HU185009B - Process for preparing trans-2-substituted-5-aryl-2,3,4,4a,5,9b,- hexahydro-1h-pyrido/4,3-b/ indole derivatives - Google Patents

Process for preparing trans-2-substituted-5-aryl-2,3,4,4a,5,9b,- hexahydro-1h-pyrido/4,3-b/ indole derivatives Download PDF

Info

Publication number
HU185009B
HU185009B HU78PI626A HUPI000626A HU185009B HU 185009 B HU185009 B HU 185009B HU 78PI626 A HU78PI626 A HU 78PI626A HU PI000626 A HUPI000626 A HU PI000626A HU 185009 B HU185009 B HU 185009B
Authority
HU
Hungary
Prior art keywords
fluorophenyl
hexahydro
trans
carboline
hydrogen
Prior art date
Application number
HU78PI626A
Other languages
German (de)
English (en)
Hungarian (hu)
Inventor
Welch Williard M Ifj
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of HU185009B publication Critical patent/HU185009B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU78PI626A 1977-05-23 1978-05-18 Process for preparing trans-2-substituted-5-aryl-2,3,4,4a,5,9b,- hexahydro-1h-pyrido/4,3-b/ indole derivatives HU185009B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79939277A 1977-05-23 1977-05-23

Publications (1)

Publication Number Publication Date
HU185009B true HU185009B (en) 1984-11-28

Family

ID=25175793

Family Applications (3)

Application Number Title Priority Date Filing Date
HU822639A HU187782B (en) 1977-05-23 1978-05-18 Process for preparing trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1h-pyrido-/4,3-b/indole derivatives
HU822638A HU188802B (en) 1977-05-23 1978-05-18 Process for preparing trans-2-substituted-5-aryl-2,3,4, 4a,5,9b-hexahydro-1h-pyrido/4,3-b/indole derivatives
HU78PI626A HU185009B (en) 1977-05-23 1978-05-18 Process for preparing trans-2-substituted-5-aryl-2,3,4,4a,5,9b,- hexahydro-1h-pyrido/4,3-b/ indole derivatives

Family Applications Before (2)

Application Number Title Priority Date Filing Date
HU822639A HU187782B (en) 1977-05-23 1978-05-18 Process for preparing trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1h-pyrido-/4,3-b/indole derivatives
HU822638A HU188802B (en) 1977-05-23 1978-05-18 Process for preparing trans-2-substituted-5-aryl-2,3,4, 4a,5,9b-hexahydro-1h-pyrido/4,3-b/indole derivatives

Country Status (31)

Country Link
JP (1) JPS53144600A (it)
AR (2) AR217688A1 (it)
AT (1) AT368995B (it)
AU (1) AU499618B1 (it)
BE (1) BE867249A (it)
CA (1) CA1094071A (it)
CH (1) CH634321A5 (it)
CS (1) CS207612B2 (it)
DD (4) DD145536A5 (it)
DE (1) DE2822465C2 (it)
DK (1) DK226678A (it)
EG (1) EG13590A (it)
FI (1) FI63402C (it)
FR (1) FR2392023A1 (it)
GB (1) GB1586655A (it)
GR (1) GR69985B (it)
HU (3) HU187782B (it)
IE (1) IE46975B1 (it)
IL (1) IL54755A (it)
IT (1) IT1096307B (it)
LU (1) LU79684A1 (it)
NL (1) NL7804210A (it)
NO (2) NO150204C (it)
NZ (1) NZ187333A (it)
PH (1) PH13756A (it)
PL (5) PL117107B1 (it)
PT (1) PT68058B (it)
SE (2) SE441448B (it)
SU (4) SU873883A3 (it)
YU (4) YU91478A (it)
ZA (1) ZA782918B (it)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4224329A (en) * 1979-01-23 1980-09-23 Pfizer Inc. 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles
US4451655A (en) * 1982-05-17 1984-05-29 Pfizer Inc. Process for preparing carboline derivatives and compounds used in their preparation
RU2106864C1 (ru) * 1995-10-23 1998-03-20 Николай Серафимович Зефиров Средство для лечения болезни альцгеймера
SE9604786D0 (sv) * 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
US6974825B1 (en) 1996-12-20 2005-12-13 Astrazeneca Canada Inc. Compounds with analgesic effect
SE9904675D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0101773D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101769D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101771D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101770D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
DE20204239U1 (de) 2002-03-16 2002-05-29 Funke Kunststoffe GmbH, 48324 Sendenhorst Universal-Rohrdichtung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR205452A1 (es) * 1973-12-06 1976-05-07 Endo Lab Metodo para preparar nuevos trans-2, 3, 4, 4a, 5, 9b-hexahidro-5-fenil-1h-pirido(4,3-b) indoles
JPS50126699A (it) * 1974-03-20 1975-10-04
US4001263A (en) * 1974-04-01 1977-01-04 Pfizer Inc. 5-Aryl-1,2,3,4-tetrahydro-γ-carbolines

Also Published As

Publication number Publication date
JPS53144600A (en) 1978-12-15
YU221882A (en) 1983-01-21
NO151862C (no) 1985-06-19
NO151862B (no) 1985-03-11
DD145536A5 (de) 1980-12-17
BE867249A (fr) 1978-11-20
AT368995B (de) 1982-11-25
SE441448B (sv) 1985-10-07
DD145537A5 (de) 1980-12-17
CH634321A5 (en) 1983-01-31
SU873883A3 (ru) 1981-10-15
NO781770L (no) 1978-11-24
DE2822465C2 (de) 1986-08-28
IL54755A0 (en) 1978-07-31
PL114541B1 (en) 1981-02-28
SU843749A3 (ru) 1981-06-30
NO150204B (no) 1984-05-28
PH13756A (en) 1980-09-17
DE2822465A1 (de) 1978-11-30
NO150204C (no) 1984-09-05
PT68058B (en) 1979-10-24
DK226678A (da) 1978-11-24
YU91478A (en) 1983-01-21
AR221721A1 (es) 1981-03-13
PL117107B1 (en) 1981-07-31
PT68058A (en) 1978-06-01
SE8305917L (sv) 1983-10-27
GR69985B (it) 1982-07-22
NO831790L (no) 1978-11-24
FI63402C (fi) 1983-06-10
SE448459B (sv) 1987-02-23
IT1096307B (it) 1985-08-26
PL116944B1 (en) 1981-07-31
HU188802B (en) 1986-05-28
JPS5711912B2 (it) 1982-03-08
SU818484A3 (ru) 1981-03-30
PL206903A1 (pl) 1979-10-22
SE7803625L (sv) 1978-11-24
NL7804210A (nl) 1978-11-27
CS207612B2 (en) 1981-08-31
IE46975B1 (en) 1983-11-16
AU499618B1 (en) 1979-04-26
ATA369678A (de) 1982-04-15
DD138321A5 (de) 1979-10-24
FI63402B (fi) 1983-02-28
YU40796B (en) 1986-06-30
CA1094071A (en) 1981-01-20
NZ187333A (en) 1984-05-31
PL114547B1 (en) 1981-02-28
IE781013L (en) 1978-11-23
YU221782A (en) 1983-01-21
FI781612A (fi) 1978-11-24
FR2392023B1 (it) 1980-11-07
AR217688A1 (es) 1980-04-15
EG13590A (en) 1982-03-31
SE8305917D0 (sv) 1983-10-27
SU841589A3 (ru) 1981-06-23
GB1586655A (en) 1981-03-25
FR2392023A1 (fr) 1978-12-22
ZA782918B (en) 1979-06-27
DD146186A5 (de) 1981-01-28
LU79684A1 (fr) 1979-12-06
YU221682A (en) 1983-01-21
IT7823673A0 (it) 1978-05-22
HU187782B (en) 1986-02-28
IL54755A (en) 1981-02-27

Similar Documents

Publication Publication Date Title
US4929734A (en) Tetrahydropyridine oxime compounds
US5100902A (en) 1,2-benzisoxazole compounds
US4500525A (en) Pharmacologically active pyrazolo/4,3-c/pyridines
US5294619A (en) Arylpiperidine derivatives
EP0291673B1 (en) Tetrahydropyridine oximes, a process for their preparation and use thereof as cholinergic agents
NO173824B (no) Analogifremgangsmaate ved fremstilling av immunomodulerende azaspiraner
JPH04230362A (ja) 新規なピペリジン、テトラヒドロピリジンおよびピロリジン誘導体およびこれらを含有する製薬組成物
NO744397L (it)
JPH0680054B2 (ja) ピペリジン誘導体
HU185009B (en) Process for preparing trans-2-substituted-5-aryl-2,3,4,4a,5,9b,- hexahydro-1h-pyrido/4,3-b/ indole derivatives
JPS60258162A (ja) ６‐酸素化‐１，３，４，５‐テトラヒドロベンズ［ｃｄ］インドール‐４‐アミン
US4306067A (en) Precursors of phenyl-quinolizidines
JP3872821B2 (ja) 新規な置換テトラヒドロピリジン化合物、それらの調製方法及びそれらを含有する医薬組成物
FI82054C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara furo/3,2-c/pyridiner.
DE1695228C2 (de) 5-Hydroxy-5-phenyl-2,3-dihydro-5H-imidazo-[2,1-a]isoindole, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE2817661A1 (de) Neue isoindolinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
EP0233483A2 (de) Pyrrolo[1,2-a][4,1]benzoxazepine, Verfahren zur ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen, sowie therapeutische Verwendung
US3985751A (en) Benzocycloheptaisoquinoline derivatives
NO151861B (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive 5-substituert-10,11-dihydro-5h-dibenzo-(a,d)-cyclohepten-5,10-iminer
DE2514084A1 (de) Neue indolverbindungen
US5073561A (en) Methods of treating depression and psychoses
EP0033797A1 (en) 1-Hydroxyalkanamine tetrahydrocarbazoles, their preparation, pharmaceutical compositions containing same and their preparation, intermediates therefor and their preparation
DE2854014A1 (de) 7,8,9,10-tetrahydrothieno eckige klammer auf 3,2-e eckige klammer zu pyrido eckige klammer auf 4,3-b eckige klammer zu indole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
AT375079B (de) Verfahren zur herstellung von neuen trans-2,3,4,4a ,5,9b-hexahydro-1h-pyrido(4,3-b)indolen und ihren pharmazeutisch annehmbaren salzen
DE69612413T2 (de) 1-(Hetero)Arylvinyl-5H-2,3-benzodiazepinderivative verwendbar zur Behandlung von Erkrankungen des Zentralnervensystems, sowie Benzopyrylium Intermediate zu ihrer Herstellung