HU229938B1 - Pharmaceutical dosage form of amorphous nelfinavir mesylate - Google Patents
Pharmaceutical dosage form of amorphous nelfinavir mesylate Download PDFInfo
- Publication number
- HU229938B1 HU229938B1 HU0401238A HUP0401238A HU229938B1 HU 229938 B1 HU229938 B1 HU 229938B1 HU 0401238 A HU0401238 A HU 0401238A HU P0401238 A HUP0401238 A HU P0401238A HU 229938 B1 HU229938 B1 HU 229938B1
- Authority
- HU
- Hungary
- Prior art keywords
- fcfc
- main
- xfc
- aaa
- fcfcfc
- Prior art date
Links
- 239000002552 dosage form Substances 0.000 title claims description 8
- 229960005230 nelfinavir mesylate Drugs 0.000 title description 5
- NQHXCOAXSHGTIA-SKXNDZRYSA-N nelfinavir mesylate Chemical compound CS(O)(=O)=O.CC1=C(O)C=CC=C1C(=O)N[C@H]([C@H](O)CN1[C@@H](C[C@@H]2CCCC[C@@H]2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 NQHXCOAXSHGTIA-SKXNDZRYSA-N 0.000 title description 5
- 239000007787 solid Substances 0.000 claims description 6
- 238000002844 melting Methods 0.000 claims description 4
- 230000008018 melting Effects 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 2
- 241001435619 Lile Species 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims 5
- 239000003826 tablet Substances 0.000 claims 3
- 240000003291 Armoracia rusticana Species 0.000 claims 2
- 235000011330 Armoracia rusticana Nutrition 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- 244000269722 Thea sinensis Species 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 235000006693 Cassia laevigata Nutrition 0.000 claims 1
- 241000282326 Felis catus Species 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 241000023813 Isia Species 0.000 claims 1
- FRTIRJDNPYMRGE-UHFFFAOYSA-N JE-III Natural products O=C1C2=C(O)C(C)=C(O)C=C2OC=C1CC1=CC=C(O)C=C1 FRTIRJDNPYMRGE-UHFFFAOYSA-N 0.000 claims 1
- 241000255777 Lepidoptera Species 0.000 claims 1
- 101100226912 Mus musculus Fcsk gene Proteins 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 240000005499 Sasa Species 0.000 claims 1
- 241000735631 Senna pendula Species 0.000 claims 1
- 235000005324 Typha latifolia Nutrition 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000002052 anaphylactic effect Effects 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 244000118869 coast club rush Species 0.000 claims 1
- 235000016213 coffee Nutrition 0.000 claims 1
- 235000013353 coffee beverage Nutrition 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 239000011888 foil Substances 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000007937 lozenge Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000000155 melt Substances 0.000 claims 1
- 229940124513 senna glycoside Drugs 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 210000003462 vein Anatomy 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 235000019640 taste Nutrition 0.000 description 17
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 9
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 5
- 241000750004 Nestor meridionalis Species 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 2
- 244000046052 Phaseolus vulgaris Species 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 241000238876 Acari Species 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 241001209177 Akis Species 0.000 description 1
- ZFXQNADNEBRERM-BJDJZHNGSA-N Ala-Ala-Pro-Pro Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(O)=O)CCC1 ZFXQNADNEBRERM-BJDJZHNGSA-N 0.000 description 1
- 241001044684 Amadina fasciata Species 0.000 description 1
- 241000726103 Atta Species 0.000 description 1
- 241000070928 Calligonum comosum Species 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 241000764238 Isis Species 0.000 description 1
- 241001446467 Mama Species 0.000 description 1
- 101100490437 Mus musculus Acvrl1 gene Proteins 0.000 description 1
- 101100107522 Mus musculus Slc1a5 gene Proteins 0.000 description 1
- 101150071716 PCSK1 gene Proteins 0.000 description 1
- 235000016496 Panda oleosa Nutrition 0.000 description 1
- 240000000220 Panda oleosa Species 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- COYHRQWNJDJCNA-NUJDXYNKSA-N Thr-Thr-Thr Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O COYHRQWNJDJCNA-NUJDXYNKSA-N 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- QWCKQJZIFLGMSD-UHFFFAOYSA-N alpha-aminobutyric acid Chemical compound CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 description 1
- 210000003423 ankle Anatomy 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 238000007909 melt granulation Methods 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28841001P | 2001-05-03 | 2001-05-03 | |
| PCT/EP2002/004711 WO2002089835A2 (en) | 2001-05-03 | 2002-04-29 | Pharmaceutical dosage form of amorphous nelfinavir mesylate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0401238A2 HUP0401238A2 (hu) | 2004-12-28 |
| HUP0401238A3 HUP0401238A3 (en) | 2012-09-28 |
| HU229938B1 true HU229938B1 (en) | 2015-01-28 |
Family
ID=23106974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401238A HU229938B1 (en) | 2001-05-03 | 2002-04-29 | Pharmaceutical dosage form of amorphous nelfinavir mesylate |
Country Status (36)
Families Citing this family (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2359945C (en) | 1999-11-12 | 2011-04-26 | Abbott Laboratories | Inhibitors of crystallization in a solid dispersion |
| DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| CA2398226A1 (en) * | 2002-01-28 | 2003-07-28 | Pfizer Inc. | Increased-dosage nelfinavir tablet and method of making same |
| US7495011B2 (en) | 2003-07-15 | 2009-02-24 | Arigen Pharmaceuticals, Inc. | Anti-coronavirus drug |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| US8377952B2 (en) * | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| BRPI0418330A (pt) * | 2003-12-31 | 2007-05-02 | Pfizer Prod Inc | composições sólidas de drogas de solubilidade baixa e poloxámeros |
| MX2007006635A (es) * | 2004-12-03 | 2007-06-19 | Merck & Co Inc | Formulacion farmaceutica de inhibidores dela carboxamida vih integrasa que contienen una composicion que controla la velocidad de liberacion. |
| DE602006011485D1 (de) * | 2005-09-23 | 2010-02-11 | Hoffmann La Roche | Neue dosierformulierung |
| WO2007068615A2 (en) * | 2005-12-14 | 2007-06-21 | F. Hoffmann-La Roche Ag | Hcv prodrug formulation |
| ES2350497T3 (es) * | 2005-12-14 | 2011-01-24 | F. Hoffmann-La Roche Ag | Formulación de profármacos para el vhc. |
| PE20080422A1 (es) * | 2006-08-10 | 2008-04-28 | Cipla Ltd | Composicion solida antirretroviral de administracion oral |
| RU2454220C2 (ru) | 2006-08-16 | 2012-06-27 | Новартис Аг | Способ получения твердых дисперсий высококристаллических терапевтических соединений |
| EP2112925A4 (en) * | 2006-11-15 | 2013-01-09 | Abbott Lab | SOLID PHARMACEUTICAL DOSAGE FORMULATIONS |
| EP2918578A1 (en) | 2007-03-16 | 2015-09-16 | Concert Pharmaceuticals, Inc. | Inhibitors of cholesterol ester transfer protein |
| JP2010524972A (ja) * | 2007-04-19 | 2010-07-22 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化したモルホリニル化合物 |
| EP2527336A1 (en) | 2007-04-25 | 2012-11-28 | Concert Pharmaceuticals Inc. | Deuterated analogues of cilostazol |
| US8567657B2 (en) * | 2007-04-30 | 2013-10-29 | Mtj Consulting Services Inc. | Coiled tubing with retainer for conduit |
| US9194512B2 (en) | 2007-04-30 | 2015-11-24 | Mark Andreychuk | Coiled tubing with heat resistant conduit |
| FI3825306T3 (fi) | 2007-05-01 | 2023-08-23 | Concert Pharmaceuticals Inc | Morfinaaniyhdisteitä |
| MX341177B (es) | 2007-05-01 | 2016-08-10 | Concert Pharmaceuticals Inc | Compuestos de morfina. |
| US7973049B2 (en) * | 2007-05-01 | 2011-07-05 | Concert Pharmaceuticals Inc. | Morphinan compounds |
| WO2008137461A1 (en) * | 2007-05-01 | 2008-11-13 | Concert Pharmaceuticals Inc. | Naphthyl(ethyl) acetamides |
| AR066972A1 (es) | 2007-06-12 | 2009-09-23 | Concert Pharmaceuticals Inc | Derivados azapeptidicos |
| WO2009051782A1 (en) * | 2007-10-18 | 2009-04-23 | Concert Pharmaceuticals Inc. | Deuterated etravirine |
| EP2214635A1 (en) * | 2007-10-19 | 2010-08-11 | Purdue Research Foundation | Solid formulations of crystalline compounds |
| ITMI20080227A1 (it) * | 2008-02-13 | 2009-08-14 | Felice Vinati | '' dispositivo di sicurezza per apparati di sollevamento a fune '' |
| KR20100121527A (ko) | 2008-02-29 | 2010-11-17 | 콘서트 파마슈티컬즈, 인크. | 치환된 잔틴 유도체 |
| WO2009146310A1 (en) * | 2008-05-28 | 2009-12-03 | Concert Pharmaceuticals Inc. | Deuterated tizanidine |
| WO2010019557A1 (en) * | 2008-08-12 | 2010-02-18 | Concert Pharmaceuticals Inc. | N-phenyl-2-pyrimidineamine derivatives |
| EP2334678B1 (en) | 2008-09-19 | 2012-12-26 | Concert Pharmaceuticals Inc. | Morphinan compounds |
| WO2010062690A1 (en) | 2008-10-30 | 2010-06-03 | Concert Pharmaceuticals Inc. | Combination of morphinan compounds and antidepressant for the treatment of pseudobulbar affect, neurological diseases, intractable and chronic pain and brain injury |
| DK2397158T3 (en) | 2008-10-30 | 2016-07-25 | Concert Pharmaceuticals Inc | COMBINATION OF MORPHINANFORBINDELSER AND antidepressants in treating pseudobulbar affect |
| AU2009311645C1 (en) | 2008-11-04 | 2014-10-02 | Acer Therapeutics Inc. | CXCR4 receptor compounds |
| US20110313004A1 (en) | 2008-12-04 | 2011-12-22 | Concert Pharmaceuticals, Inc. | Deuterated pyridinones |
| US20110053961A1 (en) | 2009-02-27 | 2011-03-03 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| AP2909A (en) | 2009-03-17 | 2014-05-31 | Concert Pharmaceuticals Inc | Pyrazinoisoquinoline Compounds |
| US20120244122A1 (en) | 2009-05-28 | 2012-09-27 | Masse Craig E | Peptides for the Treatment of HCV Infections |
| US8501738B2 (en) | 2009-06-23 | 2013-08-06 | Concert Pharmaceuticals, Inc. | Substituted triazolo-pyridazine derivatives |
| US20110015154A1 (en) * | 2009-07-20 | 2011-01-20 | Kellermann Gottfried H | Supporting acetylcholine function |
| US8278460B2 (en) | 2009-10-15 | 2012-10-02 | Concert Pharmaceuticals, Inc. | Substituted benzimidazoles |
| US20110098265A1 (en) * | 2009-10-28 | 2011-04-28 | Neuroscience, Inc. | Methods for reducing cravings and impulses associated with addictive and compulsive behaviors |
| WO2011060216A1 (en) | 2009-11-12 | 2011-05-19 | Concert Pharmaceuticals Inc. | Substituted azaindoles |
| EP2536696A1 (en) | 2010-02-18 | 2012-12-26 | Concert Pharmaceuticals Inc. | Pyrimidine derivatives |
| US9155795B2 (en) | 2010-02-26 | 2015-10-13 | Anchor Therapeutics, Inc. | CXCR4 receptor compounds |
| US8575361B2 (en) | 2010-03-02 | 2013-11-05 | Concert Pharmaceuticals Inc. | Tetrahydronaphthalene derivatives |
| US8513434B2 (en) | 2010-03-02 | 2013-08-20 | Concert Pharmaceuticals Inc. | Tetrahydronaphthalene derivatives |
| EP2579859B1 (en) * | 2010-06-14 | 2015-08-05 | ratiopharm GmbH | Solid ivabradine-containing composition |
| WO2012037060A1 (en) | 2010-09-13 | 2012-03-22 | Concert Pharmaceuticals Inc. | Substituted azaindoles |
| EP2455068A1 (en) * | 2010-11-09 | 2012-05-23 | F. Hoffmann-La Roche AG | Pharmaceutical composition for treating HCV infections |
| WO2012065028A2 (en) | 2010-11-11 | 2012-05-18 | Concert Pharmaceuticals Inc. | Substituted tetracyclines |
| WO2012079075A1 (en) | 2010-12-10 | 2012-06-14 | Concert Pharmaceuticals, Inc. | Deuterated phthalimide derivatives |
| US8447329B2 (en) | 2011-02-08 | 2013-05-21 | Longsand Limited | Method for spatially-accurate location of a device using audio-visual information |
| CA2828251A1 (en) | 2011-02-25 | 2012-08-30 | Concert Pharmaceuticals, Inc. | 2-amino-naphthyridine derivatives |
| WO2012129381A1 (en) | 2011-03-22 | 2012-09-27 | Concert Pharmaceuticals Inc. | Deuterated preladenant |
| WO2012151361A1 (en) | 2011-05-03 | 2012-11-08 | Concert Pharmaceuticals Inc. | Carbamoylpyridone derivatives |
| WO2012154728A1 (en) | 2011-05-10 | 2012-11-15 | Concert Pharmaceuticals Inc. | Deuterated n-butyl bumetanide |
| RS56096B1 (sr) | 2011-05-18 | 2017-10-31 | Concert Pharmaceuticals Inc | Deuterisani derivati ivakaftora |
| WO2013013052A1 (en) | 2011-07-19 | 2013-01-24 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| FR2985177B1 (fr) * | 2012-01-02 | 2016-04-01 | Oreal | Composition cosmetique solide aqueuse comprenant de l'alkylcellulose, au moins deux huiles non volatiles et au moins deux agents tensioactifs |
| CN104254540A (zh) | 2012-01-09 | 2014-12-31 | 安科治疗公司 | Apj受体化合物 |
| WO2013130849A1 (en) | 2012-02-29 | 2013-09-06 | Concert Pharmaceuticals, Inc. | Substituted dioxopiperidinyl phthalimide derivatives |
| IN2014DN08443A (https=) | 2012-04-13 | 2015-05-08 | Concert Pharmaceuticals Inc | |
| US9249093B2 (en) | 2012-04-20 | 2016-02-02 | Concert Pharmaceuticals, Inc. | Deuterated rigosertib |
| AU2013274030B2 (en) | 2012-06-15 | 2016-07-07 | Sun Pharmaceutical Industries, Inc. | Deuterated derivatives of ruxolitinib |
| US10017445B2 (en) | 2012-07-12 | 2018-07-10 | Concert Pharmaceuticals, Inc. | Deuterated idebenone |
| CA2880083A1 (en) | 2012-08-17 | 2014-02-20 | Concert Pharmaceuticals, Inc. | Deuterated baricitinib |
| MY183582A (en) | 2012-11-19 | 2021-02-26 | Vertex Pharmaceuticals Europe Ltd | Deuterated cftr potentiators |
| EP2935251A1 (en) | 2012-12-20 | 2015-10-28 | Concert Pharmaceuticals Inc. | Deuterated alk inhibitors |
| EP2938343B1 (en) | 2012-12-21 | 2018-09-12 | Mayo Foundation For Medical Education And Research | Methods and materials for treating calcific aortic valve stenosis |
| WO2014110322A2 (en) | 2013-01-11 | 2014-07-17 | Concert Pharmaceuticals, Inc. | Substituted dioxopiperidinyl phthalimide derivatives |
| US20160024084A1 (en) | 2013-03-15 | 2016-01-28 | Concert Pharmaceuticals, Inc. | Deuterated palbociclib |
| EP2968268B1 (en) | 2013-03-15 | 2020-07-29 | Concert Pharmaceuticals Inc. | Inhibitors of the enzyme udp-glucose: n-acyl-sphingosine glucosyltransferase |
| HU231191B1 (hu) | 2013-04-15 | 2021-08-30 | Szegedi Tudományegyetem | Izotóp tartalmú morfin molekulák |
| WO2015009889A1 (en) | 2013-07-18 | 2015-01-22 | Concert Pharmaceuticals, Inc. | Deuterated intedanib derivatives and their use for the treatment of proliferative disorders |
| EP3021861A1 (en) | 2013-07-18 | 2016-05-25 | Anchor Therapeutics, Inc. | Apj receptor compounds |
| WO2015031741A1 (en) | 2013-08-30 | 2015-03-05 | Concert Pharmaceuticals, Inc. | Deuterated derivatives of a thienotriazolodiazapine bromodomain-containing protein inhibitor |
| EP3105232B1 (en) | 2014-02-10 | 2019-08-28 | Concert Pharmaceuticals Inc. | Substituted triazolobenzodiazepines |
| US20170216296A1 (en) | 2014-04-18 | 2017-08-03 | Concert Pharmaceuticals, Inc. | Methods of treating hyperglycemia |
| WO2015179772A1 (en) | 2014-05-23 | 2015-11-26 | Concert Pharmaceuticals, Inc. | Deuterated phenylquinazolinone and phenylisoquinolinone compounds |
| WO2015188073A1 (en) | 2014-06-06 | 2015-12-10 | Research Triangle Institute | Apelin receptor (apj) agonists and uses thereof |
| WO2016022955A1 (en) | 2014-08-07 | 2016-02-11 | Mayo Foundation For Medical Education And Research | Compounds and methods for treating cancer |
| WO2016061488A1 (en) | 2014-10-17 | 2016-04-21 | Concert Pharmaceuticals, Inc. | Amine reuptake inhibitors |
| WO2016073545A1 (en) | 2014-11-06 | 2016-05-12 | Concert Pharmaceuticals, Inc. | Phenyloxadiazole benzoic acids |
| WO2016089814A1 (en) | 2014-12-02 | 2016-06-09 | Concert Pharmaceuticals, Inc. | Deuterated analogues of daclatasvir |
| WO2016094011A1 (en) * | 2014-12-11 | 2016-06-16 | Merck Sharp & Dohme Corp. | Crystal forms of a ccr5 antagonist |
| CN105769809A (zh) * | 2014-12-23 | 2016-07-20 | 上海星泰医药科技有限公司 | 提高生物利用度的雷尼司他及其制备方法 |
| WO2016105547A1 (en) | 2014-12-24 | 2016-06-30 | Concert Pharmaceuticals, Inc. | Deuterated dasabuvir |
| WO2016109795A1 (en) | 2014-12-31 | 2016-07-07 | Concert Pharmaceuticals, Inc. | Deuterated funapide and difluorofunapide |
| EP3265440A1 (en) | 2015-03-06 | 2018-01-10 | Concert Pharmaceuticals Inc. | Deuterated emricasan |
| EP3277647A1 (en) | 2015-03-31 | 2018-02-07 | Vertex Pharmaceuticals (Europe) Limited | Deuterated vx-661 |
| US10683305B2 (en) | 2015-04-27 | 2020-06-16 | Concert Pharmaceuticals, Inc. | Deuterated OTX-015 |
| WO2017020005A1 (en) | 2015-07-30 | 2017-02-02 | Concert Pharmaceuticals, Inc. | Morphinan compounds for use in treating agitation |
| WO2017020002A1 (en) | 2015-07-30 | 2017-02-02 | Concert Pharmaceuticals, Inc. | Deuterated morphinan compounds for use in treating agitation |
| KR102828163B1 (ko) | 2015-09-21 | 2025-07-02 | 버텍스 파마슈티칼스 (유럽) 리미티드 | 중수소화된 cftr 강화제의 투여 |
| WO2017087795A1 (en) | 2015-11-19 | 2017-05-26 | Concert Pharmaceuticals, Inc. | Deuterated epi-743 |
| CN108602806B (zh) | 2015-12-09 | 2022-07-12 | 研究三角协会 | 改进的爱帕琳肽受体(apj)激动剂及其用途 |
| WO2017147003A1 (en) | 2016-02-26 | 2017-08-31 | Novobiotic Pharmaceuticals, Llc | Novel macrocyclic antibiotics and uses thereof |
| US10561659B2 (en) | 2016-05-04 | 2020-02-18 | Concert Pharmaceuticals, Inc. | Treatment of hair loss disorders with deuterated JAK inhibitors |
| EP4122919A1 (en) | 2016-07-04 | 2023-01-25 | Avanir Pharmaceuticals, Inc. | Methods for the synthesis of deuterated dextromethorphan |
| CN109789103A (zh) | 2016-08-01 | 2019-05-21 | 布里格姆妇女医院 | 用于递送蛋白质和肽的颗粒 |
| CA3036382A1 (en) | 2016-12-21 | 2018-06-28 | Research Triangle Institute | Diaryl purine derivatives with improved bioavailability |
| EP3589659B1 (en) | 2017-02-28 | 2025-04-09 | Mayo Foundation for Medical Education and Research | Combinations for use in the treatment of cancer |
| US11278025B2 (en) | 2017-05-17 | 2022-03-22 | The General Hospital Corporation | Antibiotic compounds |
| BR112019024177A2 (pt) | 2017-05-19 | 2020-06-02 | Superb Wisdom Limited | Derivados de resiquimode |
| CN111491629A (zh) | 2017-11-22 | 2020-08-04 | 康塞特医药品公司 | D-丝氨酸的氘化类似物及其用途 |
| US11243207B2 (en) | 2018-03-29 | 2022-02-08 | Mayo Foundation For Medical Education And Research | Assessing and treating cancer |
| WO2020210707A1 (en) | 2019-04-10 | 2020-10-15 | Mayo Foundation For Medical Education And Research | Methods and materials for gender-dependent treatment of cardiovascular dysfunction |
| WO2021236139A1 (en) | 2020-05-21 | 2021-11-25 | Concert Pharmaceuticals, Inc. | Novel deuterated jak inhibitor and uses thereof |
| CA3184471A1 (en) | 2020-05-27 | 2021-12-02 | The Penn State Research Foundation | Antibacterial compounds |
| JP2023553253A (ja) | 2020-10-28 | 2023-12-21 | サン ファーマシューティカル インダストリーズ，インコーポレイテッド | 重水素化ｊａｋ阻害剤による脱毛障害の治療のためのレジメン |
| JP2024507574A (ja) | 2021-02-25 | 2024-02-20 | リサーチ トライアングル インスティテュート | アペリン受容体アゴニストとしてのヘテロアリール誘導体 |
| AU2022328272A1 (en) | 2021-08-11 | 2024-02-22 | Sun Pharmaceutical Industries, Inc. | Treatment of hair loss disorders with deuterated jak inhibitors |
| EP4384173A1 (en) | 2021-08-12 | 2024-06-19 | Sun Pharmaceutical Industries, Inc. | Treatment of jak-inhibition-responsive disorders with prodrugs of jak inhibitors |
| US20250275977A1 (en) | 2022-05-04 | 2025-09-04 | Sun Pharmaceutical Industries, Inc. | Dosage regimens for treatment with deuterated jak inhibitors |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5281420A (en) * | 1992-05-19 | 1994-01-25 | The Procter & Gamble Company | Solid dispersion compositions of tebufelone |
| IE80467B1 (en) * | 1995-07-03 | 1998-07-29 | Elan Corp Plc | Controlled release formulations for poorly soluble drugs |
| US5834472A (en) * | 1996-05-24 | 1998-11-10 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| US6232333B1 (en) * | 1996-11-21 | 2001-05-15 | Abbott Laboratories | Pharmaceutical composition |
| US6045829A (en) * | 1997-02-13 | 2000-04-04 | Elan Pharma International Limited | Nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors using cellulosic surface stabilizers |
| US6001851A (en) * | 1997-03-13 | 1999-12-14 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| CA2290624C (en) * | 1997-06-06 | 2006-12-05 | John W. Shell | Gastric-retentive oral drug dosage forms for controlled release of highly soluble drugs |
| WO1998057648A1 (en) * | 1997-06-16 | 1998-12-23 | Vertex Pharmaceuticals Incorporated | Methods of increasing the bioavailability of stable crystal polymorphs of a compound |
| WO1999013864A2 (en) * | 1997-09-19 | 1999-03-25 | Shire Laboratories, Inc. | Solid solution beadlet |
| DK1227797T3 (da) * | 1999-11-12 | 2005-05-30 | Abbott Lab | Farmaceutiske faststofdispersionsformuleringer |
| US6499984B1 (en) * | 2000-05-22 | 2002-12-31 | Warner-Lambert Company | Continuous production of pharmaceutical granulation |
-
2002
- 2002-04-29 HU HU0401238A patent/HU229938B1/hu not_active IP Right Cessation
- 2002-04-29 PT PT02748680T patent/PT1390063E/pt unknown
- 2002-04-29 ES ES02748680T patent/ES2231717T3/es not_active Expired - Lifetime
- 2002-04-29 PL PL02366998A patent/PL366998A1/xx unknown
- 2002-04-29 CN CNB028092953A patent/CN1255185C/zh not_active Expired - Fee Related
- 2002-04-29 GE GE5295A patent/GEP20053466B/en unknown
- 2002-04-29 UA UA20031210981A patent/UA76463C2/uk unknown
- 2002-04-29 SK SK1457-2003A patent/SK14572003A3/sk unknown
- 2002-04-29 NZ NZ528689A patent/NZ528689A/en unknown
- 2002-04-29 CA CA002444116A patent/CA2444116C/en not_active Expired - Fee Related
- 2002-04-29 RS YU83503A patent/RS83503A/sr unknown
- 2002-04-29 DE DE60201988T patent/DE60201988T2/de not_active Expired - Lifetime
- 2002-04-29 CZ CZ20033211A patent/CZ20033211A3/cs unknown
- 2002-04-29 HR HR20030873A patent/HRP20030873B1/xx not_active IP Right Cessation
- 2002-04-29 AT AT02748680T patent/ATE282428T1/de active
- 2002-04-29 JP JP2002586967A patent/JP4101661B2/ja not_active Expired - Fee Related
- 2002-04-29 IL IL15830602A patent/IL158306A0/xx unknown
- 2002-04-29 MX MXPA03009971A patent/MXPA03009971A/es active IP Right Grant
- 2002-04-29 EA EA200301166A patent/EA006627B1/ru not_active IP Right Cessation
- 2002-04-29 EP EP02748680A patent/EP1390063B1/en not_active Expired - Lifetime
- 2002-04-29 WO PCT/EP2002/004711 patent/WO2002089835A2/en not_active Ceased
- 2002-04-29 BR BR0209325-1A patent/BR0209325A/pt not_active Application Discontinuation
- 2002-04-29 KR KR1020037014234A patent/KR100554816B1/ko not_active Expired - Fee Related
- 2002-04-30 MY MYPI20021591A patent/MY128509A/en unknown
- 2002-04-30 TW TW091108967A patent/TWI234461B/zh not_active IP Right Cessation
- 2002-04-30 PA PA20028544501A patent/PA8544501A1/es unknown
- 2002-04-30 PE PE2002000369A patent/PE20021159A1/es not_active Application Discontinuation
- 2002-04-30 AR ARP020101580A patent/AR034320A1/es not_active Application Discontinuation
- 2002-05-01 JO JO200237A patent/JO2401B1/en active
- 2002-05-02 GT GT200200079A patent/GT200200079A/es unknown
- 2002-05-02 US US10/138,071 patent/US7014866B2/en not_active Expired - Fee Related
-
2003
- 2003-10-08 IL IL158306A patent/IL158306A/en not_active IP Right Cessation
- 2003-10-20 NO NO20034689A patent/NO20034689D0/no not_active Application Discontinuation
- 2003-10-30 IS IS7010A patent/IS7010A/is unknown
- 2003-10-31 EC EC2003004827A patent/ECSP034827A/es unknown
- 2003-11-03 MA MA27379A patent/MA27018A1/fr unknown
- 2003-11-03 BG BG108311A patent/BG108311A/bg unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HU229938B1 (en) | Pharmaceutical dosage form of amorphous nelfinavir mesylate | |
| Sutherland et al. | pfk13-independent treatment failure in four imported cases of Plasmodium falciparum malaria treated with artemether-lumefantrine in the United Kingdom | |
| TW580397B (en) | Solid preparation | |
| Lithgow et al. | The protein import receptor of mitochondria | |
| Damaso | Revisiting Jenner's mysteries, the role of the Beaugency lymph in the evolutionary path of ancient smallpox vaccines | |
| US7510728B2 (en) | Solid preparations | |
| HUE025013T2 (hu) | Szulfonamid-származékok | |
| Takata et al. | Roles of microglia in Alzheimer’s disease and impact of new findings on microglial heterogeneity as a target for therapeutic intervention | |
| Sandmeyer et al. | Ty3, a position‐specific retrotransposon in budding yeast | |
| US20200208142A1 (en) | Use of biological rna scaffolds with in vitro selection to generate robust small molecule binding aptamers for genetically encodable biosensors | |
| Hulpia et al. | Structure–Activity relationship exploration of 3′-deoxy-7-deazapurine nucleoside analogues as anti-Trypanosoma brucei agents | |
| Smirlis et al. | Selection of molecular targets for drug development against trypanosomatids | |
| BR0117147A (pt) | preparado de dosagem oral de desintegração instantánea | |
| SG11202110150YA (en) | Methods of treating negative symptoms of schizophrenia using deuterated dextromethorphan and quinidine | |
| Bankaitis et al. | HIV-related ototoxicity | |
| Stott et al. | Co-evolution and gene transfers drive speciation patterns in host-associated bacteria | |
| Salazar et al. | Effect of convalescent plasma on mortality in patients with COVID-19 pneumonia | |
| Lee et al. | Complete AV block in vaccinated COVID‐19 patient | |
| Donepudi et al. | Severe Bradycardia Leading to Hemodynamic Instability Associated with Remdesivir Use in a Patient with COVID‐19 Pneumonia | |
| Heller et al. | Generics: need for clinical concern? | |
| Smith et al. | Nebulized pentamidine for the prevention of Pneumocystis carinii pneumonia in AIDS patients: experience of 173 patients and a review of the literature | |
| Silva et al. | Implementation of pharmaceutical care: Important aspects for a lasting service | |
| Liu et al. | The natural history of retroviruses: exogenization vs endogenization | |
| SOMALA et al. | A Review on Utilisation of Remdesivir in TreatingCovid–19: Therapeutic Repurposing and Unmet Clinical Needs | |
| Hammen | Transmitting diseases by endogenization of ‘foreign’immune functional units IFUs spilled over from species with highly similar immune systems |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |