JP2019508455A5 - - Google Patents
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- Publication number
- JP2019508455A5 JP2019508455A5 JP2018548356A JP2018548356A JP2019508455A5 JP 2019508455 A5 JP2019508455 A5 JP 2019508455A5 JP 2018548356 A JP2018548356 A JP 2018548356A JP 2018548356 A JP2018548356 A JP 2018548356A JP 2019508455 A5 JP2019508455 A5 JP 2019508455A5
- Authority
- JP
- Japan
- Prior art keywords
- fistula
- agent according
- weeks
- patient
- remission
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 206010016717 Fistula Diseases 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 230000003890 fistula Effects 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 4
- 238000002560 therapeutic procedure Methods 0.000 claims 4
- 208000011231 Crohn disease Diseases 0.000 claims 3
- 210000000577 adipose tissue Anatomy 0.000 claims 2
- 230000000735 allogeneic effect Effects 0.000 claims 2
- -1 and HLAII Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 229960003444 immunosuppressant agent Drugs 0.000 claims 2
- 230000001861 immunosuppressant effect Effects 0.000 claims 2
- 239000003018 immunosuppressive agent Substances 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 102100022464 5'-nucleotidase Human genes 0.000 claims 1
- 102100032912 CD44 antigen Human genes 0.000 claims 1
- 102100022002 CD59 glycoprotein Human genes 0.000 claims 1
- 102100037241 Endoglin Human genes 0.000 claims 1
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 claims 1
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 1
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims 1
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 1
- 102100022338 Integrin alpha-M Human genes 0.000 claims 1
- 102100022297 Integrin alpha-X Human genes 0.000 claims 1
- 102100025304 Integrin beta-1 Human genes 0.000 claims 1
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 1
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 1
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021083406A JP2021119789A (ja) | 2016-03-14 | 2021-05-17 | クローン病における肛囲複雑瘻孔の治療において使用するための脂肪組織由来間質幹細胞 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1604304.4 | 2016-03-14 | ||
| GBGB1604304.4A GB201604304D0 (en) | 2016-03-14 | 2016-03-14 | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
| PCT/IB2017/051468 WO2017158509A1 (en) | 2016-03-14 | 2017-03-14 | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021083406A Division JP2021119789A (ja) | 2016-03-14 | 2021-05-17 | クローン病における肛囲複雑瘻孔の治療において使用するための脂肪組織由来間質幹細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019508455A JP2019508455A (ja) | 2019-03-28 |
| JP2019508455A5 true JP2019508455A5 (enExample) | 2020-04-23 |
| JP6931656B2 JP6931656B2 (ja) | 2021-09-08 |
Family
ID=55952284
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018548356A Active JP6931656B2 (ja) | 2016-03-14 | 2017-03-14 | クローン病における肛囲複雑瘻孔の治療において使用するための脂肪組織由来間質幹細胞 |
| JP2021083406A Pending JP2021119789A (ja) | 2016-03-14 | 2021-05-17 | クローン病における肛囲複雑瘻孔の治療において使用するための脂肪組織由来間質幹細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021083406A Pending JP2021119789A (ja) | 2016-03-14 | 2021-05-17 | クローン病における肛囲複雑瘻孔の治療において使用するための脂肪組織由来間質幹細胞 |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US10357518B2 (enExample) |
| EP (2) | EP3219321B1 (enExample) |
| JP (2) | JP6931656B2 (enExample) |
| KR (1) | KR102277789B1 (enExample) |
| CN (2) | CN115569151A (enExample) |
| AU (1) | AU2017232718B2 (enExample) |
| BE (1) | BE1024781B1 (enExample) |
| CA (1) | CA3017694C (enExample) |
| CY (1) | CY1125513T1 (enExample) |
| DE (1) | DE102017002458B4 (enExample) |
| DK (1) | DK3219321T3 (enExample) |
| ES (2) | ES2911718T3 (enExample) |
| FR (1) | FR3048614B1 (enExample) |
| GB (2) | GB201604304D0 (enExample) |
| HR (1) | HRP20220539T1 (enExample) |
| HU (1) | HUE058739T2 (enExample) |
| IL (2) | IL261730B2 (enExample) |
| LT (1) | LT3219321T (enExample) |
| MX (1) | MX2018010699A (enExample) |
| NL (1) | NL2018512B1 (enExample) |
| NO (1) | NO345415B1 (enExample) |
| PL (1) | PL3219321T3 (enExample) |
| RS (1) | RS63163B1 (enExample) |
| RU (1) | RU2742308C2 (enExample) |
| SG (2) | SG11201807404XA (enExample) |
| SI (1) | SI3219321T1 (enExample) |
| WO (1) | WO2017158509A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060045872A1 (en) | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
| GB201604304D0 (en) * | 2016-03-14 | 2016-04-27 | Tigenix S A U | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
| EP3601531B1 (en) | 2017-03-30 | 2023-06-07 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with live biotherapeutics |
| AU2020228979B2 (en) * | 2019-02-27 | 2025-05-29 | Takeda Pharmaceutical Company Limited | Improved stem cell populations for allogeneic therapy |
| CA3170915A1 (en) * | 2020-03-11 | 2021-09-16 | Mesoblast International Sarl | Method for treating inflammatory bowel disease i |
| US20230104108A1 (en) * | 2020-03-11 | 2023-04-06 | Mesoblast International Sárl | Method for treating inflammatory bowel disease ii |
| CN111481573A (zh) * | 2020-03-26 | 2020-08-04 | 卡替（上海）生物技术股份有限公司 | 牙髓间充质干细胞在制备克罗恩病治疗药物中的用途 |
| WO2022115609A1 (en) * | 2020-11-25 | 2022-06-02 | Flagship Pioneering, Inc. | Adipogenic cell compositions and methods |
| EP4531879A1 (en) * | 2022-05-25 | 2025-04-09 | Flagship Pioneering Innovations VI, LLC | Compositions of secretory and/or catalytic cells and methods using the same |
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-
2016
- 2016-03-14 GB GBGB1604304.4A patent/GB201604304D0/en not_active Ceased
-
2017
- 2017-03-14 PL PL17160932T patent/PL3219321T3/pl unknown
- 2017-03-14 DK DK17160932.4T patent/DK3219321T3/da active
- 2017-03-14 IL IL261730A patent/IL261730B2/en unknown
- 2017-03-14 NL NL2018512A patent/NL2018512B1/nl active
- 2017-03-14 MX MX2018010699A patent/MX2018010699A/es unknown
- 2017-03-14 CA CA3017694A patent/CA3017694C/en active Active
- 2017-03-14 NO NO20170376A patent/NO345415B1/en unknown
- 2017-03-14 IL IL298107A patent/IL298107B2/en unknown
- 2017-03-14 DE DE102017002458.8A patent/DE102017002458B4/de active Active
- 2017-03-14 EP EP17160932.4A patent/EP3219321B1/en active Active
- 2017-03-14 AU AU2017232718A patent/AU2017232718B2/en active Active
- 2017-03-14 HU HUE17160932A patent/HUE058739T2/hu unknown
- 2017-03-14 US US15/458,509 patent/US10357518B2/en active Active
- 2017-03-14 RS RS20220355A patent/RS63163B1/sr unknown
- 2017-03-14 SG SG11201807404XA patent/SG11201807404XA/en unknown
- 2017-03-14 CN CN202211257331.4A patent/CN115569151A/zh active Pending
- 2017-03-14 ES ES17160932T patent/ES2911718T3/es active Active
- 2017-03-14 SG SG10202008992YA patent/SG10202008992YA/en unknown
- 2017-03-14 FR FR1752073A patent/FR3048614B1/fr active Active
- 2017-03-14 JP JP2018548356A patent/JP6931656B2/ja active Active
- 2017-03-14 SI SI201731122T patent/SI3219321T1/sl unknown
- 2017-03-14 KR KR1020187029414A patent/KR102277789B1/ko active Active
- 2017-03-14 LT LTEP17160932.4T patent/LT3219321T/lt unknown
- 2017-03-14 CN CN201780017154.3A patent/CN108883135B/zh active Active
- 2017-03-14 BE BE2017/5156A patent/BE1024781B1/de active IP Right Grant
- 2017-03-14 WO PCT/IB2017/051468 patent/WO2017158509A1/en not_active Ceased
- 2017-03-14 EP EP22163484.3A patent/EP4074322A1/en not_active Withdrawn
- 2017-03-14 GB GB1704065.0A patent/GB2548490B/en active Active
- 2017-03-14 ES ES201700204A patent/ES2681774B1/es active Active
- 2017-03-14 HR HRP20220539TT patent/HRP20220539T1/hr unknown
- 2017-03-14 RU RU2018131519A patent/RU2742308C2/ru active
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2019
- 2019-06-25 US US16/452,321 patent/US11273182B2/en active Active
-
2021
- 2021-05-17 JP JP2021083406A patent/JP2021119789A/ja active Pending
-
2022
- 2022-02-14 US US17/671,479 patent/US12213998B2/en active Active
- 2022-04-20 CY CY20221100296T patent/CY1125513T1/el unknown
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