HUE052615T2 - PD-1 és LAG-3 immunreaktivitással rendelkezõ, kovalensen kötött diatestek és eljárások alkalmazásukra - Google Patents

PD-1 és LAG-3 immunreaktivitással rendelkezõ, kovalensen kötött diatestek és eljárások alkalmazásukra

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Publication number
HUE052615T2
HUE052615T2 HUE15811659A HUE15811659A HUE052615T2 HU E052615 T2 HUE052615 T2 HU E052615T2 HU E15811659 A HUE15811659 A HU E15811659A HU E15811659 A HUE15811659 A HU E15811659A HU E052615 T2 HUE052615 T2 HU E052615T2
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HU
Hungary
Prior art keywords
immunoreactivity
lag
methods
covalently bonded
diabodies
Prior art date
Application number
HUE15811659A
Other languages
English (en)
Hungarian (hu)
Inventor
Ezio Bonvini
Leslie S Johnson
Kalpana Shah
Motte-Mohs Ross La
Paul A Moore
Scott Koenig
Original Assignee
Macrogenics Inc
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Filing date
Publication date
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Publication of HUE052615T2 publication Critical patent/HUE052615T2/hu

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626Diabody or triabody
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74Inducing cell proliferation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HUE15811659A 2014-06-26 2015-06-19 PD-1 és LAG-3 immunreaktivitással rendelkezõ, kovalensen kötött diatestek és eljárások alkalmazásukra HUE052615T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462017467P 2014-06-26 2014-06-26

Publications (1)

Publication Number Publication Date
HUE052615T2 true HUE052615T2 (hu) 2021-05-28

Family

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Family Applications (1)

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HUE15811659A HUE052615T2 (hu) 2014-06-26 2015-06-19 PD-1 és LAG-3 immunreaktivitással rendelkezõ, kovalensen kötött diatestek és eljárások alkalmazásukra

Country Status (35)

Country Link
US (4) US10160806B2 (enExample)
EP (1) EP3161004B1 (enExample)
JP (2) JP6890421B2 (enExample)
KR (1) KR102514330B1 (enExample)
CN (1) CN106715470B (enExample)
AR (1) AR101009A1 (enExample)
AU (1) AU2015280392B2 (enExample)
CA (1) CA2953818C (enExample)
CL (1) CL2016003335A1 (enExample)
CR (1) CR20160599A (enExample)
CY (1) CY1123917T1 (enExample)
DK (1) DK3161004T3 (enExample)
EA (1) EA036737B1 (enExample)
EC (1) ECSP16096342A (enExample)
ES (1) ES2843269T3 (enExample)
GE (1) GEP20197034B (enExample)
HR (1) HRP20210041T1 (enExample)
HU (1) HUE052615T2 (enExample)
IL (1) IL249764B (enExample)
LT (1) LT3161004T (enExample)
MX (1) MX369486B (enExample)
MY (1) MY177324A (enExample)
PE (1) PE20170767A1 (enExample)
PH (1) PH12016502590B1 (enExample)
PL (1) PL3161004T3 (enExample)
PT (1) PT3161004T (enExample)
RS (1) RS61284B1 (enExample)
SA (1) SA516380600B1 (enExample)
SG (1) SG11201610715SA (enExample)
SI (1) SI3161004T1 (enExample)
SM (1) SMT202100021T1 (enExample)
TW (1) TWI693232B (enExample)
UA (1) UA119673C2 (enExample)
WO (1) WO2015200119A1 (enExample)
ZA (1) ZA201608768B (enExample)

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