BR112018068493A2 - células-tronco estromais, uso de células-tronco estromais e método de tratamento de uma fístula perianal complexa refratária - Google Patents

células-tronco estromais, uso de células-tronco estromais e método de tratamento de uma fístula perianal complexa refratária

Info

Publication number
BR112018068493A2
BR112018068493A2 BR112018068493A BR112018068493A BR112018068493A2 BR 112018068493 A2 BR112018068493 A2 BR 112018068493A2 BR 112018068493 A BR112018068493 A BR 112018068493A BR 112018068493 A BR112018068493 A BR 112018068493A BR 112018068493 A2 BR112018068493 A2 BR 112018068493A2
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BR
Brazil
Prior art keywords
stem cells
stromal stem
treatment
complex perianal
perianal fistula
Prior art date
Application number
BR112018068493A
Other languages
English (en)
Other versions
BR112018068493A8 (pt
Inventor
Bravo Eduardo
Pascual Maria
Original Assignee
Tigenix S A U
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tigenix S A U filed Critical Tigenix S A U
Publication of BR112018068493A2 publication Critical patent/BR112018068493A2/pt
Publication of BR112018068493A8 publication Critical patent/BR112018068493A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

são providas aqui células-tronco estromais derivadas de tecido adiposo, alogênicas, expandidas para uso no tratamento de fístulas perianais complexas em doença de crohn.
BR112018068493A 2016-03-14 2017-03-14 Células-tronco estromais, uso de células-tronco estromais e método de tratamento de uma fístula perianal complexa refratária BR112018068493A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1604304.4 2016-03-14
GBGB1604304.4A GB201604304D0 (en) 2016-03-14 2016-03-14 Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
IB2017158509 2017-09-21

Publications (2)

Publication Number Publication Date
BR112018068493A2 true BR112018068493A2 (pt) 2019-01-22
BR112018068493A8 BR112018068493A8 (pt) 2022-06-28

Family

ID=55952284

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018068493A BR112018068493A8 (pt) 2016-03-14 2017-03-14 Células-tronco estromais, uso de células-tronco estromais e método de tratamento de uma fístula perianal complexa refratária

Country Status (27)

Country Link
US (3) US10357518B2 (pt)
EP (2) EP3219321B1 (pt)
JP (2) JP6931656B2 (pt)
KR (1) KR102277789B1 (pt)
CN (2) CN115569151A (pt)
AU (1) AU2017232718B2 (pt)
BE (1) BE1024781B1 (pt)
BR (1) BR112018068493A8 (pt)
CA (1) CA3017694C (pt)
DE (1) DE102017002458B4 (pt)
DK (1) DK3219321T3 (pt)
ES (2) ES2681774B1 (pt)
FR (1) FR3048614B1 (pt)
GB (2) GB201604304D0 (pt)
HR (1) HRP20220539T1 (pt)
HU (1) HUE058739T2 (pt)
IL (2) IL298107B2 (pt)
LT (1) LT3219321T (pt)
MX (1) MX2018010699A (pt)
NL (1) NL2018512B1 (pt)
NO (1) NO345415B1 (pt)
PL (1) PL3219321T3 (pt)
RS (1) RS63163B1 (pt)
RU (1) RU2742308C2 (pt)
SG (2) SG10202008992YA (pt)
SI (1) SI3219321T1 (pt)
WO (1) WO2017158509A1 (pt)

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JP2020515579A (ja) 2017-03-30 2020-05-28 プロジェニティ， インコーポレイテッド 消化管疾病の生菌生物学的製剤による治療
CN113544261A (zh) * 2019-02-27 2021-10-22 泰根尼克斯独资有限公司 用于同种异体疗法的改良的干细胞群
CN111481573A (zh) * 2020-03-26 2020-08-04 卡替（上海）生物技术股份有限公司 牙髓间充质干细胞在制备克罗恩病治疗药物中的用途
KR20230113346A (ko) * 2020-11-25 2023-07-28 플래그쉽 파이어니어링, 인크. 지방생성 세포 조성물 및 방법
WO2023230524A1 (en) * 2022-05-25 2023-11-30 Flagship Pioneering Innovations Vi, Llc Compositions of secretory and/or catalytic cells and methods using the same

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Also Published As

Publication number Publication date
US10357518B2 (en) 2019-07-23
NO20170376A1 (en) 2017-09-15
NL2018512A (en) 2017-03-30
DK3219321T3 (da) 2022-04-25
IL298107B1 (en) 2023-10-01
HRP20220539T1 (hr) 2022-06-10
CA3017694A1 (en) 2017-09-21
RU2018131519A3 (pt) 2020-07-10
JP6931656B2 (ja) 2021-09-08
SG10202008992YA (en) 2020-10-29
CN108883135A (zh) 2018-11-23
HUE058739T2 (hu) 2022-09-28
GB201604304D0 (en) 2016-04-27
IL298107B2 (en) 2024-02-01
CN115569151A (zh) 2023-01-06
NO345415B1 (en) 2021-01-18
MX2018010699A (es) 2019-01-14
ES2681774B1 (es) 2019-12-26
IL261730B1 (en) 2024-01-01
EP3219321A1 (en) 2017-09-20
ES2911718T3 (es) 2022-05-20
AU2017232718A1 (en) 2018-10-04
GB2548490B (en) 2020-09-02
GB2548490A (en) 2017-09-20
CN108883135B (zh) 2022-11-04
KR102277789B1 (ko) 2021-07-15
EP3219321B1 (en) 2022-03-30
US11273182B2 (en) 2022-03-15
PL3219321T3 (pl) 2022-05-30
AU2017232718B2 (en) 2024-01-18
CA3017694C (en) 2024-02-27
GB201704065D0 (en) 2017-04-26
JP2021119789A (ja) 2021-08-19
US20220249574A1 (en) 2022-08-11
FR3048614A1 (pt) 2017-09-15
IL261730B2 (en) 2024-05-01
SG11201807404XA (en) 2018-09-27
DE102017002458B4 (de) 2019-04-25
BE1024781A1 (de) 2018-06-27
ES2681774A1 (es) 2018-09-14
DE102017002458A1 (de) 2017-09-14
IL261730A (en) 2018-10-31
RS63163B1 (sr) 2022-05-31
US20190381106A1 (en) 2019-12-19
KR20180120261A (ko) 2018-11-05
US20170258851A1 (en) 2017-09-14
RU2018131519A (ru) 2020-04-15
BR112018068493A8 (pt) 2022-06-28
JP2019508455A (ja) 2019-03-28
FR3048614B1 (fr) 2020-02-21
EP4074322A1 (en) 2022-10-19
SI3219321T1 (sl) 2022-05-31
WO2017158509A1 (en) 2017-09-21
BE1024781B1 (de) 2018-07-02
LT3219321T (lt) 2022-05-10
RU2742308C2 (ru) 2021-02-04
NL2018512B1 (en) 2017-09-07
IL298107A (en) 2023-01-01

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