-09-14
JP6931656B2 (ja) 2021-09-08
IL298107B2 (en) 2024-02-01
EP4074322A1 (en) 2022-10-19
GB201704065D0 (en) 2017-04-26
RU2018131519A3 (enExample) 2020-07-10
CA3017694A1 (en) 2017-09-21
EP3219321B1 (en) 2022-03-30
KR20180120261A (ko) 2018-11-05
DE102017002458B4 (de) 2019-04-25
IL298107A (en) 2023-01-01
AU2017232718B2 (en) 2024-01-18
NO20170376A1 (en) 2017-09-15
IL261730A (en) 2018-10-31
PL3219321T3 (pl) 2022-05-30
US20190381106A1 (en) 2019-12-19
ES2911718T3 (es) 2022-05-20
SG10202008992YA (en) 2020-10-29
WO2017158509A1 (en) 2017-09-21
CN115569151A (zh) 2023-01-06
RU2742308C2 (ru) 2021-02-04
JP2019508455A (ja) 2019-03-28
BR112018068493A8 (pt) 2022-06-28
CY1125513T1 (el) 2024-12-13
LT3219321T (lt) 2022-05-10

Similar Documents

Publication Publication Date Title
FR25C1001I1 (fr) Compositions d'anticorps pour le traitement de tumeurs
GB2548490B (en) Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in Crohn's disease
FR25C1016I2 (fr) Utilisation de l'inhibiteur de la télomérase imetelstat pour le traitement du syndrome myélodysplasique
DK3347030T3 (da) Brug af pasteuriseret akkermansia til behandling af stofskiftesygdomme
LT3206715T (lt) Kanabidiolio naudojimas tuberozinės sklerozės komplekso gydymui
DK3197472T3 (da) Rekombinante phe-frie proteiner til anvendelse i behandlingen af phenylketonuri
DK2945642T3 (da) Faktor 1 protein til anvendelse i behandling eller forebyggelse af sygdomme
MA45327A (fr) Utilisation de probiotiques pour améliorer l'absorption des protéines
DK3151851T3 (da) Ornithodoros-moubata-komplement-inhibitor til anvendelse i behandlingen af komplement-medierede sygdomme hos patienter med c5-polymorfisme
FR3013184B1 (fr) Utilisation d'hydroxyapatite pour le traitement de l'esca
EP3848022C0 (en) THERAPEUTIC AGENT FOR USE IN THE TREATMENT OF INFECTION
HUE057257T2 (hu) Folyékony készítmény gyomor- és nyelõcsõ reflux kezelésében történõ alkalmazásra
PL3377909T3 (pl) Laktoferyna do zastosowania w diagnozowaniu lub prognozowaniu choroby Alzheimera
IL251345B (en) Compositions for use in the treatment of peri-implantitis
FR3020758B1 (fr) Composition pour ameliorer l'hygiene buco-dentaire
DK3096775T5 (da) SOCS-mimetika til behandling af sygdomme
DK3413870T3 (da) Igmesin til anvendelse ved behandlingen af alzheimers sygdom
EP3406258A4 (en) MEDICINAL PRODUCT FOR USE IN THE TREATMENT OF GICHT
FR3030253B1 (fr) Composition pour ameliorer l'aspect cellulitique de la peau
IL252109A0 (en) (pigment epithelium derived factor (pedf) for the treatment of uterine fibroids
HK1242602B (en) Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
PL3960195T3 (pl) Engrailed do zastosowania w leczeniu stwardnienia zanikowego bocznego
MA40870A (fr) Utilisation d'alliage d'alumine-chrome dans un traitement thermique
FR3026952B1 (fr) Extrait organique de bulbe de lilium pour son utilisation dans les desordres ou pathologies de la peau
DE112015003204A5 (de) Mittel zur Behandlung retroviraler Infektionserkrankungen