WO2009031606A1 - 関節炎治療及び予防剤 - Google Patents

関節炎治療及び予防剤 Download PDF

Info

Publication number
WO2009031606A1
WO2009031606A1 PCT/JP2008/065943 JP2008065943W WO2009031606A1 WO 2009031606 A1 WO2009031606 A1 WO 2009031606A1 JP 2008065943 W JP2008065943 W JP 2008065943W WO 2009031606 A1 WO2009031606 A1 WO 2009031606A1
Authority
WO
WIPO (PCT)
Prior art keywords
arthritis
therapeutic
prophylactic agents
stem cell
mesenchymal stem
Prior art date
Application number
PCT/JP2008/065943
Other languages
English (en)
French (fr)
Inventor
Masahiko Kuroda
Masakatsu Takanashi
Katsuko Sudo
Shigeki Yamauchi
Hiroyuki Shirono
Toru Hirado
Kenichi Maeda
Original Assignee
Jcr Pharmaceuticals Co., Ltd.
Miracure Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jcr Pharmaceuticals Co., Ltd., Miracure Inc. filed Critical Jcr Pharmaceuticals Co., Ltd.
Priority to JP2009531268A priority Critical patent/JPWO2009031606A1/ja
Priority to US12/676,638 priority patent/US20110262402A1/en
Priority to EP08829164A priority patent/EP2191835A4/en
Publication of WO2009031606A1 publication Critical patent/WO2009031606A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

　関節炎，特に関節リウマチを治療及び／又は予防するための薬剤及び方法が提供されている。当該薬剤は，ヒト間葉系幹細胞を含んでなり，当該方法は，ヒト間葉系幹細胞の有効量を患者に投与することを含んでなる。
PCT/JP2008/065943 2007-09-07 2008-09-04 関節炎治療及び予防剤 WO2009031606A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009531268A JPWO2009031606A1 (ja) 2007-09-07 2008-09-04 関節炎治療及び予防剤
US12/676,638 US20110262402A1 (en) 2007-09-07 2008-09-04 Therapeutic and prophylactic agents for arthritis
EP08829164A EP2191835A4 (en) 2007-09-07 2008-09-04 THERAPEUTIC AND PROPHYLACTIC AGENTS FOR ARTHRITIS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-233094 2007-09-07
JP2007233094 2007-09-07

Publications (1)

Publication Number Publication Date
WO2009031606A1 true WO2009031606A1 (ja) 2009-03-12

Family

ID=40428919

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/065943 WO2009031606A1 (ja) 2007-09-07 2008-09-04 関節炎治療及び予防剤

Country Status (4)

Country Link
US (1) US20110262402A1 (ja)
EP (1) EP2191835A4 (ja)
JP (1) JPWO2009031606A1 (ja)
WO (1) WO2009031606A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015180199A (ja) * 2009-11-27 2015-10-15 ステムピューティクス リサーチ ピーブイティー．リミテッドＳｔｅｍｐｅｕｔｉｃｓ Ｒｅｓｅａｒｃｈ Ｐｖｔ． Ｌｔｄ． 間葉系幹細胞を調製する方法、その組成物及びキット
JP2016185972A (ja) * 2010-08-31 2016-10-27 クック・ジェネラル・バイオテクノロジー・エルエルシー 動物の疾病の治療のための全身的、同種間幹細胞治療
US10104880B2 (en) 2008-08-20 2018-10-23 Celularity, Inc. Cell composition and methods of making the same
WO2018225673A1 (ja) * 2017-06-06 2018-12-13 Ｄｓファーマアニマルヘルス株式会社 細胞凝集低減方法および細胞凝集が低減された治療用組成物

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
US8465733B2 (en) * 2007-11-02 2013-06-18 Jcr Pharmaceuticals Co., Ltd. Pharmaceutical composition containing human mesenchymal stem cell
JP6025329B2 (ja) 2008-08-14 2016-11-16 メゾブラスト・インターナショナル・ソシエテ・ア・レスポンサビリテ・リミテ 精製済み間葉系幹細胞組成物および間葉系幹細胞組成物を精製する方法
RU2610427C2 (ru) * 2009-07-09 2017-02-10 Тихеникс С.А. Способы и композиции для применения в клеточной терапии
CN103961373A (zh) * 2013-02-04 2014-08-06 西比曼生物科技（上海）有限公司 异体间质血管层细胞和异体间充质祖细胞在预防或治疗骨性关节炎中的应用
US20140276359A1 (en) * 2013-03-15 2014-09-18 Plum Systems Co. Apparatus and method for tissue rejuvenation
GB201604304D0 (en) 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
US10987381B2 (en) * 2017-01-27 2021-04-27 Neil Riordan Mesenchymal stem cells with enhanced efficacy in treatment of autoimmunity particularly rheumatoid arthritis

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
WO1999047163A2 (en) 1998-03-18 1999-09-23 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
JP2004129549A (ja) 2002-10-09 2004-04-30 Yasuo Kitagawa 脂肪由来細胞群からの間葉系幹細胞の選択的増殖方法
JP2004201612A (ja) 2002-12-26 2004-07-22 Minoru Ueda 未分化多能性細胞並びに、それを用いた関連組織又は歯作製方法
JP2004210713A (ja) 2002-12-27 2004-07-29 Asahi Kasei Corp 医療用胎盤由来細胞製剤
WO2005093044A1 (en) 2004-03-22 2005-10-06 Osiris Therapeutics, Inc. Mesenchymal stem cells and uses therefor
JP2006204200A (ja) * 2004-12-27 2006-08-10 Two Cells Co Ltd 間葉系幹細胞の骨化及び／又は軟骨化促進剤と骨化及び／又は軟骨化促進方法
JP2006346420A (ja) * 2005-06-13 2006-12-28 Univ Nagoya 移植材料及び骨質改善剤

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
WO1999047163A2 (en) 1998-03-18 1999-09-23 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
US6328960B1 (en) 1998-03-18 2001-12-11 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
JP2002506831A (ja) 1998-03-18 2002-03-05 オシリス セラピューティクス，インコーポレイテッド 移植で免疫応答の予防と処置のための間葉幹細胞を利用する方法とその組成物
JP2004129549A (ja) 2002-10-09 2004-04-30 Yasuo Kitagawa 脂肪由来細胞群からの間葉系幹細胞の選択的増殖方法
JP2004201612A (ja) 2002-12-26 2004-07-22 Minoru Ueda 未分化多能性細胞並びに、それを用いた関連組織又は歯作製方法
JP2004210713A (ja) 2002-12-27 2004-07-29 Asahi Kasei Corp 医療用胎盤由来細胞製剤
WO2005093044A1 (en) 2004-03-22 2005-10-06 Osiris Therapeutics, Inc. Mesenchymal stem cells and uses therefor
JP2006204200A (ja) * 2004-12-27 2006-08-10 Two Cells Co Ltd 間葉系幹細胞の骨化及び／又は軟骨化促進剤と骨化及び／又は軟骨化促進方法
JP2006346420A (ja) * 2005-06-13 2006-12-28 Univ Nagoya 移植材料及び骨質改善剤

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ARTHRITIS & RHEUMATISM, vol. 52, no. 5, 2005, pages 1595 - 1603
ARTHRITIS & RHEUMATISM, vol. 56, no. 4, 2007, pages 1175 - 1186
ARTHRITIS RHEUM., vol. 56, no. 2, 2007, pages 521 - 530
AUGELLO, A. ET AL.: "Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collage-induced arthritis", ARTHRITIS & RHEUMATISM, vol. 56, no. 4, April 2007 (2007-04-01), pages 1175 - 1186, XP002517050 *
BLOOD, vol. 105, no. 4, 2005, pages 1815 - 22
J EXP MED., vol. 191, 2000, pages 313 - 320
See also references of EP2191835A4 *
TRANSPLANTATION, vol. 81, no. 10, 2006, pages 1390 - 1397

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10104880B2 (en) 2008-08-20 2018-10-23 Celularity, Inc. Cell composition and methods of making the same
JP2015180199A (ja) * 2009-11-27 2015-10-15 ステムピューティクス リサーチ ピーブイティー．リミテッドＳｔｅｍｐｅｕｔｉｃｓ Ｒｅｓｅａｒｃｈ Ｐｖｔ． Ｌｔｄ． 間葉系幹細胞を調製する方法、その組成物及びキット
JP2016185972A (ja) * 2010-08-31 2016-10-27 クック・ジェネラル・バイオテクノロジー・エルエルシー 動物の疾病の治療のための全身的、同種間幹細胞治療
WO2018225673A1 (ja) * 2017-06-06 2018-12-13 Ｄｓファーマアニマルヘルス株式会社 細胞凝集低減方法および細胞凝集が低減された治療用組成物
JPWO2018225673A1 (ja) * 2017-06-06 2020-04-09 Ｄｓファーマアニマルヘルス株式会社 細胞凝集低減方法および細胞凝集が低減された治療用組成物
JP7133549B2 (ja) 2017-06-06 2022-09-08 住友ファーマアニマルヘルス株式会社 細胞凝集低減方法および細胞凝集が低減された治療用組成物

Also Published As

Publication number Publication date
EP2191835A4 (en) 2011-12-14
US20110262402A1 (en) 2011-10-27
JPWO2009031606A1 (ja) 2010-12-16
EP2191835A1 (en) 2010-06-02

Similar Documents

Publication Publication Date Title
WO2009031606A1 (ja) 関節炎治療及び予防剤
WO2007146426A3 (en) Nanoshells for drug delivery
EP2073752A4 (en) IMPLANTABLE DEVICES FOR THE TREATMENT OF INCONTINENCE, AND METHODS OF USE
MY173994A (en) Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
EP2097012A4 (en) DEVICES AND METHOD FOR TREATING HEART FAILURE
WO2012091956A3 (en) Continuous indentation lateral lobe apparatus and method
WO2012091954A3 (en) Median lobe destruction apparatus and method
WO2011014255A8 (en) Treatment of crohn's disease with laquinimod
WO2006085115A3 (en) Therapeutic uses of tomato extracts
WO2008030505A8 (en) Methods and compositions for the treatment of antibody mediated neuropathies
UA97653C2 (ru) Мягкие капсулы, содержащие палоносетрона гидрохлорид, которые имеют улучшенную стабильность и биологическую доступность
WO2007025005A3 (en) Sustained release formulations of nalbuphine
WO2012064667A3 (en) Treatment of addiction and impulse-control disorders using pde7 inhibitors
WO2008141308A3 (en) Gene expression and pain
EP2064319A4 (en) METHODS FOR PRODUCING GLIAL AND NEURONAL CELLS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS OF THE CENTRAL NERVOUS SYSTEM
HK1138315A1 (en) Expansion method for adult stem cells from blood, particularly peripheral blood, and relative application in medical field
WO2008052139A3 (en) Ultra low dose doxepin and methods of using the same to treat sleep disorders
WO2010151565A3 (en) Combination therapies for the treatment of obesity
WO2010088450A3 (en) Arylamide derivatives useful in the treatment of diseases associated with serca activity
WO2010151503A3 (en) Combination therapies for the treatment of obesity
WO2011044523A3 (en) Compositions and methods for treating obesity
WO2010045522A3 (en) Combination therapies for the treatment of obesity
WO2011060253A3 (en) Methods of treating diseases, pharmaceutical compositions, and pharmaceutical dosage forms
WO2008011473A3 (en) Compositions and their uses directed to hbxip
WO2010150098A3 (en) Use of quingolide in the treatment of endometriosis, pain and cancer

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08829164

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009531268

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008829164

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 12676638

Country of ref document: US