JP2019508455A5 - - Google Patents
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- JP2019508455A5 JP2019508455A5 JP2018548356A JP2018548356A JP2019508455A5 JP 2019508455 A5 JP2019508455 A5 JP 2019508455A5 JP 2018548356 A JP2018548356 A JP 2018548356A JP 2018548356 A JP2018548356 A JP 2018548356A JP 2019508455 A5 JP2019508455 A5 JP 2019508455A5
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- JP
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- Prior art keywords
- fistula
- agent according
- weeks
- patient
- remission
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 206010016717 Fistula Diseases 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 230000003890 fistula Effects 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 6
- 229940079593 drugs Drugs 0.000 claims 4
- 238000002560 therapeutic procedure Methods 0.000 claims 4
- 206010011401 Crohn's disease Diseases 0.000 claims 3
- 210000000577 Adipose Tissue Anatomy 0.000 claims 2
- 230000000735 allogeneic Effects 0.000 claims 2
- 210000004027 cells Anatomy 0.000 claims 2
- 230000001861 immunosuppresant Effects 0.000 claims 2
- 239000003018 immunosuppressive agent Substances 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 101700027514 CD14 Proteins 0.000 claims 1
- 102100003268 CD14 Human genes 0.000 claims 1
- 102100016492 CD34 Human genes 0.000 claims 1
- 108060001251 CD34 Proteins 0.000 claims 1
- 102100003735 CD44 Human genes 0.000 claims 1
- 101700078950 CD44 Proteins 0.000 claims 1
- 101700073334 CD59 Proteins 0.000 claims 1
- 102100003281 CD59 Human genes 0.000 claims 1
- 102100019451 CD80 Human genes 0.000 claims 1
- 101700080477 CD80 Proteins 0.000 claims 1
- 102100009705 ENG Human genes 0.000 claims 1
- 101710004859 ENG Proteins 0.000 claims 1
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 claims 1
- 102100019441 ITGAM Human genes 0.000 claims 1
- 101710006572 ITGAM Proteins 0.000 claims 1
- 102100019437 ITGAX Human genes 0.000 claims 1
- 101710006689 ITGAX Proteins 0.000 claims 1
- 102100001478 ITGB1 Human genes 0.000 claims 1
- 101710006661 ITGB1 Proteins 0.000 claims 1
- 102100017063 NT5E Human genes 0.000 claims 1
- 101710039712 NT5E Proteins 0.000 claims 1
- 102100018954 PECAM1 Human genes 0.000 claims 1
- 101710027269 PECAM1 Proteins 0.000 claims 1
- 102100005499 PTPRC Human genes 0.000 claims 1
- 101700059076 PTPRC Proteins 0.000 claims 1
- 102100008333 THY1 Human genes 0.000 claims 1
- 101700026084 THY1 Proteins 0.000 claims 1
- -1 and HLAII Proteins 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000003115 biocidal Effects 0.000 claims 1
- 230000003902 lesions Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
Claims (13)
- クローン病を有する患者において難治性の肛囲複雑瘻孔の複数の管の治療のための、拡大培養された同種異系脂肪組織由来間質幹細胞を含んでなる薬剤であって、
（ｉ）１回の手順で、約１億２千万の細胞が患者に投与され、かつ、
（ｉｉ）各瘻管はこの用量の一部を受容し、前記用量のおよそ半分は１または複数の内口周囲の組織に注入され、残りの半分は、瘻管に沿った瘻壁に注入される、
薬剤。 - 瘻孔が、２つの内口および／または３つの外口を含んでなる、請求項１に記載の薬剤。
- 瘻孔が（ｉ）抗生物質、（ｉｉ）免疫抑制剤および（ｉｉｉ）抗ＴＮＦ療法のうち１以上に難治性である、請求項１または請求項２に記載の薬剤。
- 患者が抗ＴＮＦ療法および免疫抑制剤療法のいずれも受けないか、または両方を受ける、請求項１〜３のいずれか一項に記載の薬剤。
- 患者が
（ａ）非活動性または軽度活動性クローン病；および／または
（ｂ）管腔型クローン病
を有する、請求項１〜４のいずれか一項に記載の薬剤。 - 細胞が病巣内に注入される、請求項１〜５のいずれか一項に記載の薬剤。
- 療法が混合寛解または臨床的寛解を誘導する、請求項１〜６のいずれか一項に記載の薬剤。
- 混合寛解または臨床的寛解が２４週間以内、１８週間以内または１２週間以内に達成される、請求項７に記載の薬剤。
- 混合寛解が２４週間以内に達成される、請求項７に記載の薬剤。
- 混合寛解または臨床的寛解が８週間以内または６週間以内に達成される、請求項８に記載の薬剤。
- 瘻孔がＭＲＩによりモニタリングされる、請求項１〜１０のいずれか一項に記載の薬剤。
- 拡大培養された同種異系脂肪組織由来間質幹細胞が表面マーカーＨＬＡ Ｉ、ＣＤ２９、ＣＤ４４、ＣＤ５９、ＣＤ７３、ＣＤ９０、およびＣＤ１０５のうち４以上を発現し、ＨＬＡＩＩ、ＣＤ１１ｂ、ＣＤ１１ｃ、ＣＤ１４、ＣＤ４５、ＣＤ３１、ＣＤ３４、ＣＤ８０およびＣＤ８６のうち４以上を発現しない、請求項１〜１１のいずれか一項に記載の薬剤。
- 瘻管に人工フィブリンシーラントが充填されていない、請求項１〜１２のいずれか一項に記載の薬剤。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021083406A JP2021119789A (ja) | 2016-03-14 | 2021-05-17 | クローン病における肛囲複雑瘻孔の治療において使用するための脂肪組織由来間質幹細胞 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1604304.4 | 2016-03-14 | ||
| GBGB1604304.4A GB201604304D0 (en) | 2016-03-14 | 2016-03-14 | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
| PCT/IB2017/051468 WO2017158509A1 (en) | 2016-03-14 | 2017-03-14 | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021083406A Division JP2021119789A (ja) | 2016-03-14 | 2021-05-17 | クローン病における肛囲複雑瘻孔の治療において使用するための脂肪組織由来間質幹細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019508455A JP2019508455A (ja) | 2019-03-28 |
| JP2019508455A5 true JP2019508455A5 (ja) | 2020-04-23 |
| JP6931656B2 JP6931656B2 (ja) | 2021-09-08 |
Family
ID=55952284
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018548356A Active JP6931656B2 (ja) | 2016-03-14 | 2017-03-14 | クローン病における肛囲複雑瘻孔の治療において使用するための脂肪組織由来間質幹細胞 |
| JP2021083406A Pending JP2021119789A (ja) | 2016-03-14 | 2021-05-17 | クローン病における肛囲複雑瘻孔の治療において使用するための脂肪組織由来間質幹細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021083406A Pending JP2021119789A (ja) | 2016-03-14 | 2021-05-17 | クローン病における肛囲複雑瘻孔の治療において使用するための脂肪組織由来間質幹細胞 |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US10357518B2 (ja) |
| EP (2) | EP3219321B1 (ja) |
| JP (2) | JP6931656B2 (ja) |
| KR (1) | KR102277789B1 (ja) |
| CN (2) | CN108883135B (ja) |
| AU (1) | AU2017232718B2 (ja) |
| BE (1) | BE1024781B1 (ja) |
| BR (1) | BR112018068493A8 (ja) |
| CA (1) | CA3017694C (ja) |
| DE (1) | DE102017002458B4 (ja) |
| DK (1) | DK3219321T3 (ja) |
| ES (2) | ES2681774B1 (ja) |
| FR (1) | FR3048614B1 (ja) |
| GB (2) | GB201604304D0 (ja) |
| HR (1) | HRP20220539T1 (ja) |
| HU (1) | HUE058739T2 (ja) |
| IL (2) | IL261730B2 (ja) |
| LT (1) | LT3219321T (ja) |
| MX (1) | MX2018010699A (ja) |
| NL (1) | NL2018512B1 (ja) |
| NO (1) | NO345415B1 (ja) |
| PL (1) | PL3219321T3 (ja) |
| RS (1) | RS63163B1 (ja) |
| RU (1) | RU2742308C2 (ja) |
| SG (2) | SG10202008992YA (ja) |
| SI (1) | SI3219321T1 (ja) |
| WO (1) | WO2017158509A1 (ja) |
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| GB201604304D0 (en) * | 2016-03-14 | 2016-04-27 | Tigenix S A U | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
| US20210401895A1 (en) | 2017-03-30 | 2021-12-30 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with live biotherapeutics |
| US20220202868A1 (en) * | 2019-02-27 | 2022-06-30 | Tigenix S.A.U. | Improved stem cell populations for allogeneic therapy |
| CN111481573A (zh) * | 2020-03-26 | 2020-08-04 | 卡替（上海）生物技术股份有限公司 | 牙髓间充质干细胞在制备克罗恩病治疗药物中的用途 |
| AU2021388154A1 (en) * | 2020-11-25 | 2023-06-22 | Flagship Pioneering, Inc. | Adipogenic cell compositions and methods |
| WO2023230524A1 (en) * | 2022-05-25 | 2023-11-30 | Flagship Pioneering Innovations Vi, Llc | Compositions of secretory and/or catalytic cells and methods using the same |
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-
2016
- 2016-03-14 GB GBGB1604304.4A patent/GB201604304D0/en not_active Ceased
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2017
- 2017-03-14 DE DE102017002458.8A patent/DE102017002458B4/de active Active
- 2017-03-14 CA CA3017694A patent/CA3017694C/en active Active
- 2017-03-14 LT LTEP17160932.4T patent/LT3219321T/lt unknown
- 2017-03-14 RS RS20220355A patent/RS63163B1/sr unknown
- 2017-03-14 ES ES201700204A patent/ES2681774B1/es active Active
- 2017-03-14 IL IL261730A patent/IL261730B2/en unknown
- 2017-03-14 NO NO20170376A patent/NO345415B1/en unknown
- 2017-03-14 SI SI201731122T patent/SI3219321T1/sl unknown
- 2017-03-14 BE BE2017/5156A patent/BE1024781B1/de active IP Right Grant
- 2017-03-14 SG SG10202008992YA patent/SG10202008992YA/en unknown
- 2017-03-14 KR KR1020187029414A patent/KR102277789B1/ko active IP Right Grant
- 2017-03-14 CN CN201780017154.3A patent/CN108883135B/zh active Active
- 2017-03-14 BR BR112018068493A patent/BR112018068493A8/pt active IP Right Grant
- 2017-03-14 ES ES17160932T patent/ES2911718T3/es active Active
- 2017-03-14 WO PCT/IB2017/051468 patent/WO2017158509A1/en active Application Filing
- 2017-03-14 MX MX2018010699A patent/MX2018010699A/es unknown
- 2017-03-14 HU HUE17160932A patent/HUE058739T2/hu unknown
- 2017-03-14 EP EP17160932.4A patent/EP3219321B1/en active Active
- 2017-03-14 US US15/458,509 patent/US10357518B2/en active Active
- 2017-03-14 SG SG11201807404XA patent/SG11201807404XA/en unknown
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