HRP20220539T1 - Stromalne matične stanice iz masnog tkiva za uporabu u liječenju refraktornih kompleksnih perianalnih fistula kod crohnove bolesti - Google Patents
Stromalne matične stanice iz masnog tkiva za uporabu u liječenju refraktornih kompleksnih perianalnih fistula kod crohnove bolesti Download PDFInfo
- Publication number
- HRP20220539T1 HRP20220539T1 HRP20220539TT HRP20220539T HRP20220539T1 HR P20220539 T1 HRP20220539 T1 HR P20220539T1 HR P20220539T T HRP20220539T T HR P20220539TT HR P20220539 T HRP20220539 T HR P20220539T HR P20220539 T1 HRP20220539 T1 HR P20220539T1
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- Prior art keywords
- weeks
- stem cells
- adipose tissue
- stromal stem
- allogeneic adipose
- Prior art date
Links
- 210000000577 adipose tissue Anatomy 0.000 title claims 18
- 210000000130 stem cell Anatomy 0.000 title claims 18
- 208000011231 Crohn disease Diseases 0.000 title claims 4
- 206010002156 anal fistula Diseases 0.000 title claims 2
- 230000000735 allogeneic effect Effects 0.000 claims 17
- 206010016717 Fistula Diseases 0.000 claims 8
- 230000003890 fistula Effects 0.000 claims 8
- 238000002560 therapeutic procedure Methods 0.000 claims 8
- -1 CD11c Proteins 0.000 claims 2
- 102100022464 5'-nucleotidase Human genes 0.000 claims 1
- 102100032912 CD44 antigen Human genes 0.000 claims 1
- 102100022002 CD59 glycoprotein Human genes 0.000 claims 1
- 102100037241 Endoglin Human genes 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 claims 1
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 1
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims 1
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 1
- 102100022338 Integrin alpha-M Human genes 0.000 claims 1
- 102100022297 Integrin alpha-X Human genes 0.000 claims 1
- 102100025304 Integrin beta-1 Human genes 0.000 claims 1
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 1
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 1
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000009266 disease activity Effects 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 238000002650 immunosuppressive therapy Methods 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0653—Adipocytes; Adipose tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1604304.4A GB201604304D0 (en) | 2016-03-14 | 2016-03-14 | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
| EP17160932.4A EP3219321B1 (en) | 2016-03-14 | 2017-03-14 | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20220539T1 true HRP20220539T1 (hr) | 2022-06-10 |
Family
ID=55952284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220539TT HRP20220539T1 (hr) | 2016-03-14 | 2017-03-14 | Stromalne matične stanice iz masnog tkiva za uporabu u liječenju refraktornih kompleksnih perianalnih fistula kod crohnove bolesti |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US10357518B2 (enExample) |
| EP (2) | EP4074322A1 (enExample) |
| JP (2) | JP6931656B2 (enExample) |
| KR (1) | KR102277789B1 (enExample) |
| CN (2) | CN115569151A (enExample) |
| AU (1) | AU2017232718B2 (enExample) |
| BE (1) | BE1024781B1 (enExample) |
| CA (1) | CA3017694C (enExample) |
| CY (1) | CY1125513T1 (enExample) |
| DE (1) | DE102017002458B4 (enExample) |
| DK (1) | DK3219321T3 (enExample) |
| ES (2) | ES2911718T3 (enExample) |
| FR (1) | FR3048614B1 (enExample) |
| GB (2) | GB201604304D0 (enExample) |
| HR (1) | HRP20220539T1 (enExample) |
| HU (1) | HUE058739T2 (enExample) |
| IL (2) | IL298107B2 (enExample) |
| LT (1) | LT3219321T (enExample) |
| MX (1) | MX2018010699A (enExample) |
| NL (1) | NL2018512B1 (enExample) |
| NO (1) | NO345415B1 (enExample) |
| PL (1) | PL3219321T3 (enExample) |
| RS (1) | RS63163B1 (enExample) |
| RU (1) | RU2742308C2 (enExample) |
| SG (2) | SG10202008992YA (enExample) |
| SI (1) | SI3219321T1 (enExample) |
| WO (1) | WO2017158509A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060045872A1 (en) | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
| GB201604304D0 (en) * | 2016-03-14 | 2016-04-27 | Tigenix S A U | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
| AU2018244922A1 (en) | 2017-03-30 | 2019-09-12 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with live biotherapeutics |
| CN113544261B (zh) * | 2019-02-27 | 2024-10-01 | 武田药品工业株式会社 | 用于同种异体疗法的改良的干细胞群 |
| WO2021180850A1 (en) * | 2020-03-11 | 2021-09-16 | Mesoblast International Sàrl | Method for treating inflammatory bowel disease i |
| BR112022018022A2 (pt) * | 2020-03-11 | 2022-10-18 | Mesoblast Int Sarl | Método para tratar doença inflamatória intestinal ii |
| CN111481573A (zh) * | 2020-03-26 | 2020-08-04 | 卡替（上海）生物技术股份有限公司 | 牙髓间充质干细胞在制备克罗恩病治疗药物中的用途 |
| CA3200227A1 (en) * | 2020-11-25 | 2022-06-02 | Alexandra Sophie DE BOER | Adipogenic cell compositions and methods |
| WO2023230524A1 (en) * | 2022-05-25 | 2023-11-30 | Flagship Pioneering Innovations Vi, Llc | Compositions of secretory and/or catalytic cells and methods using the same |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5733542A (en) | 1990-11-16 | 1998-03-31 | Haynesworth; Stephen E. | Enhancing bone marrow engraftment using MSCS |
| US6010696A (en) | 1990-11-16 | 2000-01-04 | Osiris Therapeutics, Inc. | Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| FR2680931B1 (fr) | 1991-08-27 | 1997-08-14 | Thomson Csf | Procede de detection et de suivi d'objets en mouvement par analyse de sequences d'images. |
| BR9307550A (pt) | 1992-12-02 | 1999-05-25 | Shell Int Research | Composto fungicida processo para a preparação de um composto fungicida composição fungicida processo de combate aos fungos em um local e uso |
| WO1995002698A1 (en) | 1993-07-12 | 1995-01-26 | Life Technologies, Inc. | Composition and methods for transfecting eukaryotic cells |
| US5472183A (en) | 1994-03-17 | 1995-12-05 | Nisca Corporation | Sheet feeding device with multiple sheet stackers |
| JPH10505250A (ja) | 1994-06-06 | 1998-05-26 | ケース ウエスターン リザーブ ユニバーシティ | 組織再生のためのバイオマトリックス |
| US6174333B1 (en) | 1994-06-06 | 2001-01-16 | Osiris Therapeutics, Inc. | Biomatrix for soft tissue regeneration using mesenchymal stem cells |
| US6051429A (en) | 1995-06-07 | 2000-04-18 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
| DE69634084T2 (de) | 1995-06-07 | 2005-12-08 | Inex Pharmaceuticals Corp. | Herstellung von lipid-nukleinsäure partikeln duch ein hydrophobische lipid-nukleinsäuree komplexe zwischenprodukt und zur verwendung in der gentransfer |
| US5744335A (en) | 1995-09-19 | 1998-04-28 | Mirus Corporation | Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein |
| US6546106B2 (en) | 1996-09-03 | 2003-04-08 | New Transducers Limited | Acoustic device |
| US5705308A (en) | 1996-09-30 | 1998-01-06 | Eastman Kodak Company | Infrared-sensitive, negative-working diazonaphthoquinone imaging composition and element |
| CN1166773C (zh) | 1997-12-02 | 2004-09-15 | 泽恩比奥公司 | 分离的人脂肪组织衍生的基质细胞 |
| US6368636B1 (en) | 1998-03-18 | 2002-04-09 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
| US9585916B2 (en) | 1999-03-26 | 2017-03-07 | Northern Therapeutics Inc. | Cell based therapy for the pulmonary system |
| US6797269B2 (en) | 1998-04-03 | 2004-09-28 | Osiris Therapeutics, Inc. | Mesenchymal stem cells as immunosuppressants |
| US6546105B1 (en) | 1998-10-30 | 2003-04-08 | Matsushita Electric Industrial Co., Ltd. | Sound image localization device and sound image localization method |
| US20050153442A1 (en) | 1999-03-10 | 2005-07-14 | Adam Katz | Adipose-derived stem cells and lattices |
| CN1352696A (zh) | 1999-03-10 | 2002-06-05 | 匹兹堡大学联邦制高等教育 | 脂肪来源的干细胞和网格 |
| US20030082152A1 (en) | 1999-03-10 | 2003-05-01 | Hedrick Marc H. | Adipose-derived stem cells and lattices |
| US6777231B1 (en) | 1999-03-10 | 2004-08-17 | The Regents Of The University Of California | Adipose-derived stem cells and lattices |
| CN1201268C (zh) | 1999-06-30 | 2005-05-11 | 国际商业机器公司 | 实现运动模糊化的图像处理 |
| US7670628B2 (en) | 1999-07-07 | 2010-03-02 | Angioblast Systems, Inc. | Mesenchymal precursor cell |
| US6555374B1 (en) | 1999-08-19 | 2003-04-29 | Artecel Sciences, Inc. | Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof |
| CA2438904C (en) | 2001-02-23 | 2012-09-04 | The University Of Pittsburgh | Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair |
| US20030054331A1 (en) | 2001-09-14 | 2003-03-20 | Stemsource, Inc. | Preservation of non embryonic cells from non hematopoietic tissues |
| JP2005533480A (ja) * | 2001-11-09 | 2005-11-10 | アーテセル・サイエンシズ・インコーポレーテツド | 脂肪組織由来間質細胞の膵内分泌分化およびその使用 |
| CN1596303A (zh) | 2001-11-09 | 2005-03-16 | 阿特塞尔科学公司 | 利用基质细胞支持胚胎干细胞和成体干细胞的方法和组合物 |
| US7771716B2 (en) | 2001-12-07 | 2010-08-10 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
| US7282222B2 (en) | 2002-03-15 | 2007-10-16 | The United States Of America As Represented By The Department Of Veterans Affairs | Methods and compositions for directing cells to target organs |
| DE60318706T2 (de) | 2002-06-14 | 2009-04-30 | Cartela R & D Ab | Marker für stammzellen und dessen verwendung |
| US20040101959A1 (en) | 2002-11-21 | 2004-05-27 | Olga Marko | Treatment of tissue with undifferentiated mesenchymal cells |
| CA2521217C (en) | 2003-04-01 | 2013-05-14 | United States Of America Department Of Veteran's Affairs | Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure and renal dysfunction |
| ES2265199B1 (es) | 2003-06-12 | 2008-02-01 | Cellerix, S.L. | Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones. |
| CA2530421C (en) | 2003-06-27 | 2015-04-21 | Ethicon, Incorporated | Repair and regeneration of ocular tissue using postpartum-derived cells |
| US7645229B2 (en) | 2003-09-26 | 2010-01-12 | Armstrong David N | Instrument and method for endoscopic visualization and treatment of anorectal fistula |
| US9074190B2 (en) | 2003-10-07 | 2015-07-07 | Biomaster, Inc. | Cell differentiation of adipose-derived precursor cells |
| DE602004030823D1 (de) | 2003-11-04 | 2011-02-10 | Biomaster Inc | Verfahren und system zur herstellung von stammzellen aus fettgewebe |
| US20080095749A1 (en) | 2004-03-22 | 2008-04-24 | Sudeepta Aggarwal | Mesenchymal stem cells and uses therefor |
| EP2298861B1 (en) | 2004-03-22 | 2017-09-13 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| RU2252252C1 (ru) | 2004-04-09 | 2005-05-20 | Тепляшин Александр Сергеевич | Способ выделения мезенхимальных стволовых клеток |
| ES2313805B1 (es) | 2004-10-04 | 2009-12-23 | Cellerix, S.L. | Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral. |
| US20060045872A1 (en) | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
| ES2264862B8 (es) | 2004-08-25 | 2017-01-20 | Cellerix, S.L. | Biomaterial para sutura. |
| US7732126B2 (en) | 2004-09-03 | 2010-06-08 | University Of Maryland, Baltimore | Integrin CD18 is a novel stromal stem cell marker and functions to promote osteogenesis |
| US20060286089A1 (en) | 2005-04-08 | 2006-12-21 | Xcyte Therapies, Inc. | Compositions and methods for the treatment of burns and sepsis |
| JP5925408B2 (ja) | 2005-09-23 | 2016-05-25 | タイジェニックス、ソシエダッド、アノニマ、ウニペルソナルＴｉｇｅｎｉｘ Ｓ．Ａ．Ｕ． | 免疫調節活性を有する細胞集団、単離方法および使用 |
| EP1795588A1 (en) | 2005-12-07 | 2007-06-13 | Cellerix, S.L. | Use of adipose tissue derived mesenchymal stem cells for the treatment of graft versus host disease |
| US20120269774A1 (en) | 2006-09-21 | 2012-10-25 | Medistem Laboratories, Inc | Allogeneic stem cell transplants in non-conditioned recipients |
| WO2009031606A1 (ja) | 2007-09-07 | 2009-03-12 | Jcr Pharmaceuticals Co., Ltd. | 関節炎治療及び予防剤 |
| CN107028981B (zh) | 2007-09-19 | 2021-04-20 | 普拉里斯坦有限公司 | 来自脂肪或胎盘组织的粘附细胞及其在治疗中的用途 |
| JP5539886B2 (ja) | 2007-10-17 | 2014-07-02 | ティクセル | Ｔｒ１細胞、間葉系幹細胞およびその使用 |
| GB0814249D0 (en) | 2008-08-04 | 2008-09-10 | Cellerix Sa | Uses of mesenchymal stem cells |
| ES2345867B1 (es) * | 2009-04-03 | 2011-07-28 | Fundacion Instituto Mediterraneo Para La Biotecnologia Y La Investigacion Sanitaria (Imabis) | Celulas madre multipotentes derivadas de estroma de mesenterio. |
| US20120020937A1 (en) * | 2009-04-28 | 2012-01-26 | Anterogen Co., Ltd. | Autologous and allogenic adipose-derived stromal stem cell composition for treating fistulas |
| KR101788885B1 (ko) | 2009-07-09 | 2017-10-20 | 타이제닉스, 에스.에이.유. | 세포 요법에 사용하기 위한 방법 및 조성물 |
| EP2649181B1 (en) * | 2010-12-06 | 2016-04-27 | Quark Pharmaceuticals, Inc. | Double stranded oligonucleotide compounds comprising positional modifications |
| EP2663316A2 (en) | 2011-01-12 | 2013-11-20 | TiGenix, S.A.U. | Adipose-derived mesenchymal stem cells for intralymphatic administration in autoimmune and inflammatory diseases |
| JP2014508527A (ja) | 2011-03-11 | 2014-04-10 | ティゲニクス、エセ、ア、ウ | 免疫調節活性を有する細胞集団、単離方法および使用 |
| US20140134140A1 (en) | 2012-11-09 | 2014-05-15 | Case Western Reserve University | Mesenchymal stem cell compositions for the treatment of microbial infections |
| AU2014230014B2 (en) | 2013-03-15 | 2019-11-14 | Tigenix, S.A.U. | Lymphocyte biomarkers for determining the clinical response to therapy with mesenschymal stromal cells(MSC) |
| JP6412933B2 (ja) | 2013-06-25 | 2018-10-24 | ティジェニクス エス．エー．ユー． | 免疫調節活性を有する細胞集団、その調製方法および使用 |
| SG11201610844PA (en) * | 2014-06-30 | 2017-01-27 | Tigenix S A U | Mesenchymal stromal cells for treating sepsis |
| WO2017051421A1 (en) * | 2015-09-24 | 2017-03-30 | Cellect Biotherapeutics Ltd. | Methods for propagating mesenchymal stem cells (msc) for use in transplantation |
| GB201604304D0 (en) * | 2016-03-14 | 2016-04-27 | Tigenix S A U | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
| US10152822B2 (en) | 2017-04-01 | 2018-12-11 | Intel Corporation | Motion biased foveated renderer |
| US10890966B2 (en) | 2017-07-27 | 2021-01-12 | Arm Limited | Graphics processing systems |
| US10818080B2 (en) | 2018-07-25 | 2020-10-27 | Disney Enterprises, Inc. | Piecewise-polynomial coupling layers for warp-predicting neural networks |
| US11109065B2 (en) | 2018-09-26 | 2021-08-31 | Google Llc | Video encoding by providing geometric proxies |
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