HUE041929T2 - Eljárás szaruhártya endotél sejtek irányított differenciálására - Google Patents

Eljárás szaruhártya endotél sejtek irányított differenciálására

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Publication number
HUE041929T2
HUE041929T2 HUE12856068A HUE12856068A HUE041929T2 HU E041929 T2 HUE041929 T2 HU E041929T2 HU E12856068 A HUE12856068 A HU E12856068A HU E12856068 A HUE12856068 A HU E12856068A HU E041929 T2 HUE041929 T2 HU E041929T2
Authority
HU
Hungary
Prior art keywords
endothelial cells
corneal endothelial
directed differentiation
producing corneal
differentiation producing
Prior art date
Application number
HUE12856068A
Other languages
English (en)
Inventor
Kathryn Mccabe
Shi-Jiang Lu
Robert Lanza
Original Assignee
Astellas Inst For Regenerative Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Inst For Regenerative Medicine filed Critical Astellas Inst For Regenerative Medicine
Publication of HUE041929T2 publication Critical patent/HUE041929T2/hu

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3808—Endothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
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  • Health & Medical Sciences (AREA)
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  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HUE12856068A 2011-12-06 2012-12-06 Eljárás szaruhártya endotél sejtek irányított differenciálására HUE041929T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161567479P 2011-12-06 2011-12-06

Publications (1)

Publication Number Publication Date
HUE041929T2 true HUE041929T2 (hu) 2019-06-28

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ID=48575057

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE12856068A HUE041929T2 (hu) 2011-12-06 2012-12-06 Eljárás szaruhártya endotél sejtek irányított differenciálására

Country Status (15)

Country Link
US (2) US9752118B2 (hu)
EP (2) EP2788472B1 (hu)
CA (2) CA2858173C (hu)
CY (1) CY1121383T1 (hu)
DK (1) DK2788472T3 (hu)
ES (1) ES2716200T3 (hu)
HR (1) HRP20190460T1 (hu)
HU (1) HUE041929T2 (hu)
LT (1) LT2788472T (hu)
PL (1) PL2788472T3 (hu)
PT (1) PT2788472T (hu)
RS (1) RS58526B1 (hu)
SI (1) SI2788472T1 (hu)
TR (1) TR201903889T4 (hu)
WO (1) WO2013086236A2 (hu)

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US10842669B2 (en) * 2008-11-13 2020-11-24 Gholam A. Peyman Ophthalmic drug delivery method
HUE041929T2 (hu) 2011-12-06 2019-06-28 Astellas Inst For Regenerative Medicine Eljárás szaruhártya endotél sejtek irányított differenciálására
JP6519851B2 (ja) * 2012-07-06 2019-05-29 京都府公立大学法人 眼細胞の分化マーカーおよび分化制御
EP3985102A1 (en) 2013-05-03 2022-04-20 Emmetrope Ophthalmics LLC Identificatoin and isolation of human corneal endothelial cells (hcecs)
EP3029140A4 (en) 2013-07-30 2017-06-28 Kyoto Prefectural Public University Corporation Corneal endothelial cell marker
US11730722B2 (en) 2013-07-30 2023-08-22 Kyoto Prefectural Public University Corporation Corneal endothelium ECM therapeutic medicaments
CN105518123B (zh) * 2013-08-06 2021-01-15 国立研究开发法人理化学研究所 制备眼前段组织的方法
WO2015041606A1 (en) * 2013-09-17 2015-03-26 Singapore Health Services Pte Ltd Corneal stromal keratocyte culture
EP3064222B1 (en) 2013-10-31 2020-10-21 Kyoto Prefectural Public University Corporation Therapeutic drug comprising tgf-beta signal inhibitor for diseases related to endoplasmic reticulum cell death in corneal endothelium
MX2016006915A (es) * 2013-11-27 2017-01-23 Kyoto Prefectural Public Univ Corp Aplicacion de laminina a cultivo de celulas endoteliales de la cornea.
JP6770435B2 (ja) 2014-10-31 2020-10-14 京都府公立大学法人 ラミニンによる網膜および神経の新規治療
CN107073067A (zh) * 2014-10-31 2017-08-18 京都府公立大学法人 使用层粘连蛋白的新的角膜的治疗
CA2980580C (en) 2015-03-23 2024-01-23 Astellas Institute For Regenerative Medicine Improved assays for potency of human retinal pigment epithelium (rpe) cells and photoreceptor progenitors
EA037915B1 (ru) 2015-08-18 2021-06-07 Астеллас Инститьют Фор Ридженерэйтив Медсин Клинические композиции
WO2017190136A1 (en) * 2016-04-29 2017-11-02 The Regents Of The University Of California Induction of corneal endothelial cells
US20200032202A1 (en) * 2017-04-04 2020-01-30 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College A modified cell culture medium and uses thereof
WO2018230711A1 (ja) * 2017-06-16 2018-12-20 学校法人同志社 ｍＴＯＲインヒビターを含む、眼の症状、障害または疾患を治療または予防するための医薬およびその応用
EP3639855A4 (en) * 2017-06-16 2021-03-17 The Doshisha COMPOUNDS HAVING CASPASE INHIBITORING ACTIVITY, PHARMACEUTICAL AGENT CONTAINING THEM FOR THE TREATMENT OR PREVENTION OF SYMPTOMS, DISORDERS OR DISEASES OF CORNEAL ENDOTHELIUM, AND APPLICATION OF SUCH PHARMACEUTICAL AGENT
CN107475200B (zh) * 2017-08-08 2020-12-22 浙江大学 一种背根神经节源的神经嵴干细胞的分离、培养与分化方法
KR102010478B1 (ko) * 2017-11-01 2019-08-13 차의과학대학교 산학협력단 줄기 세포의 신경 능선 세포로의 분화용 조성물, 키트, 및 이를 이용한 방법
JP7384671B2 (ja) * 2017-11-24 2023-11-21 住友化学株式会社 神経系細胞又は神経組織と非神経上皮組織とを含む細胞塊の製造方法及びその細胞塊
KR102114787B1 (ko) * 2018-04-02 2020-05-26 중앙대학교 산학협력단 리보핵산분해효소 5 고발현된 각막 내피세포를 포함하는 3차원 각막 내피 이식체 제조방법
EP3947642A4 (en) * 2019-04-05 2022-12-14 The University of Hong Kong CULTURE MEDIUM FOR MAMMALIAN PLURIPOTENTE STEM CELLS, COMPOSITION AND METHODS
KR102446567B1 (ko) * 2019-04-17 2022-09-26 연세대학교 산학협력단 각막 내피 세포의 기능 부전 진단용 바이오마커
EP4334437A1 (en) 2021-05-03 2024-03-13 Astellas Institute for Regenerative Medicine Methods of generating mature corneal endothelial cells
CN113355424B (zh) * 2021-07-14 2022-03-25 江苏先声医学诊断有限公司 Pcdh11x突变在预测非小细胞肺癌患者对免疫检查点抑制剂疗法敏感性中的应用
WO2024128696A1 (ko) * 2022-12-13 2024-06-20 재단법인 아산사회복지재단 줄기세포의 각막 내피 세포로의 분화 유도 방법 및 이의 용도

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