BR112018068493A2 - células-tronco estromais, uso de células-tronco estromais e método de tratamento de uma fístula perianal complexa refratária - Google Patents

células-tronco estromais, uso de células-tronco estromais e método de tratamento de uma fístula perianal complexa refratária

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Publication number
BR112018068493A2
BR112018068493A2 BR112018068493A BR112018068493A BR112018068493A2 BR 112018068493 A2 BR112018068493 A2 BR 112018068493A2 BR 112018068493 A BR112018068493 A BR 112018068493A BR 112018068493 A BR112018068493 A BR 112018068493A BR 112018068493 A2 BR112018068493 A2 BR 112018068493A2
Authority
BR
Brazil
Prior art keywords
stem cells
stromal stem
treatment
complex perianal
perianal fistula
Prior art date
Application number
BR112018068493A
Other languages
English (en)
Other versions
BR112018068493B1 (pt
BR112018068493A8 (pt
Inventor
Bravo Eduardo
Pascual Maria
Original Assignee
Tigenix S A U
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tigenix S A U filed Critical Tigenix S A U
Publication of BR112018068493A2 publication Critical patent/BR112018068493A2/pt
Publication of BR112018068493A8 publication Critical patent/BR112018068493A8/pt
Publication of BR112018068493B1 publication Critical patent/BR112018068493B1/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

são providas aqui células-tronco estromais derivadas de tecido adiposo, alogênicas, expandidas para uso no tratamento de fístulas perianais complexas em doença de crohn.
BR112018068493-7A 2016-03-14 2017-03-14 Uso de células-tronco estromais BR112018068493B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1604304.4A GB201604304D0 (en) 2016-03-14 2016-03-14 Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
GB1604304.4 2016-03-14
IB2017158509 2017-09-21

Publications (3)

Publication Number Publication Date
BR112018068493A2 true BR112018068493A2 (pt) 2019-01-22
BR112018068493A8 BR112018068493A8 (pt) 2022-06-28
BR112018068493B1 BR112018068493B1 (pt) 2024-06-18

Family

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Also Published As

Publication number Publication date
NO345415B1 (en) 2021-01-18
JP6931656B2 (ja) 2021-09-08
CN108883135A (zh) 2018-11-23
BE1024781A1 (de) 2018-06-27
GB2548490B (en) 2020-09-02
RU2018131519A (ru) 2020-04-15
EP3219321A1 (en) 2017-09-20
IL261730A (en) 2018-10-31
IL298107B2 (en) 2024-02-01
MX2018010699A (es) 2019-01-14
RU2742308C2 (ru) 2021-02-04
US20170258851A1 (en) 2017-09-14
FR3048614B1 (fr) 2020-02-21
AU2017232718B2 (en) 2024-01-18
WO2017158509A1 (en) 2017-09-21
NO20170376A1 (en) 2017-09-15
ES2911718T3 (es) 2022-05-20
US20190381106A1 (en) 2019-12-19
RU2018131519A3 (pt) 2020-07-10
GB2548490A (en) 2017-09-20
PL3219321T3 (pl) 2022-05-30
DE102017002458A1 (de) 2017-09-14
BR112018068493A8 (pt) 2022-06-28
RS63163B1 (sr) 2022-05-31
SI3219321T1 (sl) 2022-05-31
GB201704065D0 (en) 2017-04-26
CA3017694C (en) 2024-02-27
ES2681774B1 (es) 2019-12-26
BE1024781B1 (de) 2018-07-02
US11273182B2 (en) 2022-03-15
EP4074322A1 (en) 2022-10-19
SG11201807404XA (en) 2018-09-27
ES2681774A1 (es) 2018-09-14
IL298107A (en) 2023-01-01
JP2021119789A (ja) 2021-08-19
HRP20220539T1 (hr) 2022-06-10
DK3219321T3 (da) 2022-04-25
CN115569151A (zh) 2023-01-06
IL261730B1 (en) 2024-01-01
DE102017002458B4 (de) 2019-04-25
LT3219321T (lt) 2022-05-10
EP3219321B1 (en) 2022-03-30
CN108883135B (zh) 2022-11-04
AU2017232718A1 (en) 2018-10-04
KR102277789B1 (ko) 2021-07-15
IL261730B2 (en) 2024-05-01
SG10202008992YA (en) 2020-10-29
US10357518B2 (en) 2019-07-23
JP2019508455A (ja) 2019-03-28
HUE058739T2 (hu) 2022-09-28
NL2018512A (en) 2017-03-30
GB201604304D0 (en) 2016-04-27
FR3048614A1 (pt) 2017-09-15
NL2018512B1 (en) 2017-09-07
CA3017694A1 (en) 2017-09-21
KR20180120261A (ko) 2018-11-05
US20220249574A1 (en) 2022-08-11
IL298107B1 (en) 2023-10-01

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Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B25A Requested transfer of rights approved

Owner name: TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP)

B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/03/2017, OBSERVADAS AS CONDICOES LEGAIS