KR102277789B1 - 크론병의 난치성 복합 항문주위 누공 치료용 지방 조직 유래 기질 줄기 세포 - Google Patents

크론병의 난치성 복합 항문주위 누공 치료용 지방 조직 유래 기질 줄기 세포 Download PDF

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KR102277789B1
KR102277789B1 KR1020187029414A KR20187029414A KR102277789B1 KR 102277789 B1 KR102277789 B1 KR 102277789B1 KR 1020187029414 A KR1020187029414 A KR 1020187029414A KR 20187029414 A KR20187029414 A KR 20187029414A KR 102277789 B1 KR102277789 B1 KR 102277789B1
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fistula
cells
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에두아르도 브라보
마리아 파스쿠알
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타이제닉스, 에스.에이.유.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Wood Science & Technology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020187029414A 2016-03-14 2017-03-14 크론병의 난치성 복합 항문주위 누공 치료용 지방 조직 유래 기질 줄기 세포 Active KR102277789B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1604304.4 2016-03-14
GBGB1604304.4A GB201604304D0 (en) 2016-03-14 2016-03-14 Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
PCT/IB2017/051468 WO2017158509A1 (en) 2016-03-14 2017-03-14 Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease

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KR20180120261A KR20180120261A (ko) 2018-11-05
KR102277789B1 true KR102277789B1 (ko) 2021-07-15

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US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
GB201604304D0 (en) * 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
EP3601531B1 (en) 2017-03-30 2023-06-07 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with live biotherapeutics
US20220202868A1 (en) * 2019-02-27 2022-06-30 Tigenix S.A.U. Improved stem cell populations for allogeneic therapy
BR112022018022A2 (pt) * 2020-03-11 2022-10-18 Mesoblast Int Sarl Método para tratar doença inflamatória intestinal ii
AU2021234104A1 (en) * 2020-03-11 2022-09-29 Mesoblast International Sàrl Method for treating inflammatory bowel disease I
CN111481573A (zh) * 2020-03-26 2020-08-04 卡替（上海）生物技术股份有限公司 牙髓间充质干细胞在制备克罗恩病治疗药物中的用途
KR20230113346A (ko) * 2020-11-25 2023-07-28 플래그쉽 파이어니어링, 인크. 지방생성 세포 조성물 및 방법
EP4531879A1 (en) * 2022-05-25 2025-04-09 Flagship Pioneering Innovations VI, LLC Compositions of secretory and/or catalytic cells and methods using the same

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GB201704065D0 (en) 2017-04-26
RU2018131519A (ru) 2020-04-15
PL3219321T3 (pl) 2022-05-30
CY1125513T1 (el) 2024-12-13
RU2742308C2 (ru) 2021-02-04
DE102017002458B4 (de) 2019-04-25
US11273182B2 (en) 2022-03-15
US12213998B2 (en) 2025-02-04
GB201604304D0 (en) 2016-04-27
IL298107B1 (en) 2023-10-01
ES2681774B1 (es) 2019-12-26
FR3048614B1 (fr) 2020-02-21
IL261730B1 (en) 2024-01-01
AU2017232718A1 (en) 2018-10-04
JP2021119789A (ja) 2021-08-19
CN115569151A (zh) 2023-01-06
BE1024781A1 (de) 2018-06-27
KR20180120261A (ko) 2018-11-05
BE1024781B1 (de) 2018-07-02
US20190381106A1 (en) 2019-12-19
NL2018512B1 (en) 2017-09-07
HRP20220539T1 (hr) 2022-06-10
ES2911718T3 (es) 2022-05-20
DE102017002458A1 (de) 2017-09-14
BR112018068493A8 (pt) 2022-06-28
EP3219321B1 (en) 2022-03-30
CN108883135A (zh) 2018-11-23
EP3219321A1 (en) 2017-09-20
SG10202008992YA (en) 2020-10-29
GB2548490B (en) 2020-09-02
WO2017158509A1 (en) 2017-09-21
LT3219321T (lt) 2022-05-10
JP6931656B2 (ja) 2021-09-08
AU2017232718B2 (en) 2024-01-18
IL298107B2 (en) 2024-02-01
CN108883135B (zh) 2022-11-04
US20220249574A1 (en) 2022-08-11
ES2681774A1 (es) 2018-09-14
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NO20170376A1 (en) 2017-09-15
CA3017694A1 (en) 2017-09-21
SG11201807404XA (en) 2018-09-27
US10357518B2 (en) 2019-07-23
EP4074322A1 (en) 2022-10-19
RS63163B1 (sr) 2022-05-31
US20170258851A1 (en) 2017-09-14
RU2018131519A3 (enExample) 2020-07-10
HUE058739T2 (hu) 2022-09-28
CA3017694C (en) 2024-02-27
MX2018010699A (es) 2019-01-14
NL2018512A (en) 2017-03-30
DK3219321T3 (da) 2022-04-25
GB2548490A (en) 2017-09-20
NO345415B1 (en) 2021-01-18
FR3048614A1 (enExample) 2017-09-15
JP2019508455A (ja) 2019-03-28
IL298107A (en) 2023-01-01
SI3219321T1 (sl) 2022-05-31
BR112018068493A2 (pt) 2019-01-22

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